JP2010535495A5 - - Google Patents
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- JP2010535495A5 JP2010535495A5 JP2010519544A JP2010519544A JP2010535495A5 JP 2010535495 A5 JP2010535495 A5 JP 2010535495A5 JP 2010519544 A JP2010519544 A JP 2010519544A JP 2010519544 A JP2010519544 A JP 2010519544A JP 2010535495 A5 JP2010535495 A5 JP 2010535495A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- vsv
- compounds according
- lentiviral vector
- envelope protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 62
- 239000013598 vector Substances 0.000 claims 40
- 101710091045 Envelope protein Proteins 0.000 claims 23
- 102100034349 Integrase Human genes 0.000 claims 23
- 101710188315 Protein X Proteins 0.000 claims 23
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 19
- 241000725303 Human immunodeficiency virus Species 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 241000700605 Viruses Species 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 14
- 241001430294 unidentified retrovirus Species 0.000 claims 12
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 11
- 101710177291 Gag polyprotein Proteins 0.000 claims 10
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 208000015181 infectious disease Diseases 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102100034347 Integrase Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000013612 plasmid Substances 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 230000028993 immune response Effects 0.000 claims 6
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 5
- 206010061598 Immunodeficiency Diseases 0.000 claims 5
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 5
- 230000007813 immunodeficiency Effects 0.000 claims 5
- 230000037452 priming Effects 0.000 claims 5
- 208000031886 HIV Infections Diseases 0.000 claims 4
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 4
- 230000000798 anti-retroviral effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 101710170658 Endogenous retrovirus group K member 10 Gag polyprotein Proteins 0.000 claims 3
- 101710186314 Endogenous retrovirus group K member 21 Gag polyprotein Proteins 0.000 claims 3
- 101710162093 Endogenous retrovirus group K member 24 Gag polyprotein Proteins 0.000 claims 3
- 101710094596 Endogenous retrovirus group K member 8 Gag polyprotein Proteins 0.000 claims 3
- 101710177443 Endogenous retrovirus group K member 9 Gag polyprotein Proteins 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 3
- 102000030782 GTP binding Human genes 0.000 claims 3
- 108091000058 GTP-Binding Proteins 0.000 claims 3
- 101710203526 Integrase Proteins 0.000 claims 3
- 230000005867 T cell response Effects 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 230000001177 retroviral effect Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 108010061833 Integrases Proteins 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 241000712464 Orthomyxoviridae Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 241000710924 Togaviridae Species 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 108060003393 Granulin Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 108010076039 Polyproteins Proteins 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000712907 Retroviridae Species 0.000 claims 1
- 241000711931 Rhabdoviridae Species 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 206010058874 Viraemia Diseases 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940124522 antiretrovirals Drugs 0.000 claims 1
- 239000003903 antiretrovirus agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000007969 cellular immunity Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 210000005220 cytoplasmic tail Anatomy 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 108010089520 pol Gene Products Proteins 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- FLNVBBPBGKOJHN-KKAOYSRWSA-N sivmac Chemical compound O=C([C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O FLNVBBPBGKOJHN-KKAOYSRWSA-N 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290979 | 2007-08-03 | ||
| EP07290979.9 | 2007-08-03 | ||
| EP07290980.7 | 2007-08-03 | ||
| EP07290980.7A EP2020444B1 (en) | 2007-08-03 | 2007-08-03 | Defective non-integrative lentiviral transfer vectors for vaccines |
| EP07291251.2 | 2007-10-12 | ||
| EP07291251.2A EP2047861B1 (en) | 2007-10-12 | 2007-10-12 | Lentiviral gene transfer vectors suitable for iterative administration and their medicinal applications |
| EP08156405.6 | 2008-05-16 | ||
| EP08156405 | 2008-05-16 | ||
| PCT/IB2008/002930 WO2009019612A2 (en) | 2007-08-03 | 2008-08-01 | Lentiviral gene transfer vectors and their medicinal applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237117A Division JP2015062425A (ja) | 2007-08-03 | 2014-11-21 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535495A JP2010535495A (ja) | 2010-11-25 |
| JP2010535495A5 true JP2010535495A5 (enExample) | 2011-09-15 |
| JP5773648B2 JP5773648B2 (ja) | 2015-09-02 |
Family
ID=40341833
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519544A Active JP5773648B2 (ja) | 2007-08-03 | 2008-08-01 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
| JP2014237117A Pending JP2015062425A (ja) | 2007-08-03 | 2014-11-21 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
| JP2018000479A Active JP6480028B2 (ja) | 2007-08-03 | 2018-01-05 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237117A Pending JP2015062425A (ja) | 2007-08-03 | 2014-11-21 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
| JP2018000479A Active JP6480028B2 (ja) | 2007-08-03 | 2018-01-05 | レンチウイルス遺伝子導入ベクター及びそれらの医薬品への適用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8420104B2 (enExample) |
| EP (1) | EP2185192B1 (enExample) |
| JP (3) | JP5773648B2 (enExample) |
| CN (2) | CN108114276A (enExample) |
| AU (1) | AU2008285224B2 (enExample) |
| BR (1) | BRPI0813194B8 (enExample) |
| CA (1) | CA2695433C (enExample) |
| DK (1) | DK2185192T3 (enExample) |
| ES (1) | ES2708856T3 (enExample) |
| HK (1) | HK1252608A1 (enExample) |
| IL (1) | IL243569A (enExample) |
| MX (2) | MX342449B (enExample) |
| PT (1) | PT2185192T (enExample) |
| WO (1) | WO2009019612A2 (enExample) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
| WO2009019612A2 (en) | 2007-08-03 | 2009-02-12 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
| EP2427577A4 (en) | 2009-05-04 | 2013-10-23 | Hutchinson Fred Cancer Res | PSEUDOTYPED RETROVIRAL VECTORS WITH COCAL VESICULOVIRUS SHELL |
| EP2366776A1 (en) * | 2010-03-01 | 2011-09-21 | Epixis | A method for measuring viral infectivity |
| EP2385107B1 (en) | 2010-05-03 | 2016-08-24 | Institut Pasteur | Lentiviral vector based immunological compounds against malaria |
| EP2666477A1 (en) | 2012-05-23 | 2013-11-27 | Theravectys | Lentiviral vectors containing an MHC class I promoter |
| WO2011147622A1 (en) | 2010-05-26 | 2011-12-01 | Deutsches Rheuma-Forschungszentrum Berlin | Antigen-presenting modified naïve b cells for immune suppression and a method for producing said modified cells |
| CN102277380B (zh) * | 2010-06-08 | 2013-03-27 | 齐鲁制药有限公司 | 一种dhfr互补表达的共转染真核表达载体及其制备方法与应用 |
| KR20130036354A (ko) | 2010-06-25 | 2013-04-11 | 오말코 네트워크 솔루션스 리미티드 | 연성 기판에 대한 보안 개선 |
| WO2012069657A1 (en) | 2010-11-26 | 2012-05-31 | Institut Pasteur | Identification of a human gyrovirus and applications. |
| WO2012141984A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| EP2788477A2 (en) | 2011-12-07 | 2014-10-15 | Institut Pasteur | Identification of a swine parecho-like virus and applications |
| GB201202516D0 (en) | 2012-02-13 | 2012-03-28 | Ucl Business Plc | Materials and methods relating to packaging cell lines |
| WO2013140169A1 (en) * | 2012-03-20 | 2013-09-26 | Isis Innovation Limited | Immunogenic composition and methods of use thereof |
| EP2831095B1 (en) | 2012-03-30 | 2018-11-28 | Immune Design Corp. | Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign |
| US9713635B2 (en) | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| WO2014016383A2 (en) | 2012-07-25 | 2014-01-30 | Theravectys | Glycoproteins for pseudotyping lentivectors |
| FR2996856B1 (fr) * | 2012-10-15 | 2015-06-05 | Agronomique Inst Nat Rech | Novirhabdovirus recombinant utilisable comme vecteur d'antigenes |
| EP2931903B1 (en) | 2012-12-14 | 2021-07-28 | The Regents of the University of California | Viral vector nanocapsule for targeting gene therapy and its preparation |
| JP2016520316A (ja) * | 2013-06-03 | 2016-07-14 | テラベクティ | ＭＨＣクラスＩ、ＭＨＣクラスＩＩまたはβ２ミクログロブリン上流プロモーター配列を含有するレンチウイルスベクター |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| EP3009144A1 (en) * | 2014-10-15 | 2016-04-20 | Theravectys | Lentiviral vectors for inducing CD4+ and CD8+ immune responses in vaccination of humans |
| WO2015063707A1 (en) * | 2013-10-31 | 2015-05-07 | Theravectys | LENTIVIRAL VECTORS FOR INDUCING CD4+ and CD8+ IMMUNE RESPONSES IN VACCINATION OF HUMANS |
| EP2878674A1 (en) * | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| EP2878667A1 (en) | 2013-11-29 | 2015-06-03 | Institut Pasteur | TAL effector means useful for partial or full deletion of DNA tandem repeats |
| BR112016017242A2 (pt) * | 2014-01-27 | 2017-10-03 | Theravectys | Vetores lentivirais para gerar respostas imunes contra o vírus linfotrópico-t humano do tipo 1 |
| KR102416194B1 (ko) * | 2014-03-01 | 2022-07-04 | 프로펙츄스 바이오사이언스, 인크. | 재조합 이스파한 바이러스 벡터 |
| WO2016037163A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses |
| EP3031923A1 (en) | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| EP3211003A1 (en) | 2016-02-24 | 2017-08-30 | Institut Pasteur | T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US11185555B2 (en) | 2016-04-11 | 2021-11-30 | Noah James Harrison | Method to kill pathogenic microbes in a patient |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| EP3235828A1 (en) * | 2016-04-21 | 2017-10-25 | Genethon | Stable pseudotyped lentiviral particles and uses thereof |
| EP3455239B1 (fr) * | 2016-05-13 | 2021-04-07 | Flash Therapeutics | Particule pour l'encapsidation d'un système d'ingénierie du génome |
| CN106399376A (zh) * | 2016-08-31 | 2017-02-15 | 河南省华隆生物技术有限公司 | 一种整合缺陷型慢病毒载体、其制备方法及应用 |
| KR20190104194A (ko) | 2017-01-07 | 2019-09-06 | 셀렉타 바이오사이언시즈, 인크. | 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여 |
| WO2018140946A1 (en) | 2017-01-30 | 2018-08-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant virus vectors for the treatment of glycogen storage disease |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| BR112019019813A2 (pt) | 2017-03-30 | 2020-04-22 | Univ Queensland | moléculas quiméricas e usos das mesmas |
| FR3065967B1 (fr) * | 2017-05-05 | 2022-06-03 | Univ Paris Descartes | Procede in vitro de detection et de quantification de l'adn du vih-2 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP4400174A3 (en) | 2017-09-01 | 2024-10-23 | The Francis Crick Institute Limited | Immunoregulatory molecules and uses therefor |
| SI3684786T1 (sl) * | 2017-09-22 | 2025-03-31 | Centre National De La Recherche Scientifique (Cnrs) | Mutirani glikoprotein virusa vezikularnega stomatitisa |
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| JP6994714B2 (ja) | 2017-10-03 | 2022-01-14 | 東亞合成株式会社 | 抗ウイルス性ペプチドおよびその利用 |
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| CN111225682A (zh) * | 2017-10-20 | 2020-06-02 | 吉尼松公司 | 合胞素用于将药物和基因靶向递送至肺组织的用途 |
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