JP2011507536A5 - - Google Patents
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- Publication number
- JP2011507536A5 JP2011507536A5 JP2010540060A JP2010540060A JP2011507536A5 JP 2011507536 A5 JP2011507536 A5 JP 2011507536A5 JP 2010540060 A JP2010540060 A JP 2010540060A JP 2010540060 A JP2010540060 A JP 2010540060A JP 2011507536 A5 JP2011507536 A5 JP 2011507536A5
- Authority
- JP
- Japan
- Prior art keywords
- arenavirus
- antigen
- rna
- foreign nucleic
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712891 Arenavirus Species 0.000 claims 24
- 239000002245 particle Substances 0.000 claims 15
- 102000003886 Glycoproteins Human genes 0.000 claims 10
- 108090000288 Glycoproteins Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 108700026244 Open Reading Frames Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 230000003612 virological effect Effects 0.000 claims 5
- 230000002458 infectious effect Effects 0.000 claims 4
- 239000004055 small Interfering RNA Substances 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- 108010061100 Nucleoproteins Proteins 0.000 claims 2
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000024556 Mendelian disease Diseases 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000017143 RNA Polymerase I Human genes 0.000 claims 1
- 108010013845 RNA Polymerase I Proteins 0.000 claims 1
- 102000009572 RNA Polymerase II Human genes 0.000 claims 1
- 108010009460 RNA Polymerase II Proteins 0.000 claims 1
- 102000014450 RNA Polymerase III Human genes 0.000 claims 1
- 108010078067 RNA Polymerase III Proteins 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 201000006152 substance dependence Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07025099.8 | 2007-12-27 | ||
| EP07025099 | 2007-12-27 | ||
| PCT/EP2008/010994 WO2009083210A1 (en) | 2007-12-27 | 2008-12-22 | Replication-defective arenavirus vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014151617A Division JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507536A JP2011507536A (ja) | 2011-03-10 |
| JP2011507536A5 true JP2011507536A5 (enExample) | 2013-02-21 |
| JP5642556B2 JP5642556B2 (ja) | 2014-12-17 |
Family
ID=40428182
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540060A Active JP5642556B2 (ja) | 2007-12-27 | 2008-12-22 | 複製欠損アレナウイルスベクター |
| JP2014151617A Pending JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
| JP2016216877A Active JP6227094B2 (ja) | 2007-12-27 | 2016-11-07 | 複製欠損アレナウイルスベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014151617A Pending JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
| JP2016216877A Active JP6227094B2 (ja) | 2007-12-27 | 2016-11-07 | 複製欠損アレナウイルスベクター |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US8592205B2 (enExample) |
| EP (3) | EP4186978A1 (enExample) |
| JP (3) | JP5642556B2 (enExample) |
| CN (3) | CN103993012B (enExample) |
| CA (1) | CA2744910C (enExample) |
| DK (2) | DK2604695T3 (enExample) |
| ES (2) | ES2438773T3 (enExample) |
| FI (1) | FI2604695T3 (enExample) |
| HR (1) | HRP20221475T3 (enExample) |
| HU (1) | HUE061060T2 (enExample) |
| LT (1) | LT2604695T (enExample) |
| PL (2) | PL2604695T3 (enExample) |
| PT (1) | PT2604695T (enExample) |
| SI (1) | SI2604695T1 (enExample) |
| WO (1) | WO2009083210A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2604695T3 (pl) | 2007-12-27 | 2023-04-11 | Universität Zürich | Cząstka arenawirusa z defektem replikacji |
| EP2478103A4 (en) * | 2009-09-16 | 2014-02-19 | Univ Tulane | LASSAVIRUS-like PARTICLES AND METHOD FOR THE PRODUCTION THEREOF |
| CN103068835A (zh) * | 2010-06-06 | 2013-04-24 | 西奈山医学院 | 重组rna 病毒及其用途 |
| WO2012162428A1 (en) | 2011-05-23 | 2012-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prime-boost vaccination for viral infection |
| CN103687625B (zh) * | 2011-07-11 | 2017-06-13 | 艾诺奥医药品有限公司 | 交叉保护性沙粒病毒疫苗及其使用方法 |
| CN105473604B (zh) | 2013-03-13 | 2021-01-22 | 美国政府(由卫生和人类服务部的部长所代表) | 融合前rsv f蛋白和其用途 |
| ES2751423T3 (es) | 2013-03-15 | 2020-03-31 | Univ Geneve | Vacunas antimicobacterianas |
| DK3077519T3 (en) * | 2013-12-03 | 2021-06-14 | Hookipa Biotech Gmbh | Cmv-vacciner |
| WO2015123592A2 (en) | 2014-02-13 | 2015-08-20 | Synthetic Genomics, Inc. | Recombinant rna particles and methods of use |
| US10836998B2 (en) | 2014-02-14 | 2020-11-17 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| BR112017005744B1 (pt) | 2014-09-22 | 2023-11-28 | Regents Of The University Of Minnesota | "vírus pichinde geneticamente manipulado, método de fabricação e uso do mesmo, partícula viral infecciosa, composição, coleção de vetores, sistema de genética reversa e método de uso do mesmo" |
| HUE051390T2 (hu) | 2014-11-13 | 2021-03-01 | Univ Geneve | Háromszegmensû arenavírusok mint vakcinavektorok |
| DE102015207036A1 (de) | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
| HK1246183A1 (zh) * | 2015-06-10 | 2018-09-07 | Hookipa Biotech Gmbh | Hpv疫苗 |
| WO2018045029A1 (en) * | 2016-09-02 | 2018-03-08 | The United States Of America, As Represented By The Secretary Of The Army | Pan south american arenavirus live attenuated vaccine |
| CN115948467A (zh) | 2015-11-04 | 2023-04-11 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
| CA3003548A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
| US11260090B2 (en) * | 2016-03-08 | 2022-03-01 | University Of Vermont And State Agricultural College | Modified arenavirus |
| IL314272A (en) * | 2016-05-18 | 2024-09-01 | Hookipa Biotech Gmbh | Three-segmented PICHINDE viruses as vaccine vectors |
| JP2019533690A (ja) | 2016-11-04 | 2019-11-21 | ホオキパ バイオテック ジーエムビーエイチ | 癌ワクチンとしての複製欠損性アレナウイルス粒子及び３セグメント型アレナウイルス粒子 |
| EP3554538A2 (en) | 2016-12-16 | 2019-10-23 | Institute for Research in Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| AU2018247958A1 (en) * | 2017-04-07 | 2019-10-10 | Hookipa Biotech Gmbh | Arenavirus particles to treat solid tumors |
| DE102018215551A1 (de) | 2018-09-12 | 2020-03-12 | Virolutions Biotech Gmbh | Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten |
| AU2020297011A1 (en) | 2019-06-18 | 2022-02-10 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis B virus (HBV) vaccines and uses thereof |
| CA3145791A1 (en) | 2019-07-16 | 2021-01-21 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| EP4045672A4 (en) * | 2019-10-18 | 2023-11-22 | University of Virginia Patent Foundation | COMPOSITIONS AND METHODS FOR PRODUCING ENHANCED IMMUNE RESPONSES AND RAPID ANTIBODY PRODUCTION |
| US20220380805A1 (en) | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| KR20230131481A (ko) | 2021-01-14 | 2023-09-13 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신 및 이의 사용 방법 |
| BR112023019365A2 (pt) | 2021-03-23 | 2023-12-26 | Hookipa Biotech Gmbh | Segmento s de arenavírus, cdna, vetor de expressão de dna, célula hospedeira, partícula de arenavírus trissegmentada, método para gerar uma partícula de arenavírus trissegmentada, composição farmacêutica, método para tratar câncer de próstata e kit |
| US20240229073A1 (en) | 2021-05-13 | 2024-07-11 | Hookipa Biotech Gmbh | Arenaviruses as vectors |
| JP2024540385A (ja) | 2021-11-08 | 2024-10-31 | ホオキパ バイオテック ジーエムビーエイチ | 変異型ｋｒａｓ、変異したがんドライバー遺伝子、または腫瘍関連抗原を発現する、がん免疫療法としての改変アレナウイルス粒子 |
| EP4475879A1 (en) | 2022-02-08 | 2024-12-18 | Hookipa Biotech GmbH | Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines |
| CN117343911A (zh) * | 2022-06-28 | 2024-01-05 | 中国科学院上海药物研究所 | 一种缺陷型丝状病毒的制备方法及其应用 |
| JP2025523043A (ja) | 2022-07-12 | 2025-07-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ免疫原性ポリペプチド及びワクチン、並びにその使用 |
| AU2024343172A1 (en) | 2023-09-15 | 2026-03-05 | Gilead Sciences, Inc. | Arenavirus formulations, methods and uses thereof |
| CN117264909B (zh) * | 2023-10-25 | 2024-11-26 | 深圳湾实验室 | 反式互补缺陷猴痘病毒及其应用 |
| WO2025191169A1 (en) | 2024-03-15 | 2025-09-18 | Hookipa Biotech Gmbh | Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US7267823B2 (en) | 1998-06-29 | 2007-09-11 | United States Of America As Represented By The Secretary Of The Army | Ebola peptides and immunogenic compositions containing same |
| DE19856463B4 (de) * | 1998-11-26 | 2006-02-02 | Heinrich-Pette-Institut | Retrovirale, mit LCMV pseudotypisierte Hybrid-Vektoren |
| JP2000279178A (ja) * | 1999-02-24 | 2000-10-10 | Japan Found Cancer Res | ウイルスベクター |
| AU2002331572A1 (en) | 2002-04-17 | 2003-11-03 | Astropower, Inc. | Maximum power sensor for photovoltaic system |
| US7135339B2 (en) * | 2003-11-20 | 2006-11-14 | University Of Iowa Research Foundation | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) |
| WO2005061534A2 (en) | 2003-12-23 | 2005-07-07 | Statens Serum Institut | Improved tuberculosis vaccines |
| EA012037B1 (ru) | 2004-11-16 | 2009-06-30 | Круселл Холланд Б.В. | Поливалентные вакцины, содержащие рекомбинантные вирусные векторы |
| DE102005006388A1 (de) | 2005-02-11 | 2006-08-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Replikationsdefiziente RNA-Viren als Impfstoffe |
| US20070005929A1 (en) * | 2005-06-30 | 2007-01-04 | Post Daniel J | Method, system, and article of manufacture for sector mapping in a flash device |
| PL2604695T3 (pl) * | 2007-12-27 | 2023-04-11 | Universität Zürich | Cząstka arenawirusa z defektem replikacji |
| EP2664680A1 (en) | 2011-01-07 | 2013-11-20 | Bioscience Slovakia | Antibody-based methods of diagnosing infections with lymphocytic choriomeningitis virus (LCMV) |
| ES2751423T3 (es) | 2013-03-15 | 2020-03-31 | Univ Geneve | Vacunas antimicobacterianas |
| DK3077519T3 (en) | 2013-12-03 | 2021-06-14 | Hookipa Biotech Gmbh | Cmv-vacciner |
| HUE051390T2 (hu) | 2014-11-13 | 2021-03-01 | Univ Geneve | Háromszegmensû arenavírusok mint vakcinavektorok |
| HK1246183A1 (zh) | 2015-06-10 | 2018-09-07 | Hookipa Biotech Gmbh | Hpv疫苗 |
| CN115948467A (zh) | 2015-11-04 | 2023-04-11 | 霍欧奇帕生物科技有限公司 | 针对乙型肝炎病毒的疫苗 |
| CA3003548A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
| IL314272A (en) | 2016-05-18 | 2024-09-01 | Hookipa Biotech Gmbh | Three-segmented PICHINDE viruses as vaccine vectors |
| JP2019533690A (ja) | 2016-11-04 | 2019-11-21 | ホオキパ バイオテック ジーエムビーエイチ | 癌ワクチンとしての複製欠損性アレナウイルス粒子及び３セグメント型アレナウイルス粒子 |
| AU2018247958A1 (en) | 2017-04-07 | 2019-10-10 | Hookipa Biotech Gmbh | Arenavirus particles to treat solid tumors |
| US20220380805A1 (en) | 2019-11-07 | 2022-12-01 | Universität Basel | Arenaviruses as vectors |
| BR112022024404A2 (pt) | 2020-05-29 | 2023-02-07 | Hookipa Biotech Gmbh | Método para tratar câncer, sequência de nucleotídeos, célula hospedeira, partícula de lcmv, partícula de picv, composição farmacêutica, partícula de arenavírus |
| BR112023019365A2 (pt) | 2021-03-23 | 2023-12-26 | Hookipa Biotech Gmbh | Segmento s de arenavírus, cdna, vetor de expressão de dna, célula hospedeira, partícula de arenavírus trissegmentada, método para gerar uma partícula de arenavírus trissegmentada, composição farmacêutica, método para tratar câncer de próstata e kit |
-
2008
- 2008-12-22 PL PL13152727.7T patent/PL2604695T3/pl unknown
- 2008-12-22 EP EP22207314.0A patent/EP4186978A1/en active Pending
- 2008-12-22 US US12/810,382 patent/US8592205B2/en active Active
- 2008-12-22 WO PCT/EP2008/010994 patent/WO2009083210A1/en not_active Ceased
- 2008-12-22 EP EP13152727.7A patent/EP2604695B1/en active Active
- 2008-12-22 CN CN201410126161.5A patent/CN103993012B/zh active Active
- 2008-12-22 PL PL08868316T patent/PL2238255T3/pl unknown
- 2008-12-22 LT LTEP13152727.7T patent/LT2604695T/lt unknown
- 2008-12-22 CN CN2012104612347A patent/CN103255169A/zh active Pending
- 2008-12-22 DK DK13152727.7T patent/DK2604695T3/da active
- 2008-12-22 ES ES08868316.4T patent/ES2438773T3/es active Active
- 2008-12-22 EP EP08868316.4A patent/EP2238255B1/en active Active
- 2008-12-22 HU HUE13152727A patent/HUE061060T2/hu unknown
- 2008-12-22 SI SI200832203T patent/SI2604695T1/sl unknown
- 2008-12-22 JP JP2010540060A patent/JP5642556B2/ja active Active
- 2008-12-22 PT PT131527277T patent/PT2604695T/pt unknown
- 2008-12-22 HR HRP20221475TT patent/HRP20221475T3/hr unknown
- 2008-12-22 FI FIEP13152727.7T patent/FI2604695T3/fi active
- 2008-12-22 CA CA2744910A patent/CA2744910C/en active Active
- 2008-12-22 CN CN200880123157.6A patent/CN101918565B/zh active Active
- 2008-12-22 DK DK08868316.4T patent/DK2238255T3/da active
- 2008-12-22 ES ES13152727T patent/ES2937147T3/es active Active
-
2013
- 2013-10-23 US US14/061,025 patent/US9309289B2/en active Active
-
2014
- 2014-07-25 JP JP2014151617A patent/JP2014239688A/ja active Pending
-
2016
- 2016-03-14 US US15/069,773 patent/US9944952B2/en active Active
- 2016-11-07 JP JP2016216877A patent/JP6227094B2/ja active Active
-
2018
- 2018-03-21 US US15/928,003 patent/US10655145B2/en active Active
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2020
- 2020-04-29 US US16/861,758 patent/US11401528B2/en active Active
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2022
- 2022-06-22 US US17/846,817 patent/US12227755B2/en active Active
-
2025
- 2025-01-07 US US19/012,351 patent/US20250369015A1/en active Pending
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