JP2011507536A5 - - Google Patents
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- Publication number
- JP2011507536A5 JP2011507536A5 JP2010540060A JP2010540060A JP2011507536A5 JP 2011507536 A5 JP2011507536 A5 JP 2011507536A5 JP 2010540060 A JP2010540060 A JP 2010540060A JP 2010540060 A JP2010540060 A JP 2010540060A JP 2011507536 A5 JP2011507536 A5 JP 2011507536A5
- Authority
- JP
- Japan
- Prior art keywords
- arenavirus
- antigen
- rna
- foreign nucleic
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712891 Arenavirus Species 0.000 claims 24
- 239000002245 particle Substances 0.000 claims 15
- 102000003886 Glycoproteins Human genes 0.000 claims 10
- 108090000288 Glycoproteins Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 108700026244 Open Reading Frames Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 230000003612 virological effect Effects 0.000 claims 5
- 230000002458 infectious effect Effects 0.000 claims 4
- 239000004055 small Interfering RNA Substances 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 2
- 102000011931 Nucleoproteins Human genes 0.000 claims 2
- 108010061100 Nucleoproteins Proteins 0.000 claims 2
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 244000045947 parasite Species 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000024556 Mendelian disease Diseases 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000017143 RNA Polymerase I Human genes 0.000 claims 1
- 108010013845 RNA Polymerase I Proteins 0.000 claims 1
- 102000009572 RNA Polymerase II Human genes 0.000 claims 1
- 108010009460 RNA Polymerase II Proteins 0.000 claims 1
- 102000014450 RNA Polymerase III Human genes 0.000 claims 1
- 108010078067 RNA Polymerase III Proteins 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 201000006152 substance dependence Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07025099.8 | 2007-12-27 | ||
| EP07025099 | 2007-12-27 | ||
| PCT/EP2008/010994 WO2009083210A1 (en) | 2007-12-27 | 2008-12-22 | Replication-defective arenavirus vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014151617A Division JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507536A JP2011507536A (ja) | 2011-03-10 |
| JP2011507536A5 true JP2011507536A5 (enExample) | 2013-02-21 |
| JP5642556B2 JP5642556B2 (ja) | 2014-12-17 |
Family
ID=40428182
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540060A Active JP5642556B2 (ja) | 2007-12-27 | 2008-12-22 | 複製欠損アレナウイルスベクター |
| JP2014151617A Pending JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
| JP2016216877A Active JP6227094B2 (ja) | 2007-12-27 | 2016-11-07 | 複製欠損アレナウイルスベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014151617A Pending JP2014239688A (ja) | 2007-12-27 | 2014-07-25 | 複製欠損アレナウイルスベクター |
| JP2016216877A Active JP6227094B2 (ja) | 2007-12-27 | 2016-11-07 | 複製欠損アレナウイルスベクター |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US8592205B2 (enExample) |
| EP (3) | EP4186978A1 (enExample) |
| JP (3) | JP5642556B2 (enExample) |
| CN (3) | CN101918565B (enExample) |
| CA (1) | CA2744910C (enExample) |
| DK (2) | DK2238255T3 (enExample) |
| ES (2) | ES2937147T3 (enExample) |
| FI (1) | FI2604695T3 (enExample) |
| HR (1) | HRP20221475T3 (enExample) |
| HU (1) | HUE061060T2 (enExample) |
| LT (1) | LT2604695T (enExample) |
| PL (2) | PL2238255T3 (enExample) |
| PT (1) | PT2604695T (enExample) |
| SI (1) | SI2604695T1 (enExample) |
| WO (1) | WO2009083210A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4186978A1 (en) * | 2007-12-27 | 2023-05-31 | Universität Zürich | Replication-defective arenavirus vectors |
| WO2011034953A2 (en) * | 2009-09-16 | 2011-03-24 | The Administrators Of The Tulane Educational Fund | Lassa virus-like particles and methods of production thereof |
| CA2836977A1 (en) * | 2010-06-06 | 2011-12-15 | Benjamin R. Tenoever | Recombinant rna viruses and uses thereof |
| WO2012162428A1 (en) | 2011-05-23 | 2012-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prime-boost vaccination for viral infection |
| ES2758713T3 (es) * | 2011-07-11 | 2020-05-06 | Inovio Pharmaceuticals Inc | Vacuna de ADN contra el virus de Lassa |
| SMT202400297T1 (it) | 2013-03-13 | 2024-09-16 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Proteine f del rsv pre-fusione e loro uso |
| EP2968506B1 (en) | 2013-03-15 | 2019-07-31 | Université de Genève | Anti-mycobacterial vaccines |
| HRP20211015T1 (hr) | 2013-12-03 | 2021-10-01 | Hookipa Biotech Gmbh | Cjepivo protiv citomegalovirusa (cmv) |
| WO2015123592A2 (en) | 2014-02-13 | 2015-08-20 | Synthetic Genomics, Inc. | Recombinant rna particles and methods of use |
| JP6673838B2 (ja) | 2014-02-14 | 2020-04-01 | セレクティスＣｅｌｌｅｃｔｉｓ | 免疫細胞と病的細胞の両方に存在する抗原を標的とするように操作された、免疫療法のための細胞 |
| AU2015321557B2 (en) | 2014-09-22 | 2020-05-14 | Regents Of The University Of Minnesota | Pichinde virus reverse genetics system and methods of use |
| US10722564B2 (en) * | 2014-11-13 | 2020-07-28 | Université de Genéve | Tri-segmented arenaviruses as vaccine vectors |
| DE102015207036A1 (de) | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
| CN107921117B (zh) * | 2015-06-10 | 2022-06-07 | 霍欧奇帕生物科技有限公司 | Hpv疫苗 |
| WO2018045029A1 (en) * | 2016-09-02 | 2018-03-08 | The United States Of America, As Represented By The Secretary Of The Army | Pan south american arenavirus live attenuated vaccine |
| US11214598B2 (en) * | 2015-11-04 | 2022-01-04 | Hookipa Biotech Gmbh | Vaccines against hepatitis B virus |
| EP3960197A1 (en) * | 2015-11-12 | 2022-03-02 | Hookipa Biotech GmbH | Arenavirus particles as cancer vaccines |
| US11260090B2 (en) * | 2016-03-08 | 2022-03-01 | University Of Vermont And State Agricultural College | Modified arenavirus |
| CN117486979A (zh) * | 2016-05-18 | 2024-02-02 | 巴塞尔大学 | 作为疫苗载体的三区段pichinde病毒 |
| CA3039356A1 (en) | 2016-11-04 | 2018-05-11 | Hookipa Biotech Gmbh | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| CA3043790A1 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| CN110719788A (zh) | 2017-04-07 | 2020-01-21 | 霍欧奇帕生物科技有限公司 | 治疗实体瘤的沙粒病毒颗粒 |
| DE102018215551A1 (de) | 2018-09-12 | 2020-03-12 | Virolutions Biotech Gmbh | Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten |
| WO2020255023A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis b virus (hbv) vaccines and uses thereof |
| EP3999107A1 (en) | 2019-07-16 | 2022-05-25 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| EP4458975A3 (en) | 2019-09-30 | 2025-02-12 | Gilead Sciences, Inc. | Hbv vaccines and methods treating hbv |
| US20220362361A1 (en) * | 2019-10-18 | 2022-11-17 | University Of Virginia Patent Foundation | Compositions and methods for producing enhanced immune responses and rapid antibody production |
| EP4055173A1 (en) * | 2019-11-07 | 2022-09-14 | Universität Basel Vizerektorat Forschung | Arenaviruses as vectors |
| US12053517B2 (en) | 2021-01-14 | 2024-08-06 | Gilead Sciences, Inc. | HIV vaccines and methods of using |
| BR112023019365A2 (pt) | 2021-03-23 | 2023-12-26 | Hookipa Biotech Gmbh | Segmento s de arenavírus, cdna, vetor de expressão de dna, célula hospedeira, partícula de arenavírus trissegmentada, método para gerar uma partícula de arenavírus trissegmentada, composição farmacêutica, método para tratar câncer de próstata e kit |
| WO2022238546A1 (en) | 2021-05-13 | 2022-11-17 | Hookipa Biotech Gmbh | Arenaviruses as vectors |
| EP4429698A1 (en) | 2021-11-08 | 2024-09-18 | Hookipa Biotech GmbH | Modified arenavirus particles expressing mutant kras, mutated cancer driver gene, or tumor-associated antigen as cancer immunotherapies |
| WO2023152116A1 (en) | 2022-02-08 | 2023-08-17 | Hookipa Biotech Gmbh | Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines |
| CN117343911A (zh) * | 2022-06-28 | 2024-01-05 | 中国科学院上海药物研究所 | 一种缺陷型丝状病毒的制备方法及其应用 |
| CN119677546A (zh) | 2022-07-12 | 2025-03-21 | 吉利德科学公司 | Hiv免疫原性多肽和疫苗及其用途 |
| WO2025056782A1 (en) | 2023-09-15 | 2025-03-20 | Hookipa Biotech Gmbh | Arenavirus formulations, methods and uses thereof |
| CN117264909B (zh) * | 2023-10-25 | 2024-11-26 | 深圳湾实验室 | 反式互补缺陷猴痘病毒及其应用 |
| WO2025191169A1 (en) | 2024-03-15 | 2025-09-18 | Hookipa Biotech Gmbh | Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US7267823B2 (en) | 1998-06-29 | 2007-09-11 | United States Of America As Represented By The Secretary Of The Army | Ebola peptides and immunogenic compositions containing same |
| DE19856463B4 (de) * | 1998-11-26 | 2006-02-02 | Heinrich-Pette-Institut | Retrovirale, mit LCMV pseudotypisierte Hybrid-Vektoren |
| JP2000279178A (ja) * | 1999-02-24 | 2000-10-10 | Japan Found Cancer Res | ウイルスベクター |
| AU2002331572A1 (en) | 2002-04-17 | 2003-11-03 | Astropower, Inc. | Maximum power sensor for photovoltaic system |
| US7135339B2 (en) * | 2003-11-20 | 2006-11-14 | University Of Iowa Research Foundation | Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) |
| WO2005061534A2 (en) | 2003-12-23 | 2005-07-07 | Statens Serum Institut | Improved tuberculosis vaccines |
| NZ555907A (en) | 2004-11-16 | 2009-12-24 | Aeras Global Tb Vaccine Found | Multivalent vaccines comprising recombinant viral vectors |
| DE102005006388A1 (de) | 2005-02-11 | 2006-08-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Replikationsdefiziente RNA-Viren als Impfstoffe |
| US20070005929A1 (en) * | 2005-06-30 | 2007-01-04 | Post Daniel J | Method, system, and article of manufacture for sector mapping in a flash device |
| EP4186978A1 (en) | 2007-12-27 | 2023-05-31 | Universität Zürich | Replication-defective arenavirus vectors |
| AU2012204757A1 (en) | 2011-01-07 | 2013-05-02 | Bioscience Slovakia | Viral diagnostics |
| EP2968506B1 (en) | 2013-03-15 | 2019-07-31 | Université de Genève | Anti-mycobacterial vaccines |
| HRP20211015T1 (hr) | 2013-12-03 | 2021-10-01 | Hookipa Biotech Gmbh | Cjepivo protiv citomegalovirusa (cmv) |
| US10722564B2 (en) | 2014-11-13 | 2020-07-28 | Université de Genéve | Tri-segmented arenaviruses as vaccine vectors |
| CN107921117B (zh) | 2015-06-10 | 2022-06-07 | 霍欧奇帕生物科技有限公司 | Hpv疫苗 |
| US11214598B2 (en) | 2015-11-04 | 2022-01-04 | Hookipa Biotech Gmbh | Vaccines against hepatitis B virus |
| EP3960197A1 (en) | 2015-11-12 | 2022-03-02 | Hookipa Biotech GmbH | Arenavirus particles as cancer vaccines |
| CN117486979A (zh) | 2016-05-18 | 2024-02-02 | 巴塞尔大学 | 作为疫苗载体的三区段pichinde病毒 |
| CA3039356A1 (en) | 2016-11-04 | 2018-05-11 | Hookipa Biotech Gmbh | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
| CN110719788A (zh) | 2017-04-07 | 2020-01-21 | 霍欧奇帕生物科技有限公司 | 治疗实体瘤的沙粒病毒颗粒 |
| EP4055173A1 (en) | 2019-11-07 | 2022-09-14 | Universität Basel Vizerektorat Forschung | Arenaviruses as vectors |
| EP4157342A1 (en) | 2020-05-29 | 2023-04-05 | Hookipa Biotech GmbH | Cancer treatment strategies using arenavirus vectors |
| BR112023019365A2 (pt) | 2021-03-23 | 2023-12-26 | Hookipa Biotech Gmbh | Segmento s de arenavírus, cdna, vetor de expressão de dna, célula hospedeira, partícula de arenavírus trissegmentada, método para gerar uma partícula de arenavírus trissegmentada, composição farmacêutica, método para tratar câncer de próstata e kit |
-
2008
- 2008-12-22 EP EP22207314.0A patent/EP4186978A1/en active Pending
- 2008-12-22 CN CN200880123157.6A patent/CN101918565B/zh active Active
- 2008-12-22 WO PCT/EP2008/010994 patent/WO2009083210A1/en not_active Ceased
- 2008-12-22 CN CN2012104612347A patent/CN103255169A/zh active Pending
- 2008-12-22 EP EP08868316.4A patent/EP2238255B1/en active Active
- 2008-12-22 HU HUE13152727A patent/HUE061060T2/hu unknown
- 2008-12-22 CN CN201410126161.5A patent/CN103993012B/zh active Active
- 2008-12-22 FI FIEP13152727.7T patent/FI2604695T3/fi active
- 2008-12-22 PL PL08868316T patent/PL2238255T3/pl unknown
- 2008-12-22 DK DK08868316.4T patent/DK2238255T3/da active
- 2008-12-22 PL PL13152727.7T patent/PL2604695T3/pl unknown
- 2008-12-22 SI SI200832203T patent/SI2604695T1/sl unknown
- 2008-12-22 US US12/810,382 patent/US8592205B2/en active Active
- 2008-12-22 CA CA2744910A patent/CA2744910C/en active Active
- 2008-12-22 HR HRP20221475TT patent/HRP20221475T3/hr unknown
- 2008-12-22 LT LTEP13152727.7T patent/LT2604695T/lt unknown
- 2008-12-22 ES ES13152727T patent/ES2937147T3/es active Active
- 2008-12-22 PT PT131527277T patent/PT2604695T/pt unknown
- 2008-12-22 DK DK13152727.7T patent/DK2604695T3/da active
- 2008-12-22 EP EP13152727.7A patent/EP2604695B1/en active Active
- 2008-12-22 ES ES08868316.4T patent/ES2438773T3/es active Active
- 2008-12-22 JP JP2010540060A patent/JP5642556B2/ja active Active
-
2013
- 2013-10-23 US US14/061,025 patent/US9309289B2/en active Active
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2014
- 2014-07-25 JP JP2014151617A patent/JP2014239688A/ja active Pending
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2016
- 2016-03-14 US US15/069,773 patent/US9944952B2/en active Active
- 2016-11-07 JP JP2016216877A patent/JP6227094B2/ja active Active
-
2018
- 2018-03-21 US US15/928,003 patent/US10655145B2/en active Active
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2020
- 2020-04-29 US US16/861,758 patent/US11401528B2/en active Active
-
2022
- 2022-06-22 US US17/846,817 patent/US12227755B2/en active Active
-
2025
- 2025-01-07 US US19/012,351 patent/US20250369015A1/en active Pending
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