JP2017527557A5 - - Google Patents
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- JP2017527557A5 JP2017527557A5 JP2017510880A JP2017510880A JP2017527557A5 JP 2017527557 A5 JP2017527557 A5 JP 2017527557A5 JP 2017510880 A JP2017510880 A JP 2017510880A JP 2017510880 A JP2017510880 A JP 2017510880A JP 2017527557 A5 JP2017527557 A5 JP 2017527557A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- protein
- mva vector
- recombinant
- recombinant mva
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000013598 vector Substances 0.000 claims description 118
- 239000000203 mixture Substances 0.000 claims description 115
- 150000007523 nucleic acids Chemical class 0.000 claims description 61
- 108020004707 nucleic acids Proteins 0.000 claims description 59
- 102000039446 nucleic acids Human genes 0.000 claims description 59
- 230000000890 antigenic effect Effects 0.000 claims description 42
- 241001115402 Ebolavirus Species 0.000 claims description 34
- 101710094648 Coat protein Proteins 0.000 claims description 26
- 239000003937 drug carrier Substances 0.000 claims description 26
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 230000037452 priming Effects 0.000 claims description 19
- 229960005486 vaccine Drugs 0.000 claims description 19
- 108090000288 Glycoproteins Proteins 0.000 claims description 18
- 102000003886 Glycoproteins Human genes 0.000 claims description 18
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 241001115401 Marburgvirus Species 0.000 claims description 14
- 102000011931 Nucleoproteins Human genes 0.000 claims description 13
- 108010061100 Nucleoproteins Proteins 0.000 claims description 13
- 241001115376 Sudan ebolavirus Species 0.000 claims description 13
- 241001115400 Zaire ebolavirus Species 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 12
- 101710121417 Envelope glycoprotein Proteins 0.000 claims description 8
- 102100021696 Syncytin-1 Human genes 0.000 claims description 8
- 230000006806 disease prevention Effects 0.000 claims description 8
- 241001115394 Reston ebolavirus Species 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 6
- 108060004795 Methyltransferase Proteins 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 206010001197 Adenocarcinoma of the cervix Diseases 0.000 claims description 2
- 208000034246 Adenocarcinoma of the cervix uteri Diseases 0.000 claims description 2
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 2
- 241000287828 Gallus gallus Species 0.000 claims description 2
- 241000700618 Vaccinia virus Species 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 201000006662 cervical adenocarcinoma Diseases 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000002510 keratinocyte Anatomy 0.000 claims description 2
- 210000003292 kidney cell Anatomy 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 201000008968 osteosarcoma Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 241000711950 Filoviridae Species 0.000 description 84
- 238000000034 method Methods 0.000 description 54
- 102000036639 antigens Human genes 0.000 description 39
- 108091007433 antigens Proteins 0.000 description 39
- 230000028993 immune response Effects 0.000 description 23
- 108700010787 filovirus proteins Proteins 0.000 description 17
- 229940001442 combination vaccine Drugs 0.000 description 11
- 208000000666 Fowlpox Diseases 0.000 description 9
- 230000001681 protective effect Effects 0.000 description 8
- 230000001939 inductive effect Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 241000884921 Bundibugyo ebolavirus Species 0.000 description 2
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000007136 Filoviridae Infections Diseases 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045538P | 2014-09-03 | 2014-09-03 | |
| US62/045,538 | 2014-09-03 | ||
| US201462055154P | 2014-09-25 | 2014-09-25 | |
| US62/055,154 | 2014-09-25 | ||
| PCT/EP2015/070161 WO2016034678A2 (en) | 2014-09-03 | 2015-09-03 | Recombinant modified vaccinia virus ankara (mva) filovirus vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000975A Division JP7113924B2 (ja) | 2014-09-03 | 2021-01-06 | 組み換え改変ワクシニアウイルスアンカラ（ｍｖａ）フィロウイルスワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527557A JP2017527557A (ja) | 2017-09-21 |
| JP2017527557A5 true JP2017527557A5 (enExample) | 2018-10-11 |
| JP6823586B2 JP6823586B2 (ja) | 2021-02-03 |
Family
ID=54145734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510880A Active JP6823586B2 (ja) | 2014-09-03 | 2015-09-03 | 組み換え改変ワクシニアウイルスアンカラ（ｍｖａ）フィロウイルスワクチン |
| JP2021000975A Active JP7113924B2 (ja) | 2014-09-03 | 2021-01-06 | 組み換え改変ワクシニアウイルスアンカラ（ｍｖａ）フィロウイルスワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021000975A Active JP7113924B2 (ja) | 2014-09-03 | 2021-01-06 | 組み換え改変ワクシニアウイルスアンカラ（ｍｖａ）フィロウイルスワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10576141B2 (enExample) |
| EP (1) | EP3188752A2 (enExample) |
| JP (2) | JP6823586B2 (enExample) |
| KR (2) | KR102812180B1 (enExample) |
| CN (2) | CN112972668A (enExample) |
| AU (2) | AU2015310909B2 (enExample) |
| CA (1) | CA2959105C (enExample) |
| IL (2) | IL250552B (enExample) |
| MX (1) | MX2017002791A (enExample) |
| MY (1) | MY193417A (enExample) |
| SG (2) | SG10201901735XA (enExample) |
| UA (1) | UA126848C2 (enExample) |
| WO (1) | WO2016034678A2 (enExample) |
| ZA (1) | ZA201701077B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2747778B1 (en) | 2011-08-26 | 2017-12-06 | Wisconsin Alumni Research Foundation | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| BR112017009177A2 (pt) | 2014-11-04 | 2018-12-11 | Janssen Vaccines & Prevention B.V. | vacinas terapêuticas contra hpv16 |
| HK1247066A1 (zh) * | 2014-11-26 | 2018-09-21 | Neuravi Limited | 从血管除去阻塞性血栓的取血栓装置 |
| WO2016115116A1 (en) * | 2015-01-12 | 2016-07-21 | Geovax, Inc. | Compositions and methods for generating an immune response to a hemorrhagic fever virus |
| KR20170138996A (ko) * | 2015-02-25 | 2017-12-18 | 메모리얼 슬로안-케터링 캔서 센터 | 고형 종양을 위한 단일면역요법으로서 또는 면역 체크포인트 차단제와 조합된 불활성화 비복제성 변형 백시니아 바이러스 안카라의 용도 |
| DK3283508T3 (en) | 2015-04-17 | 2021-05-31 | Alpine Immune Sciences Inc | Immunomodulatory Proteins with Tunable Affinities |
| WO2017120577A1 (en) | 2016-01-08 | 2017-07-13 | Geovax Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| WO2017136419A1 (en) | 2016-02-03 | 2017-08-10 | Geovax Inc. | Compositions and methods for generating an immune response to a flavivirus |
| JP2019510481A (ja) | 2016-02-19 | 2019-04-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ワクチン開発のための改善されたｂ型インフルエンザウイルス複製 |
| EP3443000B1 (en) | 2016-04-15 | 2025-11-12 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| KR20250095754A (ko) | 2016-04-15 | 2025-06-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| EP3452087A1 (en) * | 2016-05-02 | 2019-03-13 | Janssen Vaccines & Prevention B.V. | Therapeutic hpv vaccine combinations |
| US10925956B2 (en) | 2016-07-15 | 2021-02-23 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| CN110352245A (zh) * | 2016-10-20 | 2019-10-18 | 高山免疫科学股份有限公司 | 可分泌变体免疫调节蛋白和工程化细胞疗法 |
| AU2018235835A1 (en) | 2017-03-16 | 2019-09-05 | Alpine Immune Sciences, Inc. | PD-L2 variant immunomodulatory proteins and uses thereof |
| JP7386083B2 (ja) | 2017-03-16 | 2023-11-24 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｄ８０バリアント免疫調節タンパク質及びその使用 |
| US11173204B2 (en) | 2017-04-06 | 2021-11-16 | Janssen Vaccines & Prevention B.V. | MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen |
| EP3624851A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| CN110769850A (zh) | 2017-05-15 | 2020-02-07 | 扬森疫苗与预防公司 | 稳定的含病毒组合物 |
| WO2019018501A1 (en) * | 2017-07-18 | 2019-01-24 | Geovax Inc. | COMPOSITIONS AND METHODS FOR GENERATING LASV IMMUNE RESPONSE |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| GB201716181D0 (en) * | 2017-10-04 | 2017-11-15 | Univ Cape Town | Recombinant mva with modified hiv-1 env |
| KR102758545B1 (ko) | 2017-10-10 | 2025-01-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| TW202500579A (zh) | 2017-10-18 | 2025-01-01 | 美商艾爾潘免疫科學有限公司 | 變異型icos 配位體免疫調節蛋白及相關組合物及方法 |
| EP3700562A1 (en) | 2017-10-25 | 2020-09-02 | Wisconsin Alumni Research Foundation (WARF) | Recombinant influenza viruses with stabilized ha for replication in eggs |
| SG11202006148UA (en) | 2018-01-03 | 2020-07-29 | Alpine Immune Sciences Inc | Multi-domain immunomodulatory proteins and methods of use thereof |
| JP7783047B2 (ja) * | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| WO2020065349A2 (en) * | 2018-09-28 | 2020-04-02 | The Chancellor, Masters And Scholars Of The University Of Cambridge | Vaccines and methods |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| CA3170701A1 (en) | 2020-03-12 | 2021-09-16 | Bavarian Norcig A/S | Compositions improving poxvirus stability |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN115819616B (zh) * | 2021-07-28 | 2025-04-11 | 江苏瑞科生物技术股份有限公司 | 一种基因重组vzv融合蛋白及其制备方法和应用 |
| EP4677076A1 (en) | 2023-03-10 | 2026-01-14 | Bavarian Nordic A/S | Methods of isolating poxviruses from avian cell cultures |
| WO2024188801A1 (en) | 2023-03-10 | 2024-09-19 | Bavarian Nordic A/S | Use of quail cell lines for poxvirus production |
| CN120731268A (zh) | 2023-03-10 | 2025-09-30 | 巴法里安诺迪克有限公司 | 从鹌鹑细胞培养物产生痘病毒 |
| CN120843742A (zh) * | 2025-09-09 | 2025-10-28 | 军事科学院军事医学研究院军事兽医研究所 | 一种泛哺乳动物丝状病毒检测用引物组及其检测试剂盒和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2776272C (en) * | 2001-10-01 | 2016-05-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of a preventive vaccine for filovirus infection in primates |
| EP1586331B1 (en) * | 2001-10-01 | 2008-05-28 | The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health | Development of a preventive vaccine for filovirus infection in primates |
| WO2004042001A2 (en) * | 2002-05-17 | 2004-05-21 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
| WO2006037038A1 (en) * | 2004-09-27 | 2006-04-06 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Optimized vaccines to provide protection against ebola and other viruses |
| GB0706912D0 (en) * | 2007-04-10 | 2007-05-16 | Isis Innovation | Novel viral vaccines |
| US20120251502A1 (en) * | 2008-10-24 | 2012-10-04 | The Government of the US as Represented by the Secretary of the Dept. of health | Human Ebola Virus Species and Compositions and Methods Thereof |
| CA2742247C (en) * | 2008-11-21 | 2017-07-04 | Bavarian Nordic A/S | Vector comprising multiple homologous nucleotide sequences |
| WO2011071574A2 (en) * | 2009-09-02 | 2011-06-16 | United States Deparment Of The Army, As Represented By The Secretary Of The Army | Monoclonal antibodies against glycoprotein of ebola sudan boniface virus |
| TR201902214T4 (tr) | 2010-04-16 | 2019-03-21 | Glaxosmithkline Biologicals Sa | Şempanze adenoviral vektörü-bazlı filovirüs aşıları. |
| CA2870293C (en) * | 2012-04-12 | 2023-05-09 | The Trustees Of The University Of Pennsylvania | Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| US10973892B2 (en) * | 2012-09-04 | 2021-04-13 | Bavarian Nordic A/S | Methods and compositions for enhancing vaccine immune responses |
| GB201303406D0 (en) | 2013-02-26 | 2013-04-10 | Health Prot Agency | Crimean-Congo Haemorrhagic Fever Virus Antigenic Composition |
-
2015
- 2015-09-03 CN CN202110238900.XA patent/CN112972668A/zh active Pending
- 2015-09-03 MY MYPI2017700483A patent/MY193417A/en unknown
- 2015-09-03 KR KR1020237030452A patent/KR102812180B1/ko active Active
- 2015-09-03 EP EP15763853.7A patent/EP3188752A2/en active Pending
- 2015-09-03 JP JP2017510880A patent/JP6823586B2/ja active Active
- 2015-09-03 AU AU2015310909A patent/AU2015310909B2/en active Active
- 2015-09-03 CA CA2959105A patent/CA2959105C/en active Active
- 2015-09-03 CN CN201580047328.1A patent/CN106999565B/zh active Active
- 2015-09-03 UA UAA201702987A patent/UA126848C2/uk unknown
- 2015-09-03 WO PCT/EP2015/070161 patent/WO2016034678A2/en not_active Ceased
- 2015-09-03 SG SG10201901735XA patent/SG10201901735XA/en unknown
- 2015-09-03 US US15/508,851 patent/US10576141B2/en active Active
- 2015-09-03 SG SG11201701506PA patent/SG11201701506PA/en unknown
- 2015-09-03 KR KR1020177006091A patent/KR102736868B1/ko active Active
- 2015-09-03 MX MX2017002791A patent/MX2017002791A/es unknown
-
2017
- 2017-02-12 IL IL250552A patent/IL250552B/en unknown
- 2017-02-13 ZA ZA2017/01077A patent/ZA201701077B/en unknown
-
2020
- 2020-02-27 US US16/802,805 patent/US11338030B2/en active Active
-
2021
- 2021-01-06 JP JP2021000975A patent/JP7113924B2/ja active Active
- 2021-07-28 AU AU2021209228A patent/AU2021209228A1/en not_active Abandoned
-
2022
- 2022-01-23 IL IL290052A patent/IL290052A/en unknown
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