JP2024544012A5 - - Google Patents
Info
- Publication number
- JP2024544012A5 JP2024544012A5 JP2024533013A JP2024533013A JP2024544012A5 JP 2024544012 A5 JP2024544012 A5 JP 2024544012A5 JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024544012 A5 JP2024544012 A5 JP 2024544012A5
- Authority
- JP
- Japan
- Prior art keywords
- gag
- approximately
- protein
- fusion protein
- napdnabp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163285995P | 2021-12-03 | 2021-12-03 | |
| US63/285,995 | 2021-12-03 | ||
| US202263298621P | 2022-01-11 | 2022-01-11 | |
| US63/298,621 | 2022-01-11 | ||
| PCT/US2022/080834 WO2023102537A2 (en) | 2021-12-03 | 2022-12-02 | Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024544012A JP2024544012A (ja) | 2024-11-26 |
| JP2024544012A5 true JP2024544012A5 (enExample) | 2025-12-10 |
Family
ID=85158785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024533013A Pending JP2024544012A (ja) | 2021-12-03 | 2022-12-02 | 核酸プログラマブル融合タンパク質を送達するためのセルフアセンブルウイルス様粒子ならびにその作製方法および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250382334A1 (enExample) |
| EP (1) | EP4441073A2 (enExample) |
| JP (1) | JP2024544012A (enExample) |
| KR (1) | KR20240112361A (enExample) |
| AU (1) | AU2022400961A1 (enExample) |
| CA (1) | CA3238778A1 (enExample) |
| GB (1) | GB2630190A (enExample) |
| IL (1) | IL312889A (enExample) |
| WO (1) | WO2023102537A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20220259617A1 (en) | 2019-06-13 | 2022-08-18 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| BR112023001272A2 (pt) | 2020-07-24 | 2023-04-04 | Massachusetts Gen Hospital | Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células |
| WO2025051278A1 (en) * | 2023-09-09 | 2025-03-13 | Geneditbio Limited | Engineered protein delivery vehicle |
| WO2025096936A2 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cdkl5 |
| WO2025137543A1 (en) * | 2023-12-22 | 2025-06-26 | President And Fellows Of Harvard College | Methods for screening for next generation nucleic acid delivery vectors |
| CN118126137A (zh) * | 2024-01-19 | 2024-06-04 | 微光基因(苏州)有限公司 | 用于递送核酸和蛋白质的类病毒样蛋白颗粒及其制备方法 |
| CN118086408A (zh) * | 2024-04-25 | 2024-05-28 | 华南理工大学 | 一种可实现靶向肌肉细胞基因编辑的仿病毒颗粒及其制备方法和应用 |
| WO2026024856A2 (en) | 2024-07-23 | 2026-01-29 | The Broad Institute, Inc. | Compositions and methods for production of double-stranded dna in cells for programmable gene integration |
| TW202615664A (zh) * | 2024-08-02 | 2026-04-16 | 香港商正基基因科技有限公司 | 用於增強遞送的新型工程化蛋白質遞送載體 |
| WO2026106945A2 (en) | 2024-11-12 | 2026-05-21 | The Broad Institute, Inc. | Engineered prime editing guide rnas and methods of making and using same |
| CN119162152B (zh) * | 2024-11-18 | 2025-02-25 | 南京农业大学三亚研究院 | 一种扩大编辑范围且提高编辑效率的高精准碱基编辑器 |
| WO2026145595A1 (en) * | 2024-12-30 | 2026-07-09 | Suzhou Rocrock No.1 Biotechnology Co., Ltd. | Nucleic acid delivery systems, compositions, and methods of use thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| JP2003514564A (ja) | 1999-11-24 | 2003-04-22 | エムシーエス マイクロ キャリア システムズ ゲーエムベーハー | 核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法 |
| PT2816112T (pt) | 2009-12-10 | 2018-11-20 | Univ Iowa State Res Found Inc | Modificação do adn modificada pelo efector tal |
| DE102010025907A1 (de) | 2010-07-02 | 2012-01-05 | Robert Bosch Gmbh | Wellenenergiewandler zur Umwandlung von kinetischer Energie in elektrische Energie |
| US9181535B2 (en) | 2012-09-24 | 2015-11-10 | The Chinese University Of Hong Kong | Transcription activator-like effector nucleases (TALENs) |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP7059179B2 (ja) * | 2015-10-20 | 2022-04-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 遺伝子操作のための方法及び製品 |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019226953A1 (en) * | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020102709A1 (en) * | 2018-11-16 | 2020-05-22 | The Regents Of The University Of California | Compositions and methods for delivering crispr/cas effector polypeptides |
-
2022
- 2022-12-02 AU AU2022400961A patent/AU2022400961A1/en active Pending
- 2022-12-02 IL IL312889A patent/IL312889A/en unknown
- 2022-12-02 JP JP2024533013A patent/JP2024544012A/ja active Pending
- 2022-12-02 WO PCT/US2022/080834 patent/WO2023102537A2/en not_active Ceased
- 2022-12-02 CA CA3238778A patent/CA3238778A1/en active Pending
- 2022-12-02 US US18/715,569 patent/US20250382334A1/en active Pending
- 2022-12-02 EP EP22851442.8A patent/EP4441073A2/en active Pending
- 2022-12-02 KR KR1020247022051A patent/KR20240112361A/ko active Pending
- 2022-12-02 GB GB2409656.2A patent/GB2630190A/en active Pending
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