JP2002503477A5 - - Google Patents

Info

Publication number

JP2002503477A5

JP2002503477A5 JP2000531578A JP2000531578A JP2002503477A5 JP 2002503477 A5 JP2002503477 A5 JP 2002503477A5 JP 2000531578 A JP2000531578 A JP 2000531578A JP 2000531578 A JP2000531578 A JP 2000531578A JP 2002503477 A5 JP2002503477 A5 JP 2002503477A5

Authority

JP

Japan

Prior art keywords

nucleotide sequence

viral

virus

vector

virus particle

Prior art date

1999-02-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002773 nucleotide Substances 0.000 description 32
• 125000003729 nucleotide group Chemical group 0.000 description 32
• 241000700605 Viruses Species 0.000 description 25
• 239000002245 particle Substances 0.000 description 20
• 230000003612 virological effect Effects 0.000 description 16
• 108090000623 proteins and genes Proteins 0.000 description 13
• 239000013598 vector Substances 0.000 description 11
• 108090000765 processed proteins & peptides Proteins 0.000 description 8
• 238000004519 manufacturing process Methods 0.000 description 7
• 229920001184 polypeptide Polymers 0.000 description 7
• 102000004196 processed proteins & peptides Human genes 0.000 description 7
• 239000013603 viral vector Substances 0.000 description 7
• 108091028043 Nucleic acid sequence Proteins 0.000 description 6
• 210000004027 cell Anatomy 0.000 description 6
• 101710177291 Gag polyprotein Proteins 0.000 description 5
• 101710125418 Major capsid protein Proteins 0.000 description 5
• 238000003776 cleavage reaction Methods 0.000 description 5
• 108010089520 pol Gene Products Proteins 0.000 description 5
• 230000001177 retroviral effect Effects 0.000 description 5
• 230000007017 scission Effects 0.000 description 5
• 241000713666 Lentivirus Species 0.000 description 4
• 108020004705 Codon Proteins 0.000 description 3
• 238000000034 method Methods 0.000 description 3
• 241000725303 Human immunodeficiency virus Species 0.000 description 2
• 102100034353 Integrase Human genes 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• 239000003085 diluting agent Substances 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 108010078428 env Gene Products Proteins 0.000 description 2
• 210000004962 mammalian cell Anatomy 0.000 description 2
• 238000004806 packaging method and process Methods 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 108700010070 Codon Usage Proteins 0.000 description 1
• 101710091045 Envelope protein Proteins 0.000 description 1
• 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 description 1
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
• 102100034349 Integrase Human genes 0.000 description 1
• 101710188315 Protein X Proteins 0.000 description 1
• 239000003184 complementary RNA Substances 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1