JP2007519750A5 - - Google Patents
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- Publication number
- JP2007519750A5 JP2007519750A5 JP2006551611A JP2006551611A JP2007519750A5 JP 2007519750 A5 JP2007519750 A5 JP 2007519750A5 JP 2006551611 A JP2006551611 A JP 2006551611A JP 2006551611 A JP2006551611 A JP 2006551611A JP 2007519750 A5 JP2007519750 A5 JP 2007519750A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- monomer units
- medicament
- drug
- drug according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 8
- 229920001722 A-type proanthocyanidin Polymers 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000539 dimer Substances 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000013638 trimer Substances 0.000 claims 3
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical class C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000000391 smoking effect Effects 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000004855 vascular circulation Effects 0.000 claims 1
- PFTAWBLQPZVEMU-UHFFFAOYSA-N OC(C1)C(c(cc2)cc(O)c2O)Oc2c1c(O)cc(O)c2 Chemical compound OC(C1)C(c(cc2)cc(O)c2O)Oc2c1c(O)cc(O)c2 PFTAWBLQPZVEMU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53968904P | 2004-01-28 | 2004-01-28 | |
| US60/539,689 | 2004-01-28 | ||
| PCT/US2005/003406 WO2005072726A1 (en) | 2004-01-28 | 2005-01-28 | Compositions and methods of use of a-type procyanidins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007519750A JP2007519750A (ja) | 2007-07-19 |
| JP2007519750A5 true JP2007519750A5 (https=) | 2008-03-21 |
| JP5456955B2 JP5456955B2 (ja) | 2014-04-02 |
Family
ID=34826110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551611A Expired - Lifetime JP5456955B2 (ja) | 2004-01-28 | 2005-01-28 | Ａタイプのプロシアニジンを含有する組成物およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9675630B2 (https=) |
| EP (1) | EP1713467B1 (https=) |
| JP (1) | JP5456955B2 (https=) |
| CN (1) | CN1938015A (https=) |
| AU (1) | AU2005209317B2 (https=) |
| CA (1) | CA2554071C (https=) |
| IL (1) | IL176922A0 (https=) |
| WO (1) | WO2005072726A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137081A1 (en) * | 2003-01-13 | 2004-07-15 | Peter Rohdewald | Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins |
| EP1896041A2 (en) * | 2005-06-29 | 2008-03-12 | Mars, Incorporated | Treatment of occlusive thrombosis |
| US7615649B2 (en) | 2006-01-26 | 2009-11-10 | Iowa State University Research Foundation, Inc, | Synthesis of polycyclic procyanidins |
| WO2007086847A1 (en) * | 2006-01-26 | 2007-08-02 | Iowa State University Research Foundation, Inc. | Synthesis of polycyclic procyanidins |
| US20070207188A1 (en) * | 2006-02-16 | 2007-09-06 | Miller Debra L | Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa |
| GB0719545D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Novel use of cocoa extract |
| GB0719544D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and use thereof |
| GB0719542D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Use of cocoa extract |
| ES2311403B1 (es) | 2007-06-12 | 2010-01-12 | Consejo Superior De Investigaciones Cientificas | Extractos fenolicos de piel de almendra conteniendo procianidinas, propelargonidinas y prodelfinidinas, y su procedimiento de obtencion. |
| DE102009005201A1 (de) * | 2009-01-20 | 2010-07-22 | Universität Rostock | Verwendung von Polyphenol-haltigen Pflanzenextrakten zur Behandlung von Adipositas und Diabetes mellitus Typ 2 |
| JP5462491B2 (ja) * | 2009-01-21 | 2014-04-02 | 株式会社 エフェクト | プロアントシアニジン三量体 |
| JP5459699B2 (ja) * | 2009-03-27 | 2014-04-02 | キッコーマン株式会社 | クランベリー抽出物及びその製造方法 |
| EA026079B1 (ru) * | 2011-05-27 | 2017-02-28 | Унилевер Н.В. | Противовоспалительная композиция |
| US9861610B2 (en) | 2011-08-01 | 2018-01-09 | Akay Flavours & Aromatics Pvt Ltd. | Process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers and a stable composition thereof |
| EP2829277A1 (en) * | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
| US9682112B2 (en) | 2013-08-05 | 2017-06-20 | Akay Flavours & Aromatics PVT. LTD | Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions |
| CN104130268A (zh) * | 2014-08-12 | 2014-11-05 | 内蒙古大学 | A型原花青素二聚物与丙酮缩合物的结构、制备及生物活性 |
| US10913748B2 (en) * | 2018-11-04 | 2021-02-09 | Coeurative, Inc. | Compounds useful for treating cardiovascular diseases |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| IT1270999B (it) | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| US6297273B1 (en) | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| WO1997036497A2 (en) | 1996-04-02 | 1997-10-09 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
| US6015913A (en) | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
| EP1014969B1 (en) * | 1997-09-09 | 2008-11-12 | Rutgers, The State University of New Jersey | Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces |
| JP2975997B2 (ja) * | 1998-03-04 | 1999-11-10 | 工業技術院長 | プロアントシアニジンａおよびその誘導体 |
| JP2002505864A (ja) * | 1998-03-12 | 2002-02-26 | マーズ インコーポレーテッド | 窒素酸化物の生成を促進するためにポリフェノールおよびｌ−アルギニンを含有する製品 |
| US6805883B2 (en) * | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| EP1274319B1 (en) * | 2000-04-14 | 2009-08-12 | Mars, Incorporated | Compositions and methods for improving vascular health |
| JP2003252780A (ja) | 2002-02-26 | 2003-09-10 | Hiroshige Himawari | アポトーシス誘導剤 |
| JP2003252745A (ja) | 2002-02-28 | 2003-09-10 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 |
| CA2507704A1 (en) * | 2002-12-02 | 2004-06-17 | Mars, Incorporated | Flavanols and procyanidins promote homeostasis |
-
2005
- 2005-01-28 CN CNA200580009421XA patent/CN1938015A/zh active Pending
- 2005-01-28 EP EP05712740A patent/EP1713467B1/en not_active Expired - Lifetime
- 2005-01-28 AU AU2005209317A patent/AU2005209317B2/en not_active Expired
- 2005-01-28 JP JP2006551611A patent/JP5456955B2/ja not_active Expired - Lifetime
- 2005-01-28 WO PCT/US2005/003406 patent/WO2005072726A1/en not_active Ceased
- 2005-01-28 CA CA2554071A patent/CA2554071C/en not_active Expired - Lifetime
- 2005-01-28 US US11/045,648 patent/US9675630B2/en active Active
-
2006
- 2006-07-18 IL IL176922A patent/IL176922A0/en unknown
-
2017
- 2017-05-02 US US15/584,454 patent/US20170348339A1/en not_active Abandoned
-
2019
- 2019-05-20 US US16/416,910 patent/US20190269715A1/en not_active Abandoned
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