AU2005209317B2 - Compositions and methods of use of A-type procyanidins - Google Patents
Compositions and methods of use of A-type procyanidins Download PDFInfo
- Publication number
- AU2005209317B2 AU2005209317B2 AU2005209317A AU2005209317A AU2005209317B2 AU 2005209317 B2 AU2005209317 B2 AU 2005209317B2 AU 2005209317 A AU2005209317 A AU 2005209317A AU 2005209317 A AU2005209317 A AU 2005209317A AU 2005209317 B2 AU2005209317 B2 AU 2005209317B2
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- Australia
- Prior art keywords
- type
- treatment
- derivative
- procyanidin
- cocoa
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001722 A-type proanthocyanidin Polymers 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 58
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- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 14
- 206010019280 Heart failures Diseases 0.000 claims abstract description 13
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- 239000000539 dimer Substances 0.000 claims description 59
- 150000003839 salts Chemical class 0.000 claims description 30
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53968904P | 2004-01-28 | 2004-01-28 | |
| US60/539,689 | 2004-01-28 | ||
| PCT/US2005/003406 WO2005072726A1 (en) | 2004-01-28 | 2005-01-28 | Compositions and methods of use of a-type procyanidins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005209317A1 AU2005209317A1 (en) | 2005-08-11 |
| AU2005209317B2 true AU2005209317B2 (en) | 2011-07-07 |
Family
ID=34826110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005209317A Expired AU2005209317B2 (en) | 2004-01-28 | 2005-01-28 | Compositions and methods of use of A-type procyanidins |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9675630B2 (https=) |
| EP (1) | EP1713467B1 (https=) |
| JP (1) | JP5456955B2 (https=) |
| CN (1) | CN1938015A (https=) |
| AU (1) | AU2005209317B2 (https=) |
| CA (1) | CA2554071C (https=) |
| IL (1) | IL176922A0 (https=) |
| WO (1) | WO2005072726A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137081A1 (en) * | 2003-01-13 | 2004-07-15 | Peter Rohdewald | Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins |
| EP1896041A2 (en) * | 2005-06-29 | 2008-03-12 | Mars, Incorporated | Treatment of occlusive thrombosis |
| US7615649B2 (en) | 2006-01-26 | 2009-11-10 | Iowa State University Research Foundation, Inc, | Synthesis of polycyclic procyanidins |
| WO2007086847A1 (en) * | 2006-01-26 | 2007-08-02 | Iowa State University Research Foundation, Inc. | Synthesis of polycyclic procyanidins |
| US20070207188A1 (en) * | 2006-02-16 | 2007-09-06 | Miller Debra L | Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa |
| GB0719545D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Novel use of cocoa extract |
| GB0719544D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and use thereof |
| GB0719542D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Use of cocoa extract |
| ES2311403B1 (es) | 2007-06-12 | 2010-01-12 | Consejo Superior De Investigaciones Cientificas | Extractos fenolicos de piel de almendra conteniendo procianidinas, propelargonidinas y prodelfinidinas, y su procedimiento de obtencion. |
| DE102009005201A1 (de) * | 2009-01-20 | 2010-07-22 | Universität Rostock | Verwendung von Polyphenol-haltigen Pflanzenextrakten zur Behandlung von Adipositas und Diabetes mellitus Typ 2 |
| JP5462491B2 (ja) * | 2009-01-21 | 2014-04-02 | 株式会社 エフェクト | プロアントシアニジン三量体 |
| JP5459699B2 (ja) * | 2009-03-27 | 2014-04-02 | キッコーマン株式会社 | クランベリー抽出物及びその製造方法 |
| EA026079B1 (ru) * | 2011-05-27 | 2017-02-28 | Унилевер Н.В. | Противовоспалительная композиция |
| US9861610B2 (en) | 2011-08-01 | 2018-01-09 | Akay Flavours & Aromatics Pvt Ltd. | Process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers and a stable composition thereof |
| EP2829277A1 (en) * | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
| US9682112B2 (en) | 2013-08-05 | 2017-06-20 | Akay Flavours & Aromatics PVT. LTD | Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions |
| CN104130268A (zh) * | 2014-08-12 | 2014-11-05 | 内蒙古大学 | A型原花青素二聚物与丙酮缩合物的结构、制备及生物活性 |
| US10913748B2 (en) * | 2018-11-04 | 2021-02-09 | Coeurative, Inc. | Compounds useful for treating cardiovascular diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925871A (en) * | 1985-07-19 | 1990-05-15 | Inverni Della Beffa Spa | Therapeutic use of proanthocyanidine A2 for treatment of vascular system |
| US20030104075A1 (en) * | 1998-03-12 | 2003-06-05 | Mars Incorporated | Products containing polyphenol (s) and L-arginine to stimulate nitric oxide production |
| US20030113290A1 (en) * | 1996-04-02 | 2003-06-19 | Mars Incorporated | Cocoa extract compounds and methods for making and using the same |
| JP2003252745A (ja) * | 2002-02-28 | 2003-09-10 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1270999B (it) | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| WO1997036497A2 (en) | 1996-04-02 | 1997-10-09 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
| US6015913A (en) | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
| EP1014969B1 (en) * | 1997-09-09 | 2008-11-12 | Rutgers, The State University of New Jersey | Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces |
| JP2975997B2 (ja) * | 1998-03-04 | 1999-11-10 | 工業技術院長 | プロアントシアニジンａおよびその誘導体 |
| JP2002505864A (ja) * | 1998-03-12 | 2002-02-26 | マーズ インコーポレーテッド | 窒素酸化物の生成を促進するためにポリフェノールおよびｌ−アルギニンを含有する製品 |
| IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| EP1274319B1 (en) * | 2000-04-14 | 2009-08-12 | Mars, Incorporated | Compositions and methods for improving vascular health |
| JP2003252780A (ja) | 2002-02-26 | 2003-09-10 | Hiroshige Himawari | アポトーシス誘導剤 |
| CA2507704A1 (en) * | 2002-12-02 | 2004-06-17 | Mars, Incorporated | Flavanols and procyanidins promote homeostasis |
-
2005
- 2005-01-28 CN CNA200580009421XA patent/CN1938015A/zh active Pending
- 2005-01-28 EP EP05712740A patent/EP1713467B1/en not_active Expired - Lifetime
- 2005-01-28 AU AU2005209317A patent/AU2005209317B2/en not_active Expired
- 2005-01-28 JP JP2006551611A patent/JP5456955B2/ja not_active Expired - Lifetime
- 2005-01-28 WO PCT/US2005/003406 patent/WO2005072726A1/en not_active Ceased
- 2005-01-28 CA CA2554071A patent/CA2554071C/en not_active Expired - Lifetime
- 2005-01-28 US US11/045,648 patent/US9675630B2/en active Active
-
2006
- 2006-07-18 IL IL176922A patent/IL176922A0/en unknown
-
2017
- 2017-05-02 US US15/584,454 patent/US20170348339A1/en not_active Abandoned
-
2019
- 2019-05-20 US US16/416,910 patent/US20190269715A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925871A (en) * | 1985-07-19 | 1990-05-15 | Inverni Della Beffa Spa | Therapeutic use of proanthocyanidine A2 for treatment of vascular system |
| US20030113290A1 (en) * | 1996-04-02 | 2003-06-19 | Mars Incorporated | Cocoa extract compounds and methods for making and using the same |
| US20030104075A1 (en) * | 1998-03-12 | 2003-06-05 | Mars Incorporated | Products containing polyphenol (s) and L-arginine to stimulate nitric oxide production |
| JP2003252745A (ja) * | 2002-02-28 | 2003-09-10 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 |
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| Hammerstone et al., The Journal of Nutirition, 2000 * |
| Kiderlen, A et al., Zeitschrift Fuer Naturforschung Section C, Journal of Biosciences * |
| Taddei et al., Current Pharmaceutical Design, 2003 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1713467A1 (en) | 2006-10-25 |
| AU2005209317A1 (en) | 2005-08-11 |
| CN1938015A (zh) | 2007-03-28 |
| JP2007519750A (ja) | 2007-07-19 |
| CA2554071A1 (en) | 2005-08-11 |
| WO2005072726A1 (en) | 2005-08-11 |
| US20170348339A1 (en) | 2017-12-07 |
| US9675630B2 (en) | 2017-06-13 |
| US20190269715A1 (en) | 2019-09-05 |
| JP5456955B2 (ja) | 2014-04-02 |
| CA2554071C (en) | 2013-05-07 |
| IL176922A0 (en) | 2008-03-20 |
| EP1713467A4 (en) | 2009-06-24 |
| EP1713467B1 (en) | 2012-08-01 |
| US20050164956A1 (en) | 2005-07-28 |
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|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |