CA2554071C - A-type procyanidins useful in the treatment of nitric oxide mediated disorders - Google Patents
A-type procyanidins useful in the treatment of nitric oxide mediated disorders Download PDFInfo
- Publication number
- CA2554071C CA2554071C CA2554071A CA2554071A CA2554071C CA 2554071 C CA2554071 C CA 2554071C CA 2554071 A CA2554071 A CA 2554071A CA 2554071 A CA2554071 A CA 2554071A CA 2554071 C CA2554071 C CA 2554071C
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- Canada
- Prior art keywords
- type
- procyanidin
- cocoa
- derivative
- dimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229920001722 A-type proanthocyanidin Polymers 0.000 title claims abstract description 59
- 238000011282 treatment Methods 0.000 title claims abstract description 23
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title description 112
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Diabetes (AREA)
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- Molecular Biology (AREA)
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- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53968904P | 2004-01-28 | 2004-01-28 | |
| US60/539,689 | 2004-01-28 | ||
| PCT/US2005/003406 WO2005072726A1 (en) | 2004-01-28 | 2005-01-28 | Compositions and methods of use of a-type procyanidins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2554071A1 CA2554071A1 (en) | 2005-08-11 |
| CA2554071C true CA2554071C (en) | 2013-05-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2554071A Expired - Lifetime CA2554071C (en) | 2004-01-28 | 2005-01-28 | A-type procyanidins useful in the treatment of nitric oxide mediated disorders |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9675630B2 (https=) |
| EP (1) | EP1713467B1 (https=) |
| JP (1) | JP5456955B2 (https=) |
| CN (1) | CN1938015A (https=) |
| AU (1) | AU2005209317B2 (https=) |
| CA (1) | CA2554071C (https=) |
| IL (1) | IL176922A0 (https=) |
| WO (1) | WO2005072726A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040137081A1 (en) * | 2003-01-13 | 2004-07-15 | Peter Rohdewald | Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins |
| EP1896041A2 (en) * | 2005-06-29 | 2008-03-12 | Mars, Incorporated | Treatment of occlusive thrombosis |
| US7615649B2 (en) | 2006-01-26 | 2009-11-10 | Iowa State University Research Foundation, Inc, | Synthesis of polycyclic procyanidins |
| WO2007086847A1 (en) * | 2006-01-26 | 2007-08-02 | Iowa State University Research Foundation, Inc. | Synthesis of polycyclic procyanidins |
| US20070207188A1 (en) * | 2006-02-16 | 2007-09-06 | Miller Debra L | Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa |
| GB0719545D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Novel use of cocoa extract |
| GB0719544D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and use thereof |
| GB0719542D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Use of cocoa extract |
| ES2311403B1 (es) | 2007-06-12 | 2010-01-12 | Consejo Superior De Investigaciones Cientificas | Extractos fenolicos de piel de almendra conteniendo procianidinas, propelargonidinas y prodelfinidinas, y su procedimiento de obtencion. |
| DE102009005201A1 (de) * | 2009-01-20 | 2010-07-22 | Universität Rostock | Verwendung von Polyphenol-haltigen Pflanzenextrakten zur Behandlung von Adipositas und Diabetes mellitus Typ 2 |
| JP5462491B2 (ja) * | 2009-01-21 | 2014-04-02 | 株式会社 エフェクト | プロアントシアニジン三量体 |
| JP5459699B2 (ja) * | 2009-03-27 | 2014-04-02 | キッコーマン株式会社 | クランベリー抽出物及びその製造方法 |
| EA026079B1 (ru) * | 2011-05-27 | 2017-02-28 | Унилевер Н.В. | Противовоспалительная композиция |
| US9861610B2 (en) | 2011-08-01 | 2018-01-09 | Akay Flavours & Aromatics Pvt Ltd. | Process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers and a stable composition thereof |
| EP2829277A1 (en) * | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
| US9682112B2 (en) | 2013-08-05 | 2017-06-20 | Akay Flavours & Aromatics PVT. LTD | Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions |
| CN104130268A (zh) * | 2014-08-12 | 2014-11-05 | 内蒙古大学 | A型原花青素二聚物与丙酮缩合物的结构、制备及生物活性 |
| US10913748B2 (en) * | 2018-11-04 | 2021-02-09 | Coeurative, Inc. | Compounds useful for treating cardiovascular diseases |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| IT1270999B (it) | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| US6297273B1 (en) | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| WO1997036497A2 (en) | 1996-04-02 | 1997-10-09 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
| US6015913A (en) | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
| EP1014969B1 (en) * | 1997-09-09 | 2008-11-12 | Rutgers, The State University of New Jersey | Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces |
| JP2975997B2 (ja) * | 1998-03-04 | 1999-11-10 | 工業技術院長 | プロアントシアニジンａおよびその誘導体 |
| JP2002505864A (ja) * | 1998-03-12 | 2002-02-26 | マーズ インコーポレーテッド | 窒素酸化物の生成を促進するためにポリフェノールおよびｌ−アルギニンを含有する製品 |
| US6805883B2 (en) * | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| EP1274319B1 (en) * | 2000-04-14 | 2009-08-12 | Mars, Incorporated | Compositions and methods for improving vascular health |
| JP2003252780A (ja) | 2002-02-26 | 2003-09-10 | Hiroshige Himawari | アポトーシス誘導剤 |
| JP2003252745A (ja) | 2002-02-28 | 2003-09-10 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤 |
| CA2507704A1 (en) * | 2002-12-02 | 2004-06-17 | Mars, Incorporated | Flavanols and procyanidins promote homeostasis |
-
2005
- 2005-01-28 CN CNA200580009421XA patent/CN1938015A/zh active Pending
- 2005-01-28 EP EP05712740A patent/EP1713467B1/en not_active Expired - Lifetime
- 2005-01-28 AU AU2005209317A patent/AU2005209317B2/en not_active Expired
- 2005-01-28 JP JP2006551611A patent/JP5456955B2/ja not_active Expired - Lifetime
- 2005-01-28 WO PCT/US2005/003406 patent/WO2005072726A1/en not_active Ceased
- 2005-01-28 CA CA2554071A patent/CA2554071C/en not_active Expired - Lifetime
- 2005-01-28 US US11/045,648 patent/US9675630B2/en active Active
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2006
- 2006-07-18 IL IL176922A patent/IL176922A0/en unknown
-
2017
- 2017-05-02 US US15/584,454 patent/US20170348339A1/en not_active Abandoned
-
2019
- 2019-05-20 US US16/416,910 patent/US20190269715A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1713467A1 (en) | 2006-10-25 |
| AU2005209317A1 (en) | 2005-08-11 |
| CN1938015A (zh) | 2007-03-28 |
| JP2007519750A (ja) | 2007-07-19 |
| CA2554071A1 (en) | 2005-08-11 |
| WO2005072726A1 (en) | 2005-08-11 |
| US20170348339A1 (en) | 2017-12-07 |
| US9675630B2 (en) | 2017-06-13 |
| US20190269715A1 (en) | 2019-09-05 |
| JP5456955B2 (ja) | 2014-04-02 |
| AU2005209317B2 (en) | 2011-07-07 |
| IL176922A0 (en) | 2008-03-20 |
| EP1713467A4 (en) | 2009-06-24 |
| EP1713467B1 (en) | 2012-08-01 |
| US20050164956A1 (en) | 2005-07-28 |
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| EEER | Examination request |