CN1938015A - A型矢车菊苷配基的组合物和使用方法 - Google Patents

A型矢车菊苷配基的组合物和使用方法 Download PDF

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Publication number
CN1938015A
CN1938015A CNA200580009421XA CN200580009421A CN1938015A CN 1938015 A CN1938015 A CN 1938015A CN A200580009421X A CNA200580009421X A CN A200580009421XA CN 200580009421 A CN200580009421 A CN 200580009421A CN 1938015 A CN1938015 A CN 1938015A
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CN
China
Prior art keywords
type
procyanidin
dimer
purified
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200580009421XA
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English (en)
Chinese (zh)
Inventor
H·H·施米茨
C·L·克维克－乌里贝
M·A·凯姆
J·F·小哈默斯通
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Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Publication of CN1938015A publication Critical patent/CN1938015A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA200580009421XA 2004-01-28 2005-01-28 A型矢车菊苷配基的组合物和使用方法 Pending CN1938015A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53968904P 2004-01-28 2004-01-28
US60/539,689 2004-01-28

Publications (1)

Publication Number Publication Date
CN1938015A true CN1938015A (zh) 2007-03-28

Family

ID=34826110

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200580009421XA Pending CN1938015A (zh) 2004-01-28 2005-01-28 A型矢车菊苷配基的组合物和使用方法

Country Status (8)

Country Link
US (3) US9675630B2 (https=)
EP (1) EP1713467B1 (https=)
JP (1) JP5456955B2 (https=)
CN (1) CN1938015A (https=)
AU (1) AU2005209317B2 (https=)
CA (1) CA2554071C (https=)
IL (1) IL176922A0 (https=)
WO (1) WO2005072726A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104130268A (zh) * 2014-08-12 2014-11-05 内蒙古大学 A型原花青素二聚物与丙酮缩合物的结构、制备及生物活性
CN113226301A (zh) * 2018-11-04 2021-08-06 科由拉特夫公司 适用于治疗心血管疾病的新型化合物

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040137081A1 (en) * 2003-01-13 2004-07-15 Peter Rohdewald Attaining sexual wellness and health of the sexual vascular system with proanthocyanidins
EP1896041A2 (en) * 2005-06-29 2008-03-12 Mars, Incorporated Treatment of occlusive thrombosis
US7615649B2 (en) 2006-01-26 2009-11-10 Iowa State University Research Foundation, Inc, Synthesis of polycyclic procyanidins
WO2007086847A1 (en) * 2006-01-26 2007-08-02 Iowa State University Research Foundation, Inc. Synthesis of polycyclic procyanidins
US20070207188A1 (en) * 2006-02-16 2007-09-06 Miller Debra L Cocoa products and methods of treating cardiovascular conditions with sugar-free cocoa
GB0719545D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Novel use of cocoa extract
GB0719544D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Cocoa extract and use thereof
GB0719542D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Use of cocoa extract
ES2311403B1 (es) 2007-06-12 2010-01-12 Consejo Superior De Investigaciones Cientificas Extractos fenolicos de piel de almendra conteniendo procianidinas, propelargonidinas y prodelfinidinas, y su procedimiento de obtencion.
DE102009005201A1 (de) * 2009-01-20 2010-07-22 Universität Rostock Verwendung von Polyphenol-haltigen Pflanzenextrakten zur Behandlung von Adipositas und Diabetes mellitus Typ 2
JP5462491B2 (ja) * 2009-01-21 2014-04-02 株式会社 エフェクト プロアントシアニジン三量体
JP5459699B2 (ja) * 2009-03-27 2014-04-02 キッコーマン株式会社 クランベリー抽出物及びその製造方法
EA026079B1 (ru) * 2011-05-27 2017-02-28 Унилевер Н.В. Противовоспалительная композиция
US9861610B2 (en) 2011-08-01 2018-01-09 Akay Flavours & Aromatics Pvt Ltd. Process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers and a stable composition thereof
EP2829277A1 (en) * 2013-07-26 2015-01-28 Natac Biotech, S.L. Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease
US9682112B2 (en) 2013-08-05 2017-06-20 Akay Flavours & Aromatics PVT. LTD Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518289D0 (en) * 1985-07-19 1985-08-29 Inverni Della Beffa Spa Obtaining proanthocyanidine a2
IT1270999B (it) 1994-07-26 1997-05-26 Indena Spa Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US6297273B1 (en) 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
WO1997036497A2 (en) 1996-04-02 1997-10-09 Mars, Incorporated Cocoa extract compounds and methods for making and using the same
US6015913A (en) 1996-09-06 2000-01-18 Mars, Incorporated Method for producing fat and/or solids from cocoa beans
EP1014969B1 (en) * 1997-09-09 2008-11-12 Rutgers, The State University of New Jersey Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces
JP2975997B2 (ja) * 1998-03-04 1999-11-10 工業技術院長 プロアントシアニジンａおよびその誘導体
JP2002505864A (ja) * 1998-03-12 2002-02-26 マーズ インコーポレーテッド 窒素酸化物の生成を促進するためにポリフェノールおよびｌ−アルギニンを含有する製品
US6805883B2 (en) * 1998-03-12 2004-10-19 Mars, Incorporated Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
IT1304183B1 (it) * 1998-12-18 2001-03-08 Indena Spa Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici.
EP1274319B1 (en) * 2000-04-14 2009-08-12 Mars, Incorporated Compositions and methods for improving vascular health
JP2003252780A (ja) 2002-02-26 2003-09-10 Hiroshige Himawari アポトーシス誘導剤
JP2003252745A (ja) 2002-02-28 2003-09-10 Shiseido Co Ltd マトリックスメタロプロテアーゼ（ＭＭＰｓ）阻害剤
CA2507704A1 (en) * 2002-12-02 2004-06-17 Mars, Incorporated Flavanols and procyanidins promote homeostasis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104130268A (zh) * 2014-08-12 2014-11-05 内蒙古大学 A型原花青素二聚物与丙酮缩合物的结构、制备及生物活性
CN113226301A (zh) * 2018-11-04 2021-08-06 科由拉特夫公司 适用于治疗心血管疾病的新型化合物

Also Published As

Publication number Publication date
EP1713467A1 (en) 2006-10-25
AU2005209317A1 (en) 2005-08-11
JP2007519750A (ja) 2007-07-19
CA2554071A1 (en) 2005-08-11
WO2005072726A1 (en) 2005-08-11
US20170348339A1 (en) 2017-12-07
US9675630B2 (en) 2017-06-13
US20190269715A1 (en) 2019-09-05
JP5456955B2 (ja) 2014-04-02
CA2554071C (en) 2013-05-07
AU2005209317B2 (en) 2011-07-07
IL176922A0 (en) 2008-03-20
EP1713467A4 (en) 2009-06-24
EP1713467B1 (en) 2012-08-01
US20050164956A1 (en) 2005-07-28

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070328