JP2007518798A - 気管支弛緩性化合物 - Google Patents

気管支弛緩性化合物 Download PDF

Info

Publication number
JP2007518798A
JP2007518798A JP2006550993A JP2006550993A JP2007518798A JP 2007518798 A JP2007518798 A JP 2007518798A JP 2006550993 A JP2006550993 A JP 2006550993A JP 2006550993 A JP2006550993 A JP 2006550993A JP 2007518798 A JP2007518798 A JP 2007518798A
Authority
JP
Japan
Prior art keywords
compound according
nmr
mhz
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006550993A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007518798A5 (https=
Inventor
スコグバル，スタファン
グーツマン，マリア ダレンス
ビョルク，ヘンリク
ベルグルント，マグヌス
シュテルナー，オロフ
Original Assignee
レスピラトリウス エービー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by レスピラトリウス エービー filed Critical レスピラトリウス エービー
Publication of JP2007518798A publication Critical patent/JP2007518798A/ja
Publication of JP2007518798A5 publication Critical patent/JP2007518798A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
JP2006550993A 2004-01-22 2005-01-21 気管支弛緩性化合物 Pending JP2007518798A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/761,323 US20050165004A1 (en) 2004-01-22 2004-01-22 Bronchorelaxing compounds
PCT/SE2005/000062 WO2005070887A1 (en) 2004-01-22 2005-01-21 Bronchorelaxing compounds

Publications (2)

Publication Number Publication Date
JP2007518798A true JP2007518798A (ja) 2007-07-12
JP2007518798A5 JP2007518798A5 (https=) 2008-04-17

Family

ID=34794812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006550993A Pending JP2007518798A (ja) 2004-01-22 2005-01-21 気管支弛緩性化合物

Country Status (6)

Country Link
US (2) US20050165004A1 (https=)
EP (1) EP1708999A1 (https=)
JP (1) JP2007518798A (https=)
CN (1) CN1910149A (https=)
RU (1) RU2006126532A (https=)
WO (1) WO2005070887A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010533145A (ja) * 2007-07-12 2010-10-21 レスピラトリウス アーベー 新規な気管支拡張性α，β−不飽和イソキノリンアミド

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011290A1 (en) * 2005-07-18 2007-01-25 Respiratorius Ab Bronchorelaxing agents based on indol- and isoquinoline derivatives
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
WO2009007419A1 (en) * 2007-07-12 2009-01-15 Respiratorius Ab Novel bronchodilating isoquinoline carbamates
WO2009007418A1 (en) * 2007-07-12 2009-01-15 Respiratorius Ab Novel bronchodilating isoquinoline amides
US20090318413A1 (en) * 2008-06-18 2009-12-24 Universite Victor Segalen Bordeaux 2 Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
RU2406435C1 (ru) * 2009-09-10 2010-12-20 Государственное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию" Фармакологическая коррекция повышенного симпатического тонуса при назначении антагонистов кальция у больных с сочетанием артериальной гипертензии и бронхиальной астмы
WO2016033105A1 (en) * 2014-08-29 2016-03-03 The Board Of Regents Of The University Of Texas System Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
CN107298655B (zh) * 2017-08-24 2019-11-15 郑州轻工业学院 7,8-二甲氧基-2,3,4,5-四氢-1H-苯并[c]氮杂卓盐酸盐及其制备方法
KR20210032315A (ko) * 2018-07-06 2021-03-24 레스피라토리우스 아브 신규한 기관지 확장형 헤테로 결합된 아미드
KR102590643B1 (ko) * 2019-01-31 2023-10-17 히사미쓰 세이야꾸 가부시키가이샤 첩부제
WO2023028257A1 (en) * 2021-08-27 2023-03-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating neurodegenerative disorders

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1029326A (en) * 1964-03-18 1966-05-11 Dresden Arzneimittel Isoindoline-2-carboxylic acid amides
DE2620179A1 (de) * 1975-10-28 1977-05-12 Knoll Ag Neue isochinolin-derivate
JPH03145470A (ja) * 1989-10-13 1991-06-20 Abbott Lab ６―置換―１，２，３，４―テトラヒドロイソキノリン誘導体およびそれを含有する医薬
WO2002034760A2 (en) * 2000-10-23 2002-05-02 Smithkline Beecham Corporation Compounds and methods
WO2003000694A1 (en) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. 6-phenyldihydropyrrolopyrimidinedione derivatives
JP2003192660A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE328868T1 (de) * 2000-08-21 2006-06-15 Pacific Corp Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
AU2001280229B2 (en) * 2000-08-21 2006-12-07 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
EP1489071A1 (en) * 2003-06-18 2004-12-22 4Sc Ag N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators
EP1660454A1 (en) * 2003-07-07 2006-05-31 Vernalis (R&D) Limited Azacyclic compounds as inhibitors of sensory neurone specific channels

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1029326A (en) * 1964-03-18 1966-05-11 Dresden Arzneimittel Isoindoline-2-carboxylic acid amides
DE2620179A1 (de) * 1975-10-28 1977-05-12 Knoll Ag Neue isochinolin-derivate
JPH03145470A (ja) * 1989-10-13 1991-06-20 Abbott Lab ６―置換―１，２，３，４―テトラヒドロイソキノリン誘導体およびそれを含有する医薬
WO2002034760A2 (en) * 2000-10-23 2002-05-02 Smithkline Beecham Corporation Compounds and methods
WO2003000694A1 (en) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. 6-phenyldihydropyrrolopyrimidinedione derivatives
JP2003192660A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010533145A (ja) * 2007-07-12 2010-10-21 レスピラトリウス アーベー 新規な気管支拡張性α，β−不飽和イソキノリンアミド

Also Published As

Publication number Publication date
RU2006126532A (ru) 2008-02-27
US20050165004A1 (en) 2005-07-28
CN1910149A (zh) 2007-02-07
US20060040919A1 (en) 2006-02-23
WO2005070887A1 (en) 2005-08-04
EP1708999A1 (en) 2006-10-11

Similar Documents

Publication Publication Date Title
ES2331457T3 (es) Agonistas de beta2-adrenoceptor.
JP4288299B2 (ja) Ｌｔｂ４−アンタゴニスト活性を有するベンズアミジン誘導体及びその医薬としての使用
JP2007518798A (ja) 気管支弛緩性化合物
US20110009628A1 (en) Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same
PT1789405E (pt) Novos beta-agonistas enantiomericamente puros, processo para a sua preparação e a sua utilização como fármaco
CA2468544A1 (en) Vanilloid receptor ligands
WO2008092292A1 (en) Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2
EP1831173B1 (en) Tetrahydroisoquinoline compounds for treatment of cns disorders
JP2017019768A (ja) ヘキサヒドロジベンゾ［ａ，ｇ］キノリジン系化合物、その製造方法、医薬品組成物およびその応用
US20030195187A1 (en) Guanidino compounds
KR870001072B1 (ko) 옥타하이드로티아졸로[4,5-g] 퀴놀린의 제조방법
PT808303E (pt) Derivados do acido 5-(4-subst.-piperidinil-1)-3-aril pentanoico como antagonistas de receptor de taquiquinina
US6825213B2 (en) β3-adrenoreceptor agonists, agonist compositions and methods of using
KR20100047333A (ko) 아세트아미드 입체이성체
FI95247B (fi) Menetelmä lääkeaineina käytettävien 1,3-tiatsolidinien -karbonyylikarboksiamidien valmistamiseksi
WO2007011290A1 (en) Bronchorelaxing agents based on indol- and isoquinoline derivatives
SK39097A3 (en) Bicyclic amidine derivatives useful in therapy
JPS60218377A (ja) ４−フエニルフタラジン誘導体及びそれを有効成分とする循環改善剤
KR20010024074A (ko) 이미다졸린 화합물
JPH04178356A (ja) 光学活性なベンジルアルコール誘導体及びその用途
TW200524875A (en) Benzazepine derivatives as monoamine oxidase B inhibitors
US5079256A (en) Substituted tetrahydroisoquinoline compounds and method containing them
NZ203680A (en) Imidazolines and pharmaceutical compositions
RU2171803C2 (ru) Содержащие диол производные хинолина, способ их получения, фармацевтический препарат на их основе и способ ингибирования
CA1329398C (en) Compound active in cardiovascular therapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080117

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110128

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110802

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110802