CN1910149A - 支气管舒张化合物 - Google Patents

支气管舒张化合物 Download PDF

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Publication number
CN1910149A
CN1910149A CNA2005800025671A CN200580002567A CN1910149A CN 1910149 A CN1910149 A CN 1910149A CN A2005800025671 A CNA2005800025671 A CN A2005800025671A CN 200580002567 A CN200580002567 A CN 200580002567A CN 1910149 A CN1910149 A CN 1910149A
Authority
CN
China
Prior art keywords
compound
nmr
alkyl
chloro
thioamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800025671A
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English (en)
Chinese (zh)
Inventor
S·斯科格瓦尔
M·达伦斯古斯曼
H·比约克
M·伯格伦德
O·斯特纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Respiratorius AB
Original Assignee
Respiratorius AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Respiratorius AB filed Critical Respiratorius AB
Publication of CN1910149A publication Critical patent/CN1910149A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CNA2005800025671A 2004-01-22 2005-01-21 支气管舒张化合物 Pending CN1910149A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/761,323 US20050165004A1 (en) 2004-01-22 2004-01-22 Bronchorelaxing compounds
US10/761,323 2004-01-22

Publications (1)

Publication Number Publication Date
CN1910149A true CN1910149A (zh) 2007-02-07

Family

ID=34794812

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800025671A Pending CN1910149A (zh) 2004-01-22 2005-01-21 支气管舒张化合物

Country Status (6)

Country Link
US (2) US20050165004A1 (https=)
EP (1) EP1708999A1 (https=)
JP (1) JP2007518798A (https=)
CN (1) CN1910149A (https=)
RU (1) RU2006126532A (https=)
WO (1) WO2005070887A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107298655A (zh) * 2017-08-24 2017-10-27 郑州轻工业学院 7,8‑二甲氧基‑2,3,4,5‑四氢‑1H‑苯并[c]氮杂卓盐酸盐及其制备方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011290A1 (en) * 2005-07-18 2007-01-25 Respiratorius Ab Bronchorelaxing agents based on indol- and isoquinoline derivatives
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
WO2009007419A1 (en) * 2007-07-12 2009-01-15 Respiratorius Ab Novel bronchodilating isoquinoline carbamates
WO2009007418A1 (en) * 2007-07-12 2009-01-15 Respiratorius Ab Novel bronchodilating isoquinoline amides
SE531698C2 (sv) * 2007-07-12 2009-07-07 Respiratorius Ab Nya bronkdilaterande a,b-omättade amider
US20090318413A1 (en) * 2008-06-18 2009-12-24 Universite Victor Segalen Bordeaux 2 Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
RU2406435C1 (ru) * 2009-09-10 2010-12-20 Государственное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию" Фармакологическая коррекция повышенного симпатического тонуса при назначении антагонистов кальция у больных с сочетанием артериальной гипертензии и бронхиальной астмы
WO2016033105A1 (en) * 2014-08-29 2016-03-03 The Board Of Regents Of The University Of Texas System Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
KR20210032315A (ko) * 2018-07-06 2021-03-24 레스피라토리우스 아브 신규한 기관지 확장형 헤테로 결합된 아미드
KR102590643B1 (ko) * 2019-01-31 2023-10-17 히사미쓰 세이야꾸 가부시키가이샤 첩부제
WO2023028257A1 (en) * 2021-08-27 2023-03-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating neurodegenerative disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1029326A (en) * 1964-03-18 1966-05-11 Dresden Arzneimittel Isoindoline-2-carboxylic acid amides
DE2620179A1 (de) * 1975-10-28 1977-05-12 Knoll Ag Neue isochinolin-derivate
US4963563A (en) * 1989-10-13 1990-10-16 Abbott Laboratories 6-substituted-1,2,3,4-tetrahydroisoquinolines
ATE328868T1 (de) * 2000-08-21 2006-06-15 Pacific Corp Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
AU2001280229B2 (en) * 2000-08-21 2006-12-07 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
AU2002235277A1 (en) * 2000-10-23 2002-05-06 Smith Kline Beecham Corporation Compounds and methods
ES2193839B1 (es) * 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
JP2003192660A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
EP1489071A1 (en) * 2003-06-18 2004-12-22 4Sc Ag N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators
EP1660454A1 (en) * 2003-07-07 2006-05-31 Vernalis (R&D) Limited Azacyclic compounds as inhibitors of sensory neurone specific channels

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107298655A (zh) * 2017-08-24 2017-10-27 郑州轻工业学院 7,8‑二甲氧基‑2,3,4,5‑四氢‑1H‑苯并[c]氮杂卓盐酸盐及其制备方法
CN107298655B (zh) * 2017-08-24 2019-11-15 郑州轻工业学院 7,8-二甲氧基-2,3,4,5-四氢-1H-苯并[c]氮杂卓盐酸盐及其制备方法

Also Published As

Publication number Publication date
RU2006126532A (ru) 2008-02-27
US20050165004A1 (en) 2005-07-28
US20060040919A1 (en) 2006-02-23
WO2005070887A1 (en) 2005-08-04
EP1708999A1 (en) 2006-10-11
JP2007518798A (ja) 2007-07-12

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