JP2007516983A5 - - Google Patents
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- Publication number
- JP2007516983A5 JP2007516983A5 JP2006545846A JP2006545846A JP2007516983A5 JP 2007516983 A5 JP2007516983 A5 JP 2007516983A5 JP 2006545846 A JP2006545846 A JP 2006545846A JP 2006545846 A JP2006545846 A JP 2006545846A JP 2007516983 A5 JP2007516983 A5 JP 2007516983A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound
- salt
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- REBJYOGQHBZDEE-NRFANRHFSA-N Cc1nc(C(N(CC2)[C@](c3ccccc33)(c(cc4)ccc4Cl)N2C3=O)=O)c[s]1 Chemical compound Cc1nc(C(N(CC2)[C@](c3ccccc33)(c(cc4)ccc4Cl)N2C3=O)=O)c[s]1 REBJYOGQHBZDEE-NRFANRHFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003907196A AU2003907196A0 (en) | 2003-12-24 | Polycyclic agents for the treatment of respiratory syncytial virus infections | |
| AU2003907196 | 2003-12-24 | ||
| PCT/AU2004/001830 WO2005061513A1 (en) | 2003-12-24 | 2004-12-24 | Polycyclic agents for the treatment of respiratory syncytial virus infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204388A Division JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516983A JP2007516983A (ja) | 2007-06-28 |
| JP2007516983A5 true JP2007516983A5 (US07816364-20101019-C00082.png) | 2008-02-07 |
| JP5384793B2 JP5384793B2 (ja) | 2014-01-08 |
Family
ID=34705575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545846A Expired - Fee Related JP5384793B2 (ja) | 2003-12-24 | 2004-12-24 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
| JP2012204388A Expired - Fee Related JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204388A Expired - Fee Related JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Country Status (17)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1697377B1 (en) | 2003-12-24 | 2011-01-26 | Biota Scientific Management Pty. Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
| AR058554A1 (es) * | 2005-12-20 | 2008-02-13 | Novartis Ag | Compuestos heterociclicos nitrogenados de 6 miembros sustituidos, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por mglur5. |
| CA2661017A1 (en) | 2006-08-24 | 2008-02-28 | Novartis Ag | Organic compounds |
| US8236835B2 (en) | 2006-09-22 | 2012-08-07 | Novartis Ag | Heterocyclic inhibitors of stearoyl-CoA desaturase |
| TWI423972B (zh) * | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
| KR20090091337A (ko) | 2006-12-20 | 2009-08-27 | 노파르티스 아게 | Ｓｃｄ 억제제로서의 ２-치환 ５-원 헤테로사이클 |
| TWI508968B (zh) * | 2010-02-08 | 2015-11-21 | Biota Scient Management | 用於治療呼吸道融合性病毒感染的化合物 |
| MX2012015292A (es) * | 2010-06-24 | 2013-05-30 | Gilead Sciences Inc | Pirazolo[1, 5]pirimidinas en la forma de agentes antivirales. |
| AU2015200638B2 (en) * | 2010-06-24 | 2016-11-10 | Gilead Sciences, Inc. | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
| US8796303B2 (en) * | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| US8871756B2 (en) * | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| CN103748098B (zh) * | 2011-10-11 | 2016-06-29 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗或预防呼吸道合胞病毒疾病的化合物 |
| WO2013053658A1 (en) * | 2011-10-11 | 2013-04-18 | F. Hoffmann-La Roche Ag | Compounds for the treatment and prophylaxis of respiratory syncytial virus disease |
| GB201119538D0 (en) | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| ES2647486T3 (es) | 2011-12-22 | 2017-12-21 | Gilead Sciences, Inc. | Pirazolo[1,5-a]pirimidinas como agentes antivirales |
| DK2838900T3 (da) | 2012-04-17 | 2019-10-14 | Gilead Sciences Inc | Forbindelser og fremgangsmåder til antiviral behandling |
| CN104311559A (zh) * | 2014-09-12 | 2015-01-28 | 中山大学 | 一类光学纯手性环状n,n-缩醛的合成方法 |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| WO2016184832A1 (en) | 2015-05-20 | 2016-11-24 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| JP6779972B2 (ja) | 2015-07-16 | 2020-11-04 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス（ｒｓｖ）感染症の処置のためのｎ−［（３−アミノ−３−オキセタニル）メチル］−２−（２，３−ジヒドロ−１，１−ジオキシド−１，４−ベンゾチアゼピン−４（５ｈ）−イル）−６−メチル−４−キナゾリンアミンの結晶形 |
| EA036399B1 (ru) | 2015-11-12 | 2020-11-06 | Ф. Хоффманн-Ля Рош Аг | Композиции для лечения спинальной мышечной атрофии |
| CN108137579B (zh) | 2015-12-10 | 2022-01-07 | 豪夫迈·罗氏有限公司 | 桥连哌啶衍生物 |
| CA3119019C (en) | 2015-12-10 | 2024-06-11 | Ptc Therapeutics, Inc. | Compounds and methods for treating huntington's disease |
| WO2017196970A1 (en) * | 2016-05-10 | 2017-11-16 | Georgia State University Research Foundation, Inc. | Heterocyclic derivatives for the thratment of rsv |
| SG11201911615WA (en) | 2017-06-05 | 2020-01-30 | Ptc Therapeutics Inc | Compounds for treating huntington's disease |
| BR112019026434A2 (pt) | 2017-06-14 | 2020-07-14 | Virometix Ag | peptídeos cíclicos para proteção contra vírus sincicial respiratório |
| US11395822B2 (en) | 2017-06-28 | 2022-07-26 | Ptc Therapeutics, Inc. | Methods for treating Huntington's disease |
| BR112019027717A2 (pt) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| CN111670189A (zh) | 2018-01-31 | 2020-09-15 | 爱尔兰詹森科学公司 | 对rsv具有活性的环烷基取代的吡唑并嘧啶 |
| US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
| US12103926B2 (en) | 2018-03-27 | 2024-10-01 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| EA202092439A1 (ru) | 2018-04-23 | 2021-03-05 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Гетероароматические соединения, обладающие активностью против rsv |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| CN108997354B (zh) * | 2018-08-08 | 2021-12-31 | 青岛大学附属医院 | 二氢嘧啶并异吲哚酮类化合物及其乳膏剂和在治疗高尿酸血症中的用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1058529A (en) | 1910-12-24 | 1913-04-08 | Harry T Hickey | Car-door. |
| NL137586C (US07816364-20101019-C00082.png) * | 1963-04-11 | |||
| US3507863A (en) | 1963-12-18 | 1970-04-21 | Sandoz Ag | Isoindolones and method for preparing same |
| NL126596C (US07816364-20101019-C00082.png) * | 1964-02-11 | |||
| NL129866C (US07816364-20101019-C00082.png) | 1965-09-21 | |||
| CH480350A (de) * | 1965-09-21 | 1969-10-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| US3379733A (en) * | 1965-12-07 | 1968-04-23 | Sandoz Ag | N-(omega-aminoalkyl)isoindoles and method for preparing same |
| CH481123A (de) * | 1966-09-21 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| DE1670041A1 (de) * | 1967-03-14 | 1972-03-02 | American Home Prod | Isoindole und Isoindoline |
| CH482697A (de) | 1967-03-17 | 1969-12-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| US3885037A (en) * | 1968-09-05 | 1975-05-20 | American Home Prod | Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds |
| US3935218A (en) * | 1968-09-05 | 1976-01-27 | American Home Products Corporation | Imidazolinyl phenyl carbonyl compounds acid addition salts and related compounds |
| US3657221A (en) * | 1969-02-19 | 1972-04-18 | American Home Prod | Process for preparing 9b-substituted-1 - sulfonyl - 1 2 3 9b - tetrahydro-5h-imidazo(2 1-a)isoindol-5-ones |
| US3770766A (en) | 1970-03-10 | 1973-11-06 | American Home Prod | 2-(2-amino-2,2-dialkylamino-3-hydroxy-3-phenyl-1h-benz(f)isoindole-1-ones |
| GB1322339A (en) * | 1970-03-10 | 1973-07-04 | American Home Prod | Imidazoline derivatives |
| US3624101A (en) * | 1970-03-10 | 1971-11-30 | American Home Prod | 2,3-DIHYDRO-5-ARYL-5H-BENZ{8 f{9 IMIDAZO{8 2,1-a{9 ISOINDOL-5-OLS |
| US3966955A (en) * | 1974-08-07 | 1976-06-29 | American Home Products Corporation | Anti-ulcer therapy |
| US4056536A (en) | 1976-06-29 | 1977-11-01 | Merck & Co., Inc. | Pyrrolo[2,1-b][3]benzazepines |
| US4258529A (en) * | 1978-07-21 | 1981-03-31 | Phillips Petroleum Company | Method of sealing a container |
| US4701208A (en) | 1983-08-02 | 1987-10-20 | American Cyanamid Company | Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof |
| DE3520390A1 (de) | 1984-07-07 | 1986-02-06 | Bayer Ag, 5090 Leverkusen | Imidazo-pyrrolo-pyridin-derivate |
| EP0183993A3 (de) | 1984-11-16 | 1987-12-09 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 2H-Imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine und deren Verwendung als Unkrautbekämpfungsmittel |
| DE3674028D1 (de) | 1985-03-12 | 1990-10-18 | Ciba Geigy Ag | Heterocyclisch kondensierte pyridin-verbindungen als herbizide. |
| DE3534948A1 (de) * | 1985-10-01 | 1987-04-09 | Bayer Ag | Fungizide und wachstumsregulatorische mittel |
| US4717414A (en) | 1986-08-08 | 1988-01-05 | Ppg Industries, Inc. | Herbicidally active imidazopyrrolo-pyridine (or benzene) derivatives |
| DE3634952A1 (de) | 1986-10-14 | 1988-04-21 | Bayer Ag | Imidazo-pyrrolo-pyridin-derivate |
| EP0475908A1 (de) * | 1990-09-14 | 1992-03-18 | Ciba-Geigy Ag | Chromogene Lactamverbindungen und ihre Herstellung und Verwendung |
| DE4103177A1 (de) | 1991-02-02 | 1992-08-06 | Boehringer Mannheim Gmbh | Thiazolo-(2,3-a)isoindol-derivate und diese enthaltende arzneimittel |
| JPH06505017A (ja) * | 1991-02-28 | 1994-06-09 | ベーリンガー マンハイム ゲーエムベーハー | 三環式イソインドリノンの抗ウイルス医薬としての使用、ならびに新規な光学活性イソインドリノン |
| DE4108395A1 (de) | 1991-03-15 | 1993-01-28 | Boehringer Mannheim Gmbh | Verwendung von oxazolo-(2,3-a)isoindol-und imidazo(2,1-a)-isoindol-derivaten als antivirale arzneimittel sowie neue oxazolo(2,3-a)isoindol-derivaten |
| DE4129779A1 (de) | 1991-09-07 | 1993-03-11 | Boehringer Mannheim Gmbh | Neue tricyclische thiazol- und oxazol-derivate und diese enthaltende arzneimittel |
| CA2382528A1 (en) * | 1999-08-25 | 2001-03-01 | Banyu Pharmaceutical Co., Ltd. | Novel isoindole derivatives |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) * | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| WO2002042326A1 (en) | 2000-11-22 | 2002-05-30 | Biota Scientific Management Pty Ltd | A method of expression and agents identified thereby |
| WO2002066479A1 (fr) * | 2001-02-23 | 2002-08-29 | Banyu Pharmaceutical Co.,Ltd. | Derives de l'isoindole |
| JP2002310962A (ja) * | 2001-04-19 | 2002-10-23 | Hitachi Ltd | 画像分類方法並びに観察方法及びその装置 |
| AUPR878401A0 (en) | 2001-11-09 | 2001-12-06 | Biota Holdings Ltd | Methods for identifying or screening anti-viral agents |
| EP1697377B1 (en) | 2003-12-24 | 2011-01-26 | Biota Scientific Management Pty. Ltd. | Polycyclic agents for the treatment of respiratory syncytial virus infections |
| DK1874117T3 (da) | 2005-04-28 | 2013-09-23 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
| TWI423972B (zh) | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
-
2004
- 2004-12-24 EP EP04802131A patent/EP1697377B1/en active Active
- 2004-12-24 WO PCT/AU2004/001830 patent/WO2005061513A1/en active Application Filing
- 2004-12-24 ES ES04802131T patent/ES2360222T3/es active Active
- 2004-12-24 KR KR1020067014876A patent/KR20060127909A/ko not_active Application Discontinuation
- 2004-12-24 RU RU2006126663/04A patent/RU2422444C2/ru not_active IP Right Cessation
- 2004-12-24 CN CN2009102585362A patent/CN101723949B/zh not_active Expired - Fee Related
- 2004-12-24 CN CN200480039049A patent/CN100582109C/zh not_active Expired - Fee Related
- 2004-12-24 US US10/585,230 patent/US8598193B2/en not_active Expired - Fee Related
- 2004-12-24 EP EP10177705A patent/EP2287167A1/en not_active Withdrawn
- 2004-12-24 DE DE602004031258T patent/DE602004031258D1/de active Active
- 2004-12-24 AT AT04802131T patent/ATE496920T1/de not_active IP Right Cessation
- 2004-12-24 BR BRPI0418127-1A patent/BRPI0418127A/pt not_active IP Right Cessation
- 2004-12-24 NZ NZ551468A patent/NZ551468A/en not_active IP Right Cessation
- 2004-12-24 CA CA2551178A patent/CA2551178C/en not_active Expired - Fee Related
- 2004-12-24 JP JP2006545846A patent/JP5384793B2/ja not_active Expired - Fee Related
-
2006
- 2006-06-02 ZA ZA200604528A patent/ZA200604528B/en unknown
- 2006-06-06 IL IL176155A patent/IL176155A0/en unknown
- 2006-06-13 NO NO20062758A patent/NO20062758L/no not_active Application Discontinuation
- 2006-09-26 HK HK06110690.6A patent/HK1088607A1/xx not_active IP Right Cessation
-
2012
- 2012-09-18 JP JP2012204388A patent/JP5536842B2/ja not_active Expired - Fee Related
-
2013
- 2013-10-24 US US14/062,780 patent/US20140051689A1/en not_active Abandoned
