JP2007516211A5 - - Google Patents
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- Publication number
- JP2007516211A5 JP2007516211A5 JP2006520478A JP2006520478A JP2007516211A5 JP 2007516211 A5 JP2007516211 A5 JP 2007516211A5 JP 2006520478 A JP2006520478 A JP 2006520478A JP 2006520478 A JP2006520478 A JP 2006520478A JP 2007516211 A5 JP2007516211 A5 JP 2007516211A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- ethyl
- hydroxy
- methylsulfonyl
- phenylethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- XSRZJMIJNKWTJY-LJAQVGFWSA-N 2-(cyclohexylamino)-4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-n-methylsulfonylbenzamide Chemical compound CS(=O)(=O)NC(=O)C1=CC=C(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)C=C1NC1CCCCC1 XSRZJMIJNKWTJY-LJAQVGFWSA-N 0.000 claims 1
- WWFRXUDMACTFBI-NDEPHWFRSA-N 2-cyclohexyloxy-4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-n-methylsulfonylbenzamide Chemical compound CS(=O)(=O)NC(=O)C1=CC=C(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)C=C1OC1CCCCC1 WWFRXUDMACTFBI-NDEPHWFRSA-N 0.000 claims 1
- YLQMAAMFQNYJDU-MHZLTWQESA-N 2-cyclohexyloxy-4-[4-[2-[[(2r)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-n-methylsulfonylbenzamide Chemical compound CS(=O)(=O)NC(=O)C1=CC=C(C=2C=CC(CCNC[C@H](O)C=3C=NC=CC=3)=CC=2)C=C1OC1CCCCC1 YLQMAAMFQNYJDU-MHZLTWQESA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- SITWWMFSARAANL-KMRXNPHXSA-N 4-[4-[2-[[(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]amino]ethyl]phenyl]-2-(2-methylpropyl)-n-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NS(C)(=O)=O)C(CC(C)C)=CC(C=2C=CC(CCN[C@@H](C)[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 SITWWMFSARAANL-KMRXNPHXSA-N 0.000 claims 1
- FKGYWDPSUXSSQK-MHZLTWQESA-N 4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-(2-methylpropyl)-n-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NS(C)(=O)=O)C(CC(C)C)=CC(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 FKGYWDPSUXSSQK-MHZLTWQESA-N 0.000 claims 1
- IXBYTCUCLIPCPM-NDEPHWFRSA-N 4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-(3-methylbutyl)-n-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NS(C)(=O)=O)C(CCC(C)C)=CC(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 IXBYTCUCLIPCPM-NDEPHWFRSA-N 0.000 claims 1
- FEQQLEGJQNYEQY-SANMLTNESA-N 4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-n-methylsulfonyl-2-(propan-2-ylamino)benzamide Chemical compound C1=C(C(=O)NS(C)(=O)=O)C(NC(C)C)=CC(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 FEQQLEGJQNYEQY-SANMLTNESA-N 0.000 claims 1
- HXFKZSVPCHUKBX-VWLOTQADSA-N 4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-n-methylsulfonyl-2-propan-2-ylsulfanylbenzamide Chemical compound C1=C(C(=O)NS(C)(=O)=O)C(SC(C)C)=CC(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 HXFKZSVPCHUKBX-VWLOTQADSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- -1 benzyloxy, nitro, amino Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- HGOKKKSGWRCIHE-NDEPHWFRSA-N n-[2-cyclohexyloxy-4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]phenyl]sulfonylacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)C=C1OC1CCCCC1 HGOKKKSGWRCIHE-NDEPHWFRSA-N 0.000 claims 1
- IWTORKZSDKQKNR-LJAQVGFWSA-N n-[2-cyclohexyloxy-4-[4-[2-[[(2r)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]phenyl]sulfonylbutanamide Chemical compound CCCC(=O)NS(=O)(=O)C1=CC=C(C=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)C=C1OC1CCCCC1 IWTORKZSDKQKNR-LJAQVGFWSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003907111A AU2003907111A0 (en) | 2003-12-23 | Aminoalcohol Derivatives | |
| PCT/JP2004/019495 WO2005061433A2 (en) | 2003-12-23 | 2004-12-20 | Aminoalcohol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516211A JP2007516211A (ja) | 2007-06-21 |
| JP2007516211A5 true JP2007516211A5 (enExample) | 2008-02-14 |
| JP4618250B2 JP4618250B2 (ja) | 2011-01-26 |
Family
ID=34658494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520478A Expired - Fee Related JP4618250B2 (ja) | 2003-12-23 | 2004-12-20 | アミノアルコール誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7417060B2 (enExample) |
| EP (1) | EP1697301A2 (enExample) |
| JP (1) | JP4618250B2 (enExample) |
| KR (1) | KR101071748B1 (enExample) |
| CN (1) | CN100582088C (enExample) |
| AR (1) | AR047351A1 (enExample) |
| CA (1) | CA2551167C (enExample) |
| MX (1) | MXPA06007173A (enExample) |
| TW (1) | TW200526551A (enExample) |
| WO (1) | WO2005061433A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100693367B1 (ko) * | 2002-06-27 | 2007-03-12 | 아스텔라스세이야쿠 가부시키가이샤 | 아미노알콜 유도체 |
| BRPI0407386A (pt) | 2003-02-14 | 2006-02-07 | Kissei Pharmaceutical | Derivados de álcool de amino, composições farmacêuticas contendo os mesmos e uso destes |
| CA2541894A1 (en) | 2003-10-24 | 2005-05-06 | Kissei Pharmaceutical Co., Ltd. | Amino alcohol derivative, medicinal composition containing the same, and use of these |
| CA2551167C (en) | 2003-12-23 | 2011-10-18 | Astellas Pharma Inc. | Aminoalcohol derivatives |
| JPWO2006022237A1 (ja) * | 2004-08-24 | 2008-05-08 | キッセイ薬品工業株式会社 | 脂肪肝の予防または治療剤 |
| PT1791811E (pt) * | 2004-09-21 | 2010-02-23 | Astellas Pharma Inc | ¿derivados de aminoálcool |
| EP1860098B1 (en) * | 2005-03-16 | 2012-11-14 | Toyama Chemical Co., Ltd. | Novel anthranilic acid derivative or salt thereof |
| KR100901664B1 (ko) | 2007-08-06 | 2009-06-09 | 주식회사 오스코텍 | β-아미노알콜 유도체, 이의 제조방법 및 이를유효성분으로 함유하는 ＴＮＦ-α 매개성 질환의 예방 및치료용 약학적 조성물 |
| CN108290824B (zh) * | 2015-10-23 | 2022-03-11 | B3Ar治疗股份有限公司 | 索拉贝隆两性离子及其应用 |
| CN116640074B (zh) * | 2023-05-22 | 2025-09-23 | 河北允升精细化工有限公司 | 一种合成5-氯-2-(2-氯乙氧基)苯磺酰胺的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3718638A1 (de) * | 1987-06-04 | 1988-12-22 | Thomae Gmbh Dr K | Neue phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| JPH11504649A (ja) * | 1995-05-10 | 1999-04-27 | ファイザー・インコーポレーテッド | β−アドレナリン作働性アゴニスト |
| GB9812709D0 (en) * | 1998-06-13 | 1998-08-12 | Glaxo Group Ltd | Chemical compounds |
| WO2002032897A1 (en) * | 2000-10-20 | 2002-04-25 | Pfizer Products Inc. | Alpha-aryl ethanolamines and their use as beta-3 adrenergic receptor agonists |
| DE60225174T2 (de) * | 2001-11-20 | 2009-02-12 | Eli Lilly And Co., Indianapolis | Beta-3 adrenergische agonisten |
| DOP2003000587A (es) * | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| EP1478625A1 (en) * | 2002-02-27 | 2004-11-24 | Pfizer Products Inc. | Processes and intermediates useful in preparing beta-3-adrenergic receptor agonists |
| CA2479065A1 (en) * | 2002-03-14 | 2003-09-18 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives as beta-3 adrenergic receptor agonists |
| KR100693367B1 (ko) * | 2002-06-27 | 2007-03-12 | 아스텔라스세이야쿠 가부시키가이샤 | 아미노알콜 유도체 |
| AU2002952839A0 (en) | 2002-11-21 | 2002-12-05 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
| BRPI0407386A (pt) * | 2003-02-14 | 2006-02-07 | Kissei Pharmaceutical | Derivados de álcool de amino, composições farmacêuticas contendo os mesmos e uso destes |
| CA2551167C (en) | 2003-12-23 | 2011-10-18 | Astellas Pharma Inc. | Aminoalcohol derivatives |
-
2004
- 2004-12-20 CA CA2551167A patent/CA2551167C/en not_active Expired - Fee Related
- 2004-12-20 KR KR1020067014417A patent/KR101071748B1/ko not_active Expired - Fee Related
- 2004-12-20 EP EP04807850A patent/EP1697301A2/en not_active Withdrawn
- 2004-12-20 WO PCT/JP2004/019495 patent/WO2005061433A2/en not_active Ceased
- 2004-12-20 MX MXPA06007173A patent/MXPA06007173A/es active IP Right Grant
- 2004-12-20 JP JP2006520478A patent/JP4618250B2/ja not_active Expired - Fee Related
- 2004-12-20 CN CN200480041150A patent/CN100582088C/zh not_active Expired - Fee Related
- 2004-12-21 US US11/016,886 patent/US7417060B2/en not_active Expired - Fee Related
- 2004-12-22 TW TW093139942A patent/TW200526551A/zh unknown
- 2004-12-27 AR ARP040104909A patent/AR047351A1/es unknown
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