|
HU230302B1
(hu)
|
2000-10-20 |
2015-12-28 |
Eisai R&D Management Co., Ltd. |
Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
ATE451104T1
(de)
|
2002-07-29 |
2009-12-15 |
Rigel Pharmaceuticals Inc |
Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen
|
|
ATE508747T1
(de)
|
2003-03-10 |
2011-05-15 |
Eisai R&D Man Co Ltd |
C-kit kinase-hemmer
|
|
ES2421139T3
(es)
|
2003-07-30 |
2013-08-29 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
|
|
CN100450998C
(zh)
|
2003-11-11 |
2009-01-14 |
卫材R&D管理有限公司 |
脲衍生物的制备方法
|
|
AU2011253934C1
(en)
*
|
2004-06-17 |
2013-08-22 |
Cytokinetics, Inc. |
Substituted urea derivatives for treating cardiac diseases
|
|
US7507735B2
(en)
|
2004-06-17 |
2009-03-24 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
GB0512324D0
(en)
*
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
EP1797881B1
(en)
|
2004-09-17 |
2009-04-15 |
Eisai R&D Management Co., Ltd. |
Medicinal composition with improved stability and reduced gelation properties
|
|
EP2161275A1
(en)
|
2005-01-19 |
2010-03-10 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
US7491732B2
(en)
|
2005-06-08 |
2009-02-17 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
EP2281901B1
(en)
|
2005-08-02 |
2013-11-27 |
Eisai R&D Management Co., Ltd. |
Anti-tumour pharmaceutical composition with angiogenesis inhibitors
|
|
AR058347A1
(es)
|
2005-12-15 |
2008-01-30 |
Cytokinetics Inc |
Entidades quimias composiciones y metodos
|
|
EP1962852B1
(en)
|
2005-12-19 |
2017-01-25 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
MEP3808A
(xx)
|
2005-12-21 |
2010-02-10 |
Novartis Ag |
Derivati pirimidinil aril uree kao fgf inhibitori
|
|
TW200804349A
(en)
*
|
2005-12-23 |
2008-01-16 |
Kalypsys Inc |
Novel substituted pyrimidinyloxy ureas as inhibitors of protein kinases
|
|
DK1973545T3
(da)
|
2005-12-23 |
2013-02-25 |
Ariad Pharma Inc |
Bicykliske heteroarylforbindelser
|
|
WO2007098507A2
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
GB0605120D0
(en)
|
2006-03-14 |
2006-04-26 |
Novartis Ag |
Organic Compounds
|
|
AU2007249924B2
(en)
|
2006-05-08 |
2013-07-04 |
Ariad Pharmaceuticals, Inc. |
Acetylenic heteroaryl compounds
|
|
EP2036557B1
(en)
*
|
2006-05-18 |
2015-10-21 |
Eisai R&D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
|
EP2069535B1
(en)
*
|
2006-08-11 |
2013-04-10 |
Johns Hopkins University |
Consensus coding sequences of human breast and colorectal cancers
|
|
CN101511793B
(zh)
|
2006-08-28 |
2011-08-03 |
卫材R&D管理有限公司 |
针对未分化型胃癌的抗肿瘤剂
|
|
AU2013231117B2
(en)
*
|
2006-12-14 |
2016-06-02 |
Janssen Pharmaceutica N.V. |
Process for the preparation of piperazinyl and diazepanyl benzamide derivatives
|
|
EP2102173B1
(en)
*
|
2006-12-22 |
2010-10-20 |
F. Hoffmann-La Roche AG |
Pyrimidyl derivatives as protein kinase inhibitors
|
|
AU2008211952B2
(en)
|
2007-01-29 |
2012-07-19 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
|
GB0706932D0
(en)
*
|
2007-04-10 |
2007-05-16 |
Univ London Pharmacy |
Ureylene derivatives
|
|
EP2146964A2
(en)
|
2007-04-17 |
2010-01-27 |
Novartis Ag |
Ethers of naphtalene carboxylic acid amides as cancer cure
|
|
FR2921657A1
(fr)
*
|
2007-09-28 |
2009-04-03 |
Sanofi Aventis Sa |
Derives de nicotinamide, leur preparation et leur application en therapeutique
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
CA2702674C
(en)
*
|
2007-10-19 |
2016-05-03 |
Avila Therapeutics, Inc. |
Heteroaryl compounds and uses thereof
|
|
JP5638244B2
(ja)
|
2007-11-09 |
2014-12-10 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質と抗腫瘍性白金錯体との併用
|
|
EP2070929A1
(en)
|
2007-12-11 |
2009-06-17 |
Bayer Schering Pharma Aktiengesellschaft |
Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
|
JP2011520809A
(ja)
*
|
2008-05-05 |
2011-07-21 |
アムジエン・インコーポレーテツド |
γセクレターゼモジュレーターとしての尿素化合物
|
|
FR2943669B1
(fr)
*
|
2009-03-24 |
2011-05-06 |
Sanofi Aventis |
Derives de nicotinamide,leur preparation et leur application en therapeutique
|
|
CN101671301B
(zh)
*
|
2009-05-05 |
2014-02-26 |
江苏省药物研究所有限公司 |
杂环取代的二苯脲类衍生物及其用途
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
CN105693720B
(zh)
|
2010-05-20 |
2019-01-18 |
阵列生物制药公司 |
作为trk激酶抑制剂的大环化合物
|
|
MX2012014776A
(es)
|
2010-06-25 |
2013-01-29 |
Eisai R&D Man Co Ltd |
Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados.
|
|
FR2965263A1
(fr)
|
2010-09-24 |
2012-03-30 |
Sanofi Aventis |
Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique
|
|
FR2965262A1
(fr)
|
2010-09-24 |
2012-03-30 |
Sanofi Aventis |
Derives de nicotinamide, leur preparation et leur application en therapeutique
|
|
MX2013009931A
(es)
|
2011-04-18 |
2013-10-01 |
Eisai R&D Man Co Ltd |
Agentes terapeuticos contra tumores.
|
|
US9945862B2
(en)
|
2011-06-03 |
2018-04-17 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
EP2760843B1
(en)
|
2011-09-26 |
2016-03-02 |
Bristol-Myers Squibb Company |
Selective nr2b antagonists
|
|
CN103508961B
(zh)
|
2012-06-26 |
2015-07-22 |
中美冠科生物技术(太仓)有限公司 |
抗肿瘤药物
|
|
CA3022250A1
(en)
|
2012-12-12 |
2014-06-12 |
Ariad Pharmaceuticals, Inc. |
Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
|
|
US9334239B2
(en)
|
2012-12-21 |
2016-05-10 |
Eisai R&D Management Co., Ltd. |
Amorphous form of quinoline derivative, and method for producing same
|
|
DK2981535T3
(da)
|
2013-04-02 |
2021-03-01 |
Oxular Acquisitions Ltd |
Urinstofderivater, der er anvendelige som kinaseinhibitorer
|
|
US10517861B2
(en)
|
2013-05-14 |
2019-12-31 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
EP3083604A1
(en)
*
|
2013-12-20 |
2016-10-26 |
Respivert Limited |
Urea derivatives useful as kinase inhibitors
|
|
CN106660964B
(zh)
|
2014-08-28 |
2021-09-03 |
卫材R&D管理有限公司 |
高纯度喹啉衍生物及其生产方法
|
|
MA40775A
(fr)
|
2014-10-01 |
2017-08-08 |
Respivert Ltd |
Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
|
|
TWI746426B
(zh)
|
2014-11-16 |
2021-11-21 |
美商亞雷生物製藥股份有限公司 |
(S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
|
|
PL3263106T3
(pl)
|
2015-02-25 |
2024-04-02 |
Eisai R&D Management Co., Ltd. |
Sposób tłumienia goryczy pochodnej chinoliny
|
|
KR102662228B1
(ko)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
ES2886107T3
(es)
|
2015-06-16 |
2021-12-16 |
Prism Biolab Co Ltd |
Antineoplásico
|
|
EP3322706B1
(en)
|
2015-07-16 |
2020-11-11 |
Array Biopharma, Inc. |
Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
|
|
AU2016309356B2
(en)
|
2015-08-20 |
2021-06-24 |
Eisai R&D Management Co., Ltd. |
Tumor therapeutic agent
|
|
TN2018000138A1
(en)
|
2015-10-26 |
2019-10-04 |
Array Biopharma Inc |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
HUE068971T2
(hu)
|
2016-04-04 |
2025-02-28 |
Loxo Oncology Inc |
(S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid folyékony készítményei
|
|
RS65988B1
(sr)
|
2016-04-04 |
2024-10-31 |
Loxo Oncology Inc |
Postupak lečenja pedijatrijskih karcinoma
|
|
SI3458456T1
(sl)
|
2016-05-18 |
2021-04-30 |
Loxo Oncology, Inc. |
Priprava (S)-N-(5-((R)-2-(2,5-difluorofenil) pirolidin-1-il) pirazolo (1,5-A) pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
|
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
CN110267960B
(zh)
|
2017-01-18 |
2022-04-26 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
|
|
MX380144B
(es)
|
2017-02-08 |
2025-03-12 |
Eisai R&D Man Co Ltd |
Composicion farmaceutica de tratamiento de tumores.
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
CA3061888A1
(en)
|
2017-05-16 |
2018-11-22 |
Eisai R&D Management Co., Ltd. |
Treatment of hepatocellular carcinoma
|
|
TWI812649B
(zh)
|
2017-10-10 |
2023-08-21 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
AU2017444054B2
(en)
*
|
2017-12-21 |
2021-10-07 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Class of pyrimidine derivative kinase inhibitors
|
|
WO2019143994A1
(en)
|
2018-01-18 |
2019-07-25 |
Array Biopharma Inc. |
Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
|
|
CN111971286B
(zh)
|
2018-01-18 |
2023-04-14 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
|
|
TW201938169A
(zh)
|
2018-01-18 |
2019-10-01 |
美商亞雷生物製藥股份有限公司 |
作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
|
|
ES2922314T3
(es)
|
2018-09-10 |
2022-09-13 |
Array Biopharma Inc |
Compuestos heterocíclicos condensados como inhibidores de cinasa RET
|