JP2006502183A5 - - Google Patents
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- JP2006502183A5 JP2006502183A5 JP2004537690A JP2004537690A JP2006502183A5 JP 2006502183 A5 JP2006502183 A5 JP 2006502183A5 JP 2004537690 A JP2004537690 A JP 2004537690A JP 2004537690 A JP2004537690 A JP 2004537690A JP 2006502183 A5 JP2006502183 A5 JP 2006502183A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- inhibitor
- kinase inhibitor
- norleusyl
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003112 inhibitor Substances 0.000 claims 9
- 230000015572 biosynthetic process Effects 0.000 claims 7
- 238000003786 synthesis reaction Methods 0.000 claims 7
- 102000004127 Cytokines Human genes 0.000 claims 5
- 108090000695 Cytokines Proteins 0.000 claims 5
- 229940043355 kinase inhibitor Drugs 0.000 claims 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- RMWVZGDJPAKBDE-UHFFFAOYSA-N 2-acetyloxy-4-(trifluoromethyl)benzoic acid Chemical compound CC(=O)OC1=CC(C(F)(F)F)=CC=C1C(O)=O RMWVZGDJPAKBDE-UHFFFAOYSA-N 0.000 claims 1
- 102100034613 Annexin A2 Human genes 0.000 claims 1
- 229940115462 I kappa kinase inhibitor Drugs 0.000 claims 1
- PQFMNVGMJJMLAE-QMMMGPOBSA-N L-tyrosinamide Chemical compound NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 PQFMNVGMJJMLAE-QMMMGPOBSA-N 0.000 claims 1
- 229940122696 MAP kinase inhibitor Drugs 0.000 claims 1
- 102100023482 Mitogen-activated protein kinase 14 Human genes 0.000 claims 1
- 102000034527 Retinoid X Receptors Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- VSPFURGQAYMVAN-UHFFFAOYSA-N SB220025 Chemical compound NC1=NC=CC(C=2N(C=NC=2C=2C=CC(F)=CC=2)C2CCNCC2)=N1 VSPFURGQAYMVAN-UHFFFAOYSA-N 0.000 claims 1
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 108091006088 activator proteins Proteins 0.000 claims 1
- 229960002938 bexarotene Drugs 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003226 mitogen Substances 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229960002268 triflusal Drugs 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41246302P | 2002-09-20 | 2002-09-20 | |
| PCT/US2003/026689 WO2004026406A1 (en) | 2002-09-20 | 2003-08-26 | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502183A JP2006502183A (ja) | 2006-01-19 |
| JP2006502183A5 true JP2006502183A5 (enExample) | 2006-08-17 |
Family
ID=32030872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537690A Pending JP2006502183A (ja) | 2002-09-20 | 2003-08-26 | ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7026296B2 (enExample) |
| EP (1) | EP1542768A1 (enExample) |
| JP (1) | JP2006502183A (enExample) |
| KR (1) | KR20050057175A (enExample) |
| CN (1) | CN1684738A (enExample) |
| AR (1) | AR041262A1 (enExample) |
| AU (1) | AU2003278727A1 (enExample) |
| BR (1) | BR0314603A (enExample) |
| CA (1) | CA2497977A1 (enExample) |
| MX (1) | MXPA05003063A (enExample) |
| PL (1) | PL374700A1 (enExample) |
| TW (1) | TW200404534A (enExample) |
| WO (1) | WO2004026406A1 (enExample) |
| ZA (1) | ZA200502119B (enExample) |
Families Citing this family (61)
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| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
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| JP2007133001A (ja) * | 2005-11-08 | 2007-05-31 | Seed Co Ltd | コンタクトレンズ用ケア用剤 |
| HUE028588T2 (hu) | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
| US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
| CA2663545A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof |
| EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
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| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| BRPI1012108B8 (pt) | 2009-05-22 | 2021-05-25 | Incyte Corp | composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico |
| NZ596479A (en) | 2009-05-22 | 2014-01-31 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
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| US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
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| US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
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| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| EP2877465A4 (en) | 2012-07-25 | 2016-05-11 | Sarcode Bioscience Inc | LFA-1 HEMMER AND POLYMORPH THEREOF |
| KR102242077B1 (ko) | 2012-11-15 | 2021-04-20 | 인사이트 홀딩스 코포레이션 | 룩솔리티니브의 서방성 제형 |
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| EA201501080A1 (ru) | 2013-06-26 | 2016-07-29 | Ксижен Инфлемейшн Лтд. | Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний |
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| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| MX376856B (es) | 2013-08-07 | 2025-03-07 | Incyte Holdings Corp | Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1). |
| US10813920B2 (en) * | 2013-11-14 | 2020-10-27 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
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| US11154543B2 (en) | 2015-10-15 | 2021-10-26 | The Schepens Eye Research Institute, Inc. | P38 MAP kinase inhibitors for wound healing |
| CN105496955A (zh) * | 2015-12-11 | 2016-04-20 | 北京蓝丹医药科技有限公司 | 一种二氟泼尼酯眼用乳剂及其制备方法 |
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| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
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| US20020132823A1 (en) | 2001-01-17 | 2002-09-19 | Jiahuai Han | Assay method |
| GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| DK1393277T3 (da) * | 2001-05-21 | 2006-10-30 | Alcon Inc | Anvendelse af NF-Kappa-B inhibitorer til behandling af öjentörhedslidelser |
| US20060084684A1 (en) | 2002-05-28 | 2006-04-20 | Altana Pharma Ag | Topically applicable pharmaceutical preparation |
| JP2006502183A (ja) * | 2002-09-20 | 2006-01-19 | アルコン，インコーポレイテッド | ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用 |
-
2003
- 2003-08-26 JP JP2004537690A patent/JP2006502183A/ja active Pending
- 2003-08-26 WO PCT/US2003/026689 patent/WO2004026406A1/en not_active Ceased
- 2003-08-26 AU AU2003278727A patent/AU2003278727A1/en not_active Abandoned
- 2003-08-26 BR BR0314603-0A patent/BR0314603A/pt not_active IP Right Cessation
- 2003-08-26 EP EP03770254A patent/EP1542768A1/en not_active Withdrawn
- 2003-08-26 MX MXPA05003063A patent/MXPA05003063A/es not_active Application Discontinuation
- 2003-08-26 KR KR1020057003759A patent/KR20050057175A/ko not_active Withdrawn
- 2003-08-26 PL PL03374700A patent/PL374700A1/xx not_active Application Discontinuation
- 2003-08-26 CN CNA03822514XA patent/CN1684738A/zh active Pending
- 2003-08-26 CA CA002497977A patent/CA2497977A1/en not_active Abandoned
- 2003-08-26 US US10/650,006 patent/US7026296B2/en not_active Expired - Fee Related
- 2003-09-04 TW TW092124459A patent/TW200404534A/zh unknown
- 2003-09-15 AR ARP030103339A patent/AR041262A1/es not_active Application Discontinuation
-
2005
- 2005-03-14 ZA ZA200502119A patent/ZA200502119B/en unknown
-
2006
- 2006-03-28 US US11/390,874 patent/US20060189541A1/en not_active Abandoned
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