JP2002534508A5 - - Google Patents

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Publication number
JP2002534508A5
JP2002534508A5 JP2000593588A JP2000593588A JP2002534508A5 JP 2002534508 A5 JP2002534508 A5 JP 2002534508A5 JP 2000593588 A JP2000593588 A JP 2000593588A JP 2000593588 A JP2000593588 A JP 2000593588A JP 2002534508 A5 JP2002534508 A5 JP 2002534508A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
alkoxy
phenyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000593588A
Other languages
English (en)
Japanese (ja)
Other versions
JP4653314B2 (ja
JP2002534508A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2000/000172 external-priority patent/WO2000042020A1/en
Publication of JP2002534508A publication Critical patent/JP2002534508A/ja
Publication of JP2002534508A5 publication Critical patent/JP2002534508A5/ja
Application granted granted Critical
Publication of JP4653314B2 publication Critical patent/JP4653314B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2000593588A 1999-01-15 2000-01-12 Ｐｄｅ−ｉｖ阻害作用を有するフェニルフェナントリジン Expired - Fee Related JP4653314B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100694 1999-01-15
EP99100694.1 1999-01-15
PCT/EP2000/000172 WO2000042020A1 (en) 1999-01-15 2000-01-12 Phenylphenanthridines with pde-iv inhibiting activity

Publications (3)

Publication Number Publication Date
JP2002534508A JP2002534508A (ja) 2002-10-15
JP2002534508A5 true JP2002534508A5 (enExample) 2007-03-01
JP4653314B2 JP4653314B2 (ja) 2011-03-16

Family

ID=8237351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000593588A Expired - Fee Related JP4653314B2 (ja) 1999-01-15 2000-01-12 Ｐｄｅ−ｉｖ阻害作用を有するフェニルフェナントリジン

Country Status (32)

Country Link
US (1) US6476025B1 (enExample)
EP (2) EP1147089B1 (enExample)
JP (1) JP4653314B2 (enExample)
KR (1) KR100720906B1 (enExample)
CN (1) CN1152864C (enExample)
AT (1) ATE312081T1 (enExample)
AU (1) AU774868B2 (enExample)
BG (1) BG65126B1 (enExample)
BR (1) BR0007527B1 (enExample)
CA (1) CA2359440C (enExample)
CY (1) CY1106436T1 (enExample)
CZ (1) CZ300366B6 (enExample)
DE (1) DE60024581T2 (enExample)
DK (1) DK1147089T3 (enExample)
EA (1) EA003780B1 (enExample)
EE (1) EE05105B1 (enExample)
ES (1) ES2254132T3 (enExample)
HK (1) HK1040997B (enExample)
HR (1) HRP20010578A2 (enExample)
HU (1) HU227624B1 (enExample)
ID (1) ID29070A (enExample)
IL (2) IL144026A0 (enExample)
NO (1) NO320182B1 (enExample)
NZ (1) NZ512872A (enExample)
PL (1) PL205670B1 (enExample)
RS (1) RS50297B (enExample)
SI (1) SI1147089T1 (enExample)
SK (1) SK286946B6 (enExample)
TR (2) TR200501553T2 (enExample)
UA (1) UA69436C2 (enExample)
WO (1) WO2000042020A1 (enExample)
ZA (1) ZA200104864B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001267589A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
CA2495597A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Novel phenanthridines
CA2496459C (en) * 2002-08-29 2013-06-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
AU2003255493B8 (en) 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
JP2007500686A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
EP1658270A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenantridines
WO2005023253A1 (en) * 2003-09-05 2005-03-17 Altana Pharma Ag Use of pde4 inhibitors for the treatment of diabetes mellitus
EP1720835B1 (en) * 2004-02-18 2012-12-12 Nycomed GmbH Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AU2005220034A1 (en) * 2004-03-09 2005-09-15 Nycomed Gmbh Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
BRPI0508471A8 (pt) * 2004-03-10 2019-01-15 Altana Pharma Ag compostos de hidróxi-6-fenilfenantidinas substituídas por difluoroetóxi, composição farmacêutica e uso para a produção dos mesmos
CA2558390A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
US7411093B2 (en) * 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
CN102600144A (zh) 2005-03-08 2012-07-25 奈科明有限责任公司 治疗糖尿病的罗氟司特
AU2006221957A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
KR101178674B1 (ko) 2007-10-04 2012-08-30 에프. 호프만-라 로슈 아게 사이클로프로필 아릴 아마이드 유도체 및 이의 용도
EP2794565B1 (en) 2011-12-21 2017-07-26 Novira Therapeutics Inc. Hepatitis b antiviral agents
CA2881057C (en) 2012-08-28 2020-10-27 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
JP6466348B2 (ja) 2013-02-28 2019-02-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用
HUE033542T2 (en) 2013-04-03 2017-12-28 Janssen Sciences Ireland Uc Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B
HUE040446T2 (hu) 2013-05-17 2019-03-28 Janssen Sciences Ireland Uc Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére
TW202126620A (zh) 2013-05-17 2021-07-16 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途
WO2015011281A1 (en) 2013-07-25 2015-01-29 Janssen R&D Ireland Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
MX368158B (es) 2013-10-23 2019-09-20 Janssen Sciences Ireland Uc Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja) 2014-02-05 2019-07-31 ノヴィラ・セラピューティクス・インコーポレイテッド Ｈｂｖ感染の治療のための併用療法
PL3102572T3 (pl) 2014-02-06 2019-04-30 Janssen Sciences Ireland Uc Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B
EP3271019A1 (en) 2015-03-19 2018-01-24 Novira Therapeutics Inc. Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
AR106192A1 (es) 2015-09-29 2017-12-20 Novira Therapeutics Inc Formas cristalinas de un agente antiviral contra la hepatitis b
WO2017181141A2 (en) 2016-04-15 2017-10-19 Novira Therapeutics, Inc. Combinations and methods comprising a capsid assembly inhibitor
SG11202007097QA (en) 2018-03-14 2020-08-28 Janssen Sciences Ireland Unlimited Co Capsid assembly modulator dosing regimen
AU2020223865A1 (en) 2019-02-22 2021-07-15 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
CA2250569C (en) * 1996-03-26 2005-05-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel phenanthridines substituted in the 6 position
DK0937074T3 (da) * 1996-11-11 2003-06-23 Altana Pharma Ag Benzonaphthyridiner som bronkiale terapeutiske midler
SI0968211T1 (en) 1997-03-07 2004-02-29 Altana Pharma Ag Tetrazole derivatives
AU8106598A (en) 1997-06-03 1998-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
PT1000035E (pt) 1997-07-25 2003-04-30 Altana Pharma Ag 6-fenilfenantridinas substituidas
AU753615B2 (en) * 1997-07-25 2002-10-24 Altana Pharma Ag Novel tetrazole derivatives
EP1147103B1 (en) * 1999-01-15 2005-05-04 ALTANA Pharma AG Phenantrhridine-n-oxides with pde-iv inhibiting activity
DE60025327T2 (de) * 1999-01-15 2006-08-24 Altana Pharma Ag 6-arylphenanthridine mit pde-iv hemmender wirkung
AU2107700A (en) * 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity

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