JP2003502278A5 - - Google Patents
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- Publication number
- JP2003502278A5 JP2003502278A5 JP2000593602A JP2000593602A JP2003502278A5 JP 2003502278 A5 JP2003502278 A5 JP 2003502278A5 JP 2000593602 A JP2000593602 A JP 2000593602A JP 2000593602 A JP2000593602 A JP 2000593602A JP 2003502278 A5 JP2003502278 A5 JP 2003502278A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- hydrogen
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 150000001204 N-oxides Chemical class 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 150000002431 hydrogen Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- BIVMWDQSMDXTCT-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)cyclohexan-1-amine Chemical compound C1=C(OC)C(OC)=CC=C1C1C(N)CCCC1 BIVMWDQSMDXTCT-UHFFFAOYSA-N 0.000 description 1
- -1 2H- tetrazol-5-yl group Chemical group 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000005530 alkylenedioxy group Chemical group 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100693 | 1999-01-15 | ||
| EP99100693.3 | 1999-01-15 | ||
| PCT/EP2000/000192 WO2000042034A1 (en) | 1999-01-15 | 2000-01-13 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502278A JP2003502278A (ja) | 2003-01-21 |
| JP2003502278A5 true JP2003502278A5 (enExample) | 2007-03-01 |
Family
ID=8237350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593602A Withdrawn JP2003502278A (ja) | 1999-01-15 | 2000-01-13 | 新規のｎ−オキシド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6534519B1 (enExample) |
| EP (1) | EP1147103B1 (enExample) |
| JP (1) | JP2003502278A (enExample) |
| AT (1) | ATE294793T1 (enExample) |
| AU (1) | AU2290000A (enExample) |
| CA (1) | CA2359449A1 (enExample) |
| DE (1) | DE60019894T2 (enExample) |
| DK (1) | DK1147103T3 (enExample) |
| ES (1) | ES2241571T3 (enExample) |
| PT (1) | PT1147103E (enExample) |
| SI (1) | SI1147103T1 (enExample) |
| WO (1) | WO2000042034A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ300366B6 (cs) * | 1999-01-15 | 2009-05-06 | Nycomed Gmbh | Fenylfenanthridinová sloucenina, farmaceutický prostredek s jejím obsahem a její použití |
| WO2001051470A1 (en) | 2000-01-11 | 2001-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides |
| US6884802B2 (en) | 2000-07-14 | 2005-04-26 | Altana Pharma Ag | 6-heteroarylphenanthridines |
| ES2279215T3 (es) * | 2002-08-29 | 2007-08-16 | Altana Pharma Ag | 2-hidroxi-6-fenilfenantridinas como inhibidores de pde-4. |
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| US20060189641A1 (en) * | 2003-07-31 | 2006-08-24 | Beate Schmidt | Novel 6-phenlyphenanthridines |
| CA2533635A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenantridines |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| JP2007504201A (ja) * | 2003-09-05 | 2007-03-01 | アルタナ ファルマ アクチエンゲゼルシャフト | 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用 |
| ES2400823T3 (es) | 2004-02-18 | 2013-04-12 | Takeda Gmbh | Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| CN104803974A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| KR20060130697A (ko) * | 2004-03-10 | 2006-12-19 | 알타나 파마 아게 | 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도 |
| KR101421914B1 (ko) | 2005-03-02 | 2014-07-22 | 다케다 게엠베하 | 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염 |
| CN102600144A (zh) | 2005-03-08 | 2012-07-25 | 奈科明有限责任公司 | 治疗糖尿病的罗氟司特 |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| HU221380B1 (en) | 1996-01-31 | 2002-09-28 | Byk Gulden Lomberg Chem Fab | Phosphodiesterase inhibitor phenanthridines derivatives and use thereof |
| DK0889886T5 (da) * | 1996-03-26 | 2003-02-24 | Altana Pharma Ag | Hidtil ukendte, i 6-stilling substituerede phenanthridiner |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| PL189641B1 (pl) | 1996-11-11 | 2005-09-30 | Altana Pharma Ag | Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn |
| GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| WO1998040382A1 (en) * | 1997-03-07 | 1998-09-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazoles |
| AU8106598A (en) | 1997-06-03 | 1998-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| JP2001510825A (ja) | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規テトラゾール誘導体 |
| JP2002523505A (ja) | 1998-08-31 | 2002-07-30 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド |
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2000
- 2000-01-13 WO PCT/EP2000/000192 patent/WO2000042034A1/en not_active Ceased
- 2000-01-13 ES ES00901539T patent/ES2241571T3/es not_active Expired - Lifetime
- 2000-01-13 AU AU22900/00A patent/AU2290000A/en not_active Abandoned
- 2000-01-13 JP JP2000593602A patent/JP2003502278A/ja not_active Withdrawn
- 2000-01-13 CA CA002359449A patent/CA2359449A1/en not_active Abandoned
- 2000-01-13 DE DE60019894T patent/DE60019894T2/de not_active Expired - Fee Related
- 2000-01-13 AT AT00901539T patent/ATE294793T1/de not_active IP Right Cessation
- 2000-01-13 DK DK00901539T patent/DK1147103T3/da active
- 2000-01-13 US US09/889,146 patent/US6534519B1/en not_active Expired - Fee Related
- 2000-01-13 SI SI200030713T patent/SI1147103T1/xx unknown
- 2000-01-13 EP EP00901539A patent/EP1147103B1/en not_active Expired - Lifetime
- 2000-01-13 PT PT00901539T patent/PT1147103E/pt unknown