DK1147103T3 - Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet - Google Patents

Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Info

Publication number
DK1147103T3
DK1147103T3 DK00901539T DK00901539T DK1147103T3 DK 1147103 T3 DK1147103 T3 DK 1147103T3 DK 00901539 T DK00901539 T DK 00901539T DK 00901539 T DK00901539 T DK 00901539T DK 1147103 T3 DK1147103 T3 DK 1147103T3
Authority
DK
Denmark
Prior art keywords
oxides
phenanthridine
pde
inhibitory activity
compounds
Prior art date
Application number
DK00901539T
Other languages
Danish (da)
English (en)
Inventor
Dieter Flockerzi
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Hermann Amschler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK1147103T3 publication Critical patent/DK1147103T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
DK00901539T 1999-01-15 2000-01-13 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet DK1147103T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity
EP00901539A EP1147103B1 (en) 1999-01-15 2000-01-13 Phenantrhridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
DK1147103T3 true DK1147103T3 (da) 2005-08-29

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00901539T DK1147103T3 (da) 1999-01-15 2000-01-13 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Country Status (12)

Country Link
US (1) US6534519B1 (enExample)
EP (1) EP1147103B1 (enExample)
JP (1) JP2003502278A (enExample)
AT (1) ATE294793T1 (enExample)
AU (1) AU2290000A (enExample)
CA (1) CA2359449A1 (enExample)
DE (1) DE60019894T2 (enExample)
DK (1) DK1147103T3 (enExample)
ES (1) ES2241571T3 (enExample)
PT (1) PT1147103E (enExample)
SI (1) SI1147103T1 (enExample)
WO (1) WO2000042034A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101938T2 (tr) * 1999-01-15 2001-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pde-ıv inhibe edici aktivitesi olan fenilfenantridinler.
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
EP1539164B1 (en) * 2002-08-29 2006-12-20 ALTANA Pharma AG 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
WO2004019945A1 (en) * 2002-08-29 2004-03-11 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
US20060189641A1 (en) * 2003-07-31 2006-08-24 Beate Schmidt Novel 6-phenlyphenanthridines
WO2005012252A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
WO2005023253A1 (en) * 2003-09-05 2005-03-17 Altana Pharma Ag Use of pde4 inhibitors for the treatment of diabetes mellitus
WO2005077906A1 (en) 2004-02-18 2005-08-25 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
AU2005219576B2 (en) 2004-03-03 2011-06-30 Takeda Gmbh Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CN1926113B (zh) * 2004-03-10 2010-06-23 尼科梅德有限责任公司 新的酰氨基取代的羟基-6-苯基菲啶化合物及其作为pde4抑制剂的应用
NZ589278A (en) 2005-03-02 2012-04-27 Nycomed Gmbh Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
MX2007010560A (es) 2005-03-08 2008-02-21 Nycomed Gmbh Roflumilast para el tratamiento de diabetes mellitus.
KR101178674B1 (ko) 2007-10-04 2012-08-30 에프. 호프만-라 로슈 아게 사이클로프로필 아릴 아마이드 유도체 및 이의 용도
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
ATE233735T1 (de) 1996-01-31 2003-03-15 Altana Pharma Ag Neue phenanthridine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
PT889886E (pt) * 1996-03-26 2003-02-28 Altana Pharma Ag Novas fenantridinas substituidas na posicao 6
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
DK0937074T3 (da) 1996-11-11 2003-06-23 Altana Pharma Ag Benzonaphthyridiner som bronkiale terapeutiske midler
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
JP2001514640A (ja) 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
CA2291153A1 (en) 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
ATE260899T1 (de) 1997-07-25 2004-03-15 Altana Pharma Ag Neue tetrazolderivate
WO2000012501A1 (de) 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität

Also Published As

Publication number Publication date
DE60019894T2 (de) 2006-01-12
DE60019894D1 (de) 2005-06-09
ES2241571T3 (es) 2005-11-01
PT1147103E (pt) 2005-08-31
AU2290000A (en) 2000-08-01
WO2000042034A1 (en) 2000-07-20
EP1147103A1 (en) 2001-10-24
US6534519B1 (en) 2003-03-18
SI1147103T1 (en) 2005-10-31
EP1147103B1 (en) 2005-05-04
JP2003502278A (ja) 2003-01-21
ATE294793T1 (de) 2005-05-15
CA2359449A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
NO20013341L (no) Fenylfenantridiner med PDE-IV inhiberende aktivitet
DK1147103T3 (da) Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
DK0882021T3 (da) Nye phenanthridiner
EE200000033A (et) Uudsed tetrasoolderivaadid
PT937074E (pt) Benzonaftiridinas como terapeutica bronquica
ATE356810T1 (de) Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
DK1109810T3 (da) Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet
DK1147087T3 (da) Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
DK1147088T3 (da) 6-arylphenanthridiner med PDE-IV-inhiberende aktivitet
ATE258930T1 (de) Dihydrobenzifurane