JP2004501964A5 - - Google Patents
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- Publication number
- JP2004501964A5 JP2004501964A5 JP2002506715A JP2002506715A JP2004501964A5 JP 2004501964 A5 JP2004501964 A5 JP 2004501964A5 JP 2002506715 A JP2002506715 A JP 2002506715A JP 2002506715 A JP2002506715 A JP 2002506715A JP 2004501964 A5 JP2004501964 A5 JP 2004501964A5
- Authority
- JP
- Japan
- Prior art keywords
- methylmalonic acid
- agent
- chlorocobalamin
- acid lowering
- lowering drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21531000P | 2000-06-30 | 2000-06-30 | |
| US60/215,310 | 2000-06-30 | ||
| US23585900P | 2000-09-27 | 2000-09-27 | |
| US60/235,859 | 2000-09-27 | ||
| US28444801P | 2001-04-18 | 2001-04-18 | |
| US60/284,448 | 2001-04-18 | ||
| PCT/US2001/014860 WO2002002093A2 (en) | 2000-06-30 | 2001-06-15 | Combination containing an antifolate and methylmalonic acid lowering agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144570A Division JP5469706B2 (ja) | 2000-06-30 | 2012-06-27 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004501964A JP2004501964A (ja) | 2004-01-22 |
| JP2004501964A5 true JP2004501964A5 (enExample) | 2008-11-20 |
| JP5102928B2 JP5102928B2 (ja) | 2012-12-19 |
Family
ID=27396105
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002506715A Expired - Lifetime JP5102928B2 (ja) | 2000-06-30 | 2001-06-15 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2012144570A Expired - Lifetime JP5469706B2 (ja) | 2000-06-30 | 2012-06-27 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2013213276A Withdrawn JP2014005304A (ja) | 2000-06-30 | 2013-10-11 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2015087012A Withdrawn JP2015178501A (ja) | 2000-06-30 | 2015-04-21 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2016192173A Withdrawn JP2017019852A (ja) | 2000-06-30 | 2016-09-29 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2018156677A Withdrawn JP2018197265A (ja) | 2000-06-30 | 2018-08-23 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2020072098A Pending JP2020117536A (ja) | 2000-06-30 | 2020-04-14 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144570A Expired - Lifetime JP5469706B2 (ja) | 2000-06-30 | 2012-06-27 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2013213276A Withdrawn JP2014005304A (ja) | 2000-06-30 | 2013-10-11 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2015087012A Withdrawn JP2015178501A (ja) | 2000-06-30 | 2015-04-21 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2016192173A Withdrawn JP2017019852A (ja) | 2000-06-30 | 2016-09-29 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2018156677A Withdrawn JP2018197265A (ja) | 2000-06-30 | 2018-08-23 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
| JP2020072098A Pending JP2020117536A (ja) | 2000-06-30 | 2020-04-14 | 新規な葉酸代謝拮抗薬の組み合わせ療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7053065B2 (enExample) |
| EP (1) | EP1313508B1 (enExample) |
| JP (7) | JP5102928B2 (enExample) |
| AT (1) | ATE359823T1 (enExample) |
| AU (1) | AU2001269688A1 (enExample) |
| CY (1) | CY1107649T1 (enExample) |
| DE (1) | DE60127970T2 (enExample) |
| DK (1) | DK1313508T5 (enExample) |
| ES (1) | ES2284660T3 (enExample) |
| PT (1) | PT1313508E (enExample) |
| WO (1) | WO2002002093A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053065B2 (en) * | 2000-06-30 | 2006-05-30 | Eli Lilly And Company | Vitamin B12 and pemetrexed disodium combination therapies |
| ES2417065T3 (es) | 2005-04-26 | 2013-08-05 | Trion Pharma Gmbh | Combinación de anticuerpos con glucocorticoides para el tratamiento del cáncer |
| BRPI0706528A2 (pt) * | 2006-01-12 | 2011-03-29 | Novartis Ag | combinação de inibidor de mtor e composto antifolato |
| WO2010021843A1 (en) * | 2008-08-20 | 2010-02-25 | Eli Lilly And Company | Use of antifolates in patients with detectable levels of tff-1 for the cancer treatment |
| WO2010138955A2 (en) | 2009-05-29 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Methods and compositions for treating neoplasia |
| US10736969B2 (en) | 2010-12-21 | 2020-08-11 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds |
| WO2013179248A1 (en) | 2012-05-30 | 2013-12-05 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of pemetrexed |
| AU2015268962A1 (en) * | 2014-06-04 | 2017-01-12 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| US9746477B2 (en) * | 2015-07-30 | 2017-08-29 | Expression Pathology, Inc. | Quantifying FR-α and GART proteins for optimal cancer therapy |
| IL259512B2 (en) * | 2015-12-07 | 2024-03-01 | General Oncology Inc | Combination for the effective treatment of metastatic cancer in patients |
| WO2018031968A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| CA3033083A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| CA3049435A1 (en) | 2017-01-09 | 2018-07-12 | Scott Grindrod | Selective histone deacetylase inhibitors for the treatment of human disease |
| EP3737376B1 (en) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human diseases |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| EP3749312A4 (en) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF |
| CA3090500A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| EP3749317A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES |
| WO2019157123A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| EP3749314A4 (en) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATE METHOTREXATE AND ITS USES |
| US12246015B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| EP3749316A4 (en) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATED PRALATREXATE AND USES THEREOF |
| WO2019157140A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| EP3749319A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES |
| EP3749311A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES |
| CN111971047A (zh) | 2018-02-14 | 2020-11-20 | L.E.A.F.控股集团公司 | γ聚谷氨酸化四氢叶酸及其用途 |
| JP7462950B2 (ja) | 2018-02-14 | 2024-04-08 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化メトトレキセートおよびその使用 |
| US12048767B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| CA3090875A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| WO2023177894A1 (en) | 2022-03-18 | 2023-09-21 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and an antimetabolite agent |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US225030A (en) * | 1880-03-02 | Rotary engine | ||
| US216350A (en) * | 1879-06-10 | Improvement in car-replacers | ||
| US2920015A (en) * | 1957-08-27 | 1960-01-05 | Armour & Co | Long-acting vitamin b12 |
| CH588505A5 (enExample) * | 1972-06-08 | 1977-06-15 | Research Corp | |
| US5563126A (en) | 1986-11-20 | 1996-10-08 | Metabolite Laboratories | Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6 |
| JP2962755B2 (ja) * | 1989-02-28 | 1999-10-12 | 帝人株式会社 | 新規ビタミンｂ▲下１▼▲下２▼誘導体、その製造方法並びにその用途 |
| US5405839A (en) | 1989-02-28 | 1995-04-11 | Teijin Limited | Vitamin B12 derivative, preparation process thereof, and use thereof |
| KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| ES2077808T5 (es) * | 1991-03-29 | 2002-10-16 | Lilly Co Eli | Procedimiento terapeutico mejorado. |
| JPH05163160A (ja) * | 1991-12-13 | 1993-06-29 | Snow Brand Milk Prod Co Ltd | 免疫低下に伴う感染症の予防及び治療用栄養剤 |
| US6207651B1 (en) | 1996-08-02 | 2001-03-27 | Metabolite Laboratories | Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6 |
| WO1995027723A1 (en) | 1994-04-08 | 1995-10-19 | Receptagen Corporation | Receptor modulating agents and methods relating thereto |
| WO1996012181A1 (en) | 1994-10-12 | 1996-04-25 | Research & Diagnostics Systems, Inc. | Reticulocyte assay control |
| US7053065B2 (en) * | 2000-06-30 | 2006-05-30 | Eli Lilly And Company | Vitamin B12 and pemetrexed disodium combination therapies |
| US20040005311A1 (en) * | 2001-07-20 | 2004-01-08 | Pitman Bradford D. | Dietary supplement compositions |
-
2001
- 2001-06-15 US US10/297,821 patent/US7053065B2/en not_active Expired - Lifetime
- 2001-06-15 WO PCT/US2001/014860 patent/WO2002002093A2/en not_active Ceased
- 2001-06-15 ES ES01948214T patent/ES2284660T3/es not_active Expired - Lifetime
- 2001-06-15 AT AT01948214T patent/ATE359823T1/de active
- 2001-06-15 JP JP2002506715A patent/JP5102928B2/ja not_active Expired - Lifetime
- 2001-06-15 EP EP01948214A patent/EP1313508B1/en not_active Expired - Lifetime
- 2001-06-15 PT PT01948214T patent/PT1313508E/pt unknown
- 2001-06-15 DE DE60127970T patent/DE60127970T2/de not_active Expired - Lifetime
- 2001-06-15 DK DK01948214.0T patent/DK1313508T5/da active
- 2001-06-15 AU AU2001269688A patent/AU2001269688A1/en not_active Abandoned
-
2005
- 2005-11-29 US US11/288,807 patent/US20060079480A1/en not_active Abandoned
-
2007
- 2007-06-07 CY CY20071100756T patent/CY1107649T1/el unknown
- 2007-07-11 US US11/776,329 patent/US7772209B2/en not_active Expired - Fee Related
-
2010
- 2010-04-28 US US12/768,920 patent/US20100210583A1/en not_active Abandoned
-
2012
- 2012-06-27 JP JP2012144570A patent/JP5469706B2/ja not_active Expired - Lifetime
-
2013
- 2013-10-11 JP JP2013213276A patent/JP2014005304A/ja not_active Withdrawn
-
2015
- 2015-04-21 JP JP2015087012A patent/JP2015178501A/ja not_active Withdrawn
-
2016
- 2016-09-29 JP JP2016192173A patent/JP2017019852A/ja not_active Withdrawn
-
2018
- 2018-08-23 JP JP2018156677A patent/JP2018197265A/ja not_active Withdrawn
-
2020
- 2020-04-14 JP JP2020072098A patent/JP2020117536A/ja active Pending
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