JP2004501964A5 - - Google Patents

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Publication number
JP2004501964A5
JP2004501964A5 JP2002506715A JP2002506715A JP2004501964A5 JP 2004501964 A5 JP2004501964 A5 JP 2004501964A5 JP 2002506715 A JP2002506715 A JP 2002506715A JP 2002506715 A JP2002506715 A JP 2002506715A JP 2004501964 A5 JP2004501964 A5 JP 2004501964A5
Authority
JP
Japan
Prior art keywords
methylmalonic acid
agent
chlorocobalamin
acid lowering
lowering drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002506715A
Other languages
English (en)
Japanese (ja)
Other versions
JP5102928B2 (ja
JP2004501964A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/014860 external-priority patent/WO2002002093A2/en
Publication of JP2004501964A publication Critical patent/JP2004501964A/ja
Publication of JP2004501964A5 publication Critical patent/JP2004501964A5/ja
Application granted granted Critical
Publication of JP5102928B2 publication Critical patent/JP5102928B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2002506715A 2000-06-30 2001-06-15 新規な葉酸代謝拮抗薬の組み合わせ療法 Expired - Lifetime JP5102928B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21531000P 2000-06-30 2000-06-30
US60/215,310 2000-06-30
US23585900P 2000-09-27 2000-09-27
US60/235,859 2000-09-27
US28444801P 2001-04-18 2001-04-18
US60/284,448 2001-04-18
PCT/US2001/014860 WO2002002093A2 (en) 2000-06-30 2001-06-15 Combination containing an antifolate and methylmalonic acid lowering agent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012144570A Division JP5469706B2 (ja) 2000-06-30 2012-06-27 新規な葉酸代謝拮抗薬の組み合わせ療法

Publications (3)

Publication Number Publication Date
JP2004501964A JP2004501964A (ja) 2004-01-22
JP2004501964A5 true JP2004501964A5 (enExample) 2008-11-20
JP5102928B2 JP5102928B2 (ja) 2012-12-19

Family

ID=27396105

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2002506715A Expired - Lifetime JP5102928B2 (ja) 2000-06-30 2001-06-15 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2012144570A Expired - Lifetime JP5469706B2 (ja) 2000-06-30 2012-06-27 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2013213276A Withdrawn JP2014005304A (ja) 2000-06-30 2013-10-11 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2015087012A Withdrawn JP2015178501A (ja) 2000-06-30 2015-04-21 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2016192173A Withdrawn JP2017019852A (ja) 2000-06-30 2016-09-29 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2018156677A Withdrawn JP2018197265A (ja) 2000-06-30 2018-08-23 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2020072098A Pending JP2020117536A (ja) 2000-06-30 2020-04-14 新規な葉酸代謝拮抗薬の組み合わせ療法

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2012144570A Expired - Lifetime JP5469706B2 (ja) 2000-06-30 2012-06-27 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2013213276A Withdrawn JP2014005304A (ja) 2000-06-30 2013-10-11 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2015087012A Withdrawn JP2015178501A (ja) 2000-06-30 2015-04-21 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2016192173A Withdrawn JP2017019852A (ja) 2000-06-30 2016-09-29 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2018156677A Withdrawn JP2018197265A (ja) 2000-06-30 2018-08-23 新規な葉酸代謝拮抗薬の組み合わせ療法
JP2020072098A Pending JP2020117536A (ja) 2000-06-30 2020-04-14 新規な葉酸代謝拮抗薬の組み合わせ療法

Country Status (11)

Country Link
US (4) US7053065B2 (enExample)
EP (1) EP1313508B1 (enExample)
JP (7) JP5102928B2 (enExample)
AT (1) ATE359823T1 (enExample)
AU (1) AU2001269688A1 (enExample)
CY (1) CY1107649T1 (enExample)
DE (1) DE60127970T2 (enExample)
DK (1) DK1313508T5 (enExample)
ES (1) ES2284660T3 (enExample)
PT (1) PT1313508E (enExample)
WO (1) WO2002002093A2 (enExample)

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WO2002002093A2 (en) * 2000-06-30 2002-01-10 Eli Lilly And Company Combination containing an antifolate and methylmalonic acid lowering agent
ES2417065T3 (es) 2005-04-26 2013-08-05 Trion Pharma Gmbh Combinación de anticuerpos con glucocorticoides para el tratamiento del cáncer
CA2637069A1 (en) * 2006-01-12 2007-07-19 Novartis Ag Combination of mtor inhibitor and antipolate compound
WO2010021843A1 (en) * 2008-08-20 2010-02-25 Eli Lilly And Company Use of antifolates in patients with detectable levels of tff-1 for the cancer treatment
WO2010138955A2 (en) 2009-05-29 2010-12-02 University Of Florida Research Foundation, Inc. Methods and compositions for treating neoplasia
WO2012088282A1 (en) 2010-12-21 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
WO2013179248A1 (en) 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
CN106794181A (zh) * 2014-06-04 2017-05-31 托马斯·黑勒戴药物研究基金会 用于治疗炎性和自身免疫性病况的mth1抑制剂
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
WO2017020048A1 (en) * 2015-07-30 2017-02-02 Expression Pathology, Inc. QUANTIFYING FR-α AND GART PROTEINS FOR OPTIMAL CANCER THERAPY
FI3386546T3 (fi) * 2015-12-07 2024-12-05 General Oncology Inc Yhdistelmä metastaattisen syövän tehokkaaseen hoitoon potilailla
EA201990473A1 (ru) 2016-08-12 2019-07-31 Эл.И.Эй.Эф. ХОЛДИНГС ГРУП ЭлЭлСи Полиглутамированные антифолаты и их применение
WO2018031967A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Polyglutamated antifolates and uses thereof
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
EP3565549B1 (en) 2017-01-09 2022-03-09 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
EP3737376B1 (en) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human diseases
WO2019157123A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
US11779584B2 (en) 2018-02-07 2023-10-10 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
CA3090506A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated tetrahydrofolates and uses thereof
CN111954529A (zh) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 α聚谷氨酸化氨甲蝶呤及其用途
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
EP3749318A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATED PRALATREXATE AND USES THEREOF
US12076402B2 (en) 2018-02-07 2024-09-03 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
CA3090389A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
EP3749312A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF
US11771700B2 (en) 2018-02-14 2023-10-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
CN111936145A (zh) 2018-02-14 2020-11-13 L.E.A.F.控股集团公司 γ聚谷氨酸化氨甲蝶呤及其用途
CA3090943A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof
US12048766B2 (en) 2018-02-14 2024-07-30 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
EP3752156A4 (en) 2018-02-14 2021-10-27 L.E.A.F Holdings Group LLC GAMMA-POLYGLUTAMIZED PRALATREXATE AND USES THEREOF
WO2023177894A1 (en) 2022-03-18 2023-09-21 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and an antimetabolite agent
WO2025247952A1 (en) * 2024-05-30 2025-12-04 Université De Fribourg Inhibition of cyanide overproduction for the therapy of down syndrome and nonketotic hyperglycinemia

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US216350A (en) * 1879-06-10 Improvement in car-replacers
US225030A (en) * 1880-03-02 Rotary engine
US2920015A (en) * 1957-08-27 1960-01-05 Armour & Co Long-acting vitamin b12
CH588505A5 (enExample) * 1972-06-08 1977-06-15 Research Corp
US5563126A (en) 1986-11-20 1996-10-08 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
JP2962755B2 (ja) * 1989-02-28 1999-10-12 帝人株式会社 新規ビタミンｂ▲下１▼▲下２▼誘導体、その製造方法並びにその用途
US5405839A (en) * 1989-02-28 1995-04-11 Teijin Limited Vitamin B12 derivative, preparation process thereof, and use thereof
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
ES2077808T5 (es) * 1991-03-29 2002-10-16 Lilly Co Eli Procedimiento terapeutico mejorado.
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤
US6207651B1 (en) 1996-08-02 2001-03-27 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
CA2187346C (en) 1994-04-08 2010-06-29 A. Charles Morgan, Jr. Receptor modulating agents and methods relating thereto
AU3972195A (en) 1994-10-12 1996-05-06 Research & Diagnostics Systems, Inc. Reticulocyte assay control
WO2002002093A2 (en) * 2000-06-30 2002-01-10 Eli Lilly And Company Combination containing an antifolate and methylmalonic acid lowering agent
US20040005311A1 (en) * 2001-07-20 2004-01-08 Pitman Bradford D. Dietary supplement compositions

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