PT1313508E - Combinação contendo um antifolato e um agente redutor do ácido metilmalónico. - Google Patents
Combinação contendo um antifolato e um agente redutor do ácido metilmalónico. Download PDFInfo
- Publication number
- PT1313508E PT1313508E PT01948214T PT01948214T PT1313508E PT 1313508 E PT1313508 E PT 1313508E PT 01948214 T PT01948214 T PT 01948214T PT 01948214 T PT01948214 T PT 01948214T PT 1313508 E PT1313508 E PT 1313508E
- Authority
- PT
- Portugal
- Prior art keywords
- vitamin
- folic acid
- administered
- antifolate
- chlorocobalamin
- Prior art date
Links
- 239000004052 folic acid antagonist Substances 0.000 title abstract description 82
- 230000003432 anti-folate effect Effects 0.000 title abstract description 79
- 229940127074 antifolate Drugs 0.000 title abstract description 79
- ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical compound OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 title abstract description 43
- 239000003795 chemical substances by application Substances 0.000 title abstract description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 121
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 82
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- NYDXNILOWQXUOF-UHFFFAOYSA-L disodium;2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate Chemical compound [Na+].[Na+].C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)NC(CCC([O-])=O)C([O-])=O)C=C1 NYDXNILOWQXUOF-UHFFFAOYSA-L 0.000 claims description 37
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
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| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| WO2007080124A1 (en) * | 2006-01-12 | 2007-07-19 | Novartis Ag | Combination of mtor inhibitor and antipolate compound |
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| US8501242B2 (en) | 2009-05-29 | 2013-08-06 | University Of Florida Research Foundation | Methods and compositions for treating neoplasia |
| EP2654795B1 (en) | 2010-12-21 | 2018-03-07 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds |
| EP3210629A1 (en) | 2012-05-30 | 2017-08-30 | Fresenius Kabi Oncology Ltd | Pharmaceutical composition of pemetrexed |
| US10064869B2 (en) | 2014-06-04 | 2018-09-04 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| EP3328387B1 (en) * | 2015-07-30 | 2020-07-22 | Expression Pathology, Inc. | Quantifying fr- and gart proteins for optimal cancer therapy |
| AU2016367112B2 (en) * | 2015-12-07 | 2022-01-13 | General Oncology, Inc. | Combination for the effective treatment of metastatic cancer in patients |
| CN121177507A (zh) | 2016-08-12 | 2025-12-23 | L.E.A.F.控股集团公司 | α和γ-D聚谷氨酸化抗叶酸剂及其用途 |
| WO2018031968A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| ES2914123T3 (es) | 2017-01-09 | 2022-06-07 | Shuttle Pharmaceuticals Inc | Inhibidores selectivos de la histona desacetilasa para el tratamiento de una enfermedad humana |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| CN112004537A (zh) | 2018-01-09 | 2020-11-27 | 穿梭药业公司 | 用于治疗人疾病的选择性组蛋白去乙酰化酶抑制剂 |
| EP3749319A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES |
| CN111867593A (zh) | 2018-02-07 | 2020-10-30 | L.E.A.F.控股集团公司 | α聚谷氨酸化抗叶酸剂及其用途 |
| WO2019157121A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| WO2019157145A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| JP7491572B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化ペメトレキセドおよびその使用 |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| EP3749318A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES |
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| WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
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| JP7462950B2 (ja) | 2018-02-14 | 2024-04-08 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化メトトレキセートおよびその使用 |
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| WO2025247952A1 (en) * | 2024-05-30 | 2025-12-04 | Université De Fribourg | Inhibition of cyanide overproduction for the therapy of down syndrome and nonketotic hyperglycinemia |
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- 2001-06-15 JP JP2002506715A patent/JP5102928B2/ja not_active Expired - Lifetime
- 2001-06-15 AU AU2001269688A patent/AU2001269688A1/en not_active Abandoned
- 2001-06-15 WO PCT/US2001/014860 patent/WO2002002093A2/en not_active Ceased
- 2001-06-15 ES ES01948214T patent/ES2284660T3/es not_active Expired - Lifetime
- 2001-06-15 AT AT01948214T patent/ATE359823T1/de active
- 2001-06-15 PT PT01948214T patent/PT1313508E/pt unknown
- 2001-06-15 EP EP01948214A patent/EP1313508B1/en not_active Expired - Lifetime
- 2001-06-15 DE DE60127970T patent/DE60127970T2/de not_active Expired - Lifetime
- 2001-06-15 DK DK01948214.0T patent/DK1313508T5/da active
- 2001-06-15 US US10/297,821 patent/US7053065B2/en not_active Expired - Lifetime
-
2005
- 2005-11-29 US US11/288,807 patent/US20060079480A1/en not_active Abandoned
-
2007
- 2007-06-07 CY CY20071100756T patent/CY1107649T1/el unknown
- 2007-07-11 US US11/776,329 patent/US7772209B2/en not_active Expired - Fee Related
-
2010
- 2010-04-28 US US12/768,920 patent/US20100210583A1/en not_active Abandoned
-
2012
- 2012-06-27 JP JP2012144570A patent/JP5469706B2/ja not_active Expired - Lifetime
-
2013
- 2013-10-11 JP JP2013213276A patent/JP2014005304A/ja not_active Withdrawn
-
2015
- 2015-04-21 JP JP2015087012A patent/JP2015178501A/ja not_active Withdrawn
-
2016
- 2016-09-29 JP JP2016192173A patent/JP2017019852A/ja not_active Withdrawn
-
2018
- 2018-08-23 JP JP2018156677A patent/JP2018197265A/ja not_active Withdrawn
-
2020
- 2020-04-14 JP JP2020072098A patent/JP2020117536A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018197265A (ja) | 2018-12-13 |
| EP1313508A2 (en) | 2003-05-28 |
| US20030212038A1 (en) | 2003-11-13 |
| DE60127970T2 (de) | 2007-12-20 |
| JP2017019852A (ja) | 2017-01-26 |
| US7772209B2 (en) | 2010-08-10 |
| JP5469706B2 (ja) | 2014-04-16 |
| US20060079480A1 (en) | 2006-04-13 |
| JP2020117536A (ja) | 2020-08-06 |
| ES2284660T3 (es) | 2007-11-16 |
| DK1313508T3 (da) | 2007-08-06 |
| EP1313508B1 (en) | 2007-04-18 |
| JP2004501964A (ja) | 2004-01-22 |
| DK1313508T5 (da) | 2017-03-20 |
| ATE359823T1 (de) | 2007-05-15 |
| JP2014005304A (ja) | 2014-01-16 |
| JP2015178501A (ja) | 2015-10-08 |
| WO2002002093A3 (en) | 2003-02-06 |
| WO2002002093A2 (en) | 2002-01-10 |
| JP5102928B2 (ja) | 2012-12-19 |
| US20080032948A1 (en) | 2008-02-07 |
| JP2012180381A (ja) | 2012-09-20 |
| AU2001269688A1 (en) | 2002-01-14 |
| CY1107649T1 (el) | 2013-04-18 |
| DE60127970D1 (de) | 2007-05-31 |
| US7053065B2 (en) | 2006-05-30 |
| US20100210583A1 (en) | 2010-08-19 |
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