DE60127970D1 - Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält - Google Patents

Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält

Info

Publication number
DE60127970D1
DE60127970D1 DE60127970T DE60127970T DE60127970D1 DE 60127970 D1 DE60127970 D1 DE 60127970D1 DE 60127970 T DE60127970 T DE 60127970T DE 60127970 T DE60127970 T DE 60127970T DE 60127970 D1 DE60127970 D1 DE 60127970D1
Authority
DE
Germany
Prior art keywords
antifolate
composition containing
methylmalonic acid
substituting agent
acid substituting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60127970T
Other languages
English (en)
Other versions
DE60127970T2 (de
Inventor
Clet Niyikiza
Paolo Paoletti
James Jacob Rusthoven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27396105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60127970(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE60127970D1 publication Critical patent/DE60127970D1/de
Application granted granted Critical
Publication of DE60127970T2 publication Critical patent/DE60127970T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60127970T 2000-06-30 2001-06-15 Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält Expired - Lifetime DE60127970T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21531000P 2000-06-30 2000-06-30
US215310P 2000-06-30
US23585900P 2000-09-27 2000-09-27
US235859P 2000-09-27
US28444801P 2001-04-18 2001-04-18
US284448P 2001-04-18
PCT/US2001/014860 WO2002002093A2 (en) 2000-06-30 2001-06-15 Combination containing an antifolate and methylmalonic acid lowering agent

Publications (2)

Publication Number Publication Date
DE60127970D1 true DE60127970D1 (de) 2007-05-31
DE60127970T2 DE60127970T2 (de) 2007-12-20

Family

ID=27396105

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60127970T Expired - Lifetime DE60127970T2 (de) 2000-06-30 2001-06-15 Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält

Country Status (11)

Country Link
US (4) US7053065B2 (de)
EP (1) EP1313508B1 (de)
JP (7) JP5102928B2 (de)
AT (1) ATE359823T1 (de)
AU (1) AU2001269688A1 (de)
CY (1) CY1107649T1 (de)
DE (1) DE60127970T2 (de)
DK (1) DK1313508T5 (de)
ES (1) ES2284660T3 (de)
PT (1) PT1313508E (de)
WO (1) WO2002002093A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1313508B1 (de) * 2000-06-30 2007-04-18 Eli Lilly And Company Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält
JP5129122B2 (ja) 2005-04-26 2013-01-23 トリオン ファーマ ゲーエムベーハー 癌治療のための抗体およびグルココルチコイドの組み合わせ
KR20080085213A (ko) * 2006-01-12 2008-09-23 노파르티스 아게 Ｍｔｏｒ 억제제 및 항엽산 화합물의 조합물
WO2010021843A1 (en) * 2008-08-20 2010-02-25 Eli Lilly And Company Use of antifolates in patients with detectable levels of tff-1 for the cancer treatment
WO2010138955A2 (en) 2009-05-29 2010-12-02 University Of Florida Research Foundation, Inc. Methods and compositions for treating neoplasia
EP2654795B1 (de) 2010-12-21 2018-03-07 Nektar Therapeutics Mehrarmige polymer prodrug-konjugate aus verbindungen auf pemetrexed-basis
WO2013179248A1 (en) 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
SG11201609981RA (en) 2014-06-04 2016-12-29 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
EP3297694A1 (de) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modifizierte demineralisierte kortikale knochenfasern
WO2017020048A1 (en) * 2015-07-30 2017-02-02 Expression Pathology, Inc. QUANTIFYING FR-α AND GART PROTEINS FOR OPTIMAL CANCER THERAPY
EP3386546A1 (de) * 2015-12-07 2018-10-17 General Oncology, Inc. Kombination zur effektiven behandlung von metastasierendem krebs in patienten
CN109689104A (zh) 2016-08-12 2019-04-26 L.E.A.F.控股集团公司 α和γ-D聚谷氨酸化抗叶酸剂及其用途
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
WO2018129533A1 (en) 2017-01-09 2018-07-12 Shuttle Pharmaceuticals, Llc Selective histone deacetylase inhibitors for the treatment of human disease
EP3737376B1 (de) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen
WO2019157138A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
WO2019160735A1 (en) * 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
US11771700B2 (en) 2018-02-14 2023-10-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
WO2023177894A1 (en) 2022-03-18 2023-09-21 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and an antimetabolite agent

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US225030A (en) * 1880-03-02 Rotary engine
US216350A (en) * 1879-06-10 Improvement in car-replacers
US2920015A (en) * 1957-08-27 1960-01-05 Armour & Co Long-acting vitamin b12
CH605550A5 (de) * 1972-06-08 1978-09-29 Research Corp
US5563126A (en) * 1986-11-20 1996-10-08 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
JP2962755B2 (ja) * 1989-02-28 1999-10-12 帝人株式会社 新規ビタミンｂ▲下１▼▲下２▼誘導体、その製造方法並びにその用途
US5405839A (en) * 1989-02-28 1995-04-11 Teijin Limited Vitamin B12 derivative, preparation process thereof, and use thereof
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
DE69112376T3 (de) * 1991-03-29 2002-08-14 Lilly Co Eli Verbesserte Therapiemethode.
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤
US6207651B1 (en) 1996-08-02 2001-03-27 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
DE69528523T2 (de) 1994-04-08 2003-06-12 Receptagen Corp Rezeptor modulierendes mitteln und entsprechendes verfahren
AU3972195A (en) * 1994-10-12 1996-05-06 Research & Diagnostics Systems, Inc. Reticulocyte assay control
EP1313508B1 (de) * 2000-06-30 2007-04-18 Eli Lilly And Company Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält
US20040005311A1 (en) * 2001-07-20 2004-01-08 Pitman Bradford D. Dietary supplement compositions

Also Published As

Publication number Publication date
ATE359823T1 (de) 2007-05-15
US20080032948A1 (en) 2008-02-07
WO2002002093A3 (en) 2003-02-06
JP2012180381A (ja) 2012-09-20
US7053065B2 (en) 2006-05-30
CY1107649T1 (el) 2013-04-18
PT1313508E (pt) 2007-06-21
DE60127970T2 (de) 2007-12-20
AU2001269688A1 (en) 2002-01-14
JP2004501964A (ja) 2004-01-22
WO2002002093A2 (en) 2002-01-10
EP1313508B1 (de) 2007-04-18
US20060079480A1 (en) 2006-04-13
JP2020117536A (ja) 2020-08-06
JP5469706B2 (ja) 2014-04-16
US20030212038A1 (en) 2003-11-13
JP2014005304A (ja) 2014-01-16
JP2017019852A (ja) 2017-01-26
JP5102928B2 (ja) 2012-12-19
JP2018197265A (ja) 2018-12-13
JP2015178501A (ja) 2015-10-08
US20100210583A1 (en) 2010-08-19
US7772209B2 (en) 2010-08-10
EP1313508A2 (de) 2003-05-28
ES2284660T3 (es) 2007-11-16
DK1313508T3 (da) 2007-08-06
DK1313508T5 (da) 2017-03-20

Similar Documents

Publication Publication Date Title
DE60127970D1 (de) Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält
DE60141603D1 (de) Neue mandelsäurederivate und deren verwendung als thrombininhibitoren
DE60118975D1 (de) Tetrahydropyridinderivate, deren herstellung und deren verwendung als inhibitoren der zellproliferation
ATE309206T1 (de) Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen
NO20024309D0 (no) Intradermal penetreringsmidler for topikal lokal anestetisk administrering
TR200103233T2 (tr) Antikolinerjik etkili bileşik ve ß-mimetikler bazında yeni ilaç bileşimleri.
BR0109729A (pt) Uso de uma combinação de um agente anti-angiogênico e um agente anti-hipertensivo, kit para uso na produção de um efeito anti-angiogênico e/ou efeito redutor da permeabilidade vascular em um animal de sangue quente, e, método de tratamento de um estado doentio associado com a angiogênese
DE60009325D1 (de) Kosmetisches mittel enthaltend maulbeerbaumextrakt und retinoide
EE05104B1 (et) Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon
DE60016670D1 (de) Kosmetisches Mittel enthaltend mindestens einen Hydroxystilben und Ascorbinsäure
DE69727158D1 (de) Pharmazeutische zusammensetzungen enthaltend eine mischung von selbstvernetzter und nichtselbstvernetzter hyaluronsäure zur behandlung von arthropathien
EE04965B1 (et) Imidasoimidasoolid ja triasoolid kui p?letikuvastased hendid, nende kasutamine ravimite valmistamiseks ning farmatseutiline kompositsioon
DE60234409D1 (de) Säuregenerator, Sulfonsäure, Sulfonsäurederivate und strahlungsempfindliche Zusammensetzung
DE69927288D1 (de) Adsorbent-Zusammensetzung und deren Verwendung zur Bindung von Hautirritierenden Mittel.
EE05081B1 (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, 3-aminoasetidiini derivaadid ja nende valmistamise meetodid
NZ516349A (en) Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease
EE05001B1 (et) Heterotsüklilised ühendid, meetod nende valmistamiseks, neid sisaldav ravimkoostis ning nende kasutamine ravis
DE69718668T2 (de) Flüssige zusammensetzung, hiv protease inhibitoren und c12-c18 fettsaure enthaltend
FR2811552B1 (fr) Composition notamment cosmetique ou pharmaceutique se presentant sous forme solide
ATE272628T1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
EE04490B1 (et) Ühend, selle valmistamise meetod ning kasutamine meditsiinis
AU3287200A (en) Composition comprising isoquercetin and ascorbic acid in a sustained release form
TR199802769T2 (xx) Terpenoid bileşikler ile antihistaminik bileşiklerin bir kombinasyonunu ihtiva eden topikal bileşim.
BR9904613A (pt) Utilização de uma goma de silicone, composição tópica e utilização de uma composição
ATE311850T1 (de) Reduzierendes mittel enthaltend eine pulverförmige, die disulfid-brücken des haares spaltende zusammensetzung und verfahren zur permanenten verformung keratinischer substanzen

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN