ATE359823T1 - Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält - Google Patents

Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält

Info

Publication number
ATE359823T1
ATE359823T1 AT01948214T AT01948214T ATE359823T1 AT E359823 T1 ATE359823 T1 AT E359823T1 AT 01948214 T AT01948214 T AT 01948214T AT 01948214 T AT01948214 T AT 01948214T AT E359823 T1 ATE359823 T1 AT E359823T1
Authority
AT
Austria
Prior art keywords
antifolate
lowering agent
composition containing
methylmalonic acid
acid lowering
Prior art date
Application number
AT01948214T
Other languages
German (de)
English (en)
Inventor
Clet Niyikiza
Paolo Paoletti
James Jacob Rusthoven
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27396105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE359823(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE359823T1 publication Critical patent/ATE359823T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01948214T 2000-06-30 2001-06-15 Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält ATE359823T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21531000P 2000-06-30 2000-06-30
US23585900P 2000-09-27 2000-09-27
US28444801P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
ATE359823T1 true ATE359823T1 (de) 2007-05-15

Family

ID=27396105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01948214T ATE359823T1 (de) 2000-06-30 2001-06-15 Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält

Country Status (11)

Country Link
US (4) US7053065B2 (enExample)
EP (1) EP1313508B1 (enExample)
JP (7) JP5102928B2 (enExample)
AT (1) ATE359823T1 (enExample)
AU (1) AU2001269688A1 (enExample)
CY (1) CY1107649T1 (enExample)
DE (1) DE60127970T2 (enExample)
DK (1) DK1313508T5 (enExample)
ES (1) ES2284660T3 (enExample)
PT (1) PT1313508E (enExample)
WO (1) WO2002002093A2 (enExample)

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US7053065B2 (en) * 2000-06-30 2006-05-30 Eli Lilly And Company Vitamin B12 and pemetrexed disodium combination therapies
ES2417065T3 (es) 2005-04-26 2013-08-05 Trion Pharma Gmbh Combinación de anticuerpos con glucocorticoides para el tratamiento del cáncer
BRPI0706528A2 (pt) * 2006-01-12 2011-03-29 Novartis Ag combinação de inibidor de mtor e composto antifolato
WO2010021843A1 (en) * 2008-08-20 2010-02-25 Eli Lilly And Company Use of antifolates in patients with detectable levels of tff-1 for the cancer treatment
WO2010138955A2 (en) 2009-05-29 2010-12-02 University Of Florida Research Foundation, Inc. Methods and compositions for treating neoplasia
US10736969B2 (en) 2010-12-21 2020-08-11 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
WO2013179248A1 (en) 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
AU2015268962A1 (en) * 2014-06-04 2017-01-12 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US9746477B2 (en) * 2015-07-30 2017-08-29 Expression Pathology, Inc. Quantifying FR-α and GART proteins for optimal cancer therapy
IL259512B2 (en) * 2015-12-07 2024-03-01 General Oncology Inc Combination for the effective treatment of metastatic cancer in patients
WO2018031968A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
CA3033083A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Polyglutamated antifolates and uses thereof
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
CA3049435A1 (en) 2017-01-09 2018-07-12 Scott Grindrod Selective histone deacetylase inhibitors for the treatment of human disease
EP3737376B1 (en) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human diseases
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
EP3749312A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF
CA3090500A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
EP3749317A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC PEMETREXED ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
WO2019157123A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
EP3749314A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATE METHOTREXATE AND ITS USES
US12246015B2 (en) 2018-02-07 2025-03-11 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATED PRALATREXATE AND USES THEREOF
WO2019157140A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated raltitrexed and uses thereof
EP3749319A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
CN111971047A (zh) 2018-02-14 2020-11-20 L.E.A.F.控股集团公司 γ聚谷氨酸化四氢叶酸及其用途
JP7462950B2 (ja) 2018-02-14 2024-04-08 エル．イー．エー．エフ． ホールディングス グループ エルエルシー ガンマポリグルタミン酸化メトトレキセートおよびその使用
US12048767B2 (en) 2018-02-14 2024-07-30 L.E.A.F. Holdings Group Llc Gamma polyglutamated pralatrexate and uses thereof
CA3090875A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
CA3090943A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof
WO2023177894A1 (en) 2022-03-18 2023-09-21 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and an antimetabolite agent

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US216350A (en) * 1879-06-10 Improvement in car-replacers
US2920015A (en) * 1957-08-27 1960-01-05 Armour & Co Long-acting vitamin b12
CH588505A5 (enExample) * 1972-06-08 1977-06-15 Research Corp
US5563126A (en) 1986-11-20 1996-10-08 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
JP2962755B2 (ja) * 1989-02-28 1999-10-12 帝人株式会社 新規ビタミンｂ▲下１▼▲下２▼誘導体、その製造方法並びにその用途
US5405839A (en) 1989-02-28 1995-04-11 Teijin Limited Vitamin B12 derivative, preparation process thereof, and use thereof
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
ES2077808T5 (es) * 1991-03-29 2002-10-16 Lilly Co Eli Procedimiento terapeutico mejorado.
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤
US6207651B1 (en) 1996-08-02 2001-03-27 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
WO1995027723A1 (en) 1994-04-08 1995-10-19 Receptagen Corporation Receptor modulating agents and methods relating thereto
WO1996012181A1 (en) 1994-10-12 1996-04-25 Research & Diagnostics Systems, Inc. Reticulocyte assay control
US7053065B2 (en) * 2000-06-30 2006-05-30 Eli Lilly And Company Vitamin B12 and pemetrexed disodium combination therapies
US20040005311A1 (en) * 2001-07-20 2004-01-08 Pitman Bradford D. Dietary supplement compositions

Also Published As

Publication number Publication date
US20080032948A1 (en) 2008-02-07
WO2002002093A3 (en) 2003-02-06
DE60127970T2 (de) 2007-12-20
AU2001269688A1 (en) 2002-01-14
ES2284660T3 (es) 2007-11-16
US7772209B2 (en) 2010-08-10
US20030212038A1 (en) 2003-11-13
WO2002002093A2 (en) 2002-01-10
US20060079480A1 (en) 2006-04-13
JP2020117536A (ja) 2020-08-06
JP2012180381A (ja) 2012-09-20
JP2015178501A (ja) 2015-10-08
EP1313508B1 (en) 2007-04-18
JP2018197265A (ja) 2018-12-13
JP2017019852A (ja) 2017-01-26
JP2014005304A (ja) 2014-01-16
US7053065B2 (en) 2006-05-30
US20100210583A1 (en) 2010-08-19
JP5102928B2 (ja) 2012-12-19
DK1313508T5 (da) 2017-03-20
PT1313508E (pt) 2007-06-21
EP1313508A2 (en) 2003-05-28
DK1313508T3 (da) 2007-08-06
JP2004501964A (ja) 2004-01-22
CY1107649T1 (el) 2013-04-18
DE60127970D1 (de) 2007-05-31
JP5469706B2 (ja) 2014-04-16

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