JP5102928B2 - 新規な葉酸代謝拮抗薬の組み合わせ療法 - Google Patents
新規な葉酸代謝拮抗薬の組み合わせ療法 Download PDFInfo
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- JP5102928B2 JP5102928B2 JP2002506715A JP2002506715A JP5102928B2 JP 5102928 B2 JP5102928 B2 JP 5102928B2 JP 2002506715 A JP2002506715 A JP 2002506715A JP 2002506715 A JP2002506715 A JP 2002506715A JP 5102928 B2 JP5102928 B2 JP 5102928B2
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- Prior art keywords
- vitamin
- administration
- administered
- antifolate
- folic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
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| JP5899241B2 (ja) | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
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| US10064869B2 (en) | 2014-06-04 | 2018-09-04 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| KR20180059430A (ko) * | 2015-07-30 | 2018-06-04 | 익스프레션 패톨로지, 인크. | 최적의 암 치료를 위한 FR-α 및 GART 단백질의 정량화 |
| FI3386546T3 (fi) * | 2015-12-07 | 2024-12-05 | General Oncology Inc | Yhdistelmä metastaattisen syövän tehokkaaseen hoitoon potilailla |
| WO2018031968A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| KR102585143B1 (ko) | 2016-08-12 | 2023-10-05 | 엘.이.에이.에프. 홀딩스 그룹 엘엘씨. | 폴리글루타메이트화 항엽산 및 이의 용도 |
| WO2018129533A1 (en) | 2017-01-09 | 2018-07-12 | Shuttle Pharmaceuticals, Llc | Selective histone deacetylase inhibitors for the treatment of human disease |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| ES2983284T3 (es) | 2018-01-09 | 2024-10-22 | Shuttle Pharmaceuticals Inc | Inhibidores selectivos de histona deacetilasa para el tratamiento de enfermedades humanas |
| CA3090384A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| CN111867593A (zh) | 2018-02-07 | 2020-10-30 | L.E.A.F.控股集团公司 | α聚谷氨酸化抗叶酸剂及其用途 |
| US11730738B2 (en) | 2018-02-07 | 2023-08-22 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| US12128046B2 (en) | 2018-02-07 | 2024-10-29 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated methotrexate and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| JP7490239B2 (ja) | 2018-02-07 | 2024-05-27 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化ペメトレキセドおよびその使用 |
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| US11771700B2 (en) | 2018-02-14 | 2023-10-03 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| JP7442822B2 (ja) | 2018-02-14 | 2024-03-05 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | γポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| WO2023177894A1 (en) | 2022-03-18 | 2023-09-21 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and an antimetabolite agent |
| WO2025247952A1 (en) * | 2024-05-30 | 2025-12-04 | Université De Fribourg | Inhibition of cyanide overproduction for the therapy of down syndrome and nonketotic hyperglycinemia |
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| AU2283595A (en) | 1994-04-08 | 1995-10-30 | Receptagen Corporation | Receptor modulating agents and methods relating thereto |
| WO1996012181A1 (en) | 1994-10-12 | 1996-04-25 | Research & Diagnostics Systems, Inc. | Reticulocyte assay control |
| PT1313508E (pt) * | 2000-06-30 | 2007-06-21 | Lilly Co Eli | Combinação contendo um antifolato e um agente redutor do ácido metilmalónico. |
| US20040005311A1 (en) * | 2001-07-20 | 2004-01-08 | Pitman Bradford D. | Dietary supplement compositions |
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2001
- 2001-06-15 PT PT01948214T patent/PT1313508E/pt unknown
- 2001-06-15 EP EP01948214A patent/EP1313508B1/en not_active Expired - Lifetime
- 2001-06-15 ES ES01948214T patent/ES2284660T3/es not_active Expired - Lifetime
- 2001-06-15 AU AU2001269688A patent/AU2001269688A1/en not_active Abandoned
- 2001-06-15 JP JP2002506715A patent/JP5102928B2/ja not_active Expired - Lifetime
- 2001-06-15 DK DK01948214.0T patent/DK1313508T5/da active
- 2001-06-15 WO PCT/US2001/014860 patent/WO2002002093A2/en not_active Ceased
- 2001-06-15 DE DE60127970T patent/DE60127970T2/de not_active Expired - Lifetime
- 2001-06-15 AT AT01948214T patent/ATE359823T1/de active
- 2001-06-15 US US10/297,821 patent/US7053065B2/en not_active Expired - Lifetime
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2005
- 2005-11-29 US US11/288,807 patent/US20060079480A1/en not_active Abandoned
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2007
- 2007-06-07 CY CY20071100756T patent/CY1107649T1/el unknown
- 2007-07-11 US US11/776,329 patent/US7772209B2/en not_active Expired - Fee Related
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2010
- 2010-04-28 US US12/768,920 patent/US20100210583A1/en not_active Abandoned
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2012
- 2012-06-27 JP JP2012144570A patent/JP5469706B2/ja not_active Expired - Lifetime
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2013
- 2013-10-11 JP JP2013213276A patent/JP2014005304A/ja not_active Withdrawn
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2015
- 2015-04-21 JP JP2015087012A patent/JP2015178501A/ja not_active Withdrawn
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2020117536A (ja) | 2020-08-06 |
| US20100210583A1 (en) | 2010-08-19 |
| DE60127970D1 (de) | 2007-05-31 |
| US7772209B2 (en) | 2010-08-10 |
| JP2004501964A (ja) | 2004-01-22 |
| JP2018197265A (ja) | 2018-12-13 |
| JP2014005304A (ja) | 2014-01-16 |
| US20030212038A1 (en) | 2003-11-13 |
| AU2001269688A1 (en) | 2002-01-14 |
| EP1313508A2 (en) | 2003-05-28 |
| WO2002002093A2 (en) | 2002-01-10 |
| DE60127970T2 (de) | 2007-12-20 |
| JP2012180381A (ja) | 2012-09-20 |
| CY1107649T1 (el) | 2013-04-18 |
| ATE359823T1 (de) | 2007-05-15 |
| PT1313508E (pt) | 2007-06-21 |
| DK1313508T3 (da) | 2007-08-06 |
| WO2002002093A3 (en) | 2003-02-06 |
| US20060079480A1 (en) | 2006-04-13 |
| JP2015178501A (ja) | 2015-10-08 |
| DK1313508T5 (da) | 2017-03-20 |
| JP2017019852A (ja) | 2017-01-26 |
| ES2284660T3 (es) | 2007-11-16 |
| JP5469706B2 (ja) | 2014-04-16 |
| EP1313508B1 (en) | 2007-04-18 |
| US20080032948A1 (en) | 2008-02-07 |
| US7053065B2 (en) | 2006-05-30 |
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