DE60127970T2 - Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält - Google Patents
Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält Download PDFInfo
- Publication number
- DE60127970T2 DE60127970T2 DE60127970T DE60127970T DE60127970T2 DE 60127970 T2 DE60127970 T2 DE 60127970T2 DE 60127970 T DE60127970 T DE 60127970T DE 60127970 T DE60127970 T DE 60127970T DE 60127970 T2 DE60127970 T2 DE 60127970T2
- Authority
- DE
- Germany
- Prior art keywords
- vitamin
- folic acid
- antifolate
- administered
- pharmaceutical derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000004052 folic acid antagonist Substances 0.000 title abstract description 83
- 230000003432 anti-folate effect Effects 0.000 title abstract description 75
- 229940127074 antifolate Drugs 0.000 title abstract description 75
- ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical group OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 title abstract description 46
- 239000003795 chemical substances by application Substances 0.000 title abstract description 9
- 239000000203 mixture Substances 0.000 title description 13
- 241000124008 Mammalia Species 0.000 claims abstract description 20
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 119
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 97
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- WBSXYJYELWQLCJ-UHFFFAOYSA-K cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1h-corrin-21-id-3-yl]propanoylamino]propan-2 Chemical compound O.[OH-].[Co+3].OCC1OC(N2C3=CC(C)=C(C)C=C3N=C2)C(O)C1OP([O-])(=O)OC(C)CNC(=O)CCC1(C)C(CC(N)=O)C2[N-]\C1=C(C)/C(C(C\1(C)C)CCC(N)=O)=N/C/1=C\C(C(C/1(CC(N)=O)C)CCC(N)=O)=N\C\1=C(C)/C1=NC2(C)C(C)(CC(N)=O)C1CCC(N)=O WBSXYJYELWQLCJ-UHFFFAOYSA-K 0.000 claims description 2
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- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 claims 1
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Landscapes
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| JP5899241B2 (ja) | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
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| RU2016151390A (ru) * | 2014-06-04 | 2018-07-17 | Томас Хелледайс Стифтелсе Фёр Медисинск Форскнинг | Ингибиторы мтн1 для лечения воспалительных и аутоиммунных заболеваний |
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| AU2016298439B2 (en) * | 2015-07-30 | 2018-11-08 | Expression Pathology, Inc. | Quantifying FR-alpha and GART proteins for optimal cancer therapy |
| FI3386546T3 (fi) * | 2015-12-07 | 2024-12-05 | General Oncology Inc | Yhdistelmä metastaattisen syövän tehokkaaseen hoitoon potilailla |
| US20180236098A1 (en) | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
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| JP7487107B2 (ja) | 2018-02-07 | 2024-05-20 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化葉酸代謝拮抗薬およびその使用 |
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| CN111954531A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化培美曲塞及其用途 |
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| EP3749319A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES |
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| JP2962755B2 (ja) * | 1989-02-28 | 1999-10-12 | 帝人株式会社 | 新規ビタミンｂ▲下１▼▲下２▼誘導体、その製造方法並びにその用途 |
| US5405839A (en) * | 1989-02-28 | 1995-04-11 | Teijin Limited | Vitamin B12 derivative, preparation process thereof, and use thereof |
| KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| DK0505640T4 (da) * | 1991-03-29 | 2002-12-16 | Lilly Co Eli | Forbedret terapeutisk metode |
| JPH05163160A (ja) * | 1991-12-13 | 1993-06-29 | Snow Brand Milk Prod Co Ltd | 免疫低下に伴う感染症の予防及び治療用栄養剤 |
| US6207651B1 (en) * | 1996-08-02 | 2001-03-27 | Metabolite Laboratories | Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6 |
| DE69528523T2 (de) | 1994-04-08 | 2003-06-12 | Receptagen Corp., Edmonds | Rezeptor modulierendes mitteln und entsprechendes verfahren |
| WO1996012181A1 (en) * | 1994-10-12 | 1996-04-25 | Research & Diagnostics Systems, Inc. | Reticulocyte assay control |
| DE60127970T2 (de) * | 2000-06-30 | 2007-12-20 | Eli Lilly And Co., Indianapolis | Zusammensetzung, welche ein antifolate und ein methylmalonsäuresenkendes mittel enthält |
| US20040005311A1 (en) * | 2001-07-20 | 2004-01-08 | Pitman Bradford D. | Dietary supplement compositions |
-
2001
- 2001-06-15 DE DE60127970T patent/DE60127970T2/de not_active Expired - Lifetime
- 2001-06-15 US US10/297,821 patent/US7053065B2/en not_active Expired - Lifetime
- 2001-06-15 DK DK01948214.0T patent/DK1313508T5/da active
- 2001-06-15 PT PT01948214T patent/PT1313508E/pt unknown
- 2001-06-15 JP JP2002506715A patent/JP5102928B2/ja not_active Expired - Lifetime
- 2001-06-15 EP EP01948214A patent/EP1313508B1/en not_active Expired - Lifetime
- 2001-06-15 WO PCT/US2001/014860 patent/WO2002002093A2/en not_active Ceased
- 2001-06-15 AU AU2001269688A patent/AU2001269688A1/en not_active Abandoned
- 2001-06-15 AT AT01948214T patent/ATE359823T1/de active
- 2001-06-15 ES ES01948214T patent/ES2284660T3/es not_active Expired - Lifetime
-
2005
- 2005-11-29 US US11/288,807 patent/US20060079480A1/en not_active Abandoned
-
2007
- 2007-06-07 CY CY20071100756T patent/CY1107649T1/el unknown
- 2007-07-11 US US11/776,329 patent/US7772209B2/en not_active Expired - Fee Related
-
2010
- 2010-04-28 US US12/768,920 patent/US20100210583A1/en not_active Abandoned
-
2012
- 2012-06-27 JP JP2012144570A patent/JP5469706B2/ja not_active Expired - Lifetime
-
2013
- 2013-10-11 JP JP2013213276A patent/JP2014005304A/ja not_active Withdrawn
-
2015
- 2015-04-21 JP JP2015087012A patent/JP2015178501A/ja not_active Withdrawn
-
2016
- 2016-09-29 JP JP2016192173A patent/JP2017019852A/ja not_active Withdrawn
-
2018
- 2018-08-23 JP JP2018156677A patent/JP2018197265A/ja not_active Withdrawn
-
2020
- 2020-04-14 JP JP2020072098A patent/JP2020117536A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014005304A (ja) | 2014-01-16 |
| DK1313508T3 (da) | 2007-08-06 |
| US20060079480A1 (en) | 2006-04-13 |
| CY1107649T1 (el) | 2013-04-18 |
| US7053065B2 (en) | 2006-05-30 |
| JP2018197265A (ja) | 2018-12-13 |
| EP1313508B1 (en) | 2007-04-18 |
| DK1313508T5 (da) | 2017-03-20 |
| WO2002002093A3 (en) | 2003-02-06 |
| EP1313508A2 (en) | 2003-05-28 |
| AU2001269688A1 (en) | 2002-01-14 |
| PT1313508E (pt) | 2007-06-21 |
| US20030212038A1 (en) | 2003-11-13 |
| US20100210583A1 (en) | 2010-08-19 |
| ATE359823T1 (de) | 2007-05-15 |
| US20080032948A1 (en) | 2008-02-07 |
| JP2020117536A (ja) | 2020-08-06 |
| JP5469706B2 (ja) | 2014-04-16 |
| WO2002002093A2 (en) | 2002-01-10 |
| JP2012180381A (ja) | 2012-09-20 |
| JP5102928B2 (ja) | 2012-12-19 |
| JP2004501964A (ja) | 2004-01-22 |
| US7772209B2 (en) | 2010-08-10 |
| JP2017019852A (ja) | 2017-01-26 |
| ES2284660T3 (es) | 2007-11-16 |
| JP2015178501A (ja) | 2015-10-08 |
| DE60127970D1 (de) | 2007-05-31 |
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Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
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Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |