JP2007511545A5 - - Google Patents
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- Publication number
- JP2007511545A5 JP2007511545A5 JP2006540118A JP2006540118A JP2007511545A5 JP 2007511545 A5 JP2007511545 A5 JP 2007511545A5 JP 2006540118 A JP2006540118 A JP 2006540118A JP 2006540118 A JP2006540118 A JP 2006540118A JP 2007511545 A5 JP2007511545 A5 JP 2007511545A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome composition
- stable
- pharmaceutically acceptable
- composition
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 162
- 239000002502 liposome Substances 0.000 claims description 140
- 150000001412 amines Chemical class 0.000 claims description 39
- 239000002253 acid Substances 0.000 claims description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 150000003904 phospholipids Chemical class 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 18
- 150000007524 organic acids Chemical class 0.000 claims description 16
- 239000012736 aqueous medium Substances 0.000 claims description 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 12
- 230000008859 change Effects 0.000 claims description 11
- 239000008177 pharmaceutical agent Substances 0.000 claims description 11
- 150000007513 acids Chemical class 0.000 claims description 9
- 125000003277 amino group Chemical group 0.000 claims description 9
- 238000005538 encapsulation Methods 0.000 claims description 8
- 150000007522 mineralic acids Chemical class 0.000 claims description 7
- -1 organic acid salts Chemical class 0.000 claims description 7
- 235000005985 organic acids Nutrition 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- 239000012298 atmosphere Substances 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 5
- 229940126534 drug product Drugs 0.000 claims description 5
- 238000006460 hydrolysis reaction Methods 0.000 claims description 5
- 230000003647 oxidation Effects 0.000 claims description 5
- 238000007254 oxidation reaction Methods 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 230000007073 chemical hydrolysis Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 229930182558 Sterol Natural products 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 150000003432 sterols Chemical class 0.000 claims description 2
- 235000003702 sterols Nutrition 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 28
- 239000012071 phase Substances 0.000 description 19
- 239000000126 substance Substances 0.000 description 9
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 8
- 229940127557 pharmaceutical product Drugs 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229960002428 fentanyl Drugs 0.000 description 6
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 229960005343 ondansetron Drugs 0.000 description 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 4
- 229960003708 sumatriptan Drugs 0.000 description 4
- 238000002144 chemical decomposition reaction Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 125000001095 phosphatidyl group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229960004207 fentanyl citrate Drugs 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003248 quinolines Chemical group 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 238000011146 sterile filtration Methods 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000000733 zeta-potential measurement Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52331603P | 2003-11-20 | 2003-11-20 | |
| PCT/CA2004/002002 WO2005048986A1 (en) | 2003-11-20 | 2004-11-22 | Stable liposome compositions comprising lipophilic amine containing pharmaceutical agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007511545A JP2007511545A (ja) | 2007-05-10 |
| JP2007511545A5 true JP2007511545A5 (https=) | 2008-01-17 |
Family
ID=34619598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006540118A Pending JP2007511545A (ja) | 2003-11-20 | 2004-11-22 | 安定リポソーム組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070269502A1 (https=) |
| EP (1) | EP1689364A4 (https=) |
| JP (1) | JP2007511545A (https=) |
| KR (1) | KR20060123341A (https=) |
| CN (2) | CN1893926B (https=) |
| AU (1) | AU2004290476A1 (https=) |
| BR (1) | BRPI0416650A (https=) |
| CA (1) | CA2588012A1 (https=) |
| MX (1) | MXPA06005688A (https=) |
| NO (1) | NO20062877L (https=) |
| RU (1) | RU2369384C2 (https=) |
| WO (1) | WO2005048986A1 (https=) |
| ZA (1) | ZA200604808B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4599849B2 (ja) * | 2004-02-18 | 2010-12-15 | コニカミノルタエムジー株式会社 | リポソーム含有製剤の製造方法、およびリポソーム含有製剤 |
| US8772359B2 (en) | 2006-11-08 | 2014-07-08 | Cp Kelco U.S., Inc. | Surfactant thickened systems comprising microfibrous cellulose and methods of making same |
| US9045716B2 (en) | 2006-11-08 | 2015-06-02 | Cp Kelco U.S., Inc. | Surfactant thickened systems comprising microfibrous cellulose and methods of making same |
| WO2009107753A1 (ja) | 2008-02-29 | 2009-09-03 | 財団法人 名古屋産業科学研究所 | 後眼部到達用リポソーム及び後眼部疾患用医薬組成物 |
| US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| CH702736B1 (de) * | 2008-12-31 | 2012-12-14 | Obschestvo S Organichennoi Otvetstvennostju Scient Company Flamena | Phospholipid-Emulsion, die Dihydroquerzetin beinhaltet. |
| EP2585046A4 (en) * | 2010-06-23 | 2013-11-06 | Brightside Innovations Inc | LECITHINTRÄGERVESIKEL AND METHOD FOR THE PRODUCTION THEREOF |
| EP2771341A4 (en) * | 2011-10-28 | 2015-09-23 | Univ Texas | NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| JP2015507019A (ja) * | 2012-02-17 | 2015-03-05 | セルシオン コーポレイション | 感熱性ナノ粒子製剤およびその製造方法 |
| JPWO2014017233A1 (ja) * | 2012-07-27 | 2016-07-07 | 住友重機械工業株式会社 | 微生物用活性調節剤及び微生物の活性を調節する方法 |
| RU2529179C1 (ru) * | 2013-04-23 | 2014-09-27 | Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" | Стабилизатор липосомальных суспензий и способ его получения |
| AU2016256979B2 (en) | 2015-05-04 | 2021-01-28 | Genfit | Method for preparing transmembrane pH-gradient vesicles |
| EP3416636A4 (en) * | 2016-02-15 | 2019-10-16 | Kemin Industries, Inc. | WATER-SOLUBLE LIPOPHILIC SUBSTANCES |
| WO2019126766A1 (en) * | 2017-12-21 | 2019-06-27 | Taiwan Liposome Co., Ltd. | Sustained-release triptan compositions and method of use the same through subdermal route or the like |
| EP3991722A4 (en) * | 2019-06-28 | 2022-10-05 | Jiangsu Hengrui Medicine Co., Ltd. | LIPID COMPOSITION WITH DELAYED RELEASE AND THEIR PROCESS OF PRODUCTION |
| CN112823009A (zh) * | 2019-08-28 | 2021-05-18 | 上海谷森医药有限公司 | 糠酸氟替卡松脂质体制剂及其制备方法 |
| RU2712079C1 (ru) * | 2019-09-05 | 2020-01-24 | Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) | Липосомальное лекарственное средство для лечения местных радиационных поражений кожи |
| CN113197848B (zh) * | 2021-05-24 | 2023-06-09 | 成都欣捷高新技术开发股份有限公司 | 一种重酒石酸间羟胺药物组合物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0152379A3 (de) * | 1984-02-15 | 1986-10-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen |
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
| WO1990003808A1 (en) * | 1988-10-07 | 1990-04-19 | The Liposome Company, Inc. | Heat treating liposomes |
| WO1990014105A1 (en) * | 1989-05-15 | 1990-11-29 | The Liposome Company, Inc. | Accumulation of drugs into liposomes by a proton gradient |
| JP3383704B2 (ja) * | 1993-04-02 | 2003-03-04 | わかもと製薬株式会社 | 安定なリポソーム水分散液 |
| US5451408A (en) * | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
| GB9605915D0 (en) * | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
| GB9708066D0 (en) * | 1997-04-22 | 1997-06-11 | Woolcombers Group Plc | Compositions and their use |
| WO2003075889A1 (en) * | 2002-03-05 | 2003-09-18 | Transave, Inc. | An inhalation system for prevention and treatment of intracellular infections |
-
2004
- 2004-11-22 BR BRPI0416650-7A patent/BRPI0416650A/pt not_active IP Right Cessation
- 2004-11-22 JP JP2006540118A patent/JP2007511545A/ja active Pending
- 2004-11-22 CA CA002588012A patent/CA2588012A1/en not_active Abandoned
- 2004-11-22 CN CN2004800343913A patent/CN1893926B/zh not_active Expired - Fee Related
- 2004-11-22 AU AU2004290476A patent/AU2004290476A1/en not_active Abandoned
- 2004-11-22 KR KR1020067011847A patent/KR20060123341A/ko not_active Ceased
- 2004-11-22 US US10/580,077 patent/US20070269502A1/en not_active Abandoned
- 2004-11-22 CN CN2010101414947A patent/CN101889981A/zh active Pending
- 2004-11-22 EP EP04818742A patent/EP1689364A4/en not_active Withdrawn
- 2004-11-22 MX MXPA06005688A patent/MXPA06005688A/es not_active Application Discontinuation
- 2004-11-22 RU RU2006121554/15A patent/RU2369384C2/ru not_active IP Right Cessation
- 2004-11-22 WO PCT/CA2004/002002 patent/WO2005048986A1/en not_active Ceased
-
2006
- 2006-06-12 ZA ZA200604808A patent/ZA200604808B/xx unknown
- 2006-06-19 NO NO20062877A patent/NO20062877L/no not_active Application Discontinuation
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