CN1893926B - 包含含有药物成分的亲脂胺的稳定脂质体组合物 - Google Patents

包含含有药物成分的亲脂胺的稳定脂质体组合物 Download PDF

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Publication number
CN1893926B
CN1893926B CN2004800343913A CN200480034391A CN1893926B CN 1893926 B CN1893926 B CN 1893926B CN 2004800343913 A CN2004800343913 A CN 2004800343913A CN 200480034391 A CN200480034391 A CN 200480034391A CN 1893926 B CN1893926 B CN 1893926B
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China
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compositions
liposome
liposome composition
value
composition
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Expired - Fee Related
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CN2004800343913A
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English (en)
Chinese (zh)
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CN1893926A (zh
Inventor
黛安娜·海伦·普柳拉
布拉戈亚·里斯泰夫斯基
詹姆斯·查尔斯·博伊兰
李红
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Gilead YM ULC
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Delex Therapeutics Inc
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Publication of CN1893926A publication Critical patent/CN1893926A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2004800343913A 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物 Expired - Fee Related CN1893926B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52331603P 2003-11-20 2003-11-20
US60/523,316 2003-11-20
PCT/CA2004/002002 WO2005048986A1 (en) 2003-11-20 2004-11-22 Stable liposome compositions comprising lipophilic amine containing pharmaceutical agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010101414947A Division CN101889981A (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Publications (2)

Publication Number Publication Date
CN1893926A CN1893926A (zh) 2007-01-10
CN1893926B true CN1893926B (zh) 2010-09-08

Family

ID=34619598

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2004800343913A Expired - Fee Related CN1893926B (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物
CN2010101414947A Pending CN101889981A (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2010101414947A Pending CN101889981A (zh) 2003-11-20 2004-11-22 包含含有药物成分的亲脂胺的稳定脂质体组合物

Country Status (13)

Country Link
US (1) US20070269502A1 (https=)
EP (1) EP1689364A4 (https=)
JP (1) JP2007511545A (https=)
KR (1) KR20060123341A (https=)
CN (2) CN1893926B (https=)
AU (1) AU2004290476A1 (https=)
BR (1) BRPI0416650A (https=)
CA (1) CA2588012A1 (https=)
MX (1) MXPA06005688A (https=)
NO (1) NO20062877L (https=)
RU (1) RU2369384C2 (https=)
WO (1) WO2005048986A1 (https=)
ZA (1) ZA200604808B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020259670A1 (zh) 2019-06-28 2020-12-30 江苏恒瑞医药股份有限公司 一种缓释脂质组合物及其制备方法

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JP4599849B2 (ja) * 2004-02-18 2010-12-15 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
US8772359B2 (en) 2006-11-08 2014-07-08 Cp Kelco U.S., Inc. Surfactant thickened systems comprising microfibrous cellulose and methods of making same
US9045716B2 (en) 2006-11-08 2015-06-02 Cp Kelco U.S., Inc. Surfactant thickened systems comprising microfibrous cellulose and methods of making same
WO2009107753A1 (ja) 2008-02-29 2009-09-03 財団法人 名古屋産業科学研究所 後眼部到達用リポソーム及び後眼部疾患用医薬組成物
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
CH702736B1 (de) * 2008-12-31 2012-12-14 Obschestvo S Organichennoi Otvetstvennostju Scient Company Flamena Phospholipid-Emulsion, die Dihydroquerzetin beinhaltet.
EP2585046A4 (en) * 2010-06-23 2013-11-06 Brightside Innovations Inc LECITHINTRÄGERVESIKEL AND METHOD FOR THE PRODUCTION THEREOF
EP2771341A4 (en) * 2011-10-28 2015-09-23 Univ Texas NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
JP2015507019A (ja) * 2012-02-17 2015-03-05 セルシオン コーポレイション 感熱性ナノ粒子製剤およびその製造方法
JPWO2014017233A1 (ja) * 2012-07-27 2016-07-07 住友重機械工業株式会社 微生物用活性調節剤及び微生物の活性を調節する方法
RU2529179C1 (ru) * 2013-04-23 2014-09-27 Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" Стабилизатор липосомальных суспензий и способ его получения
AU2016256979B2 (en) 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
EP3416636A4 (en) * 2016-02-15 2019-10-16 Kemin Industries, Inc. WATER-SOLUBLE LIPOPHILIC SUBSTANCES
WO2019126766A1 (en) * 2017-12-21 2019-06-27 Taiwan Liposome Co., Ltd. Sustained-release triptan compositions and method of use the same through subdermal route or the like
CN112823009A (zh) * 2019-08-28 2021-05-18 上海谷森医药有限公司 糠酸氟替卡松脂质体制剂及其制备方法
RU2712079C1 (ru) * 2019-09-05 2020-01-24 Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) Липосомальное лекарственное средство для лечения местных радиационных поражений кожи
CN113197848B (zh) * 2021-05-24 2023-06-09 成都欣捷高新技术开发股份有限公司 一种重酒石酸间羟胺药物组合物及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003808A1 (en) * 1988-10-07 1990-04-19 The Liposome Company, Inc. Heat treating liposomes
WO1990014105A1 (en) * 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
US5451408A (en) * 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
WO1997034582A1 (en) * 1996-03-21 1997-09-25 Vrije Universiteit Brussel Liposome encapsulated amphiphilic drug compositions
WO2003075890A1 (en) * 2002-03-05 2003-09-18 Transave, Inc. Methods for entrapment of bioactive agent in a liposome or lipid complex

Family Cites Families (4)

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EP0152379A3 (de) * 1984-02-15 1986-10-29 Ciba-Geigy Ag Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen
AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
JP3383704B2 (ja) * 1993-04-02 2003-03-04 わかもと製薬株式会社 安定なリポソーム水分散液
GB9708066D0 (en) * 1997-04-22 1997-06-11 Woolcombers Group Plc Compositions and their use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003808A1 (en) * 1988-10-07 1990-04-19 The Liposome Company, Inc. Heat treating liposomes
WO1990014105A1 (en) * 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
US5451408A (en) * 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
WO1997034582A1 (en) * 1996-03-21 1997-09-25 Vrije Universiteit Brussel Liposome encapsulated amphiphilic drug compositions
WO2003075890A1 (en) * 2002-03-05 2003-09-18 Transave, Inc. Methods for entrapment of bioactive agent in a liposome or lipid complex

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Boogaerts et. al.."Biodistri-bution of liposome-associated bupivacaine afterextradural administration to rabbits".Brit. J.Anaesthesia75.1995,75319-322. *
Girke et.al.."Comparison between the activities of cationic amphiphilicdrugs to affect phospholipidmembranes and to depresscardiac function".Biochemical Pharmacology38 15.1989,38(15),2487-2490. *
S.L.Law et. al.."Preparation of desmopressin-containing liposomes forintranasal delivery".J. Controlled Release70.2001,70375-381. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020259670A1 (zh) 2019-06-28 2020-12-30 江苏恒瑞医药股份有限公司 一种缓释脂质组合物及其制备方法

Also Published As

Publication number Publication date
NO20062877L (no) 2006-08-21
ZA200604808B (en) 2007-11-28
RU2369384C2 (ru) 2009-10-10
RU2006121554A (ru) 2007-12-27
AU2004290476A1 (en) 2005-06-02
CN101889981A (zh) 2010-11-24
EP1689364A1 (en) 2006-08-16
EP1689364A4 (en) 2008-10-29
MXPA06005688A (es) 2006-12-14
US20070269502A1 (en) 2007-11-22
CN1893926A (zh) 2007-01-10
BRPI0416650A (pt) 2007-01-16
WO2005048986A1 (en) 2005-06-02
CA2588012A1 (en) 2005-06-02
KR20060123341A (ko) 2006-12-01
JP2007511545A (ja) 2007-05-10

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: YM BIOLOGY SCIENCE CO., LTD.

Free format text: FORMER OWNER: DLAX THERAPY CO., LTD.

Effective date: 20080606

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20080606

Address after: Ontario, Canada

Applicant after: Delex Therapeutics Inc.

Address before: Ontario, Canada

Applicant before: Delex Therapeutics Inc.

C14 Grant of patent or utility model
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C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100908

Termination date: 20101122