JP2007507532A5 - - Google Patents

Download PDF

Info

Publication number
JP2007507532A5
JP2007507532A5 JP2006534173A JP2006534173A JP2007507532A5 JP 2007507532 A5 JP2007507532 A5 JP 2007507532A5 JP 2006534173 A JP2006534173 A JP 2006534173A JP 2006534173 A JP2006534173 A JP 2006534173A JP 2007507532 A5 JP2007507532 A5 JP 2007507532A5
Authority
JP
Japan
Prior art keywords
international
opioid receptor
documents cited
peptidic
pamphlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006534173A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007507532A (ja
JP4976134B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/032479 external-priority patent/WO2005033073A2/en
Publication of JP2007507532A publication Critical patent/JP2007507532A/ja
Publication of JP2007507532A5 publication Critical patent/JP2007507532A5/ja
Application granted granted Critical
Publication of JP4976134B2 publication Critical patent/JP4976134B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006534173A 2003-10-01 2004-10-01 スピロ環複素環誘導体及びそれらを使用する方法 Expired - Fee Related JP4976134B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50786403P 2003-10-01 2003-10-01
US60/507,864 2003-10-01
PCT/US2004/032479 WO2005033073A2 (en) 2003-10-01 2004-10-01 Spirocyclic heterocyclic derivatives and methods of their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011107724A Division JP2011201896A (ja) 2003-10-01 2011-05-13 スピロ環複素環誘導体及びそれらを使用する方法

Publications (3)

Publication Number Publication Date
JP2007507532A JP2007507532A (ja) 2007-03-29
JP2007507532A5 true JP2007507532A5 (enExample) 2007-11-22
JP4976134B2 JP4976134B2 (ja) 2012-07-18

Family

ID=34421676

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006534173A Expired - Fee Related JP4976134B2 (ja) 2003-10-01 2004-10-01 スピロ環複素環誘導体及びそれらを使用する方法
JP2011107724A Pending JP2011201896A (ja) 2003-10-01 2011-05-13 スピロ環複素環誘導体及びそれらを使用する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011107724A Pending JP2011201896A (ja) 2003-10-01 2011-05-13 スピロ環複素環誘導体及びそれらを使用する方法

Country Status (13)

Country Link
US (6) US7338962B2 (enExample)
EP (1) EP1675847B1 (enExample)
JP (2) JP4976134B2 (enExample)
KR (2) KR101255074B1 (enExample)
CN (2) CN101921279A (enExample)
AU (1) AU2004278414B2 (enExample)
BR (1) BRPI0415165A (enExample)
CA (1) CA2541014A1 (enExample)
CO (1) CO5690640A2 (enExample)
IL (2) IL174702A (enExample)
NZ (3) NZ593444A (enExample)
WO (1) WO2005033073A2 (enExample)
ZA (1) ZA200603414B (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319939B1 (en) * 1997-12-11 2001-11-20 Janssen Pharmaceutica N.V. Retinoic acid mimetic anlides
JP4976134B2 (ja) 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2009509927A (ja) * 2005-09-01 2009-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ カリウムチャンネル開口剤としての新規ベンゾピラン誘導体
ES2379098T3 (es) 2005-09-01 2012-04-20 Janssen Pharmaceutica Nv Derivados de benzopirano novedosos como abridores del canal de potasio
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2024370A1 (en) * 2006-05-05 2009-02-18 Boehringer Ingelheim International GmbH Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
MX2009002715A (es) * 2006-09-12 2009-08-12 Adolor Corp Metodos para mejorar la funcion cognoscitiva.
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉-1-酮衍生物或其鹽
MX2010008375A (es) * 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).
EA018537B1 (ru) * 2008-01-30 2013-08-30 Сефалон, Инк. Замещенные спироциклические производные пиперидина как лиганды гистамин-3 (h) рецептора
US20110263545A1 (en) 2008-05-20 2011-10-27 Naweed Muhammad Hepatoprotectant acetaminophen mutual prodrugs
ES2573497T3 (es) 2011-02-02 2016-06-08 Vertex Pharmaceuticals Incorporated Pirrolopirazin-amidas de piperidina espirocíclicas como moduladores de canales iónicos
CA2827311A1 (en) * 2011-02-18 2012-08-23 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
CA2829803A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
WO2012129495A1 (en) 2011-03-23 2012-09-27 Trevena, Inc. Opioid receptor ligands and methods of using and making same
WO2014028800A1 (en) 2012-08-16 2014-02-20 Janssen Pharmaceutica Nv Substituted pyrazoles as n-type calcium channel blockers
EP2888287A4 (en) 2012-08-21 2016-04-20 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE HAPTENES AND THEIR USE
TR201910347T4 (tr) 2012-08-21 2019-07-22 Janssen Pharmaceutica Nv Olanzapin haptenlerine yönelik antikorlar ve bunların kullanımı.
JP6389176B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ.ベー. アリピプラゾールハプテンに対する抗体及びその使用
HK1211958A1 (en) 2012-08-21 2016-06-03 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone and use thereof
PT2888234T (pt) 2012-08-21 2018-02-22 Janssen Pharmaceutica Nv Haptenos de aripiprazol e seu uso em imunoensaios
CN104737017B (zh) 2012-08-21 2017-03-08 詹森药业有限公司 利培酮的抗体及其用途
PL3385284T3 (pl) 2012-08-21 2020-09-21 Janssen Pharmaceutica Nv Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie
EP3663316A1 (en) 2012-08-21 2020-06-10 Janssen Pharmaceutica NV Antibodies to aripiprazole and use thereof
PT2888284T (pt) 2012-08-21 2022-11-18 Janssen Pharmaceutica Nv Anticorpos dirigidos contra haptenos de risperidona e a sua utilização
AU2013305901B2 (en) 2012-08-21 2017-10-26 Saladax Biomedical Inc. Antibodies to olanzapine and use thereof
EP2888592B1 (en) 2012-08-21 2017-11-08 Janssen Pharmaceutica NV Antibodies to quetiapine and use thereof
ES2621305T3 (es) 2012-12-14 2017-07-03 Purdue Pharma Lp Morfinanos espirocíclicos y su uso
TW201441199A (zh) 2012-12-28 2014-11-01 Purdue Pharma Lp 經取代之嗎啡喃類及其用途
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
MX2016002043A (es) * 2013-08-16 2016-05-26 Janssen Pharmaceutica Nv Imidazoles sustituidos como bloqueadores de canales de calcio tipo n.
US9299409B2 (en) * 2013-09-11 2016-03-29 Tadashi Miyakawa Semiconductor storage device
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands
KR20170025848A (ko) 2015-08-31 2017-03-08 한국건설생활환경시험연구원 교류 직결형 엘이디 램프 결합 구조
CA3007020A1 (en) 2015-12-14 2017-06-22 Trevena, Inc. Methods of treating hyperalgesia
CA3008809A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
WO2017106508A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
IL310506A (en) * 2021-08-02 2024-03-01 Shujing Biopharma Co Ltd An oxaspiro derivative, a method for its preparation and use

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
MX170841B (es) 1988-09-26 1993-09-20 Goodyear Tire & Rubber Proceso mejorado para la sintesis catalizada de metacrilaminadas y acrilimidas n-substituidas
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
EP0376524B1 (en) 1988-12-13 1995-03-29 Beecham Group Plc Benzopyran and related compounds
DE69015886T2 (de) * 1989-06-05 1995-08-03 Tokuyama Corp Fotochromische Verbindung, deren Zusammensetzung und Verwendung.
JPH03173882A (ja) 1989-09-29 1991-07-29 Tanabe Seiyaku Co Ltd クロメン又はチオクロメン誘導体、その製法及びその合成中間体
JP2985322B2 (ja) 1991-03-01 1999-11-29 東レ株式会社 イソキノリン誘導体およびその医薬用途
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
GB9203596D0 (en) 1992-02-20 1992-04-08 Smithkline Beecham Plc Novel process
GB9207400D0 (en) 1992-04-02 1992-05-13 Smithkline Beecham Plc Novel use
CA2100514C (en) 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
ES2064228B1 (es) 1992-10-19 1995-09-01 Uriach & Cia Sa J Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.
AU693087B2 (en) 1993-01-28 1998-06-25 Merck & Co., Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US6031115A (en) * 1993-05-14 2000-02-29 Smithkline Beecham Plc Process for preparing epoxides
CN1043641C (zh) 1993-08-06 1999-06-16 史密丝克莱恩比彻姆制药股份公司 氢化异喹啉衍生物
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
EP0758313A4 (en) * 1994-05-06 1999-09-15 Pharmacopeia Inc COMBINATORIAL LIBRARY OF DIHYDROBENZOPYRANES
SE9401727D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds I
US5683628A (en) 1994-10-17 1997-11-04 Seiko Epson Corp. Photochromic composition and photochromic resin obtainable by using the same
US5628935A (en) * 1994-10-28 1997-05-13 Vision-Ease Lens, Inc. Photochromic spironaphthopyran compounds
AU4458996A (en) 1995-01-20 1996-08-07 Nippon Shinyaku Co. Ltd. Ethylamine derivatives and drugs
US5656420A (en) * 1995-02-24 1997-08-12 University Of Kentucky Research Foundation Method for employing the delta opioid dadle to extend tissue survival time during ischemia
IT1307327B1 (it) 1995-09-12 2001-10-30 Smithkline Beecham Spa Derivati idroisochinolinici sostituiti
JPH09301973A (ja) 1996-05-09 1997-11-25 Kumiai Chem Ind Co Ltd クロメン誘導体及びこれを有効成分とする除草剤
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
DE19805370A1 (de) 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
US6103722A (en) 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
US6319939B1 (en) * 1997-12-11 2001-11-20 Janssen Pharmaceutica N.V. Retinoic acid mimetic anlides
GB9804734D0 (en) 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
FR2787789B1 (fr) * 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
TWI243173B (en) 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
JP2005231995A (ja) 1999-12-22 2005-09-02 Meiji Seika Kaisha Ltd オピオイドδ受容体アゴニスト/アンタゴニストとして有用なスピロ化合物
JP4275288B2 (ja) 2000-03-31 2009-06-10 新明和工業株式会社 ダンプ車輌の油圧制御装置
ATE284882T1 (de) * 2000-04-27 2005-01-15 Basilea Pharmaceutica Ag Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
US20010036949A1 (en) 2000-05-09 2001-11-01 Coe Jotham Wadsworth Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal
GB0011426D0 (en) 2000-05-11 2000-06-28 Charteris Limited A method for transforming documents written in different XML-based languages
KR20020012346A (ko) 2000-08-07 2002-02-16 유현식 신디오탁틱 폴리스티렌을 고수율로 제조하고 반응기부착물을 감소시키는 담지촉매
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
SE0101766D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
NZ529401A (en) 2001-05-18 2005-09-30 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101768D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101767D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101765D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
EP1279666A1 (en) * 2001-07-24 2003-01-29 Pfizer Products Inc. 1-diphenylmethyl-pyrazole derivatives as opioid receptor ligands
SE0103313D0 (sv) 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
AU2002346994B2 (en) 2001-10-15 2007-09-06 Janssen Pharmaceutica N.V. Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
US7030124B2 (en) 2001-10-29 2006-04-18 Ardent Pharmaceuticals, Inc. Method of treating depression with delta receptor agonist compounds
US6715527B2 (en) * 2001-12-11 2004-04-06 Raymond V. Ardoin Ventilation apparatus for garages
EP1469850B1 (en) 2002-01-02 2013-01-02 Versi Group, LLC Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
WO2004026819A2 (en) 2002-09-18 2004-04-01 The Curators Of The University Of Missouri OPIATE ANALOGS SELECTIVE FOR THE delta-OPIOID RECEPTOR
ATE387443T1 (de) 2002-10-15 2008-03-15 Janssen Pharmaceutica Nv Substituierte aminochinuclidin verbindungen und deren verwendung als delta-opioid rezeptor liganden
AU2003301299A1 (en) 2002-10-15 2004-05-04 Janssen Pharmaceutica, N.V. Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203301D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
SE0300105D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300103D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005019157A1 (en) 2003-08-15 2005-03-03 Patel Hasmukh B Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
MX2009002715A (es) * 2006-09-12 2009-08-12 Adolor Corp Metodos para mejorar la funcion cognoscitiva.

Similar Documents

Publication Publication Date Title
JP2007507532A5 (enExample)
JP2014528601A5 (enExample)
JP2008523153A5 (enExample)
JP2008508189A5 (enExample)
JP2008530345A5 (enExample)
JP2012504317A5 (enExample)
BRPI0910656A2 (pt) ´´compostos ligantes de receptor de estrogênio, uso dos mesmos e composição farmacéutica´´
SI1830855T1 (sl) Trdne oralno aplikabilne farmacevtske dajalne oblike z modificiranim sproščanjem ki vsebujejo rivaroksaban
NO20082387L (no) Kompetitive domene-antistofformater som binder interleukin 1 reseptor type 1
WO2007048066A3 (en) Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators
WO2006113017A3 (en) Retention of information about digital-media rights in transformed digital media content
ATE397933T1 (de) Kristallinform gamma-d von ivabradine- hydrochlorid, verfahren zu dessen herstellung und diesen enthaltende pharmazeutische zusammensetzung
CY1109956T1 (el) Στερεα φαρμακευτικη συνθεση περιλαμβανουσα υδροχλωρικη ντονεπεζιλη
JP2014533241A5 (enExample)
JP2006517944A5 (enExample)
JP2007530539A5 (enExample)
WO2007096707A3 (en) Improved synthesis and preparations of duloxetine salts
JP2014508098A5 (enExample)
BRPI0612189A2 (pt) composto, composiÇço farmacÊutica, mÉtodo para ligar receptores opiàides
WO2006138373A3 (en) MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
JPWO2020112635A5 (enExample)
WO2008156046A1 (ja) プロジェクタ及びプロジェクタシステム
JPWO2021118798A5 (enExample)
JP2017532647A5 (enExample)
Christensen From Direct Public Use to Indirect Public Benefit: Kelo v. New London's Bridge from Rational Basis to Heightened Scrutiny for Eminent Domain Takings