CA2541014A1 - Spirocyclic heterocyclic derivatives and methods of their use - Google Patents

Spirocyclic heterocyclic derivatives and methods of their use Download PDF

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Publication number
CA2541014A1
CA2541014A1 CA002541014A CA2541014A CA2541014A1 CA 2541014 A1 CA2541014 A1 CA 2541014A1 CA 002541014 A CA002541014 A CA 002541014A CA 2541014 A CA2541014 A CA 2541014A CA 2541014 A1 CA2541014 A1 CA 2541014A1
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alkyl
aryl
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membered
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CA002541014A
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English (en)
French (fr)
Inventor
Roland E. Dolle
Bertrand Le Bourdonnec
Christopher W. Ajello
Minghua Gu
Guo-Hua Chu
Paul Anson Tuthill
Lara K. Leister
Jean Q. Zhou
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Adolor Corp
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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  • Pain & Pain Management (AREA)
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  • Urology & Nephrology (AREA)
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CA002541014A 2003-10-01 2004-10-01 Spirocyclic heterocyclic derivatives and methods of their use Abandoned CA2541014A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50786403P 2003-10-01 2003-10-01
US60/507,864 2003-10-01
PCT/US2004/032479 WO2005033073A2 (en) 2003-10-01 2004-10-01 Spirocyclic heterocyclic derivatives and methods of their use

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CA2541014A1 true CA2541014A1 (en) 2005-04-14

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CA002541014A Abandoned CA2541014A1 (en) 2003-10-01 2004-10-01 Spirocyclic heterocyclic derivatives and methods of their use

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US (6) US7338962B2 (enExample)
EP (1) EP1675847B1 (enExample)
JP (2) JP4976134B2 (enExample)
KR (2) KR101255074B1 (enExample)
CN (2) CN101921279A (enExample)
AU (1) AU2004278414B2 (enExample)
BR (1) BRPI0415165A (enExample)
CA (1) CA2541014A1 (enExample)
CO (1) CO5690640A2 (enExample)
IL (2) IL174702A (enExample)
NZ (3) NZ546834A (enExample)
WO (1) WO2005033073A2 (enExample)
ZA (1) ZA200603414B (enExample)

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TR200001645T2 (tr) * 1997-12-11 2000-12-21 Janssen Pharmaceutica N.V. Retinoyik asit taklidi anilürler.
AU2004278414B2 (en) 2003-10-01 2012-05-24 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
SI1937669T1 (sl) 2005-09-01 2012-05-31 Janssen Pharmaceutica Nv Novi derivati benzopirana kot odpiralci kalijevega kanala
JP2009509927A (ja) 2005-09-01 2009-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ カリウムチャンネル開口剤としての新規ベンゾピラン誘導体
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CA2648831A1 (en) * 2006-05-05 2007-11-15 Ulrich Reiser Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
EP2399577A1 (en) 2006-09-12 2011-12-28 Adolor Corporation Use of N-containing spirocompounds for the enhancement of cognitive function
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
ES2370378T3 (es) * 2008-01-30 2011-12-14 Cephalon, Inc. Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de histamina h3.
EP2250176B1 (en) * 2008-01-30 2012-08-01 Cephalon, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
BRPI0912820A2 (pt) 2008-05-20 2015-10-13 Neurogesx Inc pró-fármacos de relação hepatoprotetora de acetaminofeno
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