JP2007504157A - 無水クエン酸二水素銀組成物 - Google Patents
無水クエン酸二水素銀組成物 Download PDFInfo
- Publication number
- JP2007504157A JP2007504157A JP2006524884A JP2006524884A JP2007504157A JP 2007504157 A JP2007504157 A JP 2007504157A JP 2006524884 A JP2006524884 A JP 2006524884A JP 2006524884 A JP2006524884 A JP 2006524884A JP 2007504157 A JP2007504157 A JP 2007504157A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dihydrogen citrate
- silver dihydrogen
- anhydrous
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QZRSVBDWRWTHMT-UHFFFAOYSA-M silver;3-carboxy-3,5-dihydroxy-5-oxopentanoate Chemical compound [Ag+].OC(=O)CC(O)(C([O-])=O)CC(O)=O QZRSVBDWRWTHMT-UHFFFAOYSA-M 0.000 title claims abstract description 92
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 150
- 239000000243 solution Substances 0.000 claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 71
- 238000000034 method Methods 0.000 claims abstract description 42
- 239000003085 diluting agent Substances 0.000 claims abstract description 24
- 239000011550 stock solution Substances 0.000 claims abstract description 23
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 18
- 239000000758 substrate Substances 0.000 claims abstract description 8
- 238000007710 freezing Methods 0.000 claims abstract description 5
- 230000008014 freezing Effects 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- HMHPTACWIPORMJ-UHFFFAOYSA-M C(CC(O)(C(=O)O)CC(=O)O)(=O)[O-].C(CC(O)(C(=O)O)CC(=O)O)(=O)O.[Ag+] Chemical compound C(CC(O)(C(=O)O)CC(=O)O)(=O)[O-].C(CC(O)(C(=O)O)CC(=O)O)(=O)O.[Ag+] HMHPTACWIPORMJ-UHFFFAOYSA-M 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 8
- 235000013305 food Nutrition 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims 1
- 238000009920 food preservation Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 abstract description 6
- 229960004106 citric acid Drugs 0.000 description 39
- 229910052709 silver Inorganic materials 0.000 description 21
- 239000004332 silver Substances 0.000 description 20
- 239000000523 sample Substances 0.000 description 17
- 238000012360 testing method Methods 0.000 description 15
- -1 silver ions Chemical class 0.000 description 12
- 230000000844 anti-bacterial effect Effects 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 10
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 9
- 244000005700 microbiome Species 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 238000012792 lyophilization process Methods 0.000 description 8
- 229920001817 Agar Polymers 0.000 description 7
- 239000008272 agar Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 6
- 238000005868 electrolysis reaction Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000003755 preservative agent Substances 0.000 description 6
- 238000011109 contamination Methods 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000002335 preservative effect Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 241000228212 Aspergillus Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 239000008151 electrolyte solution Substances 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000000417 fungicide Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000008247 solid mixture Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 2
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 241000675108 Citrus tangerina Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010410 dusting Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 239000012520 frozen sample Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000005297 pyrex Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-M 3-carboxy-2-(carboxymethyl)-2-hydroxypropanoate Chemical compound OC(=O)CC(O)(C(O)=O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-M 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 235000012905 Brassica oleracea var viridis Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000219122 Cucurbita Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 241000709704 Human poliovirus 2 Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 241000186781 Listeria Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 241000207836 Olea <angiosperm> Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 238000009408 flooring Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 235000021384 green leafy vegetables Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000012994 industrial processing Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000015073 liquid stocks Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 229940054334 silver cation Drugs 0.000 description 1
- 229940071575 silver citrate Drugs 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000005092 sublimation method Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Organic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
Description
本発明は、一般的には、抗菌組成物に関する。特に、本発明は、無水クエン酸二水素銀とクエン酸とを含む組成物を提供する。本発明は、その組成物を生成するプロセスを提供する。本発明は、上記固体組成物を使用する抗菌方法を提供する。
抗菌金属イオン溶液が、殺菌剤として使用されている。銀溶液は、冷却塔(cooling tower)、用水プール(swimming pool)、病院の温水システム、携帯型水システム、および鉱泉プール(spa pool)において、殺菌剤として使用されている。さらに、銀イオン溶液は、創傷の処置のために調製されている。しかし、提唱される方法において使用される銀イオンは、不安定である。その銀イオンは、創傷部位へと治療用量を送達するためには、その創傷付近にて生成されなければならない。
本発明は、無水クエン酸二水素銀とクエン酸とを含む組成物を提供し、その組成物を生成するプロセスを提供する。そのプロセスは、水性クエン酸二水素銀のストック溶液を凍結させる工程、その後、その凍結ストック溶液を凍結乾燥させて、無水クエン酸二水素銀を生成する工程を包含する。
本発明は、無水クエン酸二水素銀とクエン酸とを含む組成物を提供する。驚くべきことに、この無水クエン酸二水素銀組成物は、有効な抗菌活性を有する安定なクエン酸二水素銀溶液を生成するために、一定期間後に再構成され得ることが、見出された。この無水組成物は、保存が容易であり経済的であるという利点を提供する。この無水組成物はまた、クエン酸二水素銀水溶液よりも輸送が経済的であるという利点を提供する。この無水組成物は、水または別の水性希釈剤を用いて簡便に再構成され得るので、この無水組成物は、クエン酸二水素銀水溶液に対する簡便な代替法を提供する。
水を、逆浸透ユニット中に導入し、半透膜を通して通過させて不純物を除去し、そして脱イオン水を生成した。99%純度の無水クエン酸を、上記水と混合し、200ガロンの20%(重量/体積)(水1ガロン当たりクエン酸796g)溶液を生成した。この200ガロンの20%クエン酸を、陽極および陰極を有するイオンチャンバ中に入れた。これらの電極の各々は、200トロイオンスの999純銀からなった。これらの陽極および陰極を、少なくとも2.0mm離して間隔をあけ、上記クエン酸溶液がこの2つの電極の間を通過することを可能にした。陽性伝導体および陰性伝導体を備えるイオン発生コントローラ(ion generation controller(IGC))電源を、上記陽極および陰極に取り付けた。そのIGCで、17ボルトで5アンペアの電流を印加し、9秒毎にパルス化し、1分間間隔で極性を変化させた。上記プロセス全体にわたって、5アンペア−17ボルトの出力を維持するために、電極間隙を調整した。電流フローは、イオン電流が上記陽極と陰極との間を流れることを引き起こし、上記希釈されたクエン酸溶液中に遊離の銀イオンを生成した。この銀イオンは、上記クエン酸溶液中のクエン酸と反応して、クエン酸二水素銀溶液を生成した。20%のクエン酸溶液を、所望の銀イオン濃度が得られるまで、1分間あたり50ガロンで、144時間、上記イオンチャンバを通して再循環させた。次いで、このクエン酸二水素銀溶液を、上記手順の間に形成されたあらゆる固体を沈殿させるために、静置した。得られた生成物は、2400ppmの銀イオン濃度を有するクエン酸二水素銀溶液であった。本明細書中で今後は、この溶液をストック溶液と呼ぶ。このストック溶液は、以下の実施例ですぐに使用され得るし、後の使用のために保存もされ得る。
上記実施例1で調製したストック溶液の1,000mlサンプルを、SSAバッチ番号04.06.03から入手し、イオン選択性電極(ion specific electrode(ISE))を備えるOrionTM 290Aプロセッサを使用して、このサンプルが2400ppmのイオン性銀の濃度を有することを確認した。
次いで、実施例2からの結晶の粉末を、約794mlの薬学等級の純水を使用して、1,000ml Pyrexガラスフラスコ中で再構成した。次いで、この溶液を、磁気的スターラーによって30分間撹拌し、遮光性保存キャビネット中に24時間置いた。
クエン酸二水素銀組成物の防腐剤としての効力を実証するために、実施例1に記載したクエン酸二水素銀のストック溶液を、防腐剤負荷試験に供した。この防腐剤負荷試験を、カテゴリー2の生成物(水性基剤またはビヒクルを用いて生成された局所的に使用される生成物、無菌性でない経鼻生成物、粘膜に適用されるエマルジョンを含むエマルジョン)についてのヨーロッパ薬局方試験法4.04/5.01.03.00に従って、実施した。
Pseudomonas aeruginosa ATCC 9027;NCIMB 8626;CIP 82.118
Staphylococcus aureus ATCC 6538;NCTC 10788;NCIMB 9518;CIP 4.83
Candida albicans ATCC 10231;NCPF 3179;IP 48.72
Aspergillus niger ATCC 16404;IMI 149007;IP 1431.83。
Claims (17)
- 無水クエン酸二水素銀とクエン酸とを含む、組成物。
- 請求項1に記載の無水組成物であって、該組成物は、水を実質的には含まない、組成物。
- 請求項1に記載の無水組成物であって、該組成物は、約0.5%未満の水を含む、組成物。
- 請求項1に記載の無水組成物であって、該組成物は、結晶性である、組成物。
- 請求項1に記載の無水組成物であって、該組成物は、クエン酸二水素銀に対してモル過剰のクエン酸を含む、組成物。
- 請求項1に記載の無水組成物であって、該組成物は、クエン酸二水素銀に対して少なくとも5倍モル過剰のクエン酸を含む、組成物。
- 無水クエン酸二水素銀とクエン酸とを含む組成物を生成するプロセスであって、該プロセスは、
(a)クエン酸二水素銀とクエン酸と水とを含むストック溶液を提供する工程;
(b)該ストック溶液を凍結させて凍結溶液を形成する工程;および
(c)該凍結溶液を凍結乾燥させて、該無水組成物を形成する工程;
を包含する、プロセス。 - 請求項7に記載のプロセスであって、前記クエン酸は、クエン酸二水素銀よりもモル過剰のクエン酸である、プロセス。
- 請求項7に記載のプロセスであって、前記工程(c)は、前記凍結溶液を加熱する工程をさらに包含する、プロセス。
- 無水クエン酸二水素銀−クエン酸組成物を使用する方法であって、該方法は、該無水クエン酸二水素銀組成物を、再構成された抗菌的に活性なクエン酸二水素銀組成物を生成するために充分な量の水性希釈剤と合わせる工程を包含する、方法。
- 請求項10に記載の方法であって、前記水性希釈剤は、実質的に純粋な水である、方法。
- 請求項10に記載の方法であって、前記水性希釈剤は、水と、アルコールおよび界面活性剤からなる群のうちの少なくとも1つの成員とを含む、方法。
- 無水クエン酸二水素銀−クエン酸組成物を使用する方法であって、該方法は、該無水クエン酸二水素銀組成物を、抗菌的に有効なクエン酸二水素銀溶液を生成するために充分な水性希釈剤と合わせる工程;および該抗菌的に有効なクエン酸二水素銀溶液を基材に適用し、それによって抗菌効果を達成する工程を包含する、方法。
- 請求項13に記載の方法であって、前記基材は、固体表面、食料品、または非食料物品である、方法。
- 請求項14に記載の方法であって、前記固体表面は、管の内側、貯蔵槽、用水プール、鉱泉、冷却システム、または冷却塔である、方法。
- 請求項13に記載の方法であって、前記抗菌効果は、殺生物制御または生物膜制御である、方法。
- 請求項13に記載の方法であって、前記抗菌効果は、食品保存である、方法。
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JP2008512387A (ja) * | 2004-09-07 | 2008-04-24 | ピュア バイオサイエンス | クエン酸二水素銀組成物 |
JP2011522819A (ja) * | 2008-06-06 | 2011-08-04 | ピュア バイオサイエンス | クエン酸二水素銀の農業適用 |
JP2011530542A (ja) * | 2008-08-14 | 2011-12-22 | エキシトン テクノロジーズ インコーポレイテッド | 抗菌性銀溶液 |
WO2021261467A1 (ja) | 2020-06-23 | 2021-12-30 | 佐々木化学工業株式会社 | クエン酸水素二銀含有組成物及びその製造方法、並びにこれを用いた抗菌剤又は抗ウイルス剤及びその製造方法 |
JP2022003018A (ja) * | 2020-06-23 | 2022-01-11 | 佐々木化学工業株式会社 | クエン酸水素二銀及び/又はクエン酸二水素銀の製造方法並びにこれを用いた抗菌又は抗ウイルス溶液の製造方法 |
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