JP2007502608A5 - - Google Patents
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- Publication number
- JP2007502608A5 JP2007502608A5 JP2006523593A JP2006523593A JP2007502608A5 JP 2007502608 A5 JP2007502608 A5 JP 2007502608A5 JP 2006523593 A JP2006523593 A JP 2006523593A JP 2006523593 A JP2006523593 A JP 2006523593A JP 2007502608 A5 JP2007502608 A5 JP 2007502608A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- mammalian
- feeder
- free conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 83
- 210000004962 mammalian cell Anatomy 0.000 claims 41
- 238000000034 method Methods 0.000 claims 26
- 241000699800 Cricetinae Species 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 230000000394 mitotic effect Effects 0.000 claims 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 7
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 7
- 201000000050 myeloid neoplasm Diseases 0.000 claims 7
- 239000002609 medium Substances 0.000 claims 5
- 238000004113 cell culture Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 230000003362 replicative effect Effects 0.000 claims 3
- 230000001464 adherent effect Effects 0.000 claims 2
- 239000012228 culture supernatant Substances 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10338531.2 | 2003-08-19 | ||
| DE10338531A DE10338531A1 (de) | 2003-08-19 | 2003-08-19 | Verfahren zur Reklonierung von Produktionszellen |
| PCT/EP2004/009204 WO2005019442A2 (de) | 2003-08-19 | 2004-08-17 | Verfahren zur reklonierung von produktionszellen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2007502608A JP2007502608A (ja) | 2007-02-15 |
| JP2007502608A6 JP2007502608A6 (ja) | 2007-05-10 |
| JP2007502608A5 true JP2007502608A5 (cg-RX-API-DMAC7.html) | 2007-10-04 |
| JP5129959B2 JP5129959B2 (ja) | 2013-01-30 |
Family
ID=34201814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523593A Expired - Fee Related JP5129959B2 (ja) | 2003-08-19 | 2004-08-17 | 生産細胞の再クローン化方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7833787B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1658365B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5129959B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101184572B1 (cg-RX-API-DMAC7.html) |
| AT (2) | ATE515565T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2536239C (cg-RX-API-DMAC7.html) |
| DE (2) | DE10338531A1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK1658365T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2317023T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI337201B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005019442A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060223183A1 (en) * | 2005-03-11 | 2006-10-05 | Bates Steven E | Gamma irradiation of frozen feeder cells |
| EP1901068A1 (en) * | 2006-09-15 | 2008-03-19 | Boehringer Ingelheim Pharma GmbH & Co. KG | Methods of selecting cell clones |
| US20080268470A1 (en) * | 2006-09-15 | 2008-10-30 | Hitto Kaufmann | Methods of selecting cell clones |
| EP2257620A1 (de) * | 2008-03-19 | 2010-12-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Methode zur steigerung der reklonierungseffizienz |
| JP5304275B2 (ja) * | 2009-01-29 | 2013-10-02 | Ｊｎｃ株式会社 | アポクライティン−ｉｉをコードするコドン最適化核酸およびその使用方法 |
| US8597943B2 (en) | 2009-04-09 | 2013-12-03 | Cellca Gmbh | Method for improved single cell cloning |
| JP5697042B2 (ja) * | 2009-11-19 | 2015-04-08 | 国立大学法人 岡山大学 | 遺伝子発現を上昇させるシステム及び該システムを保持したベクター |
| PE20141568A1 (es) | 2011-10-28 | 2014-11-21 | Neotope Biosciences Ltd | Anticuerpos humanizados que reconocen la alfa-sinucleina |
| AU2013211874B2 (en) | 2012-01-27 | 2017-11-02 | Prothena Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
| US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| WO2015004632A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize iapp |
| US9951131B2 (en) | 2013-07-12 | 2018-04-24 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
| TW201623331A (zh) | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子（ｍｃａｍ）抗體類及使用彼等之相關方法 |
| US20170158755A1 (en) | 2014-03-12 | 2017-06-08 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg1-3 |
| WO2015136472A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
| DK3116911T3 (da) | 2014-03-12 | 2019-09-30 | Prothena Biosciences Ltd | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse |
| EP3129051A1 (en) | 2014-04-08 | 2017-02-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| TWI786505B (zh) | 2015-01-28 | 2022-12-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI718121B (zh) | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI769570B (zh) | 2015-01-28 | 2022-07-01 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| JP2018530540A (ja) | 2015-09-16 | 2018-10-18 | プロセナ バイオサイエンシーズ リミテッド | 巨細胞動脈炎、リウマチ性多発筋痛症又は高安動脈炎の処置又は予防のための抗ｍｃａｍ抗体の使用 |
| WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017153955A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| WO2017153953A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| BR112018072394A2 (pt) | 2016-05-02 | 2019-02-19 | Prothena Biosciences Limited | anticorpos que reconhecem a tau |
| ES2933491T3 (es) | 2016-05-02 | 2023-02-09 | Prothena Biosciences Ltd | Inmunoterapia tau |
| US10889638B2 (en) | 2016-05-02 | 2021-01-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2018007922A2 (en) | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| EP3478715A2 (en) | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| WO2018007924A2 (en) | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US11958896B2 (en) | 2017-05-02 | 2024-04-16 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2019064053A1 (en) | 2017-09-28 | 2019-04-04 | Prothena Biosciences Limited | DOSAGE REGIMES FOR THE TREATMENT OF SYNUCLEINOPATHIES |
| EP3691626A4 (en) | 2017-10-06 | 2021-06-30 | Prothena Biosciences Limited | METHODS OF DETECTION OF TRANSTHYRETINE |
| PH12020550694A1 (en) | 2017-11-29 | 2021-04-12 | Prothena Biosciences Ltd | Lyophilized formulation of a monoclonal antibody against transthyretin |
| CN119409813A (zh) | 2018-11-08 | 2025-02-11 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| UA128431C2 (uk) | 2018-11-26 | 2024-07-10 | Форті Севен, Інк. | ГУМАНІЗОВАНЕ АНТИТІЛО ДО c-Kit |
| PE20212324A1 (es) | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| US20230235048A1 (en) | 2020-06-24 | 2023-07-27 | Andriani IOANNOU | Antibodies recognizing sortilin |
| AR133829A1 (es) | 2023-09-15 | 2025-11-05 | Othair Prothena Ltd | Agentes penetrantes de células y usos de los mismos |
| TW202530253A (zh) | 2023-09-15 | 2025-08-01 | 愛爾蘭商普羅希那生物科學有限公司 | 抗ｔｄｐ－４３抗體及其用途 |
| AR133834A1 (es) | 2023-09-15 | 2025-11-05 | Prothena Biosciences Ltd | Agentes de penetración célular y sus usos |
| WO2025059491A2 (en) | 2023-09-15 | 2025-03-20 | Prothena Platform Technologies Limited | Methods, compositions, and kits including cell-penetrating agents |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| US5008198A (en) | 1984-09-14 | 1991-04-16 | Scripps Clinic And Research Foundation | Merozoite surface glycoproteins |
| EP0557459B1 (en) | 1990-11-13 | 1997-10-22 | Immunex Corporation | Bifunctional selectable fusion genes |
| US5459058A (en) * | 1991-03-28 | 1995-10-17 | Benjamin Rich | Cell culture system |
| CA2163427A1 (en) | 1993-05-21 | 1994-12-08 | Stephen D. Lupton | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| CN1299409A (zh) | 1998-04-17 | 2001-06-13 | 雀巢制品公司 | 由正常人皮肤组织衍生的无限增殖细胞系 |
| WO2000034326A1 (en) | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| WO2000034325A1 (en) | 1998-12-11 | 2000-06-15 | Clontech Laboratories, Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| EP1135532B1 (en) | 1998-12-11 | 2011-03-16 | Clontech Laboratories Inc. | Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof |
| JP2003504059A (ja) | 1999-07-12 | 2003-02-04 | ジェネンテック・インコーポレーテッド | 発現ベクターと方法 |
| AU780810B2 (en) * | 1999-08-05 | 2005-04-21 | Baxalta GmbH | Recombinant stable cell clone, its production and use thereof |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| AU783767B2 (en) | 1999-10-14 | 2005-12-01 | Takara Bio Usa, Inc. | Anthozoa derived chromophores/fluorophores and methods for using the same |
| JP2004510434A (ja) * | 2000-10-03 | 2004-04-08 | ユニバーシティ オブ ノース カロライナ | 肝前駆細胞のクローン増殖方法 |
| US20030073234A1 (en) * | 2001-10-12 | 2003-04-17 | Michal Amit | Clonal human embryonic stem cell lines and methods of generating same |
-
2003
- 2003-08-19 DE DE10338531A patent/DE10338531A1/de not_active Ceased
-
2004
- 2004-08-17 EP EP04764194A patent/EP1658365B1/de not_active Expired - Lifetime
- 2004-08-17 AT AT08151018T patent/ATE515565T1/de active
- 2004-08-17 DK DK04764194T patent/DK1658365T3/da active
- 2004-08-17 DE DE502004008542T patent/DE502004008542D1/de not_active Expired - Lifetime
- 2004-08-17 JP JP2006523593A patent/JP5129959B2/ja not_active Expired - Fee Related
- 2004-08-17 ES ES04764194T patent/ES2317023T3/es not_active Expired - Lifetime
- 2004-08-17 ES ES08151018T patent/ES2368772T3/es not_active Expired - Lifetime
- 2004-08-17 CA CA2536239A patent/CA2536239C/en not_active Expired - Fee Related
- 2004-08-17 AT AT04764194T patent/ATE415471T1/de active
- 2004-08-17 WO PCT/EP2004/009204 patent/WO2005019442A2/de not_active Ceased
- 2004-08-17 DK DK08151018.2T patent/DK1918364T3/da active
- 2004-08-17 KR KR1020067003371A patent/KR101184572B1/ko not_active Expired - Fee Related
- 2004-08-17 EP EP08151018A patent/EP1918364B1/de not_active Expired - Lifetime
- 2004-08-18 TW TW093124872A patent/TWI337201B/zh not_active IP Right Cessation
- 2004-08-19 US US10/922,577 patent/US7833787B2/en not_active Expired - Lifetime
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