JP2007502131A5 - - Google Patents
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- Publication number
- JP2007502131A5 JP2007502131A5 JP2006533451A JP2006533451A JP2007502131A5 JP 2007502131 A5 JP2007502131 A5 JP 2007502131A5 JP 2006533451 A JP2006533451 A JP 2006533451A JP 2006533451 A JP2006533451 A JP 2006533451A JP 2007502131 A5 JP2007502131 A5 JP 2007502131A5
- Authority
- JP
- Japan
- Prior art keywords
- paf
- solution
- contacting
- bsa
- serum albumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 claims 11
- 108091003117 Bovine Serum Albumin Proteins 0.000 claims 10
- 229940098773 Bovine Serum Albumin Drugs 0.000 claims 10
- 108010003541 Platelet Activating Factor Proteins 0.000 claims 7
- 108091006822 Human Serum Albumin Proteins 0.000 claims 5
- 102000008100 Human Serum Albumin Human genes 0.000 claims 5
- 239000011541 reaction mixture Substances 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 229960004319 Trichloroacetic Acid Drugs 0.000 claims 3
- YNJBWRMUSHSURL-UHFFFAOYSA-N Trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 3
- 238000011166 aliquoting Methods 0.000 claims 3
- 239000007853 buffer solution Substances 0.000 claims 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000006166 lysate Substances 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N HEPES Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 102100010404 PLA2G4A Human genes 0.000 claims 1
- 108010058864 Phospholipases A2 Proteins 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 210000002966 Serum Anatomy 0.000 claims 1
- 210000002700 Urine Anatomy 0.000 claims 1
- 230000024881 catalytic activity Effects 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000003345 scintillation counting Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47377703P | 2003-05-28 | 2003-05-28 | |
| US60/473,777 | 2003-05-28 | ||
| PCT/US2004/016716 WO2005001416A2 (en) | 2003-05-28 | 2004-05-27 | High throughput assay of lp-pla2 activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207479A Division JP5637959B2 (ja) | 2003-05-28 | 2011-09-22 | Ｌｐ−ＰＬＡ２活性のハイスループットアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502131A JP2007502131A (ja) | 2007-02-08 |
| JP2007502131A5 true JP2007502131A5 (de) | 2011-11-10 |
| JP4892350B2 JP4892350B2 (ja) | 2012-03-07 |
Family
ID=33551459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533451A Expired - Fee Related JP4892350B2 (ja) | 2003-05-28 | 2004-05-27 | Ｌｐ−ＰＬＡ２活性のハイスループットアッセイ |
| JP2011207479A Expired - Fee Related JP5637959B2 (ja) | 2003-05-28 | 2011-09-22 | Ｌｐ−ＰＬＡ２活性のハイスループットアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207479A Expired - Fee Related JP5637959B2 (ja) | 2003-05-28 | 2011-09-22 | Ｌｐ−ＰＬＡ２活性のハイスループットアッセイ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7531316B2 (de) |
| EP (2) | EP1633864B1 (de) |
| JP (2) | JP4892350B2 (de) |
| AT (1) | ATE463562T1 (de) |
| CY (1) | CY1110138T1 (de) |
| DE (1) | DE602004026439D1 (de) |
| DK (1) | DK1633864T3 (de) |
| ES (1) | ES2341772T3 (de) |
| HR (1) | HRP20100285T1 (de) |
| PL (1) | PL1633864T3 (de) |
| PT (1) | PT1633864E (de) |
| SI (1) | SI1633864T1 (de) |
| WO (1) | WO2005001416A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1633864T3 (pl) | 2003-05-28 | 2010-09-30 | Glaxo Group Ltd | Wysokowydajny test aktywności Lp-PLA2 |
| EP2280282A1 (de) | 2004-02-03 | 2011-02-02 | Diadexus, Inc. | Verfahren zur Erkennung der Lp-PLA2-Aktivität |
| US20150017671A1 (en) | 2004-04-16 | 2015-01-15 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| US20070166777A1 (en) | 2004-04-16 | 2007-07-19 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| US20140283157A1 (en) | 2013-03-15 | 2014-09-18 | Diadexus, Inc. | Lipoprotein-associated phospholipase a2 antibody compositions and methods of use |
| EP3258269B1 (de) * | 2015-02-10 | 2019-06-05 | Shenzhen New Industries Biomedical Engineering Co. Ltd. | Reagenzienkit für den nachweis von lipoproteinassoziierter phospholipase a2 und herstellungsverfahren sowie anwendung für reagenzienkit |
| CN104820097A (zh) * | 2015-05-22 | 2015-08-05 | 北京协和洛克生物技术有限责任公司 | 一种定量检测样本中脂蛋白磷脂酶a2浓度的液态芯片试剂盒及其制备方法 |
| JP6691212B2 (ja) | 2016-06-22 | 2020-04-28 | 旭化成ファーマ株式会社 | Ｌｐ−ＰＬＡ２活性の測定 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3204681B2 (ja) | 1991-05-24 | 2001-09-04 | 株式会社シノテスト | 新規なエーテル型チオリン脂質化合物およびその製造法 |
| EP0974663A1 (de) * | 1993-06-25 | 2000-01-26 | Smithkline Beecham Plc | An Lipoprotein gebundene Phospholipase A2, Inhibitoren dieselbe und deren Verwendung für Diagnose und Therapie |
| JPH0759597A (ja) | 1993-08-23 | 1995-03-07 | Shinotesuto:Kk | 血小板活性化因子アセチルヒドロラーゼ活性測定方法 |
| US6146625A (en) * | 1993-10-06 | 2000-11-14 | Icos Corporation | Platelet-activating factor acetylhydrolase |
| ATE315655T1 (de) * | 1993-10-06 | 2006-02-15 | Icos Corp | Acethylhydrolase des plättchen aktivierenden faktors |
| JPH1017600A (ja) | 1996-06-28 | 1998-01-20 | Suntory Ltd | 血小板活性化因子アセチルヒドロラーゼおよびその遺伝子 |
| JP4220603B2 (ja) * | 1998-12-02 | 2009-02-04 | アルフレッサファーマ株式会社 | 血小板活性化因子アセチルヒドロラーゼ活性の測定方法 |
| US20020102231A1 (en) * | 1999-05-07 | 2002-08-01 | Icos Corporation | Therapeutic uses of PAF-AH products in diabetes |
| FR2815857B1 (fr) | 2000-10-30 | 2003-02-14 | Oreal | Composition, notamment cosmetique, renfermant un retinoide et une silicone benzotriazole |
| ATE269342T1 (de) | 2001-12-07 | 2004-07-15 | Sirs Lab Gmbh | Verbindungen zur bestimmung der aktivität von phospholipase a2 |
| US20030134082A1 (en) * | 2001-12-21 | 2003-07-17 | Morin Brian G. | Carpet comprising a low-shrink backing of polypropylene tape fibers |
| US20070077614A1 (en) | 2003-04-01 | 2007-04-05 | Wolfert Robert L | Uses of lp-pla2 in combination to assess coronary risk |
| PL1633864T3 (pl) | 2003-05-28 | 2010-09-30 | Glaxo Group Ltd | Wysokowydajny test aktywności Lp-PLA2 |
| EP2280282A1 (de) | 2004-02-03 | 2011-02-02 | Diadexus, Inc. | Verfahren zur Erkennung der Lp-PLA2-Aktivität |
| US20070166777A1 (en) * | 2004-04-16 | 2007-07-19 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
-
2004
- 2004-05-27 PL PL04753533T patent/PL1633864T3/pl unknown
- 2004-05-27 US US10/557,540 patent/US7531316B2/en not_active Expired - Fee Related
- 2004-05-27 EP EP04753533A patent/EP1633864B1/de not_active Expired - Lifetime
- 2004-05-27 JP JP2006533451A patent/JP4892350B2/ja not_active Expired - Fee Related
- 2004-05-27 SI SI200431433T patent/SI1633864T1/sl unknown
- 2004-05-27 WO PCT/US2004/016716 patent/WO2005001416A2/en active Application Filing
- 2004-05-27 DK DK04753533.1T patent/DK1633864T3/da active
- 2004-05-27 EP EP10158845A patent/EP2253702A1/de not_active Withdrawn
- 2004-05-27 AT AT04753533T patent/ATE463562T1/de active
- 2004-05-27 DE DE602004026439T patent/DE602004026439D1/de not_active Expired - Lifetime
- 2004-05-27 ES ES04753533T patent/ES2341772T3/es not_active Expired - Lifetime
- 2004-05-27 PT PT04753533T patent/PT1633864E/pt unknown
-
2010
- 2010-05-21 HR HR20100285T patent/HRP20100285T1/hr unknown
- 2010-06-21 CY CY20101100572T patent/CY1110138T1/el unknown
-
2011
- 2011-09-22 JP JP2011207479A patent/JP5637959B2/ja not_active Expired - Fee Related
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