JP2007500684A5 - - Google Patents

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Publication number
JP2007500684A5
JP2007500684A5 JP2006521571A JP2006521571A JP2007500684A5 JP 2007500684 A5 JP2007500684 A5 JP 2007500684A5 JP 2006521571 A JP2006521571 A JP 2006521571A JP 2006521571 A JP2006521571 A JP 2006521571A JP 2007500684 A5 JP2007500684 A5 JP 2007500684A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
compound
stereoisomer
rectal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006521571A
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English (en)
Japanese (ja)
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JP2007500684A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2004/051550 external-priority patent/WO2005011646A2/en
Publication of JP2007500684A publication Critical patent/JP2007500684A/ja
Publication of JP2007500684A5 publication Critical patent/JP2007500684A5/ja
Pending legal-status Critical Current

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JP2006521571A 2003-07-31 2004-07-20 心臓血管疾患治療用のアンギオテンシン−ｉｉ受容体遮断薬としてのロサルタン、バルサルタン、カンデサルタン、テルミサルタン、エプロサルタンおよびオルメサルタンのニトロオキシ誘導体 Pending JP2007500684A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102379 2003-07-31
PCT/EP2004/051550 WO2005011646A2 (en) 2003-07-31 2004-07-20 Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-ii receptor blockers for the treatment of cardiovascular diseases

Publications (2)

Publication Number Publication Date
JP2007500684A JP2007500684A (ja) 2007-01-18
JP2007500684A5 true JP2007500684A5 (enExample) 2007-08-30

Family

ID=34112476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521571A Pending JP2007500684A (ja) 2003-07-31 2004-07-20 心臓血管疾患治療用のアンギオテンシン−ｉｉ受容体遮断薬としてのロサルタン、バルサルタン、カンデサルタン、テルミサルタン、エプロサルタンおよびオルメサルタンのニトロオキシ誘導体

Country Status (29)

Country Link
US (1) US20060276523A1 (enExample)
EP (1) EP1653950B1 (enExample)
JP (1) JP2007500684A (enExample)
KR (1) KR20060056352A (enExample)
CN (1) CN100496490C (enExample)
AR (1) AR045145A1 (enExample)
AT (1) ATE383155T1 (enExample)
AU (1) AU2004260830B2 (enExample)
BR (1) BRPI0413028A (enExample)
CA (1) CA2534451A1 (enExample)
CY (1) CY1110447T1 (enExample)
DE (1) DE602004011230T2 (enExample)
DK (1) DK1653950T3 (enExample)
EC (1) ECSP066334A (enExample)
ES (1) ES2299861T3 (enExample)
HR (1) HRP20060084A2 (enExample)
IL (1) IL172703A0 (enExample)
IS (1) IS2534B (enExample)
MA (1) MA27987A1 (enExample)
MX (1) MXPA06001263A (enExample)
NO (1) NO20060900L (enExample)
NZ (1) NZ544463A (enExample)
PL (2) PL1653950T3 (enExample)
PT (1) PT1653950E (enExample)
RU (1) RU2374240C2 (enExample)
SI (1) SI1653950T1 (enExample)
UA (1) UA87983C2 (enExample)
WO (1) WO2005011646A2 (enExample)
ZA (1) ZA200600856B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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WO2006008196A1 (en) * 2004-07-20 2006-01-26 Nicox S.A. Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
WO2006079610A1 (en) * 2005-01-31 2006-08-03 Nicox S.A. Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
RU2306930C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
CA2668744C (en) 2006-11-17 2015-09-15 Queen's University At Kingston Compounds and methods for treating protein folding disorders
EP2103610B1 (en) * 2006-12-06 2011-09-21 Shanghai Allist Pharmaceutical., Inc. Salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
CA2671421A1 (en) * 2006-12-13 2008-06-26 Merck & Co., Inc. Nitroderivatives as angiotensin ii receptor antagonists
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
EP1980559A1 (en) * 2007-04-10 2008-10-15 CTG Pharma S.r.l. Cardiovascular agents
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
AR069340A1 (es) 2007-11-26 2010-01-13 Merck & Co Inc Antagonistas del receptor de angiotensina ii
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
CA2711134A1 (en) * 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin ii receptor antagonists
CA2711461A1 (en) 2008-02-08 2009-08-13 Merck Sharp & Dohme Corp. Angiotensin ii receptor antagonists
WO2009106471A2 (en) * 2008-02-26 2009-09-03 Nicox S.A. New angiotensin ii receptor blocker derivatives
CA2712689A1 (en) * 2008-02-26 2009-09-03 Nicoletta Almirante Angiotensin ii receptor antagonists
JP2011523941A (ja) * 2008-05-15 2011-08-25 メルク・シャープ・エンド・ドーム・コーポレイション アンギオテンシンｉｉ受容体アンタゴニスト
CN101596189A (zh) * 2008-06-05 2009-12-09 上海艾力斯生物医药有限公司 含有咪唑-5-羧酸类衍生物的药用组合物
AU2009256822A1 (en) * 2008-06-09 2009-12-17 Nicox S.A. Angiotensin II receptor antagonists
AR073259A1 (es) * 2008-07-29 2010-10-28 Merck & Co Inc Derivados de furosemida utiles como diureticos
WO2010015447A1 (en) * 2008-08-08 2010-02-11 Nicox S.A. Angiotensin ii receptor antagonists
EP2194048A1 (en) 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
JP2012511002A (ja) * 2008-12-05 2012-05-17 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体アンタゴニストとしてのニトロオキシ誘導体
SG173044A1 (en) 2009-01-23 2011-08-29 Hanmi Holdings Co Ltd Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
AR080925A1 (es) 2010-04-19 2012-05-16 Cardiolynx Ag Derivados de valsartan que portan donadores de no para el tratamiento de las enfermedades vasculares y metabolicas
AU2011243947A1 (en) * 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
CN103275074B (zh) * 2013-06-21 2016-08-10 黄冈鲁班药业股份有限公司 一种奥美沙坦衍生物及其制备方法
CN105820125B (zh) * 2015-01-09 2018-12-07 北京中医药大学 一种用于治疗高血压的化合物及其制备方法和用途
WO2017041701A1 (zh) 2015-09-07 2017-03-16 浙江华海药业股份有限公司 可释放一氧化氮的前药分子
CN106800537B (zh) 2017-01-18 2019-02-01 广东隆赋药业股份有限公司 丁苯酞-替米沙坦杂合物及其制备方法和用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
CN114105881B (zh) * 2020-08-31 2024-01-26 沈阳海诺威医药科技有限公司 血小板聚集抑制剂及其制备方法和用途

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CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
SG52330A1 (en) * 1989-06-14 1998-09-28 Smithkline Beecham Corp Imidazolyl-alkenoic acids
RU2067581C1 (ru) * 1989-06-30 1996-10-10 Е.И.Дюпон Де Немур Энд Компани Аралкилзамещенные имидазолы, обладающие противогипертоническим действием, способ их получения и фармацевтический состав, обладающий ингибирующей активностью в отношении ангиотензина ii
KR0163595B1 (ko) * 1989-06-30 1998-12-01 미리암디, 메코너헤이 치환된 이미다졸
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
FR2725987B1 (fr) * 1994-10-19 1997-01-10 Sanofi Sa Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US20030187038A1 (en) * 2000-08-25 2003-10-02 Yoshimi Imura Fibrinogen-lowering agents
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie

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