UA87983C2 - Производные блокиратора рецептора ангиотензина ii - Google Patents

Производные блокиратора рецептора ангиотензина ii

Info

Publication number
UA87983C2
UA87983C2 UAA200600273A UAA200600273A UA87983C2 UA 87983 C2 UA87983 C2 UA 87983C2 UA A200600273 A UAA200600273 A UA A200600273A UA A200600273 A UAA200600273 A UA A200600273A UA 87983 C2 UA87983 C2 UA 87983C2
Authority
UA
Ukraine
Prior art keywords
angiotensin
receptor blocker
derivatives
onq
renal
Prior art date
Application number
UAA200600273A
Other languages
English (en)
Ukrainian (uk)
Inventor
Николетта Альмиранте
Сольдато Пьеро Дель
Эннио Оньини
Original Assignee
Никокс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никокс С.А. filed Critical Никокс С.А.
Publication of UA87983C2 publication Critical patent/UA87983C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Нитропроизводные блокиратора рецептора ангиотензина ІІ формулы R-( Y-ONO)(I), которые имеют широкое фармакологическое применение и улучшенную толерабельность. Они могут быть использованы для лечения сердечнососудистых, почечных, хронических печеночных болезней и воспалительных процессов.
UAA200600273A 2003-07-31 2004-07-20 Производные блокиратора рецептора ангиотензина ii UA87983C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03102379 2003-07-31

Publications (1)

Publication Number Publication Date
UA87983C2 true UA87983C2 (ru) 2009-09-10

Family

ID=34112476

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200600273A UA87983C2 (ru) 2003-07-31 2004-07-20 Производные блокиратора рецептора ангиотензина ii

Country Status (30)

Country Link
US (1) US20060276523A1 (ru)
EP (1) EP1653950B1 (ru)
JP (1) JP2007500684A (ru)
KR (1) KR20060056352A (ru)
CN (1) CN100496490C (ru)
AR (1) AR045145A1 (ru)
AT (1) ATE383155T1 (ru)
AU (1) AU2004260830B2 (ru)
BR (1) BRPI0413028A (ru)
CA (1) CA2534451A1 (ru)
CY (1) CY1110447T1 (ru)
DE (1) DE602004011230T2 (ru)
DK (1) DK1653950T3 (ru)
EC (1) ECSP066334A (ru)
ES (1) ES2299861T3 (ru)
HK (1) HK1095093A1 (ru)
HR (1) HRP20060084A2 (ru)
IL (1) IL172703A0 (ru)
IS (1) IS2534B (ru)
MA (1) MA27987A1 (ru)
MX (1) MXPA06001263A (ru)
NO (1) NO20060900L (ru)
NZ (1) NZ544463A (ru)
PL (2) PL379420A1 (ru)
PT (1) PT1653950E (ru)
RU (1) RU2374240C2 (ru)
SI (1) SI1653950T1 (ru)
UA (1) UA87983C2 (ru)
WO (1) WO2005011646A2 (ru)
ZA (1) ZA200600856B (ru)

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EP1778617A1 (en) 2004-07-20 2007-05-02 NicOx S.A. Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
WO2006079610A1 (en) * 2005-01-31 2006-08-03 Nicox S.A. Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
US8362066B2 (en) 2006-11-17 2013-01-29 Treventis Corporation Compounds and methods for treating protein folding disorders
EP2103610B1 (en) * 2006-12-06 2011-09-21 Shanghai Allist Pharmaceutical., Inc. Salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
AU2007334521B2 (en) * 2006-12-13 2012-03-29 Merck & Co., Inc. Angiotensin II receptor antagonists
CN101214242A (zh) 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
EP1980559A1 (en) * 2007-04-10 2008-10-15 CTG Pharma S.r.l. Cardiovascular agents
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
AR069340A1 (es) * 2007-11-26 2010-01-13 Merck & Co Inc Antagonistas del receptor de angiotensina ii
EP2534958A1 (en) 2007-12-14 2012-12-19 AeroDesigns, Inc Delivering aerosolizable food products
JP2011510082A (ja) * 2008-01-24 2011-03-31 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体拮抗薬
WO2009099853A2 (en) 2008-02-08 2009-08-13 Merck & Co., Inc. Angiotensin ii receptor antagonists
US20100311800A1 (en) * 2008-02-26 2010-12-09 Nicoletta Almirante Angiotensin ii receptor antagonists
CA2712695A1 (en) * 2008-02-26 2009-09-03 Nicoletta Almirante New angiotensin ii receptor blocker derivatives
AU2009246670A1 (en) * 2008-05-15 2009-11-19 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
CN101596189A (zh) * 2008-06-05 2009-12-09 上海艾力斯生物医药有限公司 含有咪唑-5-羧酸类衍生物的药用组合物
EP2313417A1 (en) * 2008-06-09 2011-04-27 Nicox S.A. Angiotensin ii receptor antagonists
AR073259A1 (es) * 2008-07-29 2010-10-28 Merck & Co Inc Derivados de furosemida utiles como diureticos
WO2010015447A1 (en) * 2008-08-08 2010-02-11 Nicox S.A. Angiotensin ii receptor antagonists
EP2194048A1 (en) 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
AU2009322613A1 (en) 2008-12-05 2011-06-23 Merck Sharp & Dohme Corp. Nitrooxy derivatives as angiotensin II receptor antagonists
CA2749903C (en) 2009-01-23 2016-09-06 Jae Hyun Park Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
CA2796710A1 (en) 2010-04-19 2011-10-27 Cardiolynx Ag Valsartan derivatives carrying nitrogen oxide donors for the treatment of vascular and metabolic diseases
WO2011132171A1 (en) * 2010-04-23 2011-10-27 Piramal Life Sciences Limited Nitric oxide releasing prodrugs of therapeutic agents
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
CN103275074B (zh) * 2013-06-21 2016-08-10 黄冈鲁班药业股份有限公司 一种奥美沙坦衍生物及其制备方法
CN105820125B (zh) * 2015-01-09 2018-12-07 北京中医药大学 一种用于治疗高血压的化合物及其制备方法和用途
JP2018526448A (ja) 2015-09-07 2018-09-13 浙江華海薬業股▲フン▼有限公司 一酸化窒素を放出可能なプロドラッグ分子
CN106800537B (zh) 2017-01-18 2019-02-01 广东隆赋药业股份有限公司 丁苯酞-替米沙坦杂合物及其制备方法和用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
CN114105881B (zh) * 2020-08-31 2024-01-26 沈阳海诺威医药科技有限公司 血小板聚集抑制剂及其制备方法和用途

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EP0955294B1 (en) * 1989-06-14 2003-09-24 Smithkline Beecham Corporation Imidazolyl-alkenoic acid
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
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ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie

Also Published As

Publication number Publication date
US20060276523A1 (en) 2006-12-07
CN1832742A (zh) 2006-09-13
DE602004011230T2 (de) 2009-01-02
DK1653950T3 (da) 2008-05-26
ECSP066334A (es) 2006-07-28
MXPA06001263A (es) 2006-04-11
RU2006105804A (ru) 2007-09-20
AR045145A1 (es) 2005-10-19
WO2005011646A3 (en) 2005-04-21
CA2534451A1 (en) 2005-02-10
EP1653950A2 (en) 2006-05-10
HRP20060084A2 (hr) 2006-04-30
BRPI0413028A (pt) 2006-10-03
HK1095093A1 (en) 2007-04-27
JP2007500684A (ja) 2007-01-18
NO20060900L (no) 2006-02-24
PT1653950E (pt) 2008-04-11
CY1110447T1 (el) 2015-04-29
NZ544463A (en) 2009-10-30
RU2374240C2 (ru) 2009-11-27
EP1653950B1 (en) 2008-01-09
IL172703A0 (en) 2006-04-10
CN100496490C (zh) 2009-06-10
SI1653950T1 (sl) 2008-06-30
PL1653950T3 (pl) 2008-08-29
ATE383155T1 (de) 2008-01-15
DE602004011230D1 (de) 2008-02-21
AU2004260830A1 (en) 2005-02-10
ZA200600856B (en) 2007-05-30
IS2534B (is) 2009-08-15
KR20060056352A (ko) 2006-05-24
IS8332A (is) 2006-02-27
AU2004260830B2 (en) 2010-04-29
MA27987A1 (fr) 2006-07-03
PL379420A1 (pl) 2006-09-04
ES2299861T3 (es) 2008-06-01
WO2005011646A2 (en) 2005-02-10

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