JP2007182442A - 結晶質の相で治療用の薬剤を含有している高分子組成物、およびその形成の方法 - Google Patents
結晶質の相で治療用の薬剤を含有している高分子組成物、およびその形成の方法 Download PDFInfo
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/63—Crystals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US11/321,255 US7842312B2 (en) | 2005-12-29 | 2005-12-29 | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
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| EP (2) | EP1810665B1 (cg-RX-API-DMAC7.html) |
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| CA (1) | CA2572100C (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014505714A (ja) * | 2011-02-17 | 2014-03-06 | エフ.ホフマン−ラ ロシュ アーゲー | ホットメルト押出法による過冷却液体状態からの活性医薬成分の制御された結晶化方法 |
| JP2019504633A (ja) * | 2016-02-25 | 2019-02-21 | ワッカー ケミー アクチエンゲゼルシャフトWacker Chemie AG | カプセル化甘味料およびその製造方法 |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001261625B2 (en) | 2000-05-16 | 2006-04-06 | Regents Of The University Of Minnesota | High mass throughput particle generation using multiple nozzle spraying |
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| WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
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| US7951428B2 (en) | 2006-01-31 | 2011-05-31 | Regents Of The University Of Minnesota | Electrospray coating of objects |
| WO2007089883A2 (en) * | 2006-01-31 | 2007-08-09 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
| US9108217B2 (en) | 2006-01-31 | 2015-08-18 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
| ES2540059T3 (es) | 2006-04-26 | 2015-07-08 | Micell Technologies, Inc. | Recubrimientos que contienen múltiples fármacos |
| CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
| CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| ES2393639T3 (es) | 2007-01-21 | 2012-12-26 | Hemoteq Ag | Producto médico para tratar cierres de conductos corporales y prevención de nuevos cierres |
| ES2393814T3 (es) | 2007-04-04 | 2012-12-28 | Sigmoid Pharma Limited | Una composición farmacéutica oral |
| BRPI0810370A2 (pt) * | 2007-04-17 | 2014-10-29 | Micell Technologies Inc | Stent revestido, e, método para preparar um stent |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| US20100298928A1 (en) * | 2007-10-19 | 2010-11-25 | Micell Technologies, Inc. | Drug Coated Stents |
| US8016880B2 (en) * | 2007-11-16 | 2011-09-13 | Medtronic Vascular, Inc. | Stent having spiral channel for drug delivery |
| CN102083397B (zh) | 2008-04-17 | 2013-12-25 | 米歇尔技术公司 | 具有生物可吸收层的支架 |
| WO2010005726A2 (en) * | 2008-06-16 | 2010-01-14 | Bind Biosciences Inc. | Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same |
| EA020954B1 (ru) | 2008-06-16 | 2015-03-31 | Бинд Терапьютикс, Инк. | Загруженные лекарственным средством полимерные наночастицы, фармацевтическая композиция и способ лечения рака |
| US8318211B2 (en) | 2008-06-16 | 2012-11-27 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
| US9533078B2 (en) | 2008-06-25 | 2017-01-03 | Boston Scientific Scimed, Inc. | Medical devices containing therapeutic agents |
| JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
| EP2174586B1 (de) * | 2008-10-02 | 2014-12-10 | EyeSense AG | Implantierbares Sensorelement |
| ES2645692T3 (es) | 2008-11-11 | 2017-12-07 | The Board Of Regents,The University Of Texas System | Microcápsulas de rapamicina y su uso para el tratamiento del cáncer |
| US8563041B2 (en) * | 2008-12-12 | 2013-10-22 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
| JP2012512175A (ja) | 2008-12-15 | 2012-05-31 | バインド バイオサイエンシズ インコーポレイテッド | 治療薬を徐放するための長時間循環性ナノ粒子 |
| US8834913B2 (en) * | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
| WO2010120552A2 (en) | 2009-04-01 | 2010-10-21 | Micell Technologies, Inc. | Coated stents |
| EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
| JP2012524780A (ja) * | 2009-04-21 | 2012-10-18 | セレクタ バイオサイエンシーズ インコーポレーテッド | Th1バイアス応答をもたらす免疫ナノ治療薬(Immunonanotherapeutics) |
| WO2010124098A2 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scimed, Inc. | Use of drug polymorphs to achieve controlled drug delivery from a coated medical device |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| EP2944332B1 (en) * | 2009-07-10 | 2016-08-17 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
| EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | MEDICAL DEVICE DISPENSING MEDICINE |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| CN101697963B (zh) * | 2009-10-29 | 2012-04-18 | 福建医科大学附属协和医院 | 一种载多烯紫杉醇plga缓释微球的制备方法及其在超声介导下肿瘤间质化疗中的应用 |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| DK2509634T3 (en) | 2009-12-11 | 2019-04-23 | Pfizer | Stable formulations for lyophilization of therapeutic particles |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| WO2011084521A2 (en) * | 2009-12-15 | 2011-07-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising epothilone and methods of making and using same |
| EP2515942B1 (en) | 2009-12-15 | 2020-02-12 | Pfizer Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
| EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
| ES2524402T3 (es) * | 2010-04-16 | 2014-12-09 | San-Ei Gen F.F.I., Inc. | Procedimiento para enmascarar el sabor de la curcumina |
| EP2560576B1 (en) | 2010-04-22 | 2018-07-18 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| WO2012009684A2 (en) * | 2010-07-16 | 2012-01-19 | Micell Technologies, Inc. | Drug delivery medical device |
| US8703727B2 (en) * | 2010-08-24 | 2014-04-22 | Aphios Corporation | Nanotechnology formulation of poorly soluble compounds |
| EP2611476B1 (en) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| US9636309B2 (en) | 2010-09-09 | 2017-05-02 | Micell Technologies, Inc. | Macrolide dosage forms |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| WO2012142319A1 (en) * | 2011-04-13 | 2012-10-18 | Micell Technologies, Inc. | Stents having controlled elution |
| WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
| CN104053458B (zh) | 2011-07-20 | 2016-07-20 | 布莱阿姆青年大学 | 包含洗脱塞拉集宁化合物的水凝胶材料 |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| WO2013029059A1 (en) * | 2011-08-25 | 2013-02-28 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| AU2012326010B2 (en) * | 2011-10-18 | 2017-05-11 | Micell Technologies, Inc. | Drug delivery medical device |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| WO2014043618A1 (en) | 2012-09-17 | 2014-03-20 | Bind Therapeutics, Inc. | Process for preparing therapeutic nanoparticles |
| CN104994891A (zh) * | 2012-10-18 | 2015-10-21 | 米歇尔技术公司 | 药物递送医疗装置 |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティBrigham Young University | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| CN117045653A (zh) | 2013-01-23 | 2023-11-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| WO2014164929A1 (en) * | 2013-03-11 | 2014-10-09 | Kla-Tencor Corporation | Defect detection using surface enhanced electric field |
| KR20150143476A (ko) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
| WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
| HK1222313A1 (zh) | 2013-05-15 | 2017-06-30 | Micell Technologies, Inc. | 可生物吸收的生物医学植入物 |
| US9439892B2 (en) | 2013-05-16 | 2016-09-13 | Surmodics, Inc. | Macrolide particulates, methods for preparation, and medical devices associated therewith |
| WO2014201236A1 (en) * | 2013-06-12 | 2014-12-18 | Surmodics, Inc. | Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| EP3089737B1 (en) | 2013-12-31 | 2021-11-03 | Rapamycin Holdings, LLC | Oral rapamycin nanoparticle preparations and use |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| PE20170312A1 (es) | 2014-03-14 | 2017-03-30 | Pfizer | Nanoparticulas terapeuticas que comprenden un agente terapeutico, y metodos para su elaboracion y uso |
| WO2015181826A1 (en) | 2014-05-27 | 2015-12-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Crystalline coating and release of bioactive agents |
| US11406742B2 (en) * | 2014-07-18 | 2022-08-09 | M.A. Med Alliance SA | Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs |
| JP6716582B2 (ja) | 2014-11-07 | 2020-07-01 | サブリミティ・セラピューティクス・リミテッドSublimity Therapeutics Limited | シクロスポリンを含む組成物 |
| US9789228B2 (en) * | 2014-12-11 | 2017-10-17 | Covidien Lp | Antimicrobial coatings for medical devices and processes for preparing such coatings |
| US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| US10098846B2 (en) | 2016-03-31 | 2018-10-16 | Surmodics, Inc. | Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment |
| US11123459B2 (en) | 2016-12-16 | 2021-09-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| WO2019075136A1 (en) | 2017-10-10 | 2019-04-18 | Aldeyra Therapeutics, Inc. | TREATMENT OF INFLAMMATORY DISORDERS |
| AU2019319740A1 (en) | 2018-08-06 | 2021-03-25 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| WO2020118045A1 (en) * | 2018-12-05 | 2020-06-11 | Aldeyra Therapeutics, Inc. | Injectable formulations |
| JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
| WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CN119236187A (zh) | 2020-02-21 | 2025-01-03 | 吉益医疗公司 | 聚合物包封的药物颗粒 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
| CN116102576B (zh) * | 2021-11-09 | 2025-08-29 | 上海博畅医疗科技有限公司 | 一种优美莫司晶体的制造方法及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021908A1 (en) * | 1997-10-29 | 1999-05-06 | Angiotech Pharmaceuticals, Inc. | Polymeric systems for drug delivery and uses thereof |
| JP2002512949A (ja) * | 1998-04-27 | 2002-05-08 | アルタス バイオロジックス インコーポレイテッド | 安定化されたタンパク質結晶、それを含む処方物、およびそれを作製する方法 |
| JP2005523119A (ja) * | 2002-04-24 | 2005-08-04 | サン バイオメディカル, リミテッド | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
| WO2005092264A1 (en) * | 2004-03-10 | 2005-10-06 | Ethicon, Inc. | Drug-enhanced adhesion prevention |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US6099865A (en) | 1998-07-08 | 2000-08-08 | Fmc Corporation | Croscarmellose taste masking |
| US7008645B2 (en) * | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
| DE19901687B4 (de) | 1999-01-18 | 2006-06-01 | Grünenthal GmbH | Opioide Analgetika mit kontrollierter Wirkstofffreisetzung |
| AU9445801A (en) | 2000-10-06 | 2002-04-15 | Bioglan Ab | Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight |
| US7195640B2 (en) | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
| ES2426723T3 (es) | 2001-10-17 | 2013-10-24 | Takeda Pharmaceutical Company Limited | Gránulos que contienen gran cantidad de compuesto químico inestable en medio ácido |
| US8747881B2 (en) | 2003-12-19 | 2014-06-10 | Cordis Corporation | Intraluminal medical devices in combination with therapeutic agents |
| EP1789022A2 (en) | 2004-08-31 | 2007-05-30 | Pfizer Products Incorporated | Controlled release dosage forms combining immediate release and sustained release of low-solubility drug |
| CA2535938C (en) | 2005-02-10 | 2014-11-25 | Cardinal Health 529, Llc | Biodegradable medical devices with enhanced mechanical strength and pharmacological functions |
| WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
| US7842312B2 (en) * | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
-
2005
- 2005-12-29 US US11/321,255 patent/US7842312B2/en active Active
-
2006
- 2006-12-27 CA CA2572100A patent/CA2572100C/en active Active
- 2006-12-27 EP EP06256581.7A patent/EP1810665B1/en not_active Revoked
- 2006-12-27 EP EP10174437A patent/EP2269572A1/en not_active Withdrawn
- 2006-12-28 JP JP2006355363A patent/JP2007182442A/ja active Pending
-
2010
- 2010-10-15 US US12/905,186 patent/US8617611B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021908A1 (en) * | 1997-10-29 | 1999-05-06 | Angiotech Pharmaceuticals, Inc. | Polymeric systems for drug delivery and uses thereof |
| JP2002512949A (ja) * | 1998-04-27 | 2002-05-08 | アルタス バイオロジックス インコーポレイテッド | 安定化されたタンパク質結晶、それを含む処方物、およびそれを作製する方法 |
| JP2005523119A (ja) * | 2002-04-24 | 2005-08-04 | サン バイオメディカル, リミテッド | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
| WO2005092264A1 (en) * | 2004-03-10 | 2005-10-06 | Ethicon, Inc. | Drug-enhanced adhesion prevention |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014505714A (ja) * | 2011-02-17 | 2014-03-06 | エフ.ホフマン−ラ ロシュ アーゲー | ホットメルト押出法による過冷却液体状態からの活性医薬成分の制御された結晶化方法 |
| JP2019504633A (ja) * | 2016-02-25 | 2019-02-21 | ワッカー ケミー アクチエンゲゼルシャフトWacker Chemie AG | カプセル化甘味料およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1810665B1 (en) | 2015-03-04 |
| US20110027368A1 (en) | 2011-02-03 |
| EP1810665A1 (en) | 2007-07-25 |
| US20070154554A1 (en) | 2007-07-05 |
| US7842312B2 (en) | 2010-11-30 |
| EP2269572A1 (en) | 2011-01-05 |
| CA2572100C (en) | 2016-11-22 |
| US8617611B2 (en) | 2013-12-31 |
| CA2572100A1 (en) | 2007-06-29 |
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