JP2007153894A5 - - Google Patents
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- JP2007153894A5 JP2007153894A5 JP2006327355A JP2006327355A JP2007153894A5 JP 2007153894 A5 JP2007153894 A5 JP 2007153894A5 JP 2006327355 A JP2006327355 A JP 2006327355A JP 2006327355 A JP2006327355 A JP 2006327355A JP 2007153894 A5 JP2007153894 A5 JP 2007153894A5
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- Prior art keywords
- cancer
- pharmaceutical composition
- composition according
- kinase
- mediated
- Prior art date
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Description
別の実施態様では、異常細胞成長は、少なくとも1つの遺伝子改変したチロシンキナーゼによって仲介される。別の実施態様では、異常細胞成長は、肝細胞成長因子受容体（c-Met/HGFR）キナーゼ又は未分化リンパ腫キナーゼ（ALK）によって仲介される。別の実施態様では、異常細胞成長は、肝細胞成長因子受容体（c-Met/HGFR）キナーゼによって仲介される。別の実施態様では、異常細胞成長は、未分化リンパ腫キナーゼ（ALK）によって仲介される。
Claims (10)
- (R)-3-[1-(2,6-ジクロロ-3-フルオロ-フェニル)-エトキシ]-5-(1-ピペリジン-4-イル-1H-ピラゾール-4-イル)-ピリジン-2-イルアミン又は薬学的に許容される塩を含む異常細胞の成長を処置するための医薬組成物。
- 前記哺乳動物がヒトである、請求項１記載の医薬組成物。
- 前記哺乳動物がイヌである、請求項１記載の医薬組成物。
- 前記の異常細胞成長が少なくとも1つの遺伝子組換えチロシンキナーゼにより仲介される、請求項１〜３のいずれか１項記載の医薬組成物。
- 前記の異常細胞の成長が、肝細胞成長因子受容体（c-Met/HGFR）キナーゼ又は未分化リンパ腫キナーゼ（ALK）により仲介される、請求項１〜３のいずれか１項記載の医薬組成物。
- 前記の異常細胞成長が、肝細胞成長因子受容体（c-Met/HGFR）キナーゼにより仲介される、請求項５記載の医薬組成物。
- 前記の異常細胞成長が、未分化リンパ腫キナーゼ（ALK）により仲介される、請求項５記載の医薬組成物。
- 前記の異常細胞成長が癌である、請求項１〜３のいずれか１項記載の医薬組成物。
- 前記癌が、肺癌、骨肉種、膵癌、皮膚癌、頭部又は頚部の癌、皮膚又は眼内黒色腫、子宮癌、卵巣癌、直腸癌、肛門部癌、胃癌、結腸癌、乳癌、卵管癌、子宮内膜癌、子宮頚部癌、膣癌、陰門癌、ホジキン病、食道癌、小腸癌、内分泌系癌、甲状腺癌、副甲状腺癌、副腎癌、軟組織肉腫、尿道癌、陰茎癌、前立腺癌、慢性又は急性白血病、リンパ球性リンパ腫、膀胱癌、腎臓又は尿管の癌、腎細胞癌、腎盂癌、中枢神経（CNS）腫瘍、中枢神経原発悪性リンパ腫、脊髄軸癌、脳幹膠腫、下垂体腺腫及びそれらの組合せからなる群より選ばれる、請求項８記載の医薬組成物。
- 前記癌が、非小細胞肺癌（NSCLC）、扁平上皮細胞癌、ホルモン性-難治性前立腺癌、乳頭状腎細胞癌、直腸結腸腺癌、神経芽細胞腫、未分化大細胞リンパ腫（ALCL）及び胃癌からなる群より選ばれる、請求項８記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74276605P | 2005-12-05 | 2005-12-05 | |
| US86463706P | 2006-11-07 | 2006-11-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007153894A JP2007153894A (ja) | 2007-06-21 |
| JP2007153894A5 true JP2007153894A5 (ja) | 2010-05-27 |
| JP4619346B2 JP4619346B2 (ja) | 2011-01-26 |
Family
ID=38123250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006327355A Active JP4619346B2 (ja) | 2005-12-05 | 2006-12-04 | 異常細胞成長の処置方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7825137B2 (ja) |
| EP (1) | EP1959955B1 (ja) |
| JP (1) | JP4619346B2 (ja) |
| KR (1) | KR101026676B1 (ja) |
| AR (1) | AR056832A1 (ja) |
| AT (1) | ATE488237T1 (ja) |
| AU (1) | AU2006323027B2 (ja) |
| BR (1) | BRPI0619424B1 (ja) |
| CA (1) | CA2632286C (ja) |
| CY (1) | CY1110931T1 (ja) |
| DE (1) | DE602006018354D1 (ja) |
| DK (1) | DK1959955T3 (ja) |
| HK (1) | HK1126121A1 (ja) |
| IL (1) | IL191471A (ja) |
| NZ (1) | NZ568654A (ja) |
| PL (1) | PL1959955T3 (ja) |
| PT (1) | PT1959955E (ja) |
| RU (1) | RU2384331C2 (ja) |
| SI (1) | SI1959955T1 (ja) |
| TW (1) | TWI321050B (ja) |
| WO (1) | WO2007066187A2 (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012458B2 (en) | 2010-06-25 | 2015-04-21 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
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-
2006
- 2006-11-23 NZ NZ568654A patent/NZ568654A/en unknown
- 2006-11-23 PT PT06820997T patent/PT1959955E/pt unknown
- 2006-11-23 AU AU2006323027A patent/AU2006323027B2/en active Active
- 2006-11-23 DE DE602006018354T patent/DE602006018354D1/de active Active
- 2006-11-23 SI SI200630864T patent/SI1959955T1/sl unknown
- 2006-11-23 DK DK06820997.2T patent/DK1959955T3/da active
- 2006-11-23 RU RU2008122471/14A patent/RU2384331C2/ru active
- 2006-11-23 CA CA2632286A patent/CA2632286C/en active Active
- 2006-11-23 WO PCT/IB2006/003397 patent/WO2007066187A2/en active Application Filing
- 2006-11-23 US US12/095,114 patent/US7825137B2/en active Active
- 2006-11-23 KR KR20087016376A patent/KR101026676B1/ko active Protection Beyond IP Right Term
- 2006-11-23 PL PL06820997T patent/PL1959955T3/pl unknown
- 2006-11-23 EP EP06820997A patent/EP1959955B1/en active Active
- 2006-11-23 BR BRPI0619424-9A patent/BRPI0619424B1/pt active IP Right Grant
- 2006-11-23 AT AT06820997T patent/ATE488237T1/de active
- 2006-12-04 TW TW095145034A patent/TWI321050B/zh active
- 2006-12-04 JP JP2006327355A patent/JP4619346B2/ja active Active
- 2006-12-05 AR ARP060105369A patent/AR056832A1/es not_active Application Discontinuation
-
2008
- 2008-05-15 IL IL191471A patent/IL191471A/en active IP Right Grant
-
2009
- 2009-05-15 HK HK09104434.7A patent/HK1126121A1/xx unknown
-
2010
- 2010-11-24 CY CY20101101055T patent/CY1110931T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012458B2 (en) | 2010-06-25 | 2015-04-21 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
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