JP2007091733A5 - - Google Patents
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- JP2007091733A5 JP2007091733A5 JP2006235401A JP2006235401A JP2007091733A5 JP 2007091733 A5 JP2007091733 A5 JP 2007091733A5 JP 2006235401 A JP2006235401 A JP 2006235401A JP 2006235401 A JP2006235401 A JP 2006235401A JP 2007091733 A5 JP2007091733 A5 JP 2007091733A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- lower alkyl
- alkyl group
- optionally
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006235401A JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005251055 | 2005-08-31 | ||
| JP2005251055 | 2005-08-31 | ||
| JP2006235401A JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007091733A JP2007091733A (ja) | 2007-04-12 |
| JP2007091733A5 true JP2007091733A5 (https=) | 2008-03-21 |
| JP4785677B2 JP4785677B2 (ja) | 2011-10-05 |
Family
ID=37709698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006235401A Expired - Fee Related JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8071600B2 (https=) |
| EP (4) | EP2287162B1 (https=) |
| JP (1) | JP4785677B2 (https=) |
| KR (2) | KR101008873B1 (https=) |
| CN (4) | CN101258147B (https=) |
| AR (1) | AR055203A1 (https=) |
| AT (4) | ATE499369T1 (https=) |
| AU (2) | AU2006285607B2 (https=) |
| BR (1) | BRPI0615140A2 (https=) |
| CA (1) | CA2620688C (https=) |
| CY (1) | CY1111671T1 (https=) |
| DE (1) | DE602006020294D1 (https=) |
| DK (1) | DK1919907T5 (https=) |
| ES (4) | ES2383948T3 (https=) |
| IL (1) | IL189383A (https=) |
| MX (1) | MX2008002736A (https=) |
| MY (1) | MY145670A (https=) |
| PL (1) | PL1919907T3 (https=) |
| PT (1) | PT1919907E (https=) |
| RU (1) | RU2415854C2 (https=) |
| SG (1) | SG155180A1 (https=) |
| SI (1) | SI1919907T1 (https=) |
| TW (1) | TWI329641B (https=) |
| WO (1) | WO2007026959A2 (https=) |
| ZA (1) | ZA200801888B (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| SA05260357B1 (ar) | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به |
| JP5182088B2 (ja) | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| SG171681A1 (en) | 2006-05-18 | 2011-06-29 | Arena Pharm Inc | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
| JP5406018B2 (ja) | 2006-05-18 | 2014-02-05 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2aセロトニンレセプターに関連する障害の処置に有用な5−ht2aセロトニンレセプターのモジュレーターとしての1級アミン、およびその誘導体 |
| CA2646076C (en) | 2006-05-18 | 2015-06-30 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| TWI329102B (en) * | 2006-08-15 | 2010-08-21 | Nat Health Research Institutes | Thiourea compounds and method for inhibiting hepatitis c virus infection |
| WO2008020306A2 (en) * | 2006-08-18 | 2008-02-21 | Pfizer Products Inc. | Isoindole derivatives |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物 |
| US20080186971A1 (en) * | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
| EP1972628A1 (en) * | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
| US7985763B2 (en) * | 2007-04-10 | 2011-07-26 | National Health Research Institutes | Hepatitis C virus inhibitors |
| JP5603770B2 (ja) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2受容体拮抗薬およびその使用 |
| US7897764B2 (en) * | 2007-06-08 | 2011-03-01 | National Health Research Institutes | Thiourea derivatives |
| EA201070077A1 (ru) * | 2007-06-29 | 2010-08-30 | Эмори Юниверсити | Антагонисты nmda-рецепторов с нейропротективным действием |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−HT2Aセロトニン受容体に関連した障害の治療のための5−HT2Aセロトニン受容体のモジュレーターとしてのイミダゾ[1,2−a]ピリジン誘導体 |
| WO2009025265A1 (ja) * | 2007-08-21 | 2009-02-26 | Shionogi & Co., Ltd. | ピペラジン誘導体 |
| EP2206707B1 (en) | 2007-10-24 | 2014-07-23 | Astellas Pharma Inc. | Azolecarboxamide compound or salt thereof |
| EP2225235B1 (en) * | 2007-10-29 | 2017-09-06 | Merck Sharp & Dohme Corp. | Thiazole carboxamide derivatives and their use to treat cancer |
| BRPI0908807A2 (pt) * | 2008-02-15 | 2015-07-28 | Hoffmann La Roche | Derivados de 3-alquil-piperazina e usos dos mesmos |
| ES2494366T3 (es) | 2008-02-22 | 2014-09-15 | Otsuka Pharmaceutical Co., Ltd. | Compuesto de benzodiacepina y composición farmacéutica |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US8198284B2 (en) * | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
| JP2011520815A (ja) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのnmda受容体拮抗薬 |
| EP2349484A2 (en) | 2008-07-15 | 2011-08-03 | Novartis AG | Heteroaryl derivatives as dgat1 inhibitors |
| US8653069B2 (en) * | 2008-07-28 | 2014-02-18 | Jiangsu Hengyi Pharmaceutical Co., Ltd. | Aralkyl substituted piperidine or piperazine derivatives and their use for treating schizophrenia |
| BRPI0917704A2 (pt) * | 2008-09-01 | 2016-02-16 | Neurosearch As | composto, composição farmacêutica, e, uso de um composto químico |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CA2741731A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Compositions of a 5-ht2a serotonin receptor modulator useful for the treatment of disorders related thereto |
| CN102256963B (zh) * | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| US8748623B2 (en) * | 2009-02-17 | 2014-06-10 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as CXCR2 modulators |
| US8796447B2 (en) | 2009-08-21 | 2014-08-05 | Otsuka Pharmaceutical Co., Ltd. | Process for producing benzo[B][1,4]diazepine-2,4-dione compound |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2011109679A2 (en) * | 2010-03-05 | 2011-09-09 | Amira Pharmaceuticals, Inc. | Inhibitors of 5-lipoxygenase |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011144501A1 (en) * | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| EP2608672B1 (en) | 2010-08-23 | 2020-12-16 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
| CN102206214B (zh) * | 2011-04-07 | 2014-03-12 | 华中科技大学 | 苯并吡喃酮类衍生物及其应用 |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| JP6345651B2 (ja) * | 2012-05-09 | 2018-06-20 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | ヘテロアリール化合物及びその使用方法 |
| WO2014085208A1 (en) * | 2012-11-27 | 2014-06-05 | Merck Sharp & Dohme Corp. | 2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists |
| US9745284B2 (en) * | 2013-03-08 | 2017-08-29 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ether orexin receptor antagonists |
| EP3495357B1 (en) * | 2013-03-14 | 2021-05-05 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
| CN104059046B (zh) * | 2013-03-18 | 2017-02-08 | 江苏恩华药业股份有限公司 | 黄酮类衍生物及其应用 |
| CN104447723A (zh) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法 |
| US10022355B2 (en) | 2015-06-12 | 2018-07-17 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder |
| PT3317270T (pt) | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
| CN106749219A (zh) * | 2015-11-20 | 2017-05-31 | 江苏恩华药业股份有限公司 | 一种内酰胺类衍生物及其应用 |
| US10464931B2 (en) | 2015-12-28 | 2019-11-05 | Honour (R&D) | Process for the preparation of Quinolin-2(1H)-one derivatives |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN112125896B (zh) * | 2020-09-29 | 2021-10-29 | 湖南省湘中制药有限公司 | 一种抗精神病药依匹哌唑电化学制备方法 |
| CN112079812B (zh) * | 2020-09-29 | 2021-08-06 | 浙江大学 | 哌唑类抗精神病药物关键中间体及其电还原方法 |
| JP7834096B2 (ja) * | 2020-10-27 | 2026-03-23 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5-ht2aセロトニン受容体に関連する障害を処置するために有用な5-ht2aセロトニン受容体のモジュレーターとしてのピリミジン誘導体 |
| CN115772175A (zh) * | 2021-09-07 | 2023-03-10 | 中国科学院分子细胞科学卓越创新中心 | 噻吩并环化合物及其制备方法和应用 |
| EP4469453A1 (en) | 2022-01-29 | 2024-12-04 | Suven Life Sciences Limited | Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders |
| CN116554145B (zh) * | 2022-01-29 | 2025-06-03 | 江苏恩华药业股份有限公司 | 芳烷基-4-(1h)吲哚基哌嗪衍生物、其制备方法和应用 |
| CN115521298A (zh) * | 2022-05-09 | 2022-12-27 | 江苏慧聚药业股份有限公司 | 依匹哌唑的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
| JPS5649361A (en) | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
| US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| IL92544A0 (en) * | 1988-12-08 | 1990-08-31 | Duphar Int Res | Piperazine derivatives,their preparation and pharmaceutical compositions containing them |
| FI920023A0 (fi) | 1989-07-07 | 1992-01-03 | Pfizer | Heteroarylpiperazinfoereningar som antipsykotiska aemnen. |
| CA2067475C (en) | 1991-05-08 | 2000-10-10 | Yasuo Oshiro | Carbostyril derivatives and their use |
| US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
| DK148292D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Forbindelser |
| US5576321A (en) | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| EP0732332B1 (en) * | 1995-03-17 | 2001-12-19 | Aventis Pharmaceuticals Inc. | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation |
| FR2740134B1 (fr) | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| WO1998007703A1 (en) | 1996-08-22 | 1998-02-26 | Meiji Seika Kaisha, Ltd. | Quinoline derivatives and psychotropic agent |
| FR2761068B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique |
| ES2244438T3 (es) | 1999-05-24 | 2005-12-16 | Mitsubishi Pharma Corporation | Compuestos de fenoxipropilamina. |
| AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
| AR027133A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de heteroarilo, su preparacion y uso. |
| JP4497815B2 (ja) | 2001-02-16 | 2010-07-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 新規な複素環式アミド誘導体およびドーパミンd3受容体リガンドとしてのその使用 |
| AU2002322051A1 (en) * | 2001-06-07 | 2002-12-16 | Wayne State University | Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity |
| KR20040019027A (ko) * | 2001-06-29 | 2004-03-04 | 하. 룬트벡 아크티에 셀스카브 | 신규한 인돌 유도체 |
| OA12923A (en) * | 2002-09-17 | 2006-10-13 | Warner Lambert Co | Heterocyclic substituted piperazines for the treatment of schizophrenia. |
| BR0314796A (pt) | 2002-09-26 | 2005-07-26 | Warner Lambert Co | Piperazinas substituìdas heterocìclicas para o tratamento de esquizofrenia |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
-
2006
- 2006-08-30 AR ARP060103780A patent/AR055203A1/es unknown
- 2006-08-30 TW TW095132016A patent/TWI329641B/zh not_active IP Right Cessation
- 2006-08-31 CN CN2006800320431A patent/CN101258147B/zh not_active Expired - Fee Related
- 2006-08-31 CN CN2011104423270A patent/CN102702182A/zh active Pending
- 2006-08-31 CN CN2011104410868A patent/CN102558140A/zh active Pending
- 2006-08-31 PT PT06797580T patent/PT1919907E/pt unknown
- 2006-08-31 AT AT06797580T patent/ATE499369T1/de active
- 2006-08-31 ES ES10188671T patent/ES2383948T3/es active Active
- 2006-08-31 WO PCT/JP2006/317704 patent/WO2007026959A2/en not_active Ceased
- 2006-08-31 SG SG200905174-9A patent/SG155180A1/en unknown
- 2006-08-31 AU AU2006285607A patent/AU2006285607B2/en not_active Ceased
- 2006-08-31 KR KR1020087004418A patent/KR101008873B1/ko not_active Expired - Fee Related
- 2006-08-31 ES ES06797580T patent/ES2362961T3/es active Active
- 2006-08-31 ES ES10188688T patent/ES2382445T3/es active Active
- 2006-08-31 MX MX2008002736A patent/MX2008002736A/es active IP Right Grant
- 2006-08-31 US US11/991,146 patent/US8071600B2/en not_active Expired - Fee Related
- 2006-08-31 MY MYPI20080316A patent/MY145670A/en unknown
- 2006-08-31 CN CN2011104414290A patent/CN102850336A/zh active Pending
- 2006-08-31 PL PL06797580T patent/PL1919907T3/pl unknown
- 2006-08-31 AT AT10188683T patent/ATE557022T1/de active
- 2006-08-31 EP EP10188683A patent/EP2287162B1/en not_active Not-in-force
- 2006-08-31 AT AT10188688T patent/ATE549330T1/de active
- 2006-08-31 DE DE602006020294T patent/DE602006020294D1/de active Active
- 2006-08-31 SI SI200630973T patent/SI1919907T1/sl unknown
- 2006-08-31 EP EP10188671A patent/EP2287161B1/en not_active Not-in-force
- 2006-08-31 EP EP06797580A patent/EP1919907B9/en not_active Not-in-force
- 2006-08-31 RU RU2008112224/04A patent/RU2415854C2/ru not_active IP Right Cessation
- 2006-08-31 DK DK06797580.5T patent/DK1919907T5/da active
- 2006-08-31 JP JP2006235401A patent/JP4785677B2/ja not_active Expired - Fee Related
- 2006-08-31 ZA ZA200801888A patent/ZA200801888B/xx unknown
- 2006-08-31 ES ES10188683T patent/ES2383949T3/es active Active
- 2006-08-31 AT AT10188671T patent/ATE557021T1/de active
- 2006-08-31 BR BRPI0615140-0A patent/BRPI0615140A2/pt not_active IP Right Cessation
- 2006-08-31 EP EP10188688A patent/EP2284169B1/en not_active Not-in-force
- 2006-08-31 KR KR1020107009007A patent/KR20100063807A/ko not_active Abandoned
- 2006-08-31 CA CA2620688A patent/CA2620688C/en not_active Expired - Fee Related
-
2008
- 2008-02-07 IL IL189383A patent/IL189383A/en not_active IP Right Cessation
-
2010
- 2010-02-01 AU AU2010200362A patent/AU2010200362A1/en not_active Ceased
-
2011
- 2011-04-18 CY CY20111100400T patent/CY1111671T1/el unknown
- 2011-10-11 US US13/270,544 patent/US8598162B2/en not_active Expired - Fee Related
-
2013
- 2013-09-20 US US14/032,568 patent/US20140031334A1/en not_active Abandoned
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