KR101008873B1 - Ｃｎｓ 장애의 치료에 적합한４-피페라진-１-일-４-벤조[ｂ]티오펜의 유도체 - Google Patents

Ｃｎｓ 장애의 치료에 적합한４-피페라진-１-일-４-벤조[ｂ]티오펜의 유도체 Download PDF

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KR101008873B1
KR101008873B1 KR1020087004418A KR20087004418A KR101008873B1 KR 101008873 B1 KR101008873 B1 KR 101008873B1 KR 1020087004418 A KR1020087004418 A KR 1020087004418A KR 20087004418 A KR20087004418 A KR 20087004418A KR 101008873 B1 KR101008873 B1 KR 101008873B1
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alkyl
amino
substituted
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KR20080033446A (ko
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히로시 야마시타
히데아키 구로다
노부아키 이토
신 미야무라
구니오 오시마
준 마츠바라
하루카 다카하시
다에 후쿠시마
다케시 구로다
신이치 다이라
다츠요시 다나카
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오쓰까 세이야꾸 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020087004418A 2005-08-31 2006-08-31 Ｃｎｓ 장애의 치료에 적합한４-피페라진-１-일-４-벤조[ｂ]티오펜의 유도체 Expired - Fee Related KR101008873B1 (ko)

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JPJP-P-2005-00251055 2005-08-31
JP2005251055 2005-08-31

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KR1020107009007A Division KR20100063807A (ko) 2005-08-31 2006-08-31 Ｃｎｓ 장애의 치료에 적합한 ４-피페라진-１-일-４-벤조[ｂ]티오펜의 유도체

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KR20080033446A KR20080033446A (ko) 2008-04-16
KR101008873B1 true KR101008873B1 (ko) 2011-01-19

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KR1020107009007A Abandoned KR20100063807A (ko) 2005-08-31 2006-08-31 Ｃｎｓ 장애의 치료에 적합한 ４-피페라진-１-일-４-벤조[ｂ]티오펜의 유도체

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US (3) US8071600B2 (https=)
EP (4) EP2287162B1 (https=)
JP (1) JP4785677B2 (https=)
KR (2) KR101008873B1 (https=)
CN (4) CN101258147B (https=)
AR (1) AR055203A1 (https=)
AT (4) ATE499369T1 (https=)
AU (2) AU2006285607B2 (https=)
BR (1) BRPI0615140A2 (https=)
CA (1) CA2620688C (https=)
CY (1) CY1111671T1 (https=)
DE (1) DE602006020294D1 (https=)
DK (1) DK1919907T5 (https=)
ES (4) ES2383948T3 (https=)
IL (1) IL189383A (https=)
MX (1) MX2008002736A (https=)
MY (1) MY145670A (https=)
PL (1) PL1919907T3 (https=)
PT (1) PT1919907E (https=)
RU (1) RU2415854C2 (https=)
SG (1) SG155180A1 (https=)
SI (1) SI1919907T1 (https=)
TW (1) TWI329641B (https=)
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