JP2006528677A5

JP2006528677A5 -

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Publication number: JP2006528677A5
Authority: JP; Japan
Prior art keywords: ring; compound; formula; compounds; heteroatoms
Prior art date: 2004-01-29
Legal status : Granted

Application number

JP2006532271A

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English (en)

Japanese (ja)

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JP4691033B2 (ja

JP2006528677A (ja

Filing date

2004-01-29

Publication date

2011-02-24

2004-01-29 Application filed filed Critical

2004-01-29 Priority claimed from PCT/US2004/002541 external-priority patent/WO2005012292A1/en

2006-12-21 Publication of JP2006528677A publication Critical patent/JP2006528677A/ja

2011-02-24 Publication of JP2006528677A5 publication Critical patent/JP2006528677A5/ja

2011-06-01 Application granted granted Critical

2011-06-01 Publication of JP4691033B2 publication Critical patent/JP4691033B2/ja

2024-01-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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150000001875 compounds Chemical class 0.000 claims description 144
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 65
229910052757 nitrogen Inorganic materials 0.000 claims description 42
125000005842 heteroatom Chemical group 0.000 claims description 40
125000001072 heteroaryl group Chemical group 0.000 claims description 30
229910052760 oxygen Inorganic materials 0.000 claims description 29
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 27
229910052717 sulfur Inorganic materials 0.000 claims description 27
239000011593 sulfur Substances 0.000 claims description 27
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 26
239000001301 oxygen Substances 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 23
229910052739 hydrogen Inorganic materials 0.000 claims description 18
239000001257 hydrogen Substances 0.000 claims description 18
125000003118 aryl group Chemical group 0.000 claims description 17
229910052736 halogen Inorganic materials 0.000 claims description 17
150000002367 halogens Chemical class 0.000 claims description 17
-1 imidazole-1- yl Chemical group 0.000 claims description 15
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
125000001931 aliphatic group Chemical group 0.000 claims description 10
125000000623 heterocyclic group Chemical group 0.000 claims description 9
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 7
229910052799 carbon Inorganic materials 0.000 claims description 7
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 6
125000004429 atom Chemical group 0.000 claims description 5
125000001118 alkylidene group Chemical group 0.000 claims description 4
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 4
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 3
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 3
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims description 2
125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims description 2
125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims description 2
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 2
125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
229910017464 nitrogen compound Inorganic materials 0.000 claims 1
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BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
239000011734 sodium Substances 0.000 description 6
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 6
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108091006112 ATPases Proteins 0.000 description 5
102000057290 Adenosine Triphosphatases Human genes 0.000 description 5
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229910004373 HOAc Inorganic materials 0.000 description 5
102000003855 L-lactate dehydrogenase Human genes 0.000 description 5
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GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 description 4
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241000187479 Mycobacterium tuberculosis Species 0.000 description 4
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JP2006532271A 2003-01-31 2004-01-29 ジャイレース阻害剤およびその用途 Expired - Fee Related JP4691033B2 (ja)