JP2006523672A - トリグリセリド及びコレステロールの蓄積に結びつけられる疾病の治療方法 - Google Patents

トリグリセリド及びコレステロールの蓄積に結びつけられる疾病の治療方法 Download PDF

Info

Publication number
JP2006523672A
JP2006523672A JP2006506481A JP2006506481A JP2006523672A JP 2006523672 A JP2006523672 A JP 2006523672A JP 2006506481 A JP2006506481 A JP 2006506481A JP 2006506481 A JP2006506481 A JP 2006506481A JP 2006523672 A JP2006523672 A JP 2006523672A
Authority
JP
Japan
Prior art keywords
mice
aminoisobutyric acid
human
treatment
baiba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006506481A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006523672A5 (enExample
Inventor
フロメンティー,ベルナール
メゾンヌーブ,カロリヌ
イグジル,アニッサ
レトロン,フィリップ
ベグリシュ,カリマ
Original Assignee
アンスティテュト ナショナル ド ラ サンテ エ ド ラ ルシェルシュ メディカル (アンセルム)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アンスティテュト ナショナル ド ラ サンテ エ ド ラ ルシェルシュ メディカル (アンセルム) filed Critical アンスティテュト ナショナル ド ラ サンテ エ ド ラ ルシェルシュ メディカル (アンセルム)
Publication of JP2006523672A publication Critical patent/JP2006523672A/ja
Publication of JP2006523672A5 publication Critical patent/JP2006523672A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2006506481A 2003-04-18 2004-04-15 トリグリセリド及びコレステロールの蓄積に結びつけられる疾病の治療方法 Withdrawn JP2006523672A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2003/001463 WO2004091598A1 (en) 2003-04-18 2003-04-18 Use of beta-aminoisobutyric acid for the treatment of diseases linked to the accumulation of triglycerides and cholesterol
PCT/IB2004/001166 WO2004091599A1 (en) 2003-04-18 2004-04-15 Method for the treatment of diseases linked to an accumulation of triglycerides and cholesterol

Publications (2)

Publication Number Publication Date
JP2006523672A true JP2006523672A (ja) 2006-10-19
JP2006523672A5 JP2006523672A5 (enExample) 2007-06-07

Family

ID=33187198

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006506481A Withdrawn JP2006523672A (ja) 2003-04-18 2004-04-15 トリグリセリド及びコレステロールの蓄積に結びつけられる疾病の治療方法

Country Status (7)

Country Link
US (1) US20060167098A1 (enExample)
EP (1) EP1615630A1 (enExample)
JP (1) JP2006523672A (enExample)
AU (1) AU2003226582A1 (enExample)
BR (1) BRPI0409456A (enExample)
CA (1) CA2526899A1 (enExample)
WO (2) WO2004091598A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544251A (ja) * 2010-11-15 2013-12-12 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド アミロイド線維形成関連状態を処置するためのジペプチドアナログ
JP2019510041A (ja) * 2016-03-30 2019-04-11 マイクロバイオ カンパニー, リミテッド 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法
JP2019131488A (ja) * 2018-01-29 2019-08-08 静岡県公立大学法人 Vcam−1発現抑制剤、mcp−1発現抑制剤、炎症性疾患改善用組成物、加工食品又は飲料

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367072B2 (en) * 2006-12-08 2013-02-05 Polifenoles Naturales, S.L. Composition for treating obesity and method of using the same
CN105250256A (zh) * 2015-10-16 2016-01-20 南京医科大学 β-氨基异丁酸在制备抗糖尿病药物中的应用
US20220347141A1 (en) * 2019-09-17 2022-11-03 Yale University Methods of treating phosphate concentration disorders with l-baiba
AU2022258161B2 (en) * 2021-04-14 2025-05-22 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Compositions and methods for promoting glycogen synthase activity and augmenting glycogen storage capability
CN117561056A (zh) * 2021-06-22 2024-02-13 南京纽邦生物科技有限公司 施用β-氨基异丁酸增加间歇性禁食减肥的益处
CN115606809A (zh) * 2021-10-08 2023-01-17 南京纽邦生物科技有限公司 通过施用β-氨基异丁酸模拟热量限制的生物学益处的方法和组合物
CN116059195A (zh) * 2022-01-28 2023-05-05 南京纽邦生物科技有限公司 用于提高运动表现或预防或缓解疲劳的组合物和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453941A (en) * 1980-12-29 1984-06-12 Board Of Overseers Of Goshen College Composition and process for producing pigmentation in hair or skin
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
FR2701948B1 (fr) * 1993-02-22 1996-07-26 Exsymol Sa Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
JPH07101984A (ja) * 1993-09-30 1995-04-18 Suntory Ltd ペプチド誘導体
JPH107553A (ja) * 1996-03-21 1998-01-13 Toutoushiyu Seizo Kk 生体内ラジカル消去剤及び抗潰瘍剤

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013544251A (ja) * 2010-11-15 2013-12-12 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド アミロイド線維形成関連状態を処置するためのジペプチドアナログ
US9630989B2 (en) 2010-11-15 2017-04-25 Ramot At Tel-Aviv University Ltd. Dipeptide analogs for treating conditions associated with amyloid fibril formation
JP2019510041A (ja) * 2016-03-30 2019-04-11 マイクロバイオ カンパニー, リミテッド 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法
JP2022058740A (ja) * 2016-03-30 2022-04-12 マイクロバイオ カンパニー, リミテッド 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法
JP7442555B2 (ja) 2016-03-30 2024-03-04 マイクロバイオ カンパニー, リミテッド 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法
JP2019131488A (ja) * 2018-01-29 2019-08-08 静岡県公立大学法人 Vcam−1発現抑制剤、mcp−1発現抑制剤、炎症性疾患改善用組成物、加工食品又は飲料

Also Published As

Publication number Publication date
CA2526899A1 (en) 2004-10-28
US20060167098A1 (en) 2006-07-27
WO2004091598A1 (en) 2004-10-28
AU2003226582A1 (en) 2004-11-04
EP1615630A1 (en) 2006-01-18
WO2004091599A1 (en) 2004-10-28
BRPI0409456A (pt) 2006-04-18

Similar Documents

Publication Publication Date Title
JP5057003B2 (ja) 肥満、高血圧及び脂肪肝の治療用の新規な脂肪類似体
TWI547278B (zh) 阿茲海默症及老化腦部之補缺(anaplerotic)療法
EP3197429B1 (en) Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
JP2637712B2 (ja) 3−グアニジノプロピオン酸を含有する組成物
WO1993003714A2 (en) Method for treatment of metabolic disorders
WO2013036104A1 (en) Infant nutrition for regulating food intake later in life
JP2006523672A (ja) トリグリセリド及びコレステロールの蓄積に結びつけられる疾病の治療方法
AU2005251576B2 (en) Regulator of physiological function of ghrelin and use thereof
JP2018199643A (ja) リポ多糖を用いた脳機能改善剤、食品及び医薬品
JPWO2002030418A1 (ja) 脂質代謝改善用組成物
RU2375055C2 (ru) Применение альфа-кетоглутарата и родственных соединений для снижения липидов плазмы
US11504395B2 (en) Oral pyrophosphate for use in reducing tissue calcification
JP2001240544A (ja) 抗肥満剤及び脂質代謝改善剤
Ricciolini et al. The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring
JP2007262017A (ja) ピペコリン酸含有抗糖尿病組成物
JPWO2007069744A1 (ja) メタボリックシンドローム予防・改善用組成物
JP5008910B2 (ja) 脂質代謝改善用組成物
WO2023208925A1 (en) Nutritional composition for use in preventing programmed obesity in female infants
Team High PUFA to Saturated Fat Ratio Increase All-Cause Mortality
Aguirre The Effects of LAT1 Muscle-specific Knockout on Skeletal Muscle Anabolic Responses
CN106604732A (zh) 二氢胆固醇的用途
WO2003063853A1 (en) Compositions for lessening mesenteric fat
KR20070022220A (ko) 오스페미펜의 생물학적 이용가능성 강화방법

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070412

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20100802

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100809