JP2006523672A5 - - Google Patents

Info

Publication number

JP2006523672A5

JP2006523672A5 JP2006506481A JP2006506481A JP2006523672A5 JP 2006523672 A5 JP2006523672 A5 JP 2006523672A5 JP 2006506481 A JP2006506481 A JP 2006506481A JP 2006506481 A JP2006506481 A JP 2006506481A JP 2006523672 A5 JP2006523672 A5 JP 2006523672A5

Authority

JP

Japan

Prior art keywords

treatment

aminoisobutyric acid

pharmaceutical composition

prevention

animal

Prior art date

2004-04-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• QCHPKSFMDHPSNR-UHFFFAOYSA-N 3-aminoisobutyric acid Chemical compound NCC(C)C(O)=O QCHPKSFMDHPSNR-UHFFFAOYSA-N 0.000 claims 33
• 238000000034 method Methods 0.000 claims 27
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 16
• 238000011282 treatment Methods 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 239000013543 active substance Substances 0.000 claims 13
• 239000002207 metabolite Substances 0.000 claims 13
• 239000000651 prodrug Substances 0.000 claims 13
• 229940002612 prodrug Drugs 0.000 claims 13
• 241001465754 Metazoa Species 0.000 claims 12
• 210000004369 blood Anatomy 0.000 claims 8
• 239000008280 blood Substances 0.000 claims 8
• 235000012000 cholesterol Nutrition 0.000 claims 8
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
• 230000002265 prevention Effects 0.000 claims 8
• 210000001519 tissue Anatomy 0.000 claims 7
• 238000009825 accumulation Methods 0.000 claims 5
• 230000006806 disease prevention Effects 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 235000016709 nutrition Nutrition 0.000 claims 5
• 102000004877 Insulin Human genes 0.000 claims 4
• 108090001061 Insulin Proteins 0.000 claims 4
• 229940125396 insulin Drugs 0.000 claims 4
• 238000002560 therapeutic procedure Methods 0.000 claims 4
• 150000003626 triacylglycerols Chemical class 0.000 claims 4
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
• 102000011690 Adiponectin Human genes 0.000 claims 3
• 108010076365 Adiponectin Proteins 0.000 claims 3
• 208000004930 Fatty Liver Diseases 0.000 claims 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
• 206010020772 Hypertension Diseases 0.000 claims 3
• 238000010171 animal model Methods 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 239000008103 glucose Substances 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 238000011321 prophylaxis Methods 0.000 claims 3
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 2
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
• 230000036765 blood level Effects 0.000 claims 2
• 210000004185 liver Anatomy 0.000 claims 2
• 235000020824 obesity Nutrition 0.000 claims 2
• 230000035945 sensitivity Effects 0.000 claims 2
• 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010019708 Hepatic steatosis Diseases 0.000 claims 1
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 210000000577 adipose tissue Anatomy 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 230000002950 deficient Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 208000010706 fatty liver disease Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 229910017053 inorganic salt Inorganic materials 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 230000007863 steatosis Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1