JP2006523091A - ヒト胚性幹細胞の心筋細胞への分化 - Google Patents

ヒト胚性幹細胞の心筋細胞への分化 Download PDF

Info

Publication number
JP2006523091A
JP2006523091A JP2006503961A JP2006503961A JP2006523091A JP 2006523091 A JP2006523091 A JP 2006523091A JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006523091 A JP2006523091 A JP 2006523091A
Authority
JP
Japan
Prior art keywords
cells
cell
cardiomyocytes
hes
embryonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006503961A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006523091A5 (enExample
Inventor
ママリー,クリスティン・リンゼイ
ドゥーフェンダンス,ペトルス・アドリアヌス・フレデリック・マリーア
テルトーレン,レオン・ヘラルドゥス・ヨーゼフ
Original Assignee
イーエス・セル・インターナショナル・プライヴェート・リミテッド
ネザーランズ・インスティテュート・フォール・オントヴィッケリングスビオロヒー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イーエス・セル・インターナショナル・プライヴェート・リミテッド, ネザーランズ・インスティテュート・フォール・オントヴィッケリングスビオロヒー filed Critical イーエス・セル・インターナショナル・プライヴェート・リミテッド
Publication of JP2006523091A publication Critical patent/JP2006523091A/ja
Publication of JP2006523091A5 publication Critical patent/JP2006523091A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2006503961A 2003-03-11 2004-03-11 ヒト胚性幹細胞の心筋細胞への分化 Pending JP2006523091A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003901099A AU2003901099A0 (en) 2003-03-11 2003-03-11 Methods of inducing differentiation of stem cells
PCT/AU2004/000302 WO2004081205A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Publications (2)

Publication Number Publication Date
JP2006523091A true JP2006523091A (ja) 2006-10-12
JP2006523091A5 JP2006523091A5 (enExample) 2007-05-24

Family

ID=31500143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006503961A Pending JP2006523091A (ja) 2003-03-11 2004-03-11 ヒト胚性幹細胞の心筋細胞への分化

Country Status (7)

Country Link
US (1) US20070161107A1 (enExample)
EP (1) EP1608740A4 (enExample)
JP (1) JP2006523091A (enExample)
AU (1) AU2003901099A0 (enExample)
CA (1) CA2518508A1 (enExample)
GB (1) GB2415437A (enExample)
WO (1) WO2004081205A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047133A1 (ja) * 2008-10-24 2010-04-29 株式会社クラレ 細胞保存方法、及び細胞輸送方法
WO2010134606A1 (ja) 2009-05-22 2010-11-25 学校法人 東京女子医科大学 胚性幹細胞或いは人工多能性幹細胞の分化誘導方法
JP2013531497A (ja) * 2010-06-13 2013-08-08 インスティチュート・オブ・バイオフィジックス,チャイニーズ・アカデミー・オブ・サイエンシズ 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用
JP2014525268A (ja) * 2011-08-30 2014-09-29 ザ ジェイ. デヴィッド グラッドストーン インスティテューツ 心筋細胞を生成するための方法
WO2015025958A1 (ja) * 2013-08-23 2015-02-26 国立大学法人大阪大学 ペースメーカー組織片の製造方法
US11339371B2 (en) 2012-07-23 2022-05-24 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro
WO2024162286A1 (ja) 2023-01-31 2024-08-08 富士フイルム株式会社 薬剤の評価方法、試薬およびキット

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412479A4 (en) 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
EP1756268A4 (en) * 2004-06-01 2007-12-12 Es Cell Int Pte Ltd IMPROVED CARDIOMYOCYTE DIFFERENTIATION
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
EP2206724A1 (en) 2005-12-13 2010-07-14 Kyoto University Nuclear reprogramming factor
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
KR20090086260A (ko) * 2006-12-07 2009-08-11 테바 파마슈티컬 인더스트리즈 리미티드 미손상 골수 또는 미손상 제대 조직으로부터 조직 전구체 세포 및 성숙 조직 세포를 형성 및 증식시키는 방법
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
EP2198010A4 (en) * 2007-09-12 2010-10-06 Univ California COMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFECTIVENESS OF STEM CELLS OF DERIVED HEART MUSCLES
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
KR101532442B1 (ko) 2007-12-10 2015-06-29 고쿠리츠 다이가쿠 호진 교토 다이가쿠 효율적인 핵 초기화 방법
CN101939418A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的心肌细胞的合成表面
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP5346925B2 (ja) 2008-05-02 2013-11-20 国立大学法人京都大学 核初期化方法
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
MX389666B (es) 2009-10-16 2025-03-19 Scripps Research Inst Induccion de celulas pluripotentes.
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
WO2011159726A2 (en) * 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
JP2016505276A (ja) 2013-01-23 2016-02-25 リー、ロナルドLI, Ronald 幹細胞由来心筋細胞の操作された物理的アライメント
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
CN120536341A (zh) 2014-03-04 2025-08-26 菲特治疗公司 改良的重编程方法和细胞培养平台
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
CN113662985B (zh) 2021-09-07 2022-06-24 北京中医药大学 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010303A1 (en) * 2001-07-24 2003-02-06 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533518A (ja) * 2002-07-26 2005-11-10 ウイスコンシン アラムニ リサーチ ファンデーション ヒト胚幹細胞由来の機能性心筋細胞
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010303A1 (en) * 2001-07-24 2003-02-06 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047133A1 (ja) * 2008-10-24 2010-04-29 株式会社クラレ 細胞保存方法、及び細胞輸送方法
JPWO2010047133A1 (ja) * 2008-10-24 2012-03-22 株式会社クラレ 細胞保存方法、及び細胞輸送方法
WO2010134606A1 (ja) 2009-05-22 2010-11-25 学校法人 東京女子医科大学 胚性幹細胞或いは人工多能性幹細胞の分化誘導方法
JP2013531497A (ja) * 2010-06-13 2013-08-08 インスティチュート・オブ・バイオフィジックス,チャイニーズ・アカデミー・オブ・サイエンシズ 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用
US9273286B2 (en) 2010-06-13 2016-03-01 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
US10590386B2 (en) 2010-06-13 2020-03-17 Insitute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
JP2014525268A (ja) * 2011-08-30 2014-09-29 ザ ジェイ. デヴィッド グラッドストーン インスティテューツ 心筋細胞を生成するための方法
US11339371B2 (en) 2012-07-23 2022-05-24 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro
WO2015025958A1 (ja) * 2013-08-23 2015-02-26 国立大学法人大阪大学 ペースメーカー組織片の製造方法
WO2024162286A1 (ja) 2023-01-31 2024-08-08 富士フイルム株式会社 薬剤の評価方法、試薬およびキット
KR20250130369A (ko) 2023-01-31 2025-09-01 후지필름 가부시키가이샤 약제의 평가 방법, 시약 및 키트
EP4660316A1 (en) 2023-01-31 2025-12-10 FUJIFILM Corporation Drug evaluation method, reagent and kit

Also Published As

Publication number Publication date
GB0520673D0 (en) 2005-11-16
US20070161107A1 (en) 2007-07-12
AU2003901099A0 (en) 2003-03-27
CA2518508A1 (en) 2004-09-23
WO2004081205A1 (en) 2004-09-23
WO2004081205A8 (en) 2004-10-28
GB2415437A (en) 2005-12-28
EP1608740A1 (en) 2005-12-28
EP1608740A4 (en) 2007-05-09

Similar Documents

Publication Publication Date Title
US20070161107A1 (en) Differentiation of human embryonic stem cells to cardiomyocytes
US8728457B2 (en) Methods of inducing differentiation of stem cells
US9994822B2 (en) Cardiomyocyte differentiation
JP5312804B2 (ja) 幹細胞及び胎児由来の心筋細胞及び予定心筋細胞の精製方法
AU2002317039A1 (en) Methods of inducing differentiation of stem cells
US20100183566A1 (en) METHOD FOR EFFICIENT TRANSFER OF HUMAN BLASTOCYST-DERIVED STEM CELLS (hBS CELLS) FROM A FEEDER-SUPPORTED TO A FEEDER-FREE CULTURE SYSTEM
US20080254003A1 (en) Differentiation of Human Embryonic Stem Cells and Cardiomyocytes and Cardiomyocyte Progenitors Derived Therefrom
JP2004535820A5 (enExample)
Wobus et al. Embryonic stem cell-derived cardiac differentiation: modulation of differentiation and “loss-of-function” analysis in vitro
JP2019535299A (ja) ヒト心室前駆細胞を単離するための方法
AU2004219990A1 (en) Differentiation of human embryonic stem cells to cardiomyocytes
AU2005318931A1 (en) Differentiation of human embryonic stem cells and cardiomyocytes and cardiomyocyte progenitors derived therefrom
JP2008141973A (ja) 心筋細胞の培養増殖法
Shafa et al. Stirred Suspension Bioreactor Suppresses ESC Differentiation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070312

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070312

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070328

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100413

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100917