GB2415437A - Differentiation of human embryonic stem cells to cardiomyocytes - Google Patents

Differentiation of human embryonic stem cells to cardiomyocytes Download PDF

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Publication number
GB2415437A
GB2415437A GB0520673A GB0520673A GB2415437A GB 2415437 A GB2415437 A GB 2415437A GB 0520673 A GB0520673 A GB 0520673A GB 0520673 A GB0520673 A GB 0520673A GB 2415437 A GB2415437 A GB 2415437A
Authority
GB
United Kingdom
Prior art keywords
differentiation
cardiomyocytes
stem cells
embryonic stem
human embryonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0520673A
Other languages
English (en)
Other versions
GB0520673D0 (en
Inventor
Christine Lindsay Mummery
Petrus Adrianus Fre Doevendans
Leon Gerardus Joseph Tertoolen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Original Assignee
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Es Cell International Pte Ltd, Netherlands Instituut Voor Ontwikkelingsbiologie, NETHERLANDS INST VOOR ONTWIKKE, ES Cell International Pte Ltd filed Critical Es Cell International Pte Ltd
Publication of GB0520673D0 publication Critical patent/GB0520673D0/en
Publication of GB2415437A publication Critical patent/GB2415437A/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB0520673A 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes Withdrawn GB2415437A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003901099A AU2003901099A0 (en) 2003-03-11 2003-03-11 Methods of inducing differentiation of stem cells
PCT/AU2004/000302 WO2004081205A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Publications (2)

Publication Number Publication Date
GB0520673D0 GB0520673D0 (en) 2005-11-16
GB2415437A true GB2415437A (en) 2005-12-28

Family

ID=31500143

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0520673A Withdrawn GB2415437A (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Country Status (7)

Country Link
US (1) US20070161107A1 (enExample)
EP (1) EP1608740A4 (enExample)
JP (1) JP2006523091A (enExample)
AU (1) AU2003901099A0 (enExample)
CA (1) CA2518508A1 (enExample)
GB (1) GB2415437A (enExample)
WO (1) WO2004081205A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

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EP1412479A4 (en) 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
EP2206724A1 (en) 2005-12-13 2010-07-14 Kyoto University Nuclear reprogramming factor
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
KR20090086260A (ko) * 2006-12-07 2009-08-11 테바 파마슈티컬 인더스트리즈 리미티드 미손상 골수 또는 미손상 제대 조직으로부터 조직 전구체 세포 및 성숙 조직 세포를 형성 및 증식시키는 방법
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
EP2198010A4 (en) * 2007-09-12 2010-10-06 Univ California COMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFECTIVENESS OF STEM CELLS OF DERIVED HEART MUSCLES
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
KR101532442B1 (ko) 2007-12-10 2015-06-29 고쿠리츠 다이가쿠 호진 교토 다이가쿠 효율적인 핵 초기화 방법
CN101939418A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的心肌细胞的合成表面
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP5346925B2 (ja) 2008-05-02 2013-11-20 国立大学法人京都大学 核初期化方法
US20110207215A1 (en) * 2008-10-24 2011-08-25 Kuraray Co., Ltd. Cell storage method and cell transport method
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
JPWO2010134606A1 (ja) 2009-05-22 2012-11-12 学校法人東京女子医科大学 胚性幹細胞或いは人工多能性幹細胞の分化誘導方法
MX389666B (es) 2009-10-16 2025-03-19 Scripps Research Inst Induccion de celulas pluripotentes.
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
AU2010355614B2 (en) 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
WO2011159726A2 (en) * 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
US9828585B2 (en) 2011-08-30 2017-11-28 The J. David Gladstone Instututes Methods for generating cardiomyocytes
CA2886396C (en) 2012-07-23 2023-08-22 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular cardiomyocytes in vitro
JP2016505276A (ja) 2013-01-23 2016-02-25 リー、ロナルドLI, Ronald 幹細胞由来心筋細胞の操作された物理的アライメント
JPWO2015025958A1 (ja) * 2013-08-23 2017-03-02 国立大学法人大阪大学 ペースメーカー組織片の製造方法
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
CN120536341A (zh) 2014-03-04 2025-08-26 菲特治疗公司 改良的重编程方法和细胞培养平台
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
CN113662985B (zh) 2021-09-07 2022-06-24 北京中医药大学 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用
AU2024213547A1 (en) 2023-01-31 2025-08-14 Fujifilm Corporation Drug evaluation method, reagent and kit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2452256A1 (en) * 2001-07-24 2003-02-06 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells
JP2005533518A (ja) * 2002-07-26 2005-11-10 ウイスコンシン アラムニ リサーチ ファンデーション ヒト胚幹細胞由来の機能性心筋細胞
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Circ. Res., Vol.91, 2002, Chunhui, X. et al., "Characterization and enrichment...", pp.501-508 *
Circulation, Vol.107, 2003, Mummery, C. et al., "Differentiation of human embryonic...", pp.2733-2740 *
Curr. Biol., Vol.11, 2001, Eiges, R. et al., "Establishment of human embryonic...", pp.514-518 *
Dev. Dyn., Vol.210, 1997, Arai, A. et al., "Murine cardiac progenitor...", pp.344-353 *
Heart Failure Rev., Vol.8, 2003, Kehat, I. et al., "Human embryonic stem cells...", pp.229-236 *
Herz, Vol.27, 2002, Sachinidis, A. et al., "Generation of cardiomyocytes...", pp.589-597 *
J. Anat., Vol.200, 2002, Mummery, C. et al., "Cardiomyocyte differentiation...", pp.233-242 *
Reprod. BioMed. Online, Vol.4, 2002, Trounson, A., "Human embryonic stem cells...", pp.58-63 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

Also Published As

Publication number Publication date
GB0520673D0 (en) 2005-11-16
US20070161107A1 (en) 2007-07-12
AU2003901099A0 (en) 2003-03-27
CA2518508A1 (en) 2004-09-23
WO2004081205A1 (en) 2004-09-23
WO2004081205A8 (en) 2004-10-28
EP1608740A1 (en) 2005-12-28
EP1608740A4 (en) 2007-05-09
JP2006523091A (ja) 2006-10-12

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