GB2415437A - Differentiation of human embryonic stem cells to cardiomyocytes - Google Patents

Differentiation of human embryonic stem cells to cardiomyocytes Download PDF

Info

Publication number
GB2415437A
GB2415437A GB0520673A GB0520673A GB2415437A GB 2415437 A GB2415437 A GB 2415437A GB 0520673 A GB0520673 A GB 0520673A GB 0520673 A GB0520673 A GB 0520673A GB 2415437 A GB2415437 A GB 2415437A
Authority
GB
United Kingdom
Prior art keywords
differentiation
cardiomyocytes
stem cells
embryonic stem
human embryonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0520673A
Other languages
English (en)
Other versions
GB0520673D0 (en
Inventor
Christine Lindsay Mummery
Petrus Adrianus Fre Doevendans
Leon Gerardus Joseph Tertoolen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Original Assignee
Es Cell International Pte Ltd
Netherlands Instituut Voor Ontwikkelingsbiologie
NETHERLANDS INST VOOR ONTWIKKE
ES Cell International Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Es Cell International Pte Ltd, Netherlands Instituut Voor Ontwikkelingsbiologie, NETHERLANDS INST VOOR ONTWIKKE, ES Cell International Pte Ltd filed Critical Es Cell International Pte Ltd
Publication of GB0520673D0 publication Critical patent/GB0520673D0/en
Publication of GB2415437A publication Critical patent/GB2415437A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB0520673A 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes Withdrawn GB2415437A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003901099A AU2003901099A0 (en) 2003-03-11 2003-03-11 Methods of inducing differentiation of stem cells
PCT/AU2004/000302 WO2004081205A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Publications (2)

Publication Number Publication Date
GB0520673D0 GB0520673D0 (en) 2005-11-16
GB2415437A true GB2415437A (en) 2005-12-28

Family

ID=31500143

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0520673A Withdrawn GB2415437A (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Country Status (7)

Country Link
US (1) US20070161107A1 (enExample)
EP (1) EP1608740A4 (enExample)
JP (1) JP2006523091A (enExample)
AU (1) AU2003901099A0 (enExample)
CA (1) CA2518508A1 (enExample)
GB (1) GB2415437A (enExample)
WO (1) WO2004081205A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159580A0 (en) 2001-07-12 2004-06-01 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
KR101420740B1 (ko) 2005-12-13 2014-07-17 교또 다이가꾸 핵초기화 인자
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
KR20090086260A (ko) * 2006-12-07 2009-08-11 테바 파마슈티컬 인더스트리즈 리미티드 미손상 골수 또는 미손상 제대 조직으로부터 조직 전구체 세포 및 성숙 조직 세포를 형성 및 증식시키는 방법
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
WO2009036220A2 (en) * 2007-09-12 2009-03-19 The Regents Of The University Of California Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes
KR101532442B1 (ko) 2007-12-10 2015-06-29 고쿠리츠 다이가쿠 호진 교토 다이가쿠 효율적인 핵 초기화 방법
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
SG188098A1 (en) 2008-01-30 2013-03-28 Geron Corp Synthetic surfaces for culturing stem cell derived cardiomyocytes
ES2690554T3 (es) 2008-03-17 2018-11-21 The Scripps Research Institute Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas
ES2722198T3 (es) 2008-05-02 2019-08-08 Univ Kyoto Método de reprogramación nuclear
KR101746864B1 (ko) * 2008-10-24 2017-06-14 주식회사 쿠라레 세포 보존 방법 및 세포 수송 방법
ES2645869T3 (es) 2008-12-17 2017-12-11 The Scripps Research Institute Generación y mantenimiento de células madre
EP2434007A4 (en) 2009-05-22 2013-07-31 Univ Tokyo Womens Medical METHOD FOR CREATING THE DIFFERENTIATION OF EMBRYONIC STEM CELLS OR ARTIFICIAL PLURIPOTENTER STEM CELLS
ES2638464T3 (es) 2009-10-16 2017-10-20 The Scripps Research Institute Inducción de células pluripotentes
AU2011235212B2 (en) 2010-03-31 2014-07-31 The Scripps Research Institute Reprogramming cells
AU2010355614B2 (en) * 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
CN106893692B (zh) 2010-12-22 2021-11-26 菲特治疗公司 用于单细胞分选与增强ipsc重新编程的细胞培养平台
EP2750509B1 (en) 2011-08-30 2016-12-28 The J. David Gladstone Institutes Methods for generating cardiomyocytes
EP2891712A4 (en) 2012-07-23 2016-04-06 Inst Biophysics Cn Acad Sci METHOD FOR INDUCTING PLURIPOTENTAL STEM CELLS FOR DIFFERENTIATING VENTRICULAR IN MYOCYTES IN VITRO
EP2948542A4 (en) 2013-01-23 2016-07-13 Ronald Li MANIPULATED PHYSICAL ORIENTATION OF CARDIOMYOCYTES FROM STEM CELLS
JPWO2015025958A1 (ja) * 2013-08-23 2017-03-02 国立大学法人大阪大学 ペースメーカー組織片の製造方法
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
SG10201807292YA (en) 2014-03-04 2018-09-27 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
AU2016338680B2 (en) 2015-10-16 2022-11-17 Fate Therapeutics, Inc. Platform for the induction and maintenance of ground state pluripotency
CN113662985B (zh) 2021-09-07 2022-06-24 北京中医药大学 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用
AU2024213547A1 (en) 2023-01-31 2025-08-14 Fujifilm Corporation Drug evaluation method, reagent and kit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002317039B2 (en) * 2001-07-24 2007-10-04 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells
KR20050026008A (ko) * 2002-07-26 2005-03-14 위스콘신 얼럼나이 리서어치 화운데이션 인간 배아 줄기 세포로부터의 기능성 심근 세포
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Circ. Res., Vol.91, 2002, Chunhui, X. et al., "Characterization and enrichment...", pp.501-508 *
Circulation, Vol.107, 2003, Mummery, C. et al., "Differentiation of human embryonic...", pp.2733-2740 *
Curr. Biol., Vol.11, 2001, Eiges, R. et al., "Establishment of human embryonic...", pp.514-518 *
Dev. Dyn., Vol.210, 1997, Arai, A. et al., "Murine cardiac progenitor...", pp.344-353 *
Heart Failure Rev., Vol.8, 2003, Kehat, I. et al., "Human embryonic stem cells...", pp.229-236 *
Herz, Vol.27, 2002, Sachinidis, A. et al., "Generation of cardiomyocytes...", pp.589-597 *
J. Anat., Vol.200, 2002, Mummery, C. et al., "Cardiomyocyte differentiation...", pp.233-242 *
Reprod. BioMed. Online, Vol.4, 2002, Trounson, A., "Human embryonic stem cells...", pp.58-63 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2429718B (en) * 2004-06-01 2008-12-17 Es Cell Int Pte Ltd Improved cardiomyocyte differentiation

Also Published As

Publication number Publication date
US20070161107A1 (en) 2007-07-12
EP1608740A1 (en) 2005-12-28
EP1608740A4 (en) 2007-05-09
JP2006523091A (ja) 2006-10-12
GB0520673D0 (en) 2005-11-16
WO2004081205A1 (en) 2004-09-23
AU2003901099A0 (en) 2003-03-27
WO2004081205A8 (en) 2004-10-28
CA2518508A1 (en) 2004-09-23

Similar Documents

Publication Publication Date Title
GB2415437A (en) Differentiation of human embryonic stem cells to cardiomyocytes
GB2394958A (en) Methods of inducing differentiation of stem cells
NZ520338A (en) Method of producing an undifferentiated avian cell culture using avian primordial germ cells
CA2442135A1 (en) Methods to culture circovirus
EP2471903A3 (en) Placental stem cell populations
DK1975243T3 (da) BODIPY-aminoacetaldehyddiethylacetal
WO2002052436A3 (en) Method and system for automatically updating contact information within a database
DE69734936D1 (de) Wirtszellen und methoden für die produktion von proteinen
TW200519208A (en) Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
ZA200510144B (en) Method for producing L-Lysine or L-Threonine using escherichia bacteria having attenuated malic enzyme acitivity
AU2003285172A1 (en) Human embryonic stem cell cultures, and compositions and methods for growing same
ATE414782T1 (de) Verfahren zur herstellung von polypeptiden in mutierten aspergillus zellen
WO2003008535A3 (en) Methods of generating human cardiac cells and tissues and uses thereof
EP2357478A3 (en) Diagnosis of disease
WO2003083089A3 (en) Tolerogenic antigen-presenting cells
AU2002336930A1 (en) Method for producing isolated cell cultures, culture medium for cultivating cell cultures and cell culture
WO2003080816A3 (en) Stem cell culture
WO2006017134A3 (en) Preprimitive streak and mesendoderm cells
WO2004031343A3 (en) Human foreskin cells suitable for culturing stem cells
AU2002224851A1 (en) Generation and use of dendritic cells
WO2003064630A3 (en) Cell culture medium
MY141859A (en) Method for producing gamma-carboxylated proteins
WO1999040180A3 (en) Expanded and genetically modified populations of human hematopoietic stem cells
EP1795594A3 (en) Method of evaluating the function of phagocyte and utilization thereof
CA2365626A1 (en) High production method of prenyl alcohol by microorganisms

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)