CA2518508A1 - Differentiation of human embryonic stem cells to cardiomyocytes - Google Patents

Differentiation of human embryonic stem cells to cardiomyocytes Download PDF

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Publication number
CA2518508A1
CA2518508A1 CA002518508A CA2518508A CA2518508A1 CA 2518508 A1 CA2518508 A1 CA 2518508A1 CA 002518508 A CA002518508 A CA 002518508A CA 2518508 A CA2518508 A CA 2518508A CA 2518508 A1 CA2518508 A1 CA 2518508A1
Authority
CA
Canada
Prior art keywords
cell
cardiomyocyte
cells
differentiated
hes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002518508A
Other languages
English (en)
French (fr)
Inventor
Christine Lindsay Mummery
Petrus Adrianus Frederik Maria Doevendans
Leon Gerardus Joseph Tertoolen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NETHERLANDS INSTITUUT VOOR ONTWIKKELINGSBIOLOGIE
ES Cell International Pte Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2518508A1 publication Critical patent/CA2518508A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002518508A 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes Abandoned CA2518508A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2003901099 2003-03-11
AU2003901099A AU2003901099A0 (en) 2003-03-11 2003-03-11 Methods of inducing differentiation of stem cells
PCT/AU2004/000302 WO2004081205A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Publications (1)

Publication Number Publication Date
CA2518508A1 true CA2518508A1 (en) 2004-09-23

Family

ID=31500143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002518508A Abandoned CA2518508A1 (en) 2003-03-11 2004-03-11 Differentiation of human embryonic stem cells to cardiomyocytes

Country Status (7)

Country Link
US (1) US20070161107A1 (enExample)
EP (1) EP1608740A4 (enExample)
JP (1) JP2006523091A (enExample)
AU (1) AU2003901099A0 (enExample)
CA (1) CA2518508A1 (enExample)
GB (1) GB2415437A (enExample)
WO (1) WO2004081205A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023035479A1 (zh) * 2021-09-07 2023-03-16 北京中医药大学 中药复合物、中药有效组分组合物、化合物及其应用

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
GB2393734B (en) 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
CA2569242A1 (en) * 2004-06-01 2005-12-15 Es Cell International Pte Ltd Improved cardiomyocyte differentiation
CN101228264B (zh) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 使灵长类多能干细胞分化成心肌细胞系细胞
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
CN101864392B (zh) 2005-12-13 2016-03-23 国立大学法人京都大学 核重新编程因子
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
EP2099290A4 (en) * 2006-12-07 2010-01-13 Teva Pharma PROCESS FOR GENERATING AND EXPANDING PROGENITOR CELLS OF TISSUES AND TISSUE CELLS MILLED FROM INTACT BONE MARROW OR UMBILICAL INTACT CORD TISSUE
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2009036220A2 (en) * 2007-09-12 2009-03-19 The Regents Of The University Of California Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
JP5558097B2 (ja) 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
CN105400735A (zh) 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
CN101855350B (zh) 2008-05-02 2014-12-31 国立大学法人京都大学 核重编程序方法
EP2345714B1 (en) * 2008-10-24 2018-09-12 Kuraray Co., Ltd. Cell storage method and use thereof for cell transport
JP6093110B2 (ja) 2008-12-17 2017-03-08 ザ スクリプス リサーチ インスティテュート 幹細胞の作製と維持
US20120107930A1 (en) 2009-05-22 2012-05-03 Daisuke Sasaki Method for inducing differentiation of embryonic stem cells or artificial pluripotent stem cells
US9005968B2 (en) 2009-10-16 2015-04-14 The Scripps Research Institute Induction of pluripotent cells
EP2553086B1 (en) 2010-03-31 2017-04-19 The Scripps Research Institute Reprogramming cells
AU2010355614B2 (en) * 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
EP3399026B1 (en) * 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
AU2011349446C1 (en) 2010-12-22 2016-01-21 Fate Therapauetics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
WO2013033213A1 (en) 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
EP2891712B1 (en) 2012-07-23 2026-01-28 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro
WO2014116874A1 (en) 2013-01-23 2014-07-31 Ronald Li Engineered physical alignment of stem cell-derived cardiomyocytes
JPWO2015025958A1 (ja) * 2013-08-23 2017-03-02 国立大学法人大阪大学 ペースメーカー組織片の製造方法
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
SG11201606934SA (en) 2014-03-04 2016-09-29 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
CA3001917A1 (en) 2015-10-16 2017-04-20 Fate Therapeutics, Inc. Platform for the induction & maintenance of ground state pluripotency
WO2024162286A1 (ja) 2023-01-31 2024-08-08 富士フイルム株式会社 薬剤の評価方法、試薬およびキット

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5479661B2 (ja) * 2001-07-24 2014-04-23 イーエス・セル・インターナショナル・ピーティーイー・リミテッド 幹細胞の分化を誘導する方法
US7611852B2 (en) * 2002-07-26 2009-11-03 Wisconsin Alumni Research Foundation Functional cardiomyocytes from human embryonic stem cells
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023035479A1 (zh) * 2021-09-07 2023-03-16 北京中医药大学 中药复合物、中药有效组分组合物、化合物及其应用
US12194063B2 (en) 2021-09-07 2025-01-14 Beijing University Of Chinese Medicine Traditional Chinese medicine mixture and traditional Chinese medicine effective ingredient compound with function of promoting directional differentiation of stem cells into cardiomyocytes, and applications thereof

Also Published As

Publication number Publication date
WO2004081205A8 (en) 2004-10-28
EP1608740A1 (en) 2005-12-28
US20070161107A1 (en) 2007-07-12
AU2003901099A0 (en) 2003-03-27
WO2004081205A1 (en) 2004-09-23
JP2006523091A (ja) 2006-10-12
EP1608740A4 (en) 2007-05-09
GB2415437A (en) 2005-12-28
GB0520673D0 (en) 2005-11-16

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FZDE Discontinued