BR0312764A - Cardiomiócitos funcionais originados de células-tronco embrionárias humanas - Google Patents
Cardiomiócitos funcionais originados de células-tronco embrionárias humanasInfo
- Publication number
- BR0312764A BR0312764A BR0312764-8A BR0312764A BR0312764A BR 0312764 A BR0312764 A BR 0312764A BR 0312764 A BR0312764 A BR 0312764A BR 0312764 A BR0312764 A BR 0312764A
- Authority
- BR
- Brazil
- Prior art keywords
- stem cells
- embryonic stem
- cardiomyocytes
- human embryonic
- human
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"CARDIOMIóCITOS FUNCIONAIS ORIGINADOS DE CéLULAS-TRONCO EMBRIONáRIAS HUMANAS". Células-tronco embrionárias humanas formam corpos embrióides em cultura que contêm células humanas diferenciadas. Algumas das células humanas em corpos embrióides se diferenciam em cardiomiócitos. Aqui, as características biológicas e elétricas desses cardiomiócitos são descritas com referência ao uso de cardiomiócitos derivados de células-tronco embrionárias humanas em protocolos de classificação de medicamentos para mecanismos de toxicidade cardíaca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39933002P | 2002-07-26 | 2002-07-26 | |
PCT/US2003/023174 WO2004011603A2 (en) | 2002-07-26 | 2003-07-25 | Functional cardiomyocytes from human embryonic stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312764A true BR0312764A (pt) | 2005-07-26 |
Family
ID=31188569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0312764-8A BR0312764A (pt) | 2002-07-26 | 2003-07-25 | Cardiomiócitos funcionais originados de células-tronco embrionárias humanas |
Country Status (14)
Country | Link |
---|---|
US (1) | US7611852B2 (pt) |
EP (1) | EP1551991A4 (pt) |
JP (1) | JP2005533518A (pt) |
KR (1) | KR20050026008A (pt) |
CN (1) | CN1671860A (pt) |
AU (1) | AU2003252155B2 (pt) |
BR (1) | BR0312764A (pt) |
CA (1) | CA2493588C (pt) |
IL (1) | IL165943A0 (pt) |
IS (1) | IS7663A (pt) |
MX (1) | MXPA05000283A (pt) |
NO (1) | NO20051030L (pt) |
NZ (1) | NZ537245A (pt) |
WO (1) | WO2004011603A2 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2458575C (en) * | 2001-08-24 | 2014-07-08 | Advanced Cell Technology, Inc. | Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy |
WO2005047482A2 (en) | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
US9709548B2 (en) | 2008-05-05 | 2017-07-18 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US9612234B2 (en) | 2008-05-05 | 2017-04-04 | Acea Biosciences, Inc. | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments |
AU2003901099A0 (en) * | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
DK1740945T3 (en) | 2004-04-07 | 2019-01-21 | Ncardia Ag | KKE-INVASIVE, IN-VITRO FUNCTIONAL TISSUE TEST SYSTEMS |
JP4814875B2 (ja) | 2004-05-11 | 2011-11-16 | アキシオジェネシス エージー | invitro分化細胞に基づく薬物発見のための検定 |
US20050277124A1 (en) * | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
US20100150887A1 (en) * | 2007-01-25 | 2010-06-17 | Duff Henry J | Tissue Progenitor Cells That Overexpress ERG |
EP2139988A1 (en) * | 2007-03-15 | 2010-01-06 | California Stem Cell, Inc. | Cardiomyocytes and methods of producing and purifying cardiomyocytes |
JP5786146B2 (ja) * | 2007-06-08 | 2015-09-30 | 安田 賢二 | モデル細胞チップ、モデル細胞チップによる薬効評価装置、および薬効評価方法 |
US8603817B2 (en) | 2008-11-03 | 2013-12-10 | University Of Washington | Induction of human embryonic stem cell derived cardiac pacemaker or chamber-type cardiomyocytes by manipulation of neuregulin signaling |
EP2218772A1 (en) | 2009-02-09 | 2010-08-18 | Koninklijke Philips Electronics N.V. | Cardiomyocytes-containing device and method for manufacturing the same |
WO2010094694A1 (en) * | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Assays to predict cardiotoxicity |
JP2013531497A (ja) * | 2010-06-13 | 2013-08-08 | インスティチュート・オブ・バイオフィジックス,チャイニーズ・アカデミー・オブ・サイエンシズ | 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用 |
WO2012017343A2 (en) | 2010-08-05 | 2012-02-09 | Koninklijke Philips Electronics N.V. | Cardiomyocyte containing device, manufacturing method and measuring method |
KR101364965B1 (ko) * | 2010-10-06 | 2014-02-18 | (주)차바이오앤디오스텍 | 인간 배아줄기세포 유래 심근세포의 배양 및 정제 방법 |
JP6133210B2 (ja) * | 2010-10-29 | 2017-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 不整脈のリスクを判定する方法 |
US9155765B2 (en) | 2011-07-05 | 2015-10-13 | Baylor Research Institute | Establishment of patient- or person-specific cardiac myocyte cell lines from human induced pluripotent stem cells (iPSCs) |
US9395354B2 (en) | 2011-07-21 | 2016-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof |
CN104237308B (zh) * | 2013-06-09 | 2016-08-31 | 国家纳米科学中心 | 一种在体外筛选药物的方法 |
US9983198B2 (en) | 2015-03-19 | 2018-05-29 | Axion Biosystems, Inc. | Systems and methods for assessing data collected from an electrically active cell culture |
US11674952B2 (en) | 2016-02-24 | 2023-06-13 | The Rockefeller University | Embryonic cell-based therapeutic candidate screening systems, models for Huntington's Disease and uses thereof |
CN110582569B (zh) * | 2017-03-03 | 2024-04-02 | 安捷伦科技有限公司 | 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统 |
USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4441327C1 (de) * | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung |
DE19727962A1 (de) | 1997-07-02 | 1999-01-14 | Juergen Hescheler | Fluoreszierende Proteine als zelltypspezifische Reporter |
DE19843234A1 (de) | 1998-09-09 | 2000-03-23 | Inst Pflanzengenetik & Kultur | Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen |
AU2002354893A1 (en) * | 2001-07-20 | 2003-03-03 | Technion Research And Development Foundation Ltd. | Methods of generating human cardiac cells and tissues and uses thereof |
AU2003220562A1 (en) | 2002-04-01 | 2003-10-20 | Peter K. Law | Cellular transplantation for heart regeneration |
-
2003
- 2003-07-25 US US10/627,245 patent/US7611852B2/en active Active
- 2003-07-25 KR KR1020057001457A patent/KR20050026008A/ko not_active Application Discontinuation
- 2003-07-25 CN CNA038179032A patent/CN1671860A/zh active Pending
- 2003-07-25 NZ NZ537245A patent/NZ537245A/en not_active IP Right Cessation
- 2003-07-25 BR BR0312764-8A patent/BR0312764A/pt not_active Application Discontinuation
- 2003-07-25 CA CA2493588A patent/CA2493588C/en not_active Expired - Lifetime
- 2003-07-25 AU AU2003252155A patent/AU2003252155B2/en not_active Expired
- 2003-07-25 EP EP03771801A patent/EP1551991A4/en not_active Withdrawn
- 2003-07-25 WO PCT/US2003/023174 patent/WO2004011603A2/en active Application Filing
- 2003-07-25 MX MXPA05000283A patent/MXPA05000283A/es unknown
- 2003-07-25 JP JP2004524781A patent/JP2005533518A/ja active Pending
-
2004
- 2004-12-22 IL IL16594304A patent/IL165943A0/xx active IP Right Grant
-
2005
- 2005-01-25 IS IS7663A patent/IS7663A/is unknown
- 2005-02-25 NO NO20051030A patent/NO20051030L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1551991A4 (en) | 2006-09-20 |
CA2493588A1 (en) | 2004-02-05 |
AU2003252155A1 (en) | 2004-02-16 |
US20040106095A1 (en) | 2004-06-03 |
WO2004011603A3 (en) | 2004-07-08 |
EP1551991A2 (en) | 2005-07-13 |
US7611852B2 (en) | 2009-11-03 |
KR20050026008A (ko) | 2005-03-14 |
JP2005533518A (ja) | 2005-11-10 |
CA2493588C (en) | 2012-09-11 |
NZ537245A (en) | 2010-04-30 |
MXPA05000283A (es) | 2005-03-31 |
IS7663A (is) | 2005-01-25 |
CN1671860A (zh) | 2005-09-21 |
NO20051030L (no) | 2005-04-07 |
IL165943A0 (en) | 2006-01-15 |
AU2003252155B2 (en) | 2009-01-22 |
WO2004011603A2 (en) | 2004-02-05 |
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Legal Events
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |