JP2006523091A5 - - Google Patents
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- Publication number
- JP2006523091A5 JP2006523091A5 JP2006503961A JP2006503961A JP2006523091A5 JP 2006523091 A5 JP2006523091 A5 JP 2006523091A5 JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006523091 A5 JP2006523091 A5 JP 2006523091A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- population
- ventricular
- differentiated
- cardiomyocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 50
- 210000004413 cardiac myocyte Anatomy 0.000 claims 31
- 238000000034 method Methods 0.000 claims 29
- 230000002861 ventricular Effects 0.000 claims 21
- 230000009278 visceral effect Effects 0.000 claims 15
- 241001465754 Metazoa Species 0.000 claims 10
- 210000004039 endoderm cell Anatomy 0.000 claims 10
- 238000002054 transplantation Methods 0.000 claims 10
- 230000004069 differentiation Effects 0.000 claims 6
- 230000006870 function Effects 0.000 claims 6
- 230000004217 heart function Effects 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000013553 cell monolayer Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 210000003494 hepatocyte Anatomy 0.000 claims 3
- 238000010171 animal model Methods 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 210000001900 endoderm Anatomy 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 210000005003 heart tissue Anatomy 0.000 claims 2
- 210000001308 heart ventricle Anatomy 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 108090000862 Ion Channels Proteins 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000002057 chronotropic effect Effects 0.000 claims 1
- 230000008828 contractile function Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 230000007045 gastrulation Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003901099A AU2003901099A0 (en) | 2003-03-11 | 2003-03-11 | Methods of inducing differentiation of stem cells |
| PCT/AU2004/000302 WO2004081205A1 (en) | 2003-03-11 | 2004-03-11 | Differentiation of human embryonic stem cells to cardiomyocytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523091A JP2006523091A (ja) | 2006-10-12 |
| JP2006523091A5 true JP2006523091A5 (enExample) | 2007-05-24 |
Family
ID=31500143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503961A Pending JP2006523091A (ja) | 2003-03-11 | 2004-03-11 | ヒト胚性幹細胞の心筋細胞への分化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070161107A1 (enExample) |
| EP (1) | EP1608740A4 (enExample) |
| JP (1) | JP2006523091A (enExample) |
| AU (1) | AU2003901099A0 (enExample) |
| CA (1) | CA2518508A1 (enExample) |
| GB (1) | GB2415437A (enExample) |
| WO (1) | WO2004081205A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1412479A4 (en) | 2001-07-12 | 2004-07-28 | Geron Corp | CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS |
| US7732199B2 (en) | 2001-07-12 | 2010-06-08 | Geron Corporation | Process for making transplantable cardiomyocytes from human embryonic stem cells |
| US7452718B2 (en) | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| EP1756268A4 (en) * | 2004-06-01 | 2007-12-12 | Es Cell Int Pte Ltd | IMPROVED CARDIOMYOCYTE DIFFERENTIATION |
| KR20130099253A (ko) | 2005-06-22 | 2013-09-05 | 제론 코포레이션 | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
| EP2206724A1 (en) | 2005-12-13 | 2010-07-14 | Kyoto University | Nuclear reprogramming factor |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| KR20090086260A (ko) * | 2006-12-07 | 2009-08-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 미손상 골수 또는 미손상 제대 조직으로부터 조직 전구체 세포 및 성숙 조직 세포를 형성 및 증식시키는 방법 |
| US20080300642A1 (en) * | 2007-05-30 | 2008-12-04 | Japan As Represented By President Of National Cardiovascular Center | Regeneration treatment apparatus, operating method thereof, and regeneration treatment method |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| EP2198010A4 (en) * | 2007-09-12 | 2010-10-06 | Univ California | COMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFECTIVENESS OF STEM CELLS OF DERIVED HEART MUSCLES |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| CN101939418A (zh) | 2008-01-30 | 2011-01-05 | 杰龙公司 | 用于培养干细胞衍生的心肌细胞的合成表面 |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP5346925B2 (ja) | 2008-05-02 | 2013-11-20 | 国立大学法人京都大学 | 核初期化方法 |
| US20110207215A1 (en) * | 2008-10-24 | 2011-08-25 | Kuraray Co., Ltd. | Cell storage method and cell transport method |
| SG172160A1 (en) | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
| JPWO2010134606A1 (ja) | 2009-05-22 | 2012-11-12 | 学校法人東京女子医科大学 | 胚性幹細胞或いは人工多能性幹細胞の分化誘導方法 |
| MX389666B (es) | 2009-10-16 | 2025-03-19 | Scripps Research Inst | Induccion de celulas pluripotentes. |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| AU2010355614B2 (en) | 2010-06-13 | 2015-07-02 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
| WO2011159726A2 (en) * | 2010-06-14 | 2011-12-22 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
| CA2886396C (en) | 2012-07-23 | 2023-08-22 | Institute Of Biophysics, Chinese Academy Of Sciences | Method for inducing pluripotent stem cells to differentiate into ventricular cardiomyocytes in vitro |
| JP2016505276A (ja) | 2013-01-23 | 2016-02-25 | リー、ロナルドLI, Ronald | 幹細胞由来心筋細胞の操作された物理的アライメント |
| JPWO2015025958A1 (ja) * | 2013-08-23 | 2017-03-02 | 国立大学法人大阪大学 | ペースメーカー組織片の製造方法 |
| US10087436B2 (en) | 2014-02-06 | 2018-10-02 | The Regents Of The University Of California | Electrophysiologically mature cardiomyocytes and methods for making same |
| CN120536341A (zh) | 2014-03-04 | 2025-08-26 | 菲特治疗公司 | 改良的重编程方法和细胞培养平台 |
| CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
| CN113662985B (zh) | 2021-09-07 | 2022-06-24 | 北京中医药大学 | 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用 |
| AU2024213547A1 (en) | 2023-01-31 | 2025-08-14 | Fujifilm Corporation | Drug evaluation method, reagent and kit |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452256A1 (en) * | 2001-07-24 | 2003-02-06 | Es Cell International Pte Ltd | Methods of inducing differentiation of stem cells |
| JP2005533518A (ja) * | 2002-07-26 | 2005-11-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ヒト胚幹細胞由来の機能性心筋細胞 |
| WO2005054448A1 (en) * | 2003-12-04 | 2005-06-16 | Guhathakurta Dr Soma | A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells |
-
2003
- 2003-03-11 AU AU2003901099A patent/AU2003901099A0/en not_active Abandoned
-
2004
- 2004-03-11 US US10/548,501 patent/US20070161107A1/en not_active Abandoned
- 2004-03-11 JP JP2006503961A patent/JP2006523091A/ja active Pending
- 2004-03-11 WO PCT/AU2004/000302 patent/WO2004081205A1/en not_active Ceased
- 2004-03-11 EP EP04719333A patent/EP1608740A4/en not_active Withdrawn
- 2004-03-11 GB GB0520673A patent/GB2415437A/en not_active Withdrawn
- 2004-03-11 CA CA002518508A patent/CA2518508A1/en not_active Abandoned
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