JP2006523091A5 - - Google Patents
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- Publication number
- JP2006523091A5 JP2006523091A5 JP2006503961A JP2006503961A JP2006523091A5 JP 2006523091 A5 JP2006523091 A5 JP 2006523091A5 JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006503961 A JP2006503961 A JP 2006503961A JP 2006523091 A5 JP2006523091 A5 JP 2006523091A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- population
- ventricular
- differentiated
- cardiomyocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 50
- 210000004413 cardiac myocyte Anatomy 0.000 claims 31
- 238000000034 method Methods 0.000 claims 29
- 230000002861 ventricular Effects 0.000 claims 21
- 230000009278 visceral effect Effects 0.000 claims 15
- 241001465754 Metazoa Species 0.000 claims 10
- 210000004039 endoderm cell Anatomy 0.000 claims 10
- 238000002054 transplantation Methods 0.000 claims 10
- 230000004069 differentiation Effects 0.000 claims 6
- 230000006870 function Effects 0.000 claims 6
- 230000004217 heart function Effects 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000013553 cell monolayer Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 210000003494 hepatocyte Anatomy 0.000 claims 3
- 238000010171 animal model Methods 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 210000001900 endoderm Anatomy 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 210000005003 heart tissue Anatomy 0.000 claims 2
- 210000001308 heart ventricle Anatomy 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 108090000862 Ion Channels Proteins 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000002057 chronotropic effect Effects 0.000 claims 1
- 230000008828 contractile function Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 230000007045 gastrulation Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003901099A AU2003901099A0 (en) | 2003-03-11 | 2003-03-11 | Methods of inducing differentiation of stem cells |
| PCT/AU2004/000302 WO2004081205A1 (en) | 2003-03-11 | 2004-03-11 | Differentiation of human embryonic stem cells to cardiomyocytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523091A JP2006523091A (ja) | 2006-10-12 |
| JP2006523091A5 true JP2006523091A5 (enExample) | 2007-05-24 |
Family
ID=31500143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503961A Pending JP2006523091A (ja) | 2003-03-11 | 2004-03-11 | ヒト胚性幹細胞の心筋細胞への分化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070161107A1 (enExample) |
| EP (1) | EP1608740A4 (enExample) |
| JP (1) | JP2006523091A (enExample) |
| AU (1) | AU2003901099A0 (enExample) |
| CA (1) | CA2518508A1 (enExample) |
| GB (1) | GB2415437A (enExample) |
| WO (1) | WO2004081205A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732199B2 (en) | 2001-07-12 | 2010-06-08 | Geron Corporation | Process for making transplantable cardiomyocytes from human embryonic stem cells |
| GB2393734B (en) | 2001-07-12 | 2005-07-27 | Geron Corp | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| US7452718B2 (en) | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| CA2569242A1 (en) * | 2004-06-01 | 2005-12-15 | Es Cell International Pte Ltd | Improved cardiomyocyte differentiation |
| CN101228264B (zh) | 2005-06-22 | 2017-12-26 | 阿斯特利亚斯生物治疗股份公司 | 使灵长类多能干细胞分化成心肌细胞系细胞 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| CN101864392B (zh) | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP2099290A4 (en) * | 2006-12-07 | 2010-01-13 | Teva Pharma | PROCESS FOR GENERATING AND EXPANDING PROGENITOR CELLS OF TISSUES AND TISSUE CELLS MILLED FROM INTACT BONE MARROW OR UMBILICAL INTACT CORD TISSUE |
| US20080300642A1 (en) * | 2007-05-30 | 2008-12-04 | Japan As Represented By President Of National Cardiovascular Center | Regeneration treatment apparatus, operating method thereof, and regeneration treatment method |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| WO2009036220A2 (en) * | 2007-09-12 | 2009-03-19 | The Regents Of The University Of California | Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| JP5558097B2 (ja) | 2007-12-10 | 2014-07-23 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| CN105400735A (zh) | 2008-01-30 | 2016-03-16 | 阿斯特利亚斯生物治疗股份公司 | 用于培养干细胞衍生的心肌细胞的合成表面 |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| CN101855350B (zh) | 2008-05-02 | 2014-12-31 | 国立大学法人京都大学 | 核重编程序方法 |
| EP2345714B1 (en) * | 2008-10-24 | 2018-09-12 | Kuraray Co., Ltd. | Cell storage method and use thereof for cell transport |
| JP6093110B2 (ja) | 2008-12-17 | 2017-03-08 | ザ スクリプス リサーチ インスティテュート | 幹細胞の作製と維持 |
| US20120107930A1 (en) | 2009-05-22 | 2012-05-03 | Daisuke Sasaki | Method for inducing differentiation of embryonic stem cells or artificial pluripotent stem cells |
| US9005968B2 (en) | 2009-10-16 | 2015-04-14 | The Scripps Research Institute | Induction of pluripotent cells |
| EP2553086B1 (en) | 2010-03-31 | 2017-04-19 | The Scripps Research Institute | Reprogramming cells |
| AU2010355614B2 (en) * | 2010-06-13 | 2015-07-02 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
| EP3399026B1 (en) * | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| AU2011349446C1 (en) | 2010-12-22 | 2016-01-21 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| WO2013033213A1 (en) | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| EP2891712B1 (en) | 2012-07-23 | 2026-01-28 | Institute Of Biophysics, Chinese Academy Of Sciences | Method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro |
| WO2014116874A1 (en) | 2013-01-23 | 2014-07-31 | Ronald Li | Engineered physical alignment of stem cell-derived cardiomyocytes |
| JPWO2015025958A1 (ja) * | 2013-08-23 | 2017-03-02 | 国立大学法人大阪大学 | ペースメーカー組織片の製造方法 |
| US10087436B2 (en) | 2014-02-06 | 2018-10-02 | The Regents Of The University Of California | Electrophysiologically mature cardiomyocytes and methods for making same |
| SG11201606934SA (en) | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| CA3001917A1 (en) | 2015-10-16 | 2017-04-20 | Fate Therapeutics, Inc. | Platform for the induction & maintenance of ground state pluripotency |
| CN113662985B (zh) * | 2021-09-07 | 2022-06-24 | 北京中医药大学 | 具有促进干细胞定向分化为心肌细胞作用的中药组合物、中药有效组分组合物及其应用 |
| WO2024162286A1 (ja) | 2023-01-31 | 2024-08-08 | 富士フイルム株式会社 | 薬剤の評価方法、試薬およびキット |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5479661B2 (ja) * | 2001-07-24 | 2014-04-23 | イーエス・セル・インターナショナル・ピーティーイー・リミテッド | 幹細胞の分化を誘導する方法 |
| US7611852B2 (en) * | 2002-07-26 | 2009-11-03 | Wisconsin Alumni Research Foundation | Functional cardiomyocytes from human embryonic stem cells |
| WO2005054448A1 (en) * | 2003-12-04 | 2005-06-16 | Guhathakurta Dr Soma | A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells |
-
2003
- 2003-03-11 AU AU2003901099A patent/AU2003901099A0/en not_active Abandoned
-
2004
- 2004-03-11 GB GB0520673A patent/GB2415437A/en not_active Withdrawn
- 2004-03-11 US US10/548,501 patent/US20070161107A1/en not_active Abandoned
- 2004-03-11 WO PCT/AU2004/000302 patent/WO2004081205A1/en not_active Ceased
- 2004-03-11 EP EP04719333A patent/EP1608740A4/en not_active Withdrawn
- 2004-03-11 CA CA002518508A patent/CA2518508A1/en not_active Abandoned
- 2004-03-11 JP JP2006503961A patent/JP2006523091A/ja active Pending
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