JP2007514434A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007514434A5 JP2007514434A5 JP2006544560A JP2006544560A JP2007514434A5 JP 2007514434 A5 JP2007514434 A5 JP 2007514434A5 JP 2006544560 A JP2006544560 A JP 2006544560A JP 2006544560 A JP2006544560 A JP 2006544560A JP 2007514434 A5 JP2007514434 A5 JP 2007514434A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell population
- stem cell
- stem
- angiopoietin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 85
- 210000000130 stem cell Anatomy 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 32
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 24
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 24
- 210000001519 tissue Anatomy 0.000 claims description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 7
- 210000004039 endoderm cell Anatomy 0.000 claims description 7
- 230000001464 adherent effect Effects 0.000 claims description 6
- 210000004504 adult stem cell Anatomy 0.000 claims description 6
- 210000001705 ectoderm cell Anatomy 0.000 claims description 6
- 230000001605 fetal effect Effects 0.000 claims description 6
- 210000001704 mesoblast Anatomy 0.000 claims description 6
- 210000004185 liver Anatomy 0.000 claims description 5
- 210000003981 ectoderm Anatomy 0.000 claims description 4
- 210000001900 endoderm Anatomy 0.000 claims description 4
- 210000004700 fetal blood Anatomy 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 230000003394 haemopoietic effect Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 2
- 241000283984 Rodentia Species 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 238000005138 cryopreservation Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000003494 hepatocyte Anatomy 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 5
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 4
- 108090001061 Insulin Proteins 0.000 claims 4
- 210000000981 epithelium Anatomy 0.000 claims 4
- 229940125396 insulin Drugs 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- 102000009088 Angiopoietin-1 Human genes 0.000 claims 3
- 108010048154 Angiopoietin-1 Proteins 0.000 claims 3
- 102000009075 Angiopoietin-2 Human genes 0.000 claims 3
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 3
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 3
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 claims 3
- 108010066327 Keratin-18 Proteins 0.000 claims 3
- 102100034434 Nebulin Human genes 0.000 claims 3
- 101150044441 PECAM1 gene Proteins 0.000 claims 3
- 101150045640 VWF gene Proteins 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 108010054130 nebulin Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 210000000496 pancreas Anatomy 0.000 claims 3
- XQTLDIFVVHJORV-UHFFFAOYSA-N tecnazene Chemical compound [O-][N+](=O)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl XQTLDIFVVHJORV-UHFFFAOYSA-N 0.000 claims 3
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000009094 Hepatocyte Nuclear Factor 3-beta Human genes 0.000 claims 2
- 108010087745 Hepatocyte Nuclear Factor 3-beta Proteins 0.000 claims 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 2
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 2
- 101001051093 Homo sapiens Low-density lipoprotein receptor Proteins 0.000 claims 2
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 claims 2
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 2
- 101100452019 Mus musculus Icam2 gene Proteins 0.000 claims 2
- 102100038553 Neurogenin-3 Human genes 0.000 claims 2
- 101100519293 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pdx-1 gene Proteins 0.000 claims 2
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims 2
- 108010032788 PAX6 Transcription Factor Proteins 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 108090001027 Troponin Proteins 0.000 claims 2
- 102000004903 Troponin Human genes 0.000 claims 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 2
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 210000002449 bone cell Anatomy 0.000 claims 2
- 210000004413 cardiac myocyte Anatomy 0.000 claims 2
- 210000003890 endocrine cell Anatomy 0.000 claims 2
- 230000000762 glandular Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000003292 kidney cell Anatomy 0.000 claims 2
- 210000005265 lung cell Anatomy 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 210000002363 skeletal muscle cell Anatomy 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000007675 toxicity by organ Effects 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- 230000014616 translation Effects 0.000 claims 2
- 102100036537 von Willebrand factor Human genes 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101710081722 Antitrypsin Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000001045 Connexin 43 Human genes 0.000 claims 1
- 108010069241 Connexin 43 Proteins 0.000 claims 1
- 101100480530 Danio rerio tal1 gene Proteins 0.000 claims 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 1
- 102100036912 Desmin Human genes 0.000 claims 1
- 108010044052 Desmin Proteins 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 101000851357 Homo sapiens Troponin T, slow skeletal muscle Proteins 0.000 claims 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 1
- 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 claims 1
- 101100013973 Mus musculus Gata4 gene Proteins 0.000 claims 1
- 101100480538 Mus musculus Tal1 gene Proteins 0.000 claims 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 1
- 102000008730 Nestin Human genes 0.000 claims 1
- 108010088225 Nestin Proteins 0.000 claims 1
- 101100312945 Pasteurella multocida (strain Pm70) talA gene Proteins 0.000 claims 1
- 101710150336 Protein Rex Proteins 0.000 claims 1
- 101150052863 THY1 gene Proteins 0.000 claims 1
- 102100036860 Troponin T, slow skeletal muscle Human genes 0.000 claims 1
- 102000008790 VE-cadherin Human genes 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 102000013127 Vimentin Human genes 0.000 claims 1
- 108010065472 Vimentin Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000001475 anti-trypsic effect Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000000133 brain stem Anatomy 0.000 claims 1
- 108010018828 cadherin 5 Proteins 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000005045 desmin Anatomy 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 210000005055 nestin Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 210000004248 oligodendroglia Anatomy 0.000 claims 1
- 230000033667 organ regeneration Effects 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 210000005048 vimentin Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 description 17
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 6
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 239000012981 Hank's balanced salt solution Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 101000691214 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 50S ribosomal protein L44e Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000005980 beta thalassemia Diseases 0.000 description 1
- 208000022806 beta-thalassemia major Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 231100000722 genetic damage Toxicity 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 210000003716 mesoderm Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0329449.3A GB0329449D0 (en) | 2003-12-19 | 2003-12-19 | Stem cells |
| PCT/GB2004/005365 WO2005059113A1 (en) | 2003-12-19 | 2004-12-20 | Stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185019A Division JP2013039128A (ja) | 2003-12-19 | 2012-08-24 | 幹細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514434A JP2007514434A (ja) | 2007-06-07 |
| JP2007514434A5 true JP2007514434A5 (enExample) | 2012-10-11 |
Family
ID=30776110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544560A Pending JP2007514434A (ja) | 2003-12-19 | 2004-12-20 | 幹細胞 |
| JP2012185019A Pending JP2013039128A (ja) | 2003-12-19 | 2012-08-24 | 幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185019A Pending JP2013039128A (ja) | 2003-12-19 | 2012-08-24 | 幹細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20070274970A1 (enExample) |
| EP (1) | EP1697500B1 (enExample) |
| JP (2) | JP2007514434A (enExample) |
| KR (1) | KR20070004574A (enExample) |
| CN (1) | CN1918284B (enExample) |
| AU (1) | AU2004299718A1 (enExample) |
| BR (1) | BRPI0417194A (enExample) |
| CA (1) | CA2549930C (enExample) |
| EA (1) | EA200601187A1 (enExample) |
| GB (1) | GB0329449D0 (enExample) |
| MX (1) | MXPA06006706A (enExample) |
| WO (1) | WO2005059113A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2532909T3 (es) | 2004-07-30 | 2015-04-01 | Mayo Foundation For Medical Education And Research | Tratamiento de tejido cardiovascular |
| EP1791952A4 (en) * | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| GB0509500D0 (en) * | 2005-05-10 | 2005-06-15 | Revealcyte | Method of fetal cell enrichment |
| WO2008003042A2 (en) * | 2006-06-28 | 2008-01-03 | The University Of Medicine And Dentistry Of New Jersey | Amnion-derived stem cells and uses thereof |
| US9765298B2 (en) | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| US8739148B2 (en) * | 2007-02-09 | 2014-05-27 | Elster Electricity, Llc | Automated meter reading system |
| US20100184221A1 (en) * | 2007-07-13 | 2010-07-22 | Seiichi YOKOO | Method for isolation of cell, serum-free culture medium for cell, and method for culture of cell |
| ES2325715B1 (es) * | 2007-08-03 | 2010-06-17 | Genetrix, S.L. | Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca. |
| JP2009278873A (ja) * | 2008-05-19 | 2009-12-03 | Japan Health Science Foundation | 培地および培養方法 |
| WO2009145761A1 (en) * | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| CN101314767A (zh) * | 2008-07-03 | 2008-12-03 | 上海天生生物科技有限公司 | 增强胎肝造血干细胞cd34表达的培养液及其制备方法 |
| GB0818725D0 (en) * | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
| US20110305673A1 (en) * | 2008-11-12 | 2011-12-15 | The University Of Vermont And State Agriculture College | Compositions and methods for tissue repair |
| WO2010062999A1 (en) * | 2008-11-28 | 2010-06-03 | Stematix, Inc | Diabetes cell therapy |
| WO2010151782A1 (en) * | 2009-06-25 | 2010-12-29 | Geron Corporation | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
| JPWO2011102532A1 (ja) * | 2010-02-16 | 2013-06-17 | 国立大学法人九州大学 | 誘導肝細胞 |
| US8731261B2 (en) | 2010-02-23 | 2014-05-20 | Loma Linda University | Method of analyzing a medical image |
| WO2012046065A2 (en) | 2010-10-06 | 2012-04-12 | Omnicyte Limited | Culture method |
| US8916534B2 (en) | 2010-10-08 | 2014-12-23 | Mina Therapeutics Limited | Methods of inducing insulin production |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| EP3456828B1 (en) | 2011-06-21 | 2022-04-27 | MiNA Therapeutics Limited | Albumin production and cell proliferation |
| CN105144683B (zh) | 2013-02-28 | 2019-08-09 | 株式会社尼康 | 电子设备 |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| JP6734283B2 (ja) * | 2015-01-21 | 2020-08-05 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子治療用ポイントオブケア及び/又はポータブルプラットフォーム |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| BR112022018092A2 (pt) | 2020-03-11 | 2022-11-22 | Bit Bio Ltd | Método de gerar células hepáticas |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU665042B2 (en) * | 1991-11-05 | 1995-12-14 | Board Of Trustees Of The Leland Stanford Junior University | Suppressor and progenitor cells |
| SG86980A1 (en) * | 1992-11-16 | 2002-03-19 | Applied Immunesciences | Pluripotential quiescent stem cell population |
| ES2252932T3 (es) * | 1998-02-05 | 2006-05-16 | Novartis Ag | Poblaciones expandidas y geneticamente modificadas de celulas madre hematopoyeticas humanas. |
| CA2382383A1 (en) * | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| AU2001250966A1 (en) * | 2000-03-23 | 2001-10-03 | Stem Cells, Inc. | Pluripotential stem cells |
| CA2810249A1 (en) * | 2000-06-05 | 2001-12-13 | The Trustees Of Columbia University In The City Of New York | Identification and use of human bone marrow-derived endothelial progenitor cell to improve myocardial function after ischemic injury |
| US6930222B2 (en) * | 2000-08-22 | 2005-08-16 | The Scripps Research Institute | In vivo animal model of human leukemia |
| US7560280B2 (en) * | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
| CA2438501C (en) * | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| WO2002079457A1 (en) * | 2001-03-29 | 2002-10-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
| AU2002355580A1 (en) * | 2001-08-10 | 2003-02-24 | Imclone Systems Incorporated | Isolation and mobilization of stem cells expressing vegfr-1 |
| AU2002350352A1 (en) * | 2001-12-21 | 2003-07-15 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| US20040009589A1 (en) * | 2002-03-26 | 2004-01-15 | Shulamit Levenberg | Endothelial cells derived from human embryonic stem cells |
| JPWO2003080822A1 (ja) * | 2002-03-27 | 2005-07-28 | ニプロ株式会社 | 胎盤由来の間葉系細胞およびその医学的用途 |
| WO2004087896A2 (en) * | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| WO2006060779A2 (en) * | 2004-12-03 | 2006-06-08 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| WO2007149548A2 (en) * | 2006-06-22 | 2007-12-27 | Medistem Laboratories, Inc. | Treatment of erectile dysfunction by stem cell therapy |
| WO2008024996A2 (en) * | 2006-08-24 | 2008-02-28 | Johnstone Brian H | Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith |
| EP2578081B1 (en) * | 2006-10-11 | 2016-03-09 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
-
2003
- 2003-12-19 GB GBGB0329449.3A patent/GB0329449D0/en not_active Ceased
-
2004
- 2004-12-20 WO PCT/GB2004/005365 patent/WO2005059113A1/en not_active Ceased
- 2004-12-20 CN CN200480041764XA patent/CN1918284B/zh not_active Expired - Lifetime
- 2004-12-20 EP EP04806164A patent/EP1697500B1/en not_active Expired - Lifetime
- 2004-12-20 KR KR1020067014238A patent/KR20070004574A/ko not_active Ceased
- 2004-12-20 BR BRPI0417194-2A patent/BRPI0417194A/pt active Search and Examination
- 2004-12-20 MX MXPA06006706A patent/MXPA06006706A/es active IP Right Grant
- 2004-12-20 US US10/583,188 patent/US20070274970A1/en not_active Abandoned
- 2004-12-20 CA CA2549930A patent/CA2549930C/en not_active Expired - Fee Related
- 2004-12-20 EA EA200601187A patent/EA200601187A1/ru unknown
- 2004-12-20 JP JP2006544560A patent/JP2007514434A/ja active Pending
- 2004-12-20 AU AU2004299718A patent/AU2004299718A1/en not_active Abandoned
-
2009
- 2009-03-03 US US12/397,246 patent/US20090170193A1/en not_active Abandoned
-
2012
- 2012-08-24 JP JP2012185019A patent/JP2013039128A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007514434A5 (enExample) | ||
| CN101748096B (zh) | 亚全能干细胞、其制备方法及其用途 | |
| EP1697500B1 (en) | Stem cells | |
| Mironov et al. | What is regenerative medicine? Emergence of applied stem cell and developmental biology | |
| US20070243172A1 (en) | Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same | |
| KR100871984B1 (ko) | 태반 조직 유래 다능성 줄기세포 및 이를 함유하는세포치료제 | |
| AU2016374909B2 (en) | Method for manufacturing tissue/organ by using blood cells | |
| WO2008018190A1 (en) | Fat-derived neural crest cells | |
| CN103442724A (zh) | 含有可从机体组织中分离的ssea-3阳性的多能干细胞的同种异体移植用细胞治疗用组合物 | |
| JPWO2003080822A1 (ja) | 胎盤由来の間葉系細胞およびその医学的用途 | |
| JP2011519574A (ja) | 細胞ベースの治療に関連する材料および方法 | |
| US20150329827A1 (en) | Muse cells isolation and expansion | |
| Nakatsuka et al. | Identification and characterization of lineage− CD45− Sca-1+ VSEL phenotypic cells residing in adult mouse bone tissue | |
| KR101380561B1 (ko) | 말과동물 양수 유래 다분화능 줄기세포 및 그 제조방법 | |
| KR100802011B1 (ko) | 층분리배양법을 이용한 골수에서의 중간엽 줄기세포분리방법 | |
| JP2014132830A (ja) | 生体の臍帯又は脂肪組織から単離できる多能性幹細胞 | |
| KR20120006386A (ko) | 1기 태반조직 유래 줄기세포 및 이를 함유하는 세포치료제 | |
| JPWO2018025975A1 (ja) | インビトロで多能性幹細胞を分化誘導する方法 | |
| KR20140016841A (ko) | 태아연골조직유래 줄기세포원 및 이를 포함하는 세포치료제 | |
| Lange-Consiglio et al. | In vitro studies of horse umbilical cord matrix-derived cells: from characterization to labeling for magnetic resonance imaging | |
| US20250327792A1 (en) | Method for producing mesenchymal stem cells for therapeutic applications | |
| Rizvi et al. | Clinical Characteristic and Lingering Challenges of Umbilical Cord Blood (UBC) Banking: Future Perspective to Improve Quality of Hematopoietic Stem Cells (HSC) | |
| TWI437097B (zh) | 可表現螢光蛋白質之豬骨髓間葉幹細胞 | |
| Marshall II | Neurospheres and multipotent astrocytic stem cells: Neural progenitor cells rather than neural stem cells | |
| Rebulla et al. | New horizons in Cellular Therapies |