CN1918284B - 干细胞 - Google Patents

干细胞 Download PDF

Info

Publication number
CN1918284B
CN1918284B CN200480041764XA CN200480041764A CN1918284B CN 1918284 B CN1918284 B CN 1918284B CN 200480041764X A CN200480041764X A CN 200480041764XA CN 200480041764 A CN200480041764 A CN 200480041764A CN 1918284 B CN1918284 B CN 1918284B
Authority
CN
China
Prior art keywords
cells
endoderm
ectoderm
stem
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN200480041764XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1918284A (zh
Inventor
M·戈顿
N·哈比布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnicyte Ltd
Original Assignee
Omnicyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnicyte Ltd filed Critical Omnicyte Ltd
Publication of CN1918284A publication Critical patent/CN1918284A/zh
Application granted granted Critical
Publication of CN1918284B publication Critical patent/CN1918284B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/125Stem cell factor [SCF], c-kit ligand [KL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/22Colony stimulating factors (G-CSF, GM-CSF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/78Cellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200480041764XA 2003-12-19 2004-12-20 干细胞 Expired - Lifetime CN1918284B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329449.3 2003-12-19
GBGB0329449.3A GB0329449D0 (en) 2003-12-19 2003-12-19 Stem cells
PCT/GB2004/005365 WO2005059113A1 (en) 2003-12-19 2004-12-20 Stem cells

Publications (2)

Publication Number Publication Date
CN1918284A CN1918284A (zh) 2007-02-21
CN1918284B true CN1918284B (zh) 2012-07-04

Family

ID=30776110

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480041764XA Expired - Lifetime CN1918284B (zh) 2003-12-19 2004-12-20 干细胞

Country Status (12)

Country Link
US (2) US20070274970A1 (enExample)
EP (1) EP1697500B1 (enExample)
JP (2) JP2007514434A (enExample)
KR (1) KR20070004574A (enExample)
CN (1) CN1918284B (enExample)
AU (1) AU2004299718A1 (enExample)
BR (1) BRPI0417194A (enExample)
CA (1) CA2549930C (enExample)
EA (1) EA200601187A1 (enExample)
GB (1) GB0329449D0 (enExample)
MX (1) MXPA06006706A (enExample)
WO (1) WO2005059113A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2532909T3 (es) 2004-07-30 2015-04-01 Mayo Foundation For Medical Education And Research Tratamiento de tejido cardiovascular
US8187878B2 (en) * 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
GB0509500D0 (en) * 2005-05-10 2005-06-15 Revealcyte Method of fetal cell enrichment
WO2008003042A2 (en) * 2006-06-28 2008-01-03 The University Of Medicine And Dentistry Of New Jersey Amnion-derived stem cells and uses thereof
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
US8739148B2 (en) * 2007-02-09 2014-05-27 Elster Electricity, Llc Automated meter reading system
WO2009011139A1 (ja) * 2007-07-13 2009-01-22 Mitsubishi Tanabe Pharma Corporation 細胞の単離方法、細胞用無血清培養培地および細胞の培養方法
ES2325715B1 (es) * 2007-08-03 2010-06-17 Genetrix, S.L. Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca.
JP2009278873A (ja) * 2008-05-19 2009-12-03 Japan Health Science Foundation 培地および培養方法
WO2009145761A1 (en) 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
CN101314767A (zh) * 2008-07-03 2008-12-03 上海天生生物科技有限公司 增强胎肝造血干细胞cd34表达的培养液及其制备方法
GB0818725D0 (en) 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
WO2010056341A2 (en) * 2008-11-12 2010-05-20 The University Of Vermont And State Agriculture College Compositions and methods for tissue repair
WO2010062999A1 (en) * 2008-11-28 2010-06-03 Stematix, Inc Diabetes cell therapy
EP2446021A4 (en) * 2009-06-25 2013-11-13 Geron Corp DIFFERENTIATED PLURIPOTENTIAL STEM CELL PROMOTION DERIVED WITH IRRELEVANT PHENOTYPES
US20130071365A1 (en) * 2010-02-16 2013-03-21 Kyushu University, National University Corporation Induced hepatocytes
WO2011106440A1 (en) * 2010-02-23 2011-09-01 Loma Linda University Medical Center Method of analyzing a medical image
EP2625267A2 (en) 2010-10-06 2013-08-14 Omnicyte Ltd. Culture method for culturing pluripotent cells comprising an inhibitor of mirna-181a*
AU2011311344B2 (en) 2010-10-08 2016-09-08 Mina Therapeutics Limited Short RNA molecules
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
EP3456828B1 (en) 2011-06-21 2022-04-27 MiNA Therapeutics Limited Albumin production and cell proliferation
US20160127672A1 (en) 2013-02-28 2016-05-05 Nikon Corporation Electronic apparatus
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
EP3247808B1 (en) 2015-01-21 2021-05-05 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
AU2021235252A1 (en) 2020-03-11 2022-10-06 Bit Bio Limited Method of generating hepatic cells
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001071016A1 (en) * 2000-03-23 2001-09-27 Stemcells, Inc. Pluripotential stem cells
WO2002064748A2 (en) * 2001-02-14 2002-08-22 Furcht Leo T Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69232427T2 (de) * 1991-11-05 2002-11-21 The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto Suppressorzellen
JPH08506007A (ja) * 1992-11-16 1996-07-02 アプライド イミューン サイエンシーズ,インコーポレイテッド 多能性の休止状態の幹細胞集団
DE69929174T2 (de) * 1998-02-05 2006-08-31 Novartis Ag Vermehrte und genetisch modifizierte populationen menschlicher hämatopoitischer stammzellen
CA2382383A1 (en) * 1999-08-31 2001-03-08 Genencor International, Inc. Transgenic mammal capable of facilitating production of donor-specific functional immunity
JP5414958B2 (ja) * 2000-06-05 2014-02-12 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用
US6930222B2 (en) * 2000-08-22 2005-08-16 The Scripps Research Institute In vivo animal model of human leukemia
US7560280B2 (en) * 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
EP1385935A4 (en) * 2001-03-29 2004-09-15 Ixion Biotechnology Inc METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLS IN THE PANCREAS DIFFERENTIATION PATHWAY
JP2005526482A (ja) * 2001-08-10 2005-09-08 イムクローン システムズ インコーポレイティド Vegfr−1を発現する幹細胞の単離および動員
JP2005512592A (ja) * 2001-12-21 2005-05-12 マウント・シナイ・ホスピタル 細胞性組成物ならびに細胞性組成物の作製法および細胞性組成物の使用法
US20040009589A1 (en) * 2002-03-26 2004-01-15 Shulamit Levenberg Endothelial cells derived from human embryonic stem cells
WO2003080822A1 (en) * 2002-03-27 2003-10-02 Nipro Corporation Placenta-origin mesenchymal cells and medicinal use thereof
WO2004087896A2 (en) * 2003-03-31 2004-10-14 Pfizer Products Inc. Hepatocyte differentiation of stem cells
US20060165667A1 (en) * 2004-12-03 2006-07-27 Case Western Reserve University Novel methods, compositions and devices for inducing neovascularization
US8372797B2 (en) * 2006-06-22 2013-02-12 Creative Medical Health, Inc. Treatment of erectile dysfunction by stem cell therapy
WO2008024996A2 (en) * 2006-08-24 2008-02-28 Johnstone Brian H Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
ES2583371T3 (es) * 2006-10-11 2016-09-20 The General Hospital Corporation Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001071016A1 (en) * 2000-03-23 2001-09-27 Stemcells, Inc. Pluripotential stem cells
WO2002064748A2 (en) * 2001-02-14 2002-08-22 Furcht Leo T Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bucala R,et al..Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair..《Molecular Medicine》.1994,第1卷(第1期),71-81. *
Deans Robert J, et al..Mesenchymal stem cells:Biology and potential clinical uses..《Experimental Hematology》.2000,第28卷(第8期),875-884. *
Jiang Y,et al..Pluripotecny of mesenchymal stem cells deruved from adult marrow..《Nature》.2002,第418卷(第6893期),41-49. *
Verfaillie CM.Adult stem cell:assessing the case for pluripotency.《Trends In Cell Biology》.2002,第12卷(第11期),502-508. *

Also Published As

Publication number Publication date
AU2004299718A1 (en) 2005-06-30
CA2549930C (en) 2014-02-11
US20070274970A1 (en) 2007-11-29
EP1697500B1 (en) 2013-03-20
BRPI0417194A (pt) 2007-03-06
KR20070004574A (ko) 2007-01-09
EP1697500A1 (en) 2006-09-06
JP2007514434A (ja) 2007-06-07
CN1918284A (zh) 2007-02-21
US20090170193A1 (en) 2009-07-02
CA2549930A1 (en) 2005-06-30
EA200601187A1 (ru) 2006-12-29
WO2005059113A1 (en) 2005-06-30
GB0329449D0 (en) 2004-01-28
JP2013039128A (ja) 2013-02-28
MXPA06006706A (es) 2007-01-19

Similar Documents

Publication Publication Date Title
CN1918284B (zh) 干细胞
US20080118477A1 (en) Umbilical cord mesenchymal stem cells support cord blood hematopoiesis
US7625752B2 (en) Cellular compositions and methods of making and using them
KR101119878B1 (ko) 프리미티브 간 줄기세포 및 프록시멀 간 줄기세포
US20130266543A1 (en) Multipotent Adult Stem Cell Population
JP2007536936A (ja) 幹細胞集団および使用方法
US20090004661A1 (en) Method of growing mesenchymal stem cells from bone marrow
JP2005523328A (ja) 胎盤由来の幹細胞及びその使用
JP2002534974A (ja) ヒト肝前駆細胞
US20160237408A1 (en) Adipose derived adult stem cells in hepatic regeneration
WO2007124594A1 (en) Stem cells for treating lung diseases
WO2012133948A1 (ja) 生体組織から単離できるssea-3陽性の多能性幹細胞を含む他家移植用細胞治療用組成物
US20180352792A1 (en) Method for manufacturing tissue/organ by using blood cells
Kao et al. Comparisons of differentiation potential in human mesenchymal stem cells from Wharton’s jelly, bone marrow, and pancreatic tissues
CN113557296A (zh) 造血干细胞的扩增
JP2011520470A (ja) 哺乳動物プロジェニター細胞をインスリン産生膵島細胞に分化させる方法
US12203096B2 (en) Preparation, expansion, and uses of adult pluripotent stem cells
KR20240001173A (ko) 중간엽 계통 전구체 또는 줄기 세포를 이용하는 특정 환자의 급성 호흡 곤란 증후군(ards)의 치료 방법
Kelley et al. Collection and Expansion of Stem Cells
Hongbao et al. Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA ma8080@ gmail. com
Rebulla et al. New horizons in Cellular Therapies
Kaufman Hematopoietic Progenitors Derived from Human Embryonic Stem Cells

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20120704