JP2006522055A5 - - Google Patents
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- Publication number
- JP2006522055A5 JP2006522055A5 JP2006504953A JP2006504953A JP2006522055A5 JP 2006522055 A5 JP2006522055 A5 JP 2006522055A5 JP 2006504953 A JP2006504953 A JP 2006504953A JP 2006504953 A JP2006504953 A JP 2006504953A JP 2006522055 A5 JP2006522055 A5 JP 2006522055A5
- Authority
- JP
- Japan
- Prior art keywords
- quinolin
- hydroxy
- acetyl
- substituted oxy
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *Oc(ccc([C@]1OC1)c1C=C2)c1NC2=O Chemical compound *Oc(ccc([C@]1OC1)c1C=C2)c1NC2=O 0.000 description 9
- IVKRNEMRNRFPFJ-VIFPVBQESA-N NC[C@@H](c(c(C=C1)c2NC1=O)ccc2O)O Chemical compound NC[C@@H](c(c(C=C1)c2NC1=O)ccc2O)O IVKRNEMRNRFPFJ-VIFPVBQESA-N 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45972403P | 2003-04-02 | 2003-04-02 | |
| US60/459,724 | 2003-04-02 | ||
| PCT/EP2004/003479 WO2004087668A1 (en) | 2003-04-02 | 2004-04-01 | A process for the preparation of 5-(haloacetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522055A JP2006522055A (ja) | 2006-09-28 |
| JP2006522055A5 true JP2006522055A5 (https=) | 2007-04-26 |
| JP4726778B2 JP4726778B2 (ja) | 2011-07-20 |
Family
ID=33131902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504953A Expired - Lifetime JP4726778B2 (ja) | 2003-04-02 | 2004-04-01 | ５−（ハロアセチル）−８−（置換オキシ）−（１ｈ）−キノリン−２−オン類の製造法 |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7605267B2 (https=) |
| EP (1) | EP1613599B8 (https=) |
| JP (1) | JP4726778B2 (https=) |
| KR (1) | KR101073740B1 (https=) |
| CN (1) | CN1774423A (https=) |
| AR (2) | AR043825A1 (https=) |
| AT (1) | ATE491690T1 (https=) |
| AU (1) | AU2004226212B2 (https=) |
| BR (1) | BRPI0409154B1 (https=) |
| CA (1) | CA2520990C (https=) |
| CL (1) | CL2004000706A1 (https=) |
| CO (1) | CO5700779A2 (https=) |
| CY (1) | CY1111515T1 (https=) |
| DE (1) | DE602004030553D1 (https=) |
| DK (1) | DK1613599T3 (https=) |
| EC (1) | ECSP056059A (https=) |
| ES (1) | ES2358193T3 (https=) |
| HR (1) | HRP20110184T1 (https=) |
| IL (1) | IL171053A (https=) |
| IS (1) | IS2800B (https=) |
| MA (1) | MA27761A1 (https=) |
| MX (1) | MXPA05010616A (https=) |
| MY (1) | MY141871A (https=) |
| NO (1) | NO331980B1 (https=) |
| NZ (1) | NZ542623A (https=) |
| PE (2) | PE20050211A1 (https=) |
| PL (1) | PL1613599T3 (https=) |
| PT (1) | PT1613599E (https=) |
| RU (1) | RU2339621C2 (https=) |
| SI (1) | SI1613599T1 (https=) |
| TN (1) | TNSN05245A1 (https=) |
| TW (1) | TWI324151B (https=) |
| WO (1) | WO2004087668A1 (https=) |
| ZA (1) | ZA200507603B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| GB0413960D0 (en) * | 2004-06-22 | 2004-07-28 | Novartis Ag | Organic compounds |
| MY150468A (en) | 2006-06-30 | 2014-01-30 | Novartis Ag | Quinolinone derivatives and their pharmaceutical compositions |
| WO2013132514A2 (en) * | 2012-03-09 | 2013-09-12 | Rao Davuluri Ramamohan | A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one |
| CN102633717B (zh) * | 2012-03-30 | 2013-11-20 | 西南大学 | N-乙酰-喹啉-2(1h)酮类化合物及其制备方法和应用 |
| WO2014008640A1 (zh) * | 2012-07-11 | 2014-01-16 | 上海威智医药科技有限公司 | 茚达特罗中间体及茚达特罗的合成方法 |
| CZ306252B6 (cs) | 2013-03-15 | 2016-10-26 | Zentiva, K.S. | Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu) |
| PT3092217T (pt) | 2014-01-09 | 2020-09-04 | Ramamohan Rao Davuluri | Processo inovador para preparação de indacaterol ou dos seus sais farmaceuticamente aceitáveis |
| CN105693603B (zh) * | 2014-11-24 | 2019-11-29 | 上海医药工业研究院 | 改良的马来酸茚达特罗制备工艺 |
| CN107531636B (zh) * | 2015-04-09 | 2022-11-25 | 正大天晴药业集团股份有限公司 | 茚达特罗或其盐的制备方法 |
| CN107868045A (zh) * | 2016-09-28 | 2018-04-03 | 四川海思科制药有限公司 | 一种茚达特罗中间体的制备方法 |
| CN108264483A (zh) * | 2016-12-31 | 2018-07-10 | 天津金耀集团有限公司 | 一种马来酸茚达特罗的制备方法 |
| CN109721534B (zh) * | 2018-09-25 | 2022-05-20 | 四川海思科制药有限公司 | 一种马来酸茚达特罗中间体及其制备方法和用途 |
| CN114751857A (zh) * | 2022-04-29 | 2022-07-15 | 梯尔希（南京）药物研发有限公司 | 一种茚达特罗杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539228B2 (https=) * | 1974-01-31 | 1978-04-04 | ||
| CA1164459A (en) | 1980-11-11 | 1984-03-27 | Yung-Hsiung Yang | Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives |
| JPS5896022A (ja) * | 1981-11-30 | 1983-06-07 | Otsuka Pharmaceut Co Ltd | 強心剤 |
| ES519384A0 (es) * | 1983-01-28 | 1984-03-16 | Espanola Farma Therapeut | Procedimiento para la obtencion de un compuesto derivado de la 2-quinolinona. |
| ES8605239A1 (es) | 1985-12-04 | 1986-03-16 | Astur Pharma | Un procedimiento para la preparacion de quinolonas sustitui-das |
| US4894219A (en) * | 1988-03-29 | 1990-01-16 | University Of Florida | Beta-agonist carbostyril derivatives, assay method and pharmacological composition |
| GB9405019D0 (en) | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| EP0952832B1 (en) * | 1996-05-20 | 2008-08-27 | Darwin Discovery Limited | Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors |
| GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| US6653323B2 (en) * | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI324150B (en) * | 2003-02-28 | 2010-05-01 | Novartis Ag | Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt |
-
2004
- 2004-03-31 PE PE2004000341A patent/PE20050211A1/es not_active Application Discontinuation
- 2004-03-31 PE PE2010000225A patent/PE20100399A1/es not_active Application Discontinuation
- 2004-03-31 TW TW093108942A patent/TWI324151B/zh not_active IP Right Cessation
- 2004-04-01 RU RU2005133664/04A patent/RU2339621C2/ru active
- 2004-04-01 SI SI200431618T patent/SI1613599T1/sl unknown
- 2004-04-01 ES ES04725035T patent/ES2358193T3/es not_active Expired - Lifetime
- 2004-04-01 US US10/550,621 patent/US7605267B2/en active Active
- 2004-04-01 CN CNA2004800089560A patent/CN1774423A/zh active Pending
- 2004-04-01 BR BRPI0409154-0B1A patent/BRPI0409154B1/pt not_active IP Right Cessation
- 2004-04-01 WO PCT/EP2004/003479 patent/WO2004087668A1/en not_active Ceased
- 2004-04-01 AR ARP040101105A patent/AR043825A1/es not_active Application Discontinuation
- 2004-04-01 PL PL04725035T patent/PL1613599T3/pl unknown
- 2004-04-01 DE DE602004030553T patent/DE602004030553D1/de not_active Expired - Lifetime
- 2004-04-01 CL CL200400706A patent/CL2004000706A1/es unknown
- 2004-04-01 AT AT04725035T patent/ATE491690T1/de active
- 2004-04-01 MY MYPI20041213A patent/MY141871A/en unknown
- 2004-04-01 JP JP2006504953A patent/JP4726778B2/ja not_active Expired - Lifetime
- 2004-04-01 EP EP04725035A patent/EP1613599B8/en not_active Expired - Lifetime
- 2004-04-01 CA CA2520990A patent/CA2520990C/en not_active Expired - Lifetime
- 2004-04-01 MX MXPA05010616A patent/MXPA05010616A/es active IP Right Grant
- 2004-04-01 AU AU2004226212A patent/AU2004226212B2/en not_active Expired
- 2004-04-01 DK DK04725035.2T patent/DK1613599T3/da active
- 2004-04-01 PT PT04725035T patent/PT1613599E/pt unknown
- 2004-04-01 NZ NZ542623A patent/NZ542623A/en not_active IP Right Cessation
- 2004-04-01 HR HR20110184T patent/HRP20110184T1/hr unknown
-
2005
- 2005-09-20 ZA ZA200507603A patent/ZA200507603B/en unknown
- 2005-09-22 IL IL171053A patent/IL171053A/en active IP Right Grant
- 2005-09-29 EC EC2005006059A patent/ECSP056059A/es unknown
- 2005-09-30 TN TNP2005000245A patent/TNSN05245A1/en unknown
- 2005-09-30 KR KR1020057018750A patent/KR101073740B1/ko not_active Expired - Lifetime
- 2005-10-11 MA MA28545A patent/MA27761A1/fr unknown
- 2005-10-12 CO CO05104250A patent/CO5700779A2/es active IP Right Grant
- 2005-10-27 IS IS8095A patent/IS2800B/is unknown
- 2005-11-01 NO NO20055099A patent/NO331980B1/no unknown
-
2011
- 2011-03-14 CY CY20111100284T patent/CY1111515T1/el unknown
-
2016
- 2016-01-25 AR ARP160100188A patent/AR103508A2/es unknown
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