JP2006521565A5 - - Google Patents
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- Publication number
- JP2006521565A5 JP2006521565A5 JP2006509304A JP2006509304A JP2006521565A5 JP 2006521565 A5 JP2006521565 A5 JP 2006521565A5 JP 2006509304 A JP2006509304 A JP 2006509304A JP 2006509304 A JP2006509304 A JP 2006509304A JP 2006521565 A5 JP2006521565 A5 JP 2006521565A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- biomarker
- urine sample
- complex
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000002700 urine Anatomy 0.000 claims 25
- 239000000090 biomarker Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- 230000005779 cell damage Effects 0.000 claims 6
- 208000037887 cell injury Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 206010069384 Ischaemic nephropathy Diseases 0.000 claims 4
- 206010029155 Nephropathy toxic Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 231100000417 nephrotoxicity Toxicity 0.000 claims 4
- 230000007694 nephrotoxicity Effects 0.000 claims 4
- 238000002965 ELISA Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 230000003589 nefrotoxic effect Effects 0.000 claims 2
- 231100000381 nephrotoxic Toxicity 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 210000005233 tubule cell Anatomy 0.000 claims 2
- 238000008157 ELISA kit Methods 0.000 claims 1
- 102000013382 Gelatinases Human genes 0.000 claims 1
- 108010026132 Gelatinases Proteins 0.000 claims 1
- 102000019298 Lipocalin Human genes 0.000 claims 1
- 108050006654 Lipocalin Proteins 0.000 claims 1
- 230000036770 blood supply Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 229940039231 contrast media Drugs 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45814303P | 2003-03-27 | 2003-03-27 | |
| US60/458,143 | 2003-03-27 | ||
| US48159603P | 2003-11-04 | 2003-11-04 | |
| US60/481,596 | 2003-11-04 | ||
| PCT/US2004/009191 WO2004088276A2 (en) | 2003-03-27 | 2004-03-26 | A method and kit for detecting the early onset of renal tubular cell injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011137544A Division JP2011221033A (ja) | 2003-03-27 | 2011-06-21 | 早発型の腎尿細管細胞障害を検出するための方法およびキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006521565A JP2006521565A (ja) | 2006-09-21 |
| JP2006521565A5 true JP2006521565A5 (enExample) | 2007-03-15 |
| JP5392980B2 JP5392980B2 (ja) | 2014-01-22 |
Family
ID=33135089
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509304A Expired - Fee Related JP5392980B2 (ja) | 2003-03-27 | 2004-03-26 | 早発型の腎尿細管細胞障害を検出するための方法およびキット |
| JP2011137544A Pending JP2011221033A (ja) | 2003-03-27 | 2011-06-21 | 早発型の腎尿細管細胞障害を検出するための方法およびキット |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011137544A Pending JP2011221033A (ja) | 2003-03-27 | 2011-06-21 | 早発型の腎尿細管細胞障害を検出するための方法およびキット |
Country Status (14)
| Country | Link |
|---|---|
| US (11) | US20040219603A1 (enExample) |
| EP (3) | EP2083270B1 (enExample) |
| JP (2) | JP5392980B2 (enExample) |
| CN (1) | CN102183656B (enExample) |
| AT (1) | ATE437371T1 (enExample) |
| AU (1) | AU2004225472B2 (enExample) |
| BR (1) | BRPI0408802B8 (enExample) |
| CA (1) | CA2520658A1 (enExample) |
| DE (1) | DE602004022150D1 (enExample) |
| DK (2) | DK1616184T4 (enExample) |
| ES (3) | ES2330005T5 (enExample) |
| MX (1) | MXPA05010385A (enExample) |
| NZ (1) | NZ543028A (enExample) |
| WO (1) | WO2004088276A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2425761C (en) | 2000-10-13 | 2005-11-15 | Children's Medical Center Corporation | Non-invasive enzyme screen for tissue remodelling-associated conditions |
| US20040219603A1 (en) * | 2003-03-27 | 2004-11-04 | Prasad Devarajan | Method and kit for detecting the early onset of renal tubular cell injury |
| AU2005240190C1 (en) * | 2004-05-06 | 2012-01-19 | Children's Hospital Medical Center | NGAL for reduction and amelioration of ischemic and nephrotoxic injuries |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| ES2622467T3 (es) * | 2004-12-20 | 2017-07-06 | Antibodyshop A/S | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| US20080050832A1 (en) * | 2004-12-23 | 2008-02-28 | Buechler Kenneth F | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| CN101120252A (zh) * | 2005-02-18 | 2008-02-06 | 儿童医疗中心有限公司 | 作为生物标记物用于上皮来源的癌症的诊断和预后的cyr61 |
| US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20070087387A1 (en) | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| CA2624569A1 (en) * | 2005-10-03 | 2007-04-12 | Biosite Incorporated | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| JP2009517677A (ja) * | 2005-11-30 | 2009-04-30 | モザイク・ダイアグノステイツクス・アンド・テラピユーテイツクス・アー・ゲー | 腎盂尿管移行部の診断及び評価用のポリペプチドマーカー |
| MX2008008213A (es) * | 2005-12-22 | 2008-09-03 | Neurochem Int Ltd | Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias. |
| US20070196876A1 (en) * | 2006-02-17 | 2007-08-23 | Moses Marsha A | Free NGAL as a biomarker for cancer |
| US7662578B2 (en) | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
| US20090197280A1 (en) * | 2006-05-30 | 2009-08-06 | Kristian Bangert | Methods and Devices for Rapid Assessment of Severity of Injury |
| EP2602624A1 (en) * | 2006-08-07 | 2013-06-12 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| GB0617429D0 (en) * | 2006-09-05 | 2006-10-18 | Electrophoretics Ltd | Markers of renal transplant rejection and renal damage |
| EP2095107B1 (en) * | 2006-11-14 | 2014-07-02 | Alere San Diego, Inc. | Methods for risk assignment |
| EP2095106B1 (en) | 2006-11-14 | 2013-03-20 | Alere San Diego, Inc. | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
| MX2009006768A (es) * | 2006-12-22 | 2009-08-31 | Bellus Health Int Ltd | Metodos, compuestos, y composiciones para tratar trastornos metabolicos y diabetes. |
| JP2010521694A (ja) * | 2007-03-21 | 2010-06-24 | バイオポルト・ダイアグノスティクス・アクティーゼルスカブ | 腎傷害のための診断テスト |
| US20090004755A1 (en) * | 2007-03-23 | 2009-01-01 | Biosite, Incorporated | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| US8221995B2 (en) * | 2007-03-23 | 2012-07-17 | Seok-Won Lee | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| DK2125899T3 (da) * | 2007-03-26 | 2013-02-11 | Novartis Ag | Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| WO2009059259A2 (en) * | 2007-10-31 | 2009-05-07 | Children's Hospital Medical Center | Detection of worsening renal disease in subjects with systemic lupus erythematosus |
| WO2009062520A1 (en) † | 2007-11-15 | 2009-05-22 | Bioporto Diagnostics A/S | Diagnostic use of individual molecular forms of a biomarker |
| WO2009114699A2 (en) * | 2008-03-12 | 2009-09-17 | The Trustees Of Columbia University In The City Of New York | High molecular weight ngal as a biomarker for chronic kidney disease |
| US20090238812A1 (en) * | 2008-03-18 | 2009-09-24 | Biotrin Intellectual Properties Limited | Method for the early indentification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic surgery |
| US20090239242A1 (en) * | 2008-03-18 | 2009-09-24 | Biotrin Intellectual Properties Limited | Method for the early identification and prediction of kidney injury |
| US7977110B2 (en) * | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| US20100122355A1 (en) * | 2008-07-16 | 2010-05-13 | Neal Paragas | Transgenic Reporter Mouse and Method for Use |
| HUP0800448A2 (en) * | 2008-07-21 | 2011-02-28 | Pecsi Tudomanyegyetem | Diagnosis of systemic diseases |
| US20120083421A1 (en) * | 2008-10-16 | 2012-04-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose and monitor hiv-associated nephropathy (hivan) |
| US20100105150A1 (en) * | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
| CA2742291A1 (en) * | 2008-11-05 | 2010-05-14 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, andmethods of enrichment, analysis and use |
| WO2010057184A2 (en) * | 2008-11-17 | 2010-05-20 | The Brigham And Women's Hospital, Inc. | Methods for detection of acute kidney injury in humans |
| US9476880B2 (en) * | 2008-11-21 | 2016-10-25 | Future Medical Diagnostics Co., Ltd. | Methods, devices and kits for detecting or monitoring acute kidney injury |
| ES2530574T3 (es) * | 2009-01-28 | 2015-03-03 | Ind Tech Res Inst | Biomarcadores asociados a la nefropatía |
| US20100233740A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis |
| US20100233739A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction |
| AU2010267972A1 (en) * | 2009-07-02 | 2012-01-19 | Mosaiques Diagnostics And Therapeutics Ag | Method and markers for diagnosing acute renal failure |
| WO2011025917A1 (en) * | 2009-08-28 | 2011-03-03 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011053832A1 (en) * | 2009-10-29 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose sepsis in very low birth weight infants |
| US20110229921A1 (en) * | 2010-03-18 | 2011-09-22 | Abbott Laboratories | METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS |
| ES2667066T3 (es) | 2010-05-24 | 2018-05-09 | The Trustees Of Columbia University In The City Of New York | Proteínas NGAL mutantes y usos de las mismas |
| MX2013000220A (es) * | 2010-06-23 | 2013-03-22 | Astute Medical Inc | Metodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal. |
| CA2804297A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2803498A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2012068545A1 (en) * | 2010-11-18 | 2012-05-24 | Jonathan Barasch | Ngal in acute kidney injury |
| NL2007112C2 (en) | 2011-07-14 | 2013-01-15 | Brainlabs B V | Novel diagnostic method for diagnosing depression and monitoring therapy effectiveness. |
| US9387031B2 (en) * | 2011-07-29 | 2016-07-12 | Medtronic Ablation Frontiers Llc | Mesh-overlayed ablation and mapping device |
| CN106443011A (zh) * | 2011-08-26 | 2017-02-22 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
| EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
| US10712349B2 (en) | 2014-04-15 | 2020-07-14 | The Brigham And Women's Hospital, Inc. | Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| EP3577458A4 (en) | 2017-02-06 | 2021-04-07 | Astute Medical, Inc. | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY |
| EP3736570A1 (en) | 2019-05-09 | 2020-11-11 | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Method for the diagnosis, sub-classification and prognosis of acute kidney injury by detecting cct7 |
| CN112076309A (zh) * | 2020-07-27 | 2020-12-15 | 南通大学 | 一种环状促红素衍生肽在肾损伤和环孢素a损伤保护中的应用 |
| WO2022082013A1 (en) * | 2020-10-16 | 2022-04-21 | Lmx Medtech Llc | Method for correction for urine volume |
| CN113083264A (zh) * | 2021-04-16 | 2021-07-09 | 郑州大学 | 二氧化硅-金属有机骨架核壳型复合材料及其在硫醇小分子检测方面的应用 |
| DE102023135015B3 (de) | 2023-12-13 | 2025-05-15 | Philipps-Universität Marburg, Körperschaft des öffentlichen Rechts | Diagnose und Verlaufskontrolle der akuten Nierenschädigung |
| SE2430014A1 (en) * | 2024-01-18 | 2025-05-27 | P & M Venge Ab | Urinary biomarker of kidney function |
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| US20040219603A1 (en) * | 2003-03-27 | 2004-11-04 | Prasad Devarajan | Method and kit for detecting the early onset of renal tubular cell injury |
| ES2622467T3 (es) * | 2004-12-20 | 2017-07-06 | Antibodyshop A/S | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| US7977110B2 (en) * | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
-
2004
- 2004-03-26 US US10/811,130 patent/US20040219603A1/en not_active Abandoned
- 2004-03-26 EP EP08169401.0A patent/EP2083270B1/en not_active Expired - Lifetime
- 2004-03-26 ES ES04758356.2T patent/ES2330005T5/es not_active Expired - Lifetime
- 2004-03-26 DK DK04758356.2T patent/DK1616184T4/en active
- 2004-03-26 AU AU2004225472A patent/AU2004225472B2/en not_active Expired
- 2004-03-26 AT AT04758356T patent/ATE437371T1/de not_active IP Right Cessation
- 2004-03-26 ES ES10183320T patent/ES2754753T3/es not_active Expired - Lifetime
- 2004-03-26 CN CN201110032921.2A patent/CN102183656B/zh not_active Expired - Lifetime
- 2004-03-26 DK DK10183320.0T patent/DK2360475T3/da active
- 2004-03-26 DE DE602004022150T patent/DE602004022150D1/de not_active Expired - Lifetime
- 2004-03-26 EP EP10183320.0A patent/EP2360475B1/en not_active Expired - Lifetime
- 2004-03-26 MX MXPA05010385A patent/MXPA05010385A/es active IP Right Grant
- 2004-03-26 BR BRPI0408802A patent/BRPI0408802B8/pt not_active IP Right Cessation
- 2004-03-26 CA CA002520658A patent/CA2520658A1/en not_active Abandoned
- 2004-03-26 NZ NZ543028A patent/NZ543028A/en not_active IP Right Cessation
- 2004-03-26 ES ES08169401T patent/ES2739463T3/es not_active Expired - Lifetime
- 2004-03-26 WO PCT/US2004/009191 patent/WO2004088276A2/en not_active Ceased
- 2004-03-26 EP EP04758356.2A patent/EP1616184B2/en not_active Expired - Lifetime
- 2004-03-26 JP JP2006509304A patent/JP5392980B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-28 US US11/770,422 patent/US20070254370A1/en not_active Abandoned
-
2008
- 2008-12-05 US US12/329,310 patent/US20090123941A1/en not_active Abandoned
-
2009
- 2009-02-09 US US12/367,897 patent/US20090181407A1/en not_active Abandoned
-
2010
- 2010-03-26 US US12/732,593 patent/US20100233728A1/en not_active Abandoned
- 2010-05-21 US US12/785,275 patent/US20100227418A1/en not_active Abandoned
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2011
- 2011-06-21 JP JP2011137544A patent/JP2011221033A/ja active Pending
- 2011-10-12 US US13/271,588 patent/US20120028371A1/en not_active Abandoned
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2013
- 2013-02-04 US US13/758,221 patent/US20130137191A1/en not_active Abandoned
- 2013-02-06 US US13/760,498 patent/US20130137116A1/en not_active Abandoned
- 2013-03-13 US US13/798,790 patent/US20130183693A1/en not_active Abandoned
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2015
- 2015-03-16 US US14/658,685 patent/US20150185231A1/en not_active Abandoned
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