JP2006521565A5 - - Google Patents

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Publication number
JP2006521565A5
JP2006521565A5 JP2006509304A JP2006509304A JP2006521565A5 JP 2006521565 A5 JP2006521565 A5 JP 2006521565A5 JP 2006509304 A JP2006509304 A JP 2006509304A JP 2006509304 A JP2006509304 A JP 2006509304A JP 2006521565 A5 JP2006521565 A5 JP 2006521565A5
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Japan
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antibody
biomarker
urine sample
complex
detecting
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JP2006509304A
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English (en)
Japanese (ja)
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JP2006521565A (ja
JP5392980B2 (ja
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Priority claimed from PCT/US2004/009191 external-priority patent/WO2004088276A2/en
Publication of JP2006521565A publication Critical patent/JP2006521565A/ja
Publication of JP2006521565A5 publication Critical patent/JP2006521565A5/ja
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Publication of JP5392980B2 publication Critical patent/JP5392980B2/ja
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JP2006509304A 2003-03-27 2004-03-26 早発型の腎尿細管細胞障害を検出するための方法およびキット Expired - Fee Related JP5392980B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45814303P 2003-03-27 2003-03-27
US60/458,143 2003-03-27
US48159603P 2003-11-04 2003-11-04
US60/481,596 2003-11-04
PCT/US2004/009191 WO2004088276A2 (en) 2003-03-27 2004-03-26 A method and kit for detecting the early onset of renal tubular cell injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011137544A Division JP2011221033A (ja) 2003-03-27 2011-06-21 早発型の腎尿細管細胞障害を検出するための方法およびキット

Publications (3)

Publication Number Publication Date
JP2006521565A JP2006521565A (ja) 2006-09-21
JP2006521565A5 true JP2006521565A5 (enExample) 2007-03-15
JP5392980B2 JP5392980B2 (ja) 2014-01-22

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JP2006509304A Expired - Fee Related JP5392980B2 (ja) 2003-03-27 2004-03-26 早発型の腎尿細管細胞障害を検出するための方法およびキット
JP2011137544A Pending JP2011221033A (ja) 2003-03-27 2011-06-21 早発型の腎尿細管細胞障害を検出するための方法およびキット

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JP2011137544A Pending JP2011221033A (ja) 2003-03-27 2011-06-21 早発型の腎尿細管細胞障害を検出するための方法およびキット

Country Status (14)

Country Link
US (11) US20040219603A1 (enExample)
EP (3) EP2083270B1 (enExample)
JP (2) JP5392980B2 (enExample)
CN (1) CN102183656B (enExample)
AT (1) ATE437371T1 (enExample)
AU (1) AU2004225472B2 (enExample)
BR (1) BRPI0408802B8 (enExample)
CA (1) CA2520658A1 (enExample)
DE (1) DE602004022150D1 (enExample)
DK (2) DK1616184T4 (enExample)
ES (3) ES2330005T5 (enExample)
MX (1) MXPA05010385A (enExample)
NZ (1) NZ543028A (enExample)
WO (1) WO2004088276A2 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2425761C (en) 2000-10-13 2005-11-15 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US20040219603A1 (en) * 2003-03-27 2004-11-04 Prasad Devarajan Method and kit for detecting the early onset of renal tubular cell injury
AU2005240190C1 (en) * 2004-05-06 2012-01-19 Children's Hospital Medical Center NGAL for reduction and amelioration of ischemic and nephrotoxic injuries
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
ES2622467T3 (es) * 2004-12-20 2017-07-06 Antibodyshop A/S Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
CN101120252A (zh) * 2005-02-18 2008-02-06 儿童医疗中心有限公司 作为生物标记物用于上皮来源的癌症的诊断和预后的cyr61
US20070037232A1 (en) 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20070087387A1 (en) 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
CA2624569A1 (en) * 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
JP2009517677A (ja) * 2005-11-30 2009-04-30 モザイク・ダイアグノステイツクス・アンド・テラピユーテイツクス・アー・ゲー 腎盂尿管移行部の診断及び評価用のポリペプチドマーカー
MX2008008213A (es) * 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
US20070196876A1 (en) * 2006-02-17 2007-08-23 Moses Marsha A Free NGAL as a biomarker for cancer
US7662578B2 (en) 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
US20090197280A1 (en) * 2006-05-30 2009-08-06 Kristian Bangert Methods and Devices for Rapid Assessment of Severity of Injury
EP2602624A1 (en) * 2006-08-07 2013-06-12 Antibodyshop A/S Diagnostic test to exclude significant renal injury
GB0617429D0 (en) * 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
EP2095107B1 (en) * 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
EP2095106B1 (en) 2006-11-14 2013-03-20 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
MX2009006768A (es) * 2006-12-22 2009-08-31 Bellus Health Int Ltd Metodos, compuestos, y composiciones para tratar trastornos metabolicos y diabetes.
JP2010521694A (ja) * 2007-03-21 2010-06-24 バイオポルト・ダイアグノスティクス・アクティーゼルスカブ 腎傷害のための診断テスト
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
DK2125899T3 (da) * 2007-03-26 2013-02-11 Novartis Ag Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
WO2009059259A2 (en) * 2007-10-31 2009-05-07 Children's Hospital Medical Center Detection of worsening renal disease in subjects with systemic lupus erythematosus
WO2009062520A1 (en) 2007-11-15 2009-05-22 Bioporto Diagnostics A/S Diagnostic use of individual molecular forms of a biomarker
WO2009114699A2 (en) * 2008-03-12 2009-09-17 The Trustees Of Columbia University In The City Of New York High molecular weight ngal as a biomarker for chronic kidney disease
US20090238812A1 (en) * 2008-03-18 2009-09-24 Biotrin Intellectual Properties Limited Method for the early indentification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic surgery
US20090239242A1 (en) * 2008-03-18 2009-09-24 Biotrin Intellectual Properties Limited Method for the early identification and prediction of kidney injury
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
US20100122355A1 (en) * 2008-07-16 2010-05-13 Neal Paragas Transgenic Reporter Mouse and Method for Use
HUP0800448A2 (en) * 2008-07-21 2011-02-28 Pecsi Tudomanyegyetem Diagnosis of systemic diseases
US20120083421A1 (en) * 2008-10-16 2012-04-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose and monitor hiv-associated nephropathy (hivan)
US20100105150A1 (en) * 2008-10-24 2010-04-29 Abbott Laboratories Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal
CA2742291A1 (en) * 2008-11-05 2010-05-14 Abbott Laboratories Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, andmethods of enrichment, analysis and use
WO2010057184A2 (en) * 2008-11-17 2010-05-20 The Brigham And Women's Hospital, Inc. Methods for detection of acute kidney injury in humans
US9476880B2 (en) * 2008-11-21 2016-10-25 Future Medical Diagnostics Co., Ltd. Methods, devices and kits for detecting or monitoring acute kidney injury
ES2530574T3 (es) * 2009-01-28 2015-03-03 Ind Tech Res Inst Biomarcadores asociados a la nefropatía
US20100233740A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis
US20100233739A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction
AU2010267972A1 (en) * 2009-07-02 2012-01-19 Mosaiques Diagnostics And Therapeutics Ag Method and markers for diagnosing acute renal failure
WO2011025917A1 (en) * 2009-08-28 2011-03-03 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011053832A1 (en) * 2009-10-29 2011-05-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose sepsis in very low birth weight infants
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
MX2013000220A (es) * 2010-06-23 2013-03-22 Astute Medical Inc Metodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal.
CA2804297A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2803498A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2012068545A1 (en) * 2010-11-18 2012-05-24 Jonathan Barasch Ngal in acute kidney injury
NL2007112C2 (en) 2011-07-14 2013-01-15 Brainlabs B V Novel diagnostic method for diagnosing depression and monitoring therapy effectiveness.
US9387031B2 (en) * 2011-07-29 2016-07-12 Medtronic Ablation Frontiers Llc Mesh-overlayed ablation and mapping device
CN106443011A (zh) * 2011-08-26 2017-02-22 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
US10712349B2 (en) 2014-04-15 2020-07-14 The Brigham And Women's Hospital, Inc. Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
EP3577458A4 (en) 2017-02-06 2021-04-07 Astute Medical, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY
EP3736570A1 (en) 2019-05-09 2020-11-11 Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Method for the diagnosis, sub-classification and prognosis of acute kidney injury by detecting cct7
CN112076309A (zh) * 2020-07-27 2020-12-15 南通大学 一种环状促红素衍生肽在肾损伤和环孢素a损伤保护中的应用
WO2022082013A1 (en) * 2020-10-16 2022-04-21 Lmx Medtech Llc Method for correction for urine volume
CN113083264A (zh) * 2021-04-16 2021-07-09 郑州大学 二氧化硅-金属有机骨架核壳型复合材料及其在硫醇小分子检测方面的应用
DE102023135015B3 (de) 2023-12-13 2025-05-15 Philipps-Universität Marburg, Körperschaft des öffentlichen Rechts Diagnose und Verlaufskontrolle der akuten Nierenschädigung
SE2430014A1 (en) * 2024-01-18 2025-05-27 P & M Venge Ab Urinary biomarker of kidney function

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US3635091A (en) * 1970-08-31 1972-01-18 Frederick D Linzer Midstream urine specimen and fractional fluid collectors
IT1074038B (it) * 1976-08-05 1985-04-17 Simes Esteri della epinina
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4357343A (en) * 1981-06-26 1982-11-02 Baxter Travenol Laboratories, Inc. Nutritional composition for management of renal failure
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4731326A (en) * 1984-06-04 1988-03-15 Ortho Diagnostic Systems Inc. Disease diagnosis by detection of shed normal tissue antigens
US4640909A (en) * 1985-05-07 1987-02-03 J. T. Baker Chemical Company Bonded phase of silica and carboalkoxyalkyl silanes for solid phase extraction
IL85257A (en) * 1987-02-10 1993-02-21 Tanabe Seiyaku Co Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
US4900662A (en) * 1987-07-21 1990-02-13 International Immunoassay Laboratories, Inc. CK-MM myocardial infarction immunoassay
US4870007A (en) 1987-12-18 1989-09-26 Eastman Kodak Company Immobilized biotinylated receptor in test device, kit and method for determining a ligand
US5273743A (en) 1990-03-09 1993-12-28 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
JP2912413B2 (ja) * 1990-03-28 1999-06-28 東亜医用電子株式会社 粒度分布作成方法
US5405832A (en) * 1991-11-27 1995-04-11 Immtech International Inc. Method of treating non-streptococcal bacterial infections
US5358850A (en) * 1992-06-19 1994-10-25 Shionogi Seiyaku Kabushiki Kaisha Sandwich immunoassay of β-n-acetylglucosaminidase and monoclonal antibody used therein
SE9401351D0 (sv) * 1994-04-21 1994-04-21 Venge A method for diagnosis
US6348571B1 (en) * 1994-09-12 2002-02-19 Northwestern University Corticotropin release inhibiting factor and methods of using same
US5552313A (en) * 1994-11-21 1996-09-03 Kansas University DNA encoding mouse phosphotriesterase-related protein
EP0864086A4 (en) * 1995-10-02 2001-05-02 Univ Columbia Biochemical markers of ischemia
US5750345A (en) * 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
US5627034A (en) * 1995-12-05 1997-05-06 Wisconsin Alumni Research Foundation Assay for carcinoma proliferative status by measuring NGAL expression level
EA004402B1 (ru) * 1996-05-24 2004-04-29 Байоджен, Инк. Модуляторы регенерации тканей
US5945294A (en) * 1996-11-26 1999-08-31 Heska Corporation Method to detect IgE
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
CA2289043C (en) * 1997-04-30 2008-01-22 Maruha Corporation Method for detecting or predicting ischemic disorders
US6020163A (en) * 1997-08-06 2000-02-01 Zymogenetics, Inc. Lipocalin homolog
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6500627B1 (en) 1998-02-03 2002-12-31 The Trustees Of Columbia University In The City Of New York Methods for predicting pregnancy outcome in a subject by HCG assay
US6309888B1 (en) * 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
AUPP784398A0 (en) * 1998-12-21 1999-01-21 Monash University Kidney disease detection and treatment
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
AU5330200A (en) * 1999-06-18 2001-01-09 Michigan State University Method and apparatus for the detection of volatile products in a sample
US6762032B1 (en) * 1999-08-23 2004-07-13 Biocrystal, Ltd. Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response
US20020160495A1 (en) * 2000-09-20 2002-10-31 University Of Medicine And Dentistry Soluble ischemia activated protein
CA2424431A1 (en) * 2000-10-03 2002-04-11 Rowett Research Institute Method of assaying pyrrole-containing biological compounds
CA2425761C (en) * 2000-10-13 2005-11-15 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
EP1666881B1 (en) * 2001-05-04 2010-02-17 Biosite Incorporated Diagnostic markers of acute coronary syndromes and methods of use thereof
JP2005508141A (ja) * 2001-05-25 2005-03-31 セローノ ジェネティクス インスティテュート ソシエテ アニニム ヒトcDNAおよびタンパク質、ならびにそれらの使用
US6847451B2 (en) * 2002-05-01 2005-01-25 Lifescan, Inc. Apparatuses and methods for analyte concentration determination
WO2004006941A1 (en) * 2002-07-17 2004-01-22 Index Pharmaceuticals Ab Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders
CN1220487C (zh) * 2003-03-26 2005-09-28 浙江大学 复方肾保护氨基酸组合物及其应用
US20040219603A1 (en) * 2003-03-27 2004-11-04 Prasad Devarajan Method and kit for detecting the early onset of renal tubular cell injury
ES2622467T3 (es) * 2004-12-20 2017-07-06 Antibodyshop A/S Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions

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