ATE437371T1 - Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzung - Google Patents
Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzungInfo
- Publication number
- ATE437371T1 ATE437371T1 AT04758356T AT04758356T ATE437371T1 AT E437371 T1 ATE437371 T1 AT E437371T1 AT 04758356 T AT04758356 T AT 04758356T AT 04758356 T AT04758356 T AT 04758356T AT E437371 T1 ATE437371 T1 AT E437371T1
- Authority
- AT
- Austria
- Prior art keywords
- ngal
- cell injury
- renal
- kit
- detecting
- Prior art date
Links
- 230000005779 cell damage Effects 0.000 title abstract 4
- 208000037887 cell injury Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 102000013519 Lipocalin-2 Human genes 0.000 abstract 5
- 108010051335 Lipocalin-2 Proteins 0.000 abstract 5
- 210000005233 tubule cell Anatomy 0.000 abstract 2
- 210000002700 urine Anatomy 0.000 abstract 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 206010063897 Renal ischaemia Diseases 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 230000003589 nefrotoxic effect Effects 0.000 abstract 1
- 231100000381 nephrotoxic Toxicity 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000005234 proximal tubule cell Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45814303P | 2003-03-27 | 2003-03-27 | |
| US48159603P | 2003-11-04 | 2003-11-04 | |
| PCT/US2004/009191 WO2004088276A2 (en) | 2003-03-27 | 2004-03-26 | A method and kit for detecting the early onset of renal tubular cell injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437371T1 true ATE437371T1 (de) | 2009-08-15 |
Family
ID=33135089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04758356T ATE437371T1 (de) | 2003-03-27 | 2004-03-26 | Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzung |
Country Status (14)
| Country | Link |
|---|---|
| US (11) | US20040219603A1 (enExample) |
| EP (3) | EP2083270B1 (enExample) |
| JP (2) | JP5392980B2 (enExample) |
| CN (1) | CN102183656B (enExample) |
| AT (1) | ATE437371T1 (enExample) |
| AU (1) | AU2004225472B2 (enExample) |
| BR (1) | BRPI0408802B8 (enExample) |
| CA (1) | CA2520658A1 (enExample) |
| DE (1) | DE602004022150D1 (enExample) |
| DK (2) | DK1616184T4 (enExample) |
| ES (3) | ES2330005T5 (enExample) |
| MX (1) | MXPA05010385A (enExample) |
| NZ (1) | NZ543028A (enExample) |
| WO (1) | WO2004088276A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002211697B2 (en) | 2000-10-13 | 2005-12-15 | Children's Medical Center Corporation | Non-invasive enzyme screen for tissue remodelling-associated conditions |
| BRPI0408802B8 (pt) * | 2003-03-27 | 2021-07-27 | Childrens Hospital Med Ct | método para a detecção de uma lesão de célula tubular renal isquêmica e método para identificar a extensão desta lesão |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| WO2005107793A2 (en) * | 2004-05-06 | 2005-11-17 | The Trustees Of Columbia University | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| ES2622467T3 (es) * | 2004-12-20 | 2017-07-06 | Antibodyshop A/S | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| US20070092911A1 (en) * | 2005-10-03 | 2007-04-26 | Buechler Kenneth F | Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes |
| US20080050832A1 (en) * | 2004-12-23 | 2008-02-28 | Buechler Kenneth F | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| US7858324B2 (en) * | 2005-02-18 | 2010-12-28 | Children's Medical Center Corporation | Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20070087387A1 (en) * | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| US20100062537A1 (en) * | 2005-11-30 | 2010-03-11 | Harald Mischak | Polypeptide Markers for the Diagnosis and Evaluation of Pelvi-Ureteric Junction Obstruction (PUJO) |
| DE602006016990D1 (de) * | 2005-12-22 | 2010-10-28 | Bellus Health Int Ltd | Behandlung von diabetischer nephropathie |
| WO2007098102A2 (en) * | 2006-02-17 | 2007-08-30 | Children's Medical Center Corporation | Free ngal as a biomarker for cancer |
| US7662578B2 (en) | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
| ATE539351T1 (de) | 2006-05-30 | 2012-01-15 | Antibodyshop As | Verfahren zur schnellen beurteilung der schwere eines traumas |
| EP2064553B2 (en) † | 2006-08-07 | 2023-06-07 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| GB0617429D0 (en) * | 2006-09-05 | 2006-10-18 | Electrophoretics Ltd | Markers of renal transplant rejection and renal damage |
| EP2095106B1 (en) | 2006-11-14 | 2013-03-20 | Alere San Diego, Inc. | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
| WO2008060607A2 (en) * | 2006-11-14 | 2008-05-22 | Biosite Incorporated | Methods and compositions for monitoring and risk prediction in cardiorenal syndrome |
| WO2008078176A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
| EP2137538B1 (en) | 2007-03-21 | 2014-04-09 | Bioporto Diagnostics A/s | Diagnostic test for renal injury |
| US8221995B2 (en) * | 2007-03-23 | 2012-07-17 | Seok-Won Lee | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| US20090004755A1 (en) * | 2007-03-23 | 2009-01-01 | Biosite, Incorporated | Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes |
| CN103399155A (zh) * | 2007-03-26 | 2013-11-20 | 诺瓦提斯公司 | 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签 |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| WO2009059259A2 (en) * | 2007-10-31 | 2009-05-07 | Children's Hospital Medical Center | Detection of worsening renal disease in subjects with systemic lupus erythematosus |
| CN101910845A (zh) * | 2007-11-15 | 2010-12-08 | 比奥波托诊断股份公司 | 个体分子形式的生物标志的诊断用途 |
| US8592170B2 (en) * | 2008-03-12 | 2013-11-26 | The Trustees Of Columbia University In The City Of New York | High molecular weight Ngal as a biomarker for chronic kidney disease |
| US20090239242A1 (en) * | 2008-03-18 | 2009-09-24 | Biotrin Intellectual Properties Limited | Method for the early identification and prediction of kidney injury |
| US20090238812A1 (en) * | 2008-03-18 | 2009-09-24 | Biotrin Intellectual Properties Limited | Method for the early indentification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic surgery |
| US7977110B2 (en) * | 2008-06-02 | 2011-07-12 | Children's Hospital Medical Center | Method for distinguishing between kidney dysfunctions |
| US20100122355A1 (en) * | 2008-07-16 | 2010-05-13 | Neal Paragas | Transgenic Reporter Mouse and Method for Use |
| HUP0800448A2 (en) * | 2008-07-21 | 2011-02-28 | Pecsi Tudomanyegyetem | Diagnosis of systemic diseases |
| US20120083421A1 (en) * | 2008-10-16 | 2012-04-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose and monitor hiv-associated nephropathy (hivan) |
| US20100105150A1 (en) * | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
| US8394606B2 (en) * | 2008-11-05 | 2013-03-12 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (NGAL) protein isoforms enriched from urine and recombinant chinese hamster ovary (CHO) cells and related compositions, antibodies, and methods of enrichment, analysis and use |
| WO2010057184A2 (en) * | 2008-11-17 | 2010-05-20 | The Brigham And Women's Hospital, Inc. | Methods for detection of acute kidney injury in humans |
| JP5438770B2 (ja) | 2008-11-21 | 2014-03-12 | ファディア・アクチボラグ | 急性腎臓損傷を検出またはモニターするための方法、装置およびキット |
| DK2391653T3 (en) * | 2009-01-28 | 2015-02-09 | Ind Tech Res Inst | Biomarkers associated nephropathy |
| US20100233739A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction |
| US20100233740A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis |
| JP2012531615A (ja) * | 2009-07-02 | 2012-12-10 | モザイクス ダイアグノスティクス アンド セラピューティクス アーゲー | 急性腎不全を診断するためのプロセス及びマーカー |
| CA2772336A1 (en) * | 2009-08-28 | 2011-03-03 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2011053832A1 (en) * | 2009-10-29 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose sepsis in very low birth weight infants |
| US20110229921A1 (en) * | 2010-03-18 | 2011-09-22 | Abbott Laboratories | METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS |
| JP2013529907A (ja) | 2010-05-24 | 2013-07-25 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | Ｎｇａｌタンパク質変異体及びその使用 |
| EP2585825B1 (en) | 2010-06-23 | 2018-01-10 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20130165344A1 (en) * | 2010-06-23 | 2013-06-27 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2585827A4 (en) | 2010-06-23 | 2013-12-04 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency |
| WO2012068545A1 (en) * | 2010-11-18 | 2012-05-24 | Jonathan Barasch | Ngal in acute kidney injury |
| NL2007112C2 (en) | 2011-07-14 | 2013-01-15 | Brainlabs B V | Novel diagnostic method for diagnosing depression and monitoring therapy effectiveness. |
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| AU2012312907A1 (en) | 2011-08-26 | 2014-03-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| US10712349B2 (en) | 2014-04-15 | 2020-07-14 | The Brigham And Women's Hospital, Inc. | Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney |
| CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| EP3736570A1 (en) | 2019-05-09 | 2020-11-11 | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Method for the diagnosis, sub-classification and prognosis of acute kidney injury by detecting cct7 |
| CN112076309A (zh) * | 2020-07-27 | 2020-12-15 | 南通大学 | 一种环状促红素衍生肽在肾损伤和环孢素a损伤保护中的应用 |
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| CN113083264A (zh) * | 2021-04-16 | 2021-07-09 | 郑州大学 | 二氧化硅-金属有机骨架核壳型复合材料及其在硫醇小分子检测方面的应用 |
| DE102023135015B3 (de) | 2023-12-13 | 2025-05-15 | Philipps-Universität Marburg, Körperschaft des öffentlichen Rechts | Diagnose und Verlaufskontrolle der akuten Nierenschädigung |
| SE2430014A1 (en) * | 2024-01-18 | 2025-05-27 | P & M Venge Ab | Urinary biomarker of kidney function |
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